Evaluation of clinical outcomes and risk factors associated with mortality in patients with Stenotrophomonas maltophilia bloodstream infection: a multicenter study.

Background: Stenotrophomonas maltophilia, a pathogen that colonizes medical equipment and causes nosocomial infections due to its ability to form biofilms, has high mortality rates. This study investigated the risk factors related to mortality in patients who were diagnosed with S. maltophilia bacteremia.

Use of the vertebrae and iliac bone as references for localizing the appendix vermiformis in computed tomography.

Background: The appendix vermiformis is a part of the gastrointestinal tract, situated in the lower right quadrant of the abdomen. Acute appendicitis, acute inflammation of the appendix vermiformis, is the most common cause of acute abdomen requiring surgical intervention. Although computed tomography (CT) offers high diagnostic efficacy in assessing the appendix across various anatomical positions, it also involves radiation exposure.

Anisotropic Dielectric Screened Range-Separated Hybrid Density Functional Theory Calculations of Charge Transfer States across an Anthracene-TCNQ Donor-Acceptor Interface.

A density functional theory framework is developed to study electronic excited states affected by an anisotropic dielectric environment. In particular, an anisotropic dielectric screened range-separated hybrid (SRSH[r]) functional is defined and combined with an anisotropic polarizable continuum model (PCM) implemented through a generalized Poisson equation solver. We develop the SRSH-PCM(r) approach and use it to quantify the effect of anisotropy on an excited charge transfer (CT) state energy.

The potential of lactoferrin as antiviral and immune-modulating agent in viral infectious diseases.

Emerging infectious diseases are caused by unpredictable viruses with the dangerous potential to trigger global pandemics. These viruses typically initiate infection by utilizing the anionic structures of host cell surface receptors to gain entry. Lactoferrin (Lf) is a multifunctional glycoprotein with multiple properties such as antiviral, anti-inflammatory and antioxidant activities.

Alterations in quality characteristics and bioactive compounds of blackberry fruits subjected to postharvest salicylic acid treatment during cold storage.

Blackberry deteriorates rapidly after harvest due to its sensitive structure, limiting their storage time to about a week and resulting in significant economic losses. The study was conducted to determine the effects of salicylic acid applications on postharvest fruit quality in blackberries, the harvested fruit was immersed in salicylic acid solutions prepared at concentrations of 0.5, 1, and 1.

Novel Dibenzoazepine-Substituted Triazole Hybrids as Cholinesterase and Carbonic Anhydrase Inhibitors and Anticancer Agents: Synthesis, Characterization, Biological Evaluation, and Studies.

The new dibenzoazepine-substituted triazole hybrids (-) were designed by molecular hybridization approach and synthesized utilizing the Cu(I)-catalyzed click reaction. The hybrid structures (-) were obtained in high yields (74-98%) with a simple two-step synthesis strategy and fully characterized. These compounds were assessed for their influence on various metabolic enzymes including human carbonic anhydrase isoenzymes (hCA I and hCA II), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).

Modulation of the ubiquitin-proteasome system by curcumin: Therapeutic implications in cancer.

By the ubiquitin-proteasomes, cellular proteins are structurally degraded and turnover. Many essential functions and regulations of cells are regulated and controlled by these proteins. Recent studies indicated that many cancer types have been associated with aberrations in the ubiquitination pathway, which involves three enzymatic steps.

Cross-cultural adaptation of the Turkish version of the dentin hypersensitivity experience questionnaire short form (DHEQ-15).

Background: The short form of the Dentin Hypersensitivity Experience Questionnaire (DHEQ-15) is a valid and reliable tool for Oral Health-Related Quality of Life (OHRQoL) studies. The aim of this study was cross-culturally adapt and validate the English version of DHEQ-15 for the Turkish language.

Methods: The Turkish version of the DHEQ-15 was developed using the forward-backward translation method.

Digital addiction: Are children in danger? Are parents aware?

