25,125 results match your criteria: "Ont.; Institute of Labour Economics Kantarevic[Affiliation]"

Cannabis is the most used drug worldwide with an estimated 219 million users. This narrative review aims to explore the adverse effects and therapeutic applications of cannabis and cannabinoids on the eye, given its growing clinical and non-clinical uses. The current literature reports several adverse ocular effects of cannabis and cannabinoids, including eyelid tremor, ptosis, reduced corneal endothelial cell density, dry eyes, red eyes, and neuro-retinal dysfunction.

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Article Synopsis
  • This study examined how mothers in Kween District viewed their experiences with male midwives (MMWs) during childbirth, using a qualitative approach to gather insights.
  • Data was collected from 33 mothers through in-depth interviews and focus group discussions at three health facilities, focusing on their feelings and perceptions regarding MMWs.
  • Participants expressed mixed feelings, with some discomfort around male caregivers in an intimate process, but many appreciated the supportive and respectful care provided by MMWs, highlighting the need for awareness campaigns to promote skilled birth attendance regardless of gender.
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Linear morphea: a persistent bruise on the temple of a 9-year-old boy.

CMAJ

December 2024

Division of Dermatology, Department of Medicine (DeBiasio, Gavigan), The Ottawa Hospital; Faculty of Medicine (DeBiasio) and Department of Pathology and Laboratory Medicine (Nizalik), University of Ottawa; Divisions of Anatomical Pathology (Nizalik) and Dermatology (Gavigan), Children's Hospital of Eastern Ontario, Ottawa, Ont.

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[Not Available].

CMAJ

December 2024

Temerty Faculty of Medicine (Murray, Cagliero, Kiebalo, Engelhart), University of Toronto; division de médecine générale interne (Engelhart), département de médecine, Mount Sinai Hospital, Toronto, Ont.

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Post-tonsillectomy hemorrhage in children.

CMAJ

December 2024

Department of Otolaryngology - Head and Neck Surgery, Hospital for Sick Children, University of Toronto, Toronto, Ont.

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[Not Available].

CMAJ

December 2024

Département de santé communautaire et d'épidémiologie, Collège de médecine (Rani, Hasselback), University of Saskatchewan; Saskatchewan Health Authority (Rani, Hasselback), Idylwyld Centre, Saskatoon, Sask.; École de sciences infirmières, Faculté des sciences de la santé (Coletto), Université d'Ottawa, Ottawa, Ont.

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Prognostic importance of extensive coronary calcium on lung cancer screening chest computed tomography.

CMAJ

December 2024

Medicine Division of Cardiology, (Cabral Caires, Mbondo Kasuku, Mengesha, Paterson, Chen, Chow, Small), University of Ottawa Heart Institute; Department of Cardiology (Garuba, Law, Johnson), The Ottawa Hospital; Department of Radiology (Dennie, Pena), University of Ottawa, Ottawa, Ont.

Article Synopsis
  • Low-dose chest CT, commonly used for lung cancer screening, also detects coronary artery disease by identifying coronary artery calcium.
  • In a study of 1486 high-risk lung cancer patients, 82.9% had coronary artery calcium, with 29.5% showing extensive levels.
  • Extensive coronary artery calcium significantly predicted higher risks of all-cause death and cardiovascular events, highlighting the potential benefits of lung cancer screenings for detecting heart health issues.
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Visible-Light-Stimulated Optoelectronic Neuromorphic Transistor Based on Indium-Gallium-Zinc Oxide via BiTe Light Absorption Layer.

ACS Appl Mater Interfaces

December 2024

School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.

To emulate a visual perception system, a bismuth telluride (BiTe)/indium-gallium-zinc oxide (IGZO) heterostructure is introduced for optoelectronic neuromorphic transistors (ONTs). Amorphous IGZO is applied as a channel layer to exhibit low off-current, high mobility, and persistent photoconductivity, enabling light-stimulated neuromorphic characteristics. The atomic ratio of In/Ga/Zn was 9.

