Exploring RNA modifications in infectious non-coding circular RNAs.

Viroids, small circular non-coding RNAs, act as infectious pathogens in higher plants, demonstrating high stability despite consisting solely of naked RNA. Their dependence of replication on host machinery poses the question of whether RNA modifications play a role in viroid biology. Here, we explore RNA modifications in the avocado sunblotch viroid (ASBVd) and the citrus exocortis viroid (CEVd), representative members of viroids replicating in chloroplasts and the nucleus, respectively, using LC - MS and Oxford Nanopore Technology (ONT) direct RNA sequencing.

[Rheumatology: what's new in 2024].

In 2024, CD19-CAR T cells are ubiquitous in rheumatology, with incredible therapeutic results in cases of severe and refractory disease. This major advance confirms the interest of the B lymphocyte as a therapeutic target, and also suggests the real possibility of a drug-free remission, at the price of minor and minimal side effects for the time being. However, the necessary perspective is still lacking for a therapy that remains out of reach because of its price.

[Pediatrics. Diagnosis of generalized joint hypermobility in children].

Joint hypermobility is a common feature in children and adolescents, often physiological and benign, but it is also a manifestation of hereditary connective tissue disorders. In pediatrics, there is a real need to differentiate Ehlers-Danlos syndrome (EDS) hypermobile type (hEDS) from benign hypermobility, in the absence of a genetic marker specific to this form of EDS. In 2023, the International Ehlers-Danlos Consortium revised the diagnostic criteria for children and adolescents, introducing the concept of hypermobility spectrum disorder.

[Nutrition-obesity. New therapeutic education programme for migrant and allophone people living with obesity].

Migrant and allophone people often face linguistic, cultural and structural barriers, with limited access to healthcare. To address this issue, the Therapeutic Patient Education Unit has created at the University Hospitals of Geneva a new therapeutic programme specifically for these people living with obesity. It includes educational workshops tailored to their language skills, health literacy and migratory background.

[Cardiology. Heart failure, cardiac imaging, congenital heart diseases, and cardio-oncology].

The year 2024 has seen significant progress in the management of heart failure. New treatments have demonstrated their efficacy, particularly for heart failure with preserved ejection fraction, cardiac amyloidosis, and hypertrophic cardiomyopathy. Advances in imaging, such as MRI and PET-CT, highlight the growing integration of innovative technologies and artificial intelligence in cardiology for diagnosing complex cardiovascular diseases.

[Addiction : what's new in 2024].

Addiction medicine is confronting challenges brought about by changes in our modern world, including shifts in the drug market and the increasing digitalization of our environments. This article highlights some of these challenges and explores potential strategies to address them. The field is also advancing through robust research momentum in psychedelic-assisted psychotherapy.

[Physical activity and mental health : the role of psychiatric supervision].

Regular physical activity plays a crucial role in the prevention of chronic disease and the management of mental health disorders. Its integration into the care of individuals with mental health issues is fully justified, with clear benefits to involving trained physical activity professionals. The complexity associated with behavior change processes and the diversity of individuals' situations require specific skills that can be enhanced by the supervision of a psychiatrist.

[Perspectives in internal medicine].

Through the analysis of notable studies from 2024, this article offers an overview of key advances in internal medicine with a selection of essential themes. The topics covered include advances in common internal medicine conditions such as cardiovascular diseases, pulmonary disorders, antibiotic use, and fever of unknown origin. This article provides a practical summary to help clinicians stay informed about the latest diagnostic and therapeutic developments.

[Updates in promotion of health and prevention in the context of the Geneva landscape].

This article presents the latest recommendations for the promotion of health and prevention. This article is primarily addressed to public health actors and stakeholders. The recommendations are contextualized to the local reality, based on Geneva-specific data from the longitudinal Specchio studywhich evaluates the health status of the Geneva population and its determinants.

[The year 2024 placed in perspective by hospital internists].

This article presents a selection of ten key topics, carefully analyzed and commented on by chief residents at the Department of Internal Medicine at CHUV. This curated selection highlights the major advances and essential reminders in internal medicine for 2024. By reviewing this year's leading publications, it sheds light on progress in diagnostic and therapeutic approaches, both for hospitalized patients and the continuity of care in outpatient settings.