Purpose: To determine the digital game addiction levels of secondary school students and to examine the parental awareness against digital game addiction levels of students.

Design And Methods: This is a descriptive and correlational study. The population of the study consisted of students in a secondary school and 392 students were included in the study.

The Relationship Between Belief in a Just World and Antisocial Behavior Through Anticipated Guilt, Victim Deservedness, and Punishment Frame.

According to the just world hypothesis, people need to believe that they deserve what they get and get what they deserve. This belief in a just world (BJW) seems to be related to antisocial behavior. However, the mechanisms that underlie this relationship have not been fully explored.

Prothrombotic state and thrombotic events in COVID-19 pandemic period, including portal vein and splenic artery thromboses.

This editorial article is intended to perform a discussion on the manuscript entitled "Simultaneous portal vein thrombosis and splenic vein thrombosis in a COVID-19 patient: A case report and review of literature" written by Abramowitz . The article focuses on the diagnostic processes in a 77-year-old-male patient with a simultaneous portal vein and splenic artery thrombosis accompanying coronavirus disease 2019 (COVID-19). The authors postulated that splanchnic thrombosis should be on the list of differential diagnoses in a patient presenting with abdominal pain in presence of a COVID-19 infection.

Turkish Society of Gastroenterology: Pancreas Working Group, Acute Pancreatitis Committee Consensus Report.

Acute pancreatitis (AP) is a clinical condition that arises acutely in the pancreas through various inflammatory pathways due to multiple causes. Turkish Society of Gastroenterology Pancreas Working Group developed comprehensive guidance statements regarding the management of AP that include its epidemiology, etiology, clinical presentation, diagnostic criteria, disease severity, treatment, prognosis, local and systemic complications. The statements were developed through literature review, deliberation, and consensus opinion.

Evaluation of the Antimicrobial Effects of Olive Mill Wastewater Extract Against Food Spoiling/Poisoning, Fish-Pathogenic and Non-Pathogenic Microorganisms.

Although antibiotics are the main therapy for bacterial infections, the reports showed that the overuse (or misuse) of antibiotics will results in several problems such as the development of antibiotic-resistant strains, persistence of drug residues, and numerous environmental concerns. Therefore, finding antibiotic alternatives is considered of vital importance. Investigation of the antimicrobial properties of several plant substances and extracts is of great value to replace antibiotics.

Gallic Acid Induces HeLa Cell Lines Apoptosis via the P53/Bax Signaling Pathway.

Background: Cervical cancer is a type of cancer that originates from the endometrium and is more common in developed countries and its incidence is increasing day by day in developing countries. The most commonly prescribed chemotherapeutic drugs limit their use due to serious side effects and the development of drug resistance. For this reason, interest in new active ingredients obtained from natural products is increasing.

Antipathogenic Activity of Betainized Polyethyleneimine Sprays Without Toxicity.

: The design of alternative antipathogenic sprays has recently attracted much attention due to the limitations of existing formulations, such as toxicity and low and narrow efficacy. Polyethyleneimine (PEI) is a great antimicrobial polymer against a wide range of pathogens, but toxicity limits its use. Here, betainized PEI (B-PEI) was synthesized to decrease the toxicity of PEI and protonated with citric acid (CA), boric acid (BA), and HCl to improve antimicrobial activity.

Updated Review of Metal Nanoparticles Fabricated by Green Chemistry Using Natural Extracts: Biosynthesis, Mechanisms, and Applications.

Metallic nanoparticles have found wide applications due to their unique physical and chemical properties. Green biosynthesis using plants, microbes, and plant/microbial extracts provides an environmentally friendly approach for nanoparticle synthesis. This review discusses the mechanisms and factors governing the biosynthesis of metallic nanoparticles such as silver, gold, and zinc using various plant extracts and microorganisms, including bacteria, fungi, and algae.

Determination of the relationship between competencies in disaster nursing management and perceived stress: The intermediary role of resilience.

Background: Türkiye encounters various natural disasters, foremost earthquakes, and