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The implementation of Hi-C reads in the genome assembly process allows the ordering of large regions of the genome in scaffolds and the generation of chromosome-level assemblies. Several bioinformatics tools have been developed for genome scaffolding with Hi-C, and each tool has advantages and disadvantages that need to be carefully evaluated before their adoption. We generated two assemblies of obtained from the same raw PacBio HiFi and Oxford Nanopore Technologies data.

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  • The 2022 mpox outbreak in Belgium involved extensive genomic analysis, revealing 248 complete monkeypox virus genomes related to the MPXV Clade IIb B.1.
  • Researchers identified at least 79 introduction events of the virus into Belgium, but local transmission remained limited.
  • Tecovirimat showed the strongest in vitro effectiveness against the 2022 MPXV strain, indicating its potential as a treatment option.
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  • * Current cfDNA methods face challenges like fragment interruption and GC bias, which could be addressed with emerging technology from Oxford Nanopore Technologies (ONT) that offers long reads and rapid processing.
  • * The review highlights the potential of cfDNA liquid biopsies using ONT for cancer management, suggesting its effectiveness for early screening, diagnosis, and treatment monitoring through multimodal biomarker detection.
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The biological relevance and dynamics of mRNA modifications have been extensively studied; however, whether rRNA modifications are dynamically regulated, and under which conditions, remains unclear. Here, we systematically characterize bacterial rRNA modifications upon exposure to diverse antibiotics using native RNA nanopore sequencing. To identify significant rRNA modification changes, we develop NanoConsensus, a novel pipeline that is robust across RNA modification types, stoichiometries and coverage, with very low false positive rates, outperforming all individual algorithms tested.

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Nanopore sequencing of intact aminoacylated tRNAs.

bioRxiv

November 2024

University of Colorado School of Medicine, Department of Biochemistry and Molecular Genetics, RNA Bioscience Initiative, Aurora, Colorado.

Transfer RNAs (tRNA) are decorated during biogenesis with a variety of modifications that modulate their stability, aminoacylation, and decoding potential during translation. The complex landscape of tRNA modification presents significant analysis challenges and to date no single approach enables the simultaneous measurement of important but disparate chemical properties of individual, mature tRNA molecules. We developed a new, integrated approach to analyze the sequence, modification, and aminoacylation state of tRNA molecules in a high throughput nanopore sequencing experiment, leveraging a chemical ligation that embeds the charged amino acid in an adapted tRNA molecule.

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[Peripheral arterial disease: 2024 update].

Rev Med Suisse

November 2024

Département de médecine et centre vasculaire, Réseau hospitalier neuchâtelois, 2000 Neuchâtel.

Peripheral arterial disease (PAD) is a major public health issue, with a growing prevalence due to the aging population and the rise in risk factors such as diabetes, hypertension, and dyslipidemia. Managing PAD involves a multidisciplinary approach, with the primary care physician playing a crucial role in early screening. This article compiles the latest data from 2024 and current practices for the management of this disease.

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[Spinal cord injury at the office. Management of frequent complications].

Rev Med Suisse

November 2024

Service de paraplégie, Clinique romande de réadaptation, 1951 Sion.

Article Synopsis
  • Despite being followed by specialists, 88% of spinal cord injury patients in Switzerland still see their general practitioners within a year.
  • Common health issues for these patients include pain, spasticity, neurogenic bladder and bowel disorders, and urinary tract infections.
  • General practitioners need to understand the unique needs of spinal cord injury patients to provide effective outpatient care.
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[Urinary tract infections in adults : a guideline-based management].

Rev Med Suisse

November 2024

Service d'urologie, Département de chirurgie, Hôpitaux universitaires de Genève, 1211 Genève 14.

Urinary tract infections (UTIs) are frequent, especially in women. The increase in antibiotic resistance and changing epidemiological profiles require the recommendations to be regularly updated. This article reviews current guidelines for the management of uncomplicated and recurrent UTIs, taking into account recommendations from the European Association of Urology (EAU), the Association Française d'Urologie (AFU) and the American Association of Urology (AUA).

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The treatment of upper urinary tract stones is one of the main urological activities. Endoscopic surgical techniques, namely semirigid or flexible ureteroscopy (URS) and percutaneous nephrolithotomy (PCNL), represent a major therapeutic modality, alternatively to chemolysis, extracorporeal shock wave lithotripsy and open, laparoscopic or robotic-assisted surgery. In this article, the specificities of these endoscopic techniques, their clinical performances, as well as their development following recent technological advances are discussed.

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  • - Testicular cancer, though a rare adult cancer, is rising in incidence and primarily consists of germ cell tumors, subdivided into seminomas and non-seminomas, with notable risk factors such as cryptorchidism and family history.
  • - Diagnosis involves a detailed clinical evaluation, imaging studies, and tumor markers, while orchidectomy (surgical removal of the testicle) is the standard treatment, often followed by chemotherapy to prevent recurrence.
  • - Education on testicular self-examination and fertility preservation options pre-surgery is crucial, along with ongoing multidisciplinary follow-up to enhance treatment outcomes and patients' quality of life.
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Small renal masses (SRMs), which are tumors less than 4 cm in diameter, are increasingly discovered incidentally due to the rise in diagnostic imaging. Although many of these masses are benign, managing SRMs remains challenging. Active surveillance (AS) offers a viable alternative to surgery, particularly for patients with high surgical risks or limited life expectancy.

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Penile cancer is a rare but serious disease, with major consequences for patients' quality of life. Although it accounts for less than 1 % of male cancers in the Western world, its incidence is higher in certain regions of the world. His staging, particularly the evaluation of lymph nodes according to the TNM system, is crucial in determining prognosis and guiding treatment.

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Urological cancers are substantial burden for public health worldwide, due to their considerable incidence, morbidity and mortality. The cornerstone of an effective disease management is an appropriate diagnostic strategy and early detection. Based on the data from the population-based Geneva cancer registry, this article aimed to report epidemiological trends in urological cancers in Geneva from the last 26 years.

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Hybrid sequencing for detailed genetic characterization of human adenoviruses.

Sci Rep

November 2024

GeneMind Biosciences Company Limited, Shenzhen, 518001, China.

Human adenoviruses (HAdVs) are highly contagious and have significant clinical implications in the pediatric population. In the present study, we employed a combination of long-read sequencing and short-read sequencing to accurately reconstruct 32 genomes of HAdVs. The phylogenetic analyses based on the whole genome and genes revealed distinct sub-clusters within HAdV-B and -E.

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During a bacterial infection or colonization, the detection of antimicrobial resistance (AMR) is critical, but slow due to culture-based approaches for clinical and screening samples. Culture-based phenotypic AMR detection and confirmation require up to 72 hours (h) or even weeks for slow-growing bacteria. Direct shotgun metagenomics by long-read sequencing using Oxford Nanopore Technologies (ONT) may reduce the time for bacterial species and AMR gene identification.

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Full-length transcriptome sequencing of the longissimus dorsi muscle of yak and cattle-yak using nanopore technology.

Int J Biol Macromol

January 2025

Key Laboratory of Yak Breeding in Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China; Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou 730050, China. Electronic address:

Article Synopsis
  • Short-read RNA sequencing previously used for yak and cattle-yak only provided partial transcript data, lacking full-length transcripts and alternative splicing events.
  • Oxford Nanopore Technologies (ONT) was employed for full-length sequencing, leading to the discovery of 20,323 novel genes and 172,870 novel transcripts, along with significant findings related to alternative splicing and muscle development.
  • The study revealed potential links between specific differentially expressed transcripts and muscle growth, particularly highlighting TNNI2's role in differences in meat quality between yak and cattle-yak, ultimately supporting enhanced yak meat production.
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The T2T Genome of the Domesticated Silkworm .

Int J Mol Sci

November 2024

Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City, Biological Science Research Center, Southwest University, Chongqing 400715, China.

Genome sequences contain the fundamental genetic information that largely determines the biology of a species. Over the past 20 years, advancements in high-throughput sequencing technologies and bioinformatics tools have matured, facilitating genome assembly and ushering in the telomere-to-telomere (T2T) era. is renowned as a silk-producing insect and serves as an important model organism extensively studied across various fields of biology.

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