25,125 results match your criteria: "Ont.; Institute of Labour Economics Kantarevic[Affiliation]"
Clin Ophthalmol
November 2024
Department of Ophthalmology, Stanford University School of Medicine, Stanford, CA, USA.
Cannabis is the most used drug worldwide with an estimated 219 million users. This narrative review aims to explore the adverse effects and therapeutic applications of cannabis and cannabinoids on the eye, given its growing clinical and non-clinical uses. The current literature reports several adverse ocular effects of cannabis and cannabinoids, including eyelid tremor, ptosis, reduced corneal endothelial cell density, dry eyes, red eyes, and neuro-retinal dysfunction.
View Article and Find Full Text PDFCMAJ
December 2024
Division of Dermatology, Department of Medicine (DeBiasio, Gavigan), The Ottawa Hospital; Faculty of Medicine (DeBiasio) and Department of Pathology and Laboratory Medicine (Nizalik), University of Ottawa; Divisions of Anatomical Pathology (Nizalik) and Dermatology (Gavigan), Children's Hospital of Eastern Ontario, Ottawa, Ont.
CMAJ
December 2024
Temerty Faculty of Medicine (Murray, Cagliero, Kiebalo, Engelhart), University of Toronto; division de médecine générale interne (Engelhart), département de médecine, Mount Sinai Hospital, Toronto, Ont.
CMAJ
December 2024
Department of Otolaryngology - Head and Neck Surgery, Hospital for Sick Children, University of Toronto, Toronto, Ont.
CMAJ
December 2024
Département de santé communautaire et d'épidémiologie, Collège de médecine (Rani, Hasselback), University of Saskatchewan; Saskatchewan Health Authority (Rani, Hasselback), Idylwyld Centre, Saskatoon, Sask.; École de sciences infirmières, Faculté des sciences de la santé (Coletto), Université d'Ottawa, Ottawa, Ont.
CMAJ
December 2024
Medicine Division of Cardiology, (Cabral Caires, Mbondo Kasuku, Mengesha, Paterson, Chen, Chow, Small), University of Ottawa Heart Institute; Department of Cardiology (Garuba, Law, Johnson), The Ottawa Hospital; Department of Radiology (Dennie, Pena), University of Ottawa, Ottawa, Ont.
ACS Appl Mater Interfaces
December 2024
School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
To emulate a visual perception system, a bismuth telluride (BiTe)/indium-gallium-zinc oxide (IGZO) heterostructure is introduced for optoelectronic neuromorphic transistors (ONTs). Amorphous IGZO is applied as a channel layer to exhibit low off-current, high mobility, and persistent photoconductivity, enabling light-stimulated neuromorphic characteristics. The atomic ratio of In/Ga/Zn was 9.
View Article and Find Full Text PDFFront Bioinform
November 2024
Department of Agricultural Sciences, University of Sassari, Sassari, Sardinia, Italy.
The implementation of Hi-C reads in the genome assembly process allows the ordering of large regions of the genome in scaffolds and the generation of chromosome-level assemblies. Several bioinformatics tools have been developed for genome scaffolding with Hi-C, and each tool has advantages and disadvantages that need to be carefully evaluated before their adoption. We generated two assemblies of obtained from the same raw PacBio HiFi and Oxford Nanopore Technologies data.
View Article and Find Full Text PDFEBioMedicine
December 2024
Department of Microbiology, Immunology and Transplantation, KU Leuven, Rega Institute, Laboratory of Clinical and Epidemiological Virology, 3000, Leuven, Belgium. Electronic address:
Mol Cancer
November 2024
Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Nat Commun
November 2024
Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
The biological relevance and dynamics of mRNA modifications have been extensively studied; however, whether rRNA modifications are dynamically regulated, and under which conditions, remains unclear. Here, we systematically characterize bacterial rRNA modifications upon exposure to diverse antibiotics using native RNA nanopore sequencing. To identify significant rRNA modification changes, we develop NanoConsensus, a novel pipeline that is robust across RNA modification types, stoichiometries and coverage, with very low false positive rates, outperforming all individual algorithms tested.
View Article and Find Full Text PDFbioRxiv
November 2024
University of Colorado School of Medicine, Department of Biochemistry and Molecular Genetics, RNA Bioscience Initiative, Aurora, Colorado.
Transfer RNAs (tRNA) are decorated during biogenesis with a variety of modifications that modulate their stability, aminoacylation, and decoding potential during translation. The complex landscape of tRNA modification presents significant analysis challenges and to date no single approach enables the simultaneous measurement of important but disparate chemical properties of individual, mature tRNA molecules. We developed a new, integrated approach to analyze the sequence, modification, and aminoacylation state of tRNA molecules in a high throughput nanopore sequencing experiment, leveraging a chemical ligation that embeds the charged amino acid in an adapted tRNA molecule.
View Article and Find Full Text PDFRev Med Suisse
November 2024
Département de médecine et centre vasculaire, Réseau hospitalier neuchâtelois, 2000 Neuchâtel.
Peripheral arterial disease (PAD) is a major public health issue, with a growing prevalence due to the aging population and the rise in risk factors such as diabetes, hypertension, and dyslipidemia. Managing PAD involves a multidisciplinary approach, with the primary care physician playing a crucial role in early screening. This article compiles the latest data from 2024 and current practices for the management of this disease.
View Article and Find Full Text PDFRev Med Suisse
November 2024
Service de paraplégie, Clinique romande de réadaptation, 1951 Sion.
Rev Med Suisse
November 2024
Service d'urologie, Département de chirurgie, Hôpitaux universitaires de Genève, 1211 Genève 14.
Urinary tract infections (UTIs) are frequent, especially in women. The increase in antibiotic resistance and changing epidemiological profiles require the recommendations to be regularly updated. This article reviews current guidelines for the management of uncomplicated and recurrent UTIs, taking into account recommendations from the European Association of Urology (EAU), the Association Française d'Urologie (AFU) and the American Association of Urology (AUA).
View Article and Find Full Text PDFRev Med Suisse
November 2024
Service d'urologie, Département de chirurgie, Hôpitaux universitaires de Genève, 1211 Genève 14.
The treatment of upper urinary tract stones is one of the main urological activities. Endoscopic surgical techniques, namely semirigid or flexible ureteroscopy (URS) and percutaneous nephrolithotomy (PCNL), represent a major therapeutic modality, alternatively to chemolysis, extracorporeal shock wave lithotripsy and open, laparoscopic or robotic-assisted surgery. In this article, the specificities of these endoscopic techniques, their clinical performances, as well as their development following recent technological advances are discussed.
View Article and Find Full Text PDFRev Med Suisse
November 2024
Service d'urologie, Centre hospitalier universitaire vaudois, 1011 Lausanne.
Rev Med Suisse
November 2024
Service d'urologie, Département de chirurgie, Centre hospitalier universitaire vaudois, 1011 Lausanne.
Small renal masses (SRMs), which are tumors less than 4 cm in diameter, are increasingly discovered incidentally due to the rise in diagnostic imaging. Although many of these masses are benign, managing SRMs remains challenging. Active surveillance (AS) offers a viable alternative to surgery, particularly for patients with high surgical risks or limited life expectancy.
View Article and Find Full Text PDFRev Med Suisse
November 2024
Service d'urologie, Département de chirurgie, Centre hospitalier universitaire vaudois, 1011 Lausanne.
Penile cancer is a rare but serious disease, with major consequences for patients' quality of life. Although it accounts for less than 1 % of male cancers in the Western world, its incidence is higher in certain regions of the world. His staging, particularly the evaluation of lymph nodes according to the TNM system, is crucial in determining prognosis and guiding treatment.
View Article and Find Full Text PDFRev Med Suisse
November 2024
Service d'urologie, Département de chirurgie, Hôpitaux universitaires de Genève, 1211 Genève 14.
Urological cancers are substantial burden for public health worldwide, due to their considerable incidence, morbidity and mortality. The cornerstone of an effective disease management is an appropriate diagnostic strategy and early detection. Based on the data from the population-based Geneva cancer registry, this article aimed to report epidemiological trends in urological cancers in Geneva from the last 26 years.
View Article and Find Full Text PDFSci Rep
November 2024
GeneMind Biosciences Company Limited, Shenzhen, 518001, China.
Human adenoviruses (HAdVs) are highly contagious and have significant clinical implications in the pediatric population. In the present study, we employed a combination of long-read sequencing and short-read sequencing to accurately reconstruct 32 genomes of HAdVs. The phylogenetic analyses based on the whole genome and genes revealed distinct sub-clusters within HAdV-B and -E.
View Article and Find Full Text PDFSci Rep
November 2024
Institute of Medical Microbiology, University of Zurich, Gloriastrasse 30, Zurich, 8006, Switzerland.
During a bacterial infection or colonization, the detection of antimicrobial resistance (AMR) is critical, but slow due to culture-based approaches for clinical and screening samples. Culture-based phenotypic AMR detection and confirmation require up to 72 hours (h) or even weeks for slow-growing bacteria. Direct shotgun metagenomics by long-read sequencing using Oxford Nanopore Technologies (ONT) may reduce the time for bacterial species and AMR gene identification.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Key Laboratory of Yak Breeding in Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China; Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou 730050, China. Electronic address:
Int J Mol Sci
November 2024
Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City, Biological Science Research Center, Southwest University, Chongqing 400715, China.
Genome sequences contain the fundamental genetic information that largely determines the biology of a species. Over the past 20 years, advancements in high-throughput sequencing technologies and bioinformatics tools have matured, facilitating genome assembly and ushering in the telomere-to-telomere (T2T) era. is renowned as a silk-producing insect and serves as an important model organism extensively studied across various fields of biology.
View Article and Find Full Text PDF