[2024 scientific breakthroughs in ambulatory general internal medicine].

In this article, we present eight studies published in the past two years that are likely to influence general practice in 2025. The key messages highlight the importance of physical activity in reducing cardiovascular risk, the effectiveness of aripiprazole for treatment-resistant depression, and the positive impact of guidelines on antibiotic use for acute cystitis. Furthermore, teleconsultation is more effective when supported by a pre-existing therapeutic relationship, extended leave reduces physician burnout, electronic cigarettes aid smoking cessation, and AI improves the management of electronic communications.

Unravelling phylogenetic relationships within the genus Lispe (Diptera: Muscidae) through genome-assisted and de novo analyses of RAD-seq data.

Lispe represents a species-rich genus within the family Muscidae. The current subdivision of Lispe species into species groups is based mainly on adult morphology and ecology, with the only available phylogenetic study based on three molecular markers. Nonetheless, certain species groups remain unclear and the relationships and composition of these groups are still unresolved.

BSN Learning Pathways: A Leadership Collaboration to Prepare and Retain New Nurses in Specialized Practice Areas.

Current nursing shortages, particularly in complex practice or specialty areas, coupled with high attrition rates of both seasoned and new graduate nurses, have required nursing leaders to consider creative approaches to recruit, prepare and retain nurses in specialty areas. This article describes a collaborative partnership between post-secondary institutions and health authorities in one province to address the need to prepare and retain nurses in high-priority specialized areas, such as the intensive care unit or the emergency department. This partnership allows for a proactive connection that leverages the strengths and resources of both healthcare and educational institutions.

From Federal Policy to Bedside Care: A Canadian Perspective on Key Considerations for Nurse Executive Action for AI Adoption - A Commentary.

The integration of artificial intelligence (AI) into healthcare represents a paradigm shift with the potential to enhance patient care and streamline clinical operations. This commentary explores the Canadian perspective on key organizational considerations for nurse executives, emphasizing the critical role they play in fostering the establishment of AI governance structures and advancing the front-line adoption of AI in nursing practice. The discussion delves into five domains of consideration, analyzing recent developments and implications for nursing executives.

Commentary: Understanding and Disrupting Whiteness in Nursing.

for the opportunity to provide a commentary on the article, How Whiteness Shapes Nursing in Canada - What Does the Literature Say? A Rapid Review (Walker et al. 2025). I want to begin by congratulating the authors on completing a rapid review on a very important topic.

How Whiteness Shapes Nursing in Canada - What Does the Literature Say? A Rapid Review.

Globally and nationally, there has been growing understanding and acknowledgment of systemic racism and its impact as a structural determinant of health. The profession of nursing has an obligation to carefully self-examine so it does not further contribute to systemic racism. Using the National Collaborating Centre for Methods and Tools' rapid review methodology, this rapid review of the literature seeks to understand how whiteness shapes the Canadian nursing profession.

Organizational Initiatives for the Recruitment, Retention and Advancement of Black Nurses: A Rapid Review.

Introduction: Black nurses are under-represented in the Canadian nursing workforce. A legacy of discrimination and systemic barriers reinforce the under-representation of Black nurses in the nursing workforce throughout the health system.

Objective: The objective of this study was to identify and describe organizational initiatives for the recruitment, retention and advancement of Black nurses in the healthcare system.

Grounded in the Present and Anticipating the Future.

and along with it, the first issue of the () for the year 2025. We begin the year with significant and persistent health and healthcare challenges. Recently released data from the Canadian Institute for Health Information indicate that 5.

High-Throughput Oxford Nanopore Sequencing Unveils Complex Viral Population in Kansas Wheat: Implications for Sustainable Virus Management.

Wheat viruses are major yield-reducing factors, with mixed infections causing substantial economic losses. Determining field virus populations is crucial for effective management and developing virus-resistant cultivars. This study utilized the high-throughput Oxford Nanopore sequencing technique (ONT) to characterize wheat viral populations in major wheat-growing counties of Kansas from 2019 to 2021.