[Abnormal uterine bleeding and hemostasis disorders].

Abnormal uterine bleeding (AUB) are common in adolescents and young adults. They may be secondary to inherited bleeding disorders such as von Willebrand disease or platelet function disorders. These conditions are often under-recognized, leading to diagnostic delays and inadequate management.

[Deep vein thrombosis of the lower limb : from diagnosis to treatment].

When a deep vein thrombosis (DVT) is suspected, management should begin with a well-defined diagnostic approach based on clinical evaluation and pre-test probability, D-dimer testing, and venous ultrasound. Once the diagnosis is confirmed, it is important to differentiate between proximal and distal DVT, as their treatment strategies differs. While numerous robust studies with a high level of evidence are available for proximal DVT, the optimal management of distal DVT remains debated.

Clinical Applicability of 2-Field High-Resolution and Extended HLA-Allele Typing in Deceased Donor Kidney Allocation.

HLA-compatibility remains an important triage test for deceased donor kidney allocation. Low-intermediate resolution donor HLA-typing is typically available at allocation, but its accuracy in assigning pre-transplant donor-specific anti-HLA antibody (DSA) and HLA mismatches compared to 2-field high-resolution typing is poorly characterised. Consecutive deceased donor/recipient pairs from a single centre between 2016 and 2020 were included.

Adverse Ocular Impact and Emerging Therapeutic Potential of Cannabis and Cannabinoids: A Narrative Review.

Cannabis is the most used drug worldwide with an estimated 219 million users. This narrative review aims to explore the adverse effects and therapeutic applications of cannabis and cannabinoids on the eye, given its growing clinical and non-clinical uses. The current literature reports several adverse ocular effects of cannabis and cannabinoids, including eyelid tremor, ptosis, reduced corneal endothelial cell density, dry eyes, red eyes, and neuro-retinal dysfunction.

Visible-Light-Stimulated Optoelectronic Neuromorphic Transistor Based on Indium-Gallium-Zinc Oxide via BiTe Light Absorption Layer.

To emulate a visual perception system, a bismuth telluride (BiTe)/indium-gallium-zinc oxide (IGZO) heterostructure is introduced for optoelectronic neuromorphic transistors (ONTs). Amorphous IGZO is applied as a channel layer to exhibit low off-current, high mobility, and persistent photoconductivity, enabling light-stimulated neuromorphic characteristics. The atomic ratio of In/Ga/Zn was 9.

Benchmarking of Hi-C tools for scaffolding plant genomes obtained from PacBio HiFi and ONT reads.

The implementation of Hi-C reads in the genome assembly process allows the ordering of large regions of the genome in scaffolds and the generation of chromosome-level assemblies. Several bioinformatics tools have been developed for genome scaffolding with Hi-C, and each tool has advantages and disadvantages that need to be carefully evaluated before their adoption. We generated two assemblies of obtained from the same raw PacBio HiFi and Oxford Nanopore Technologies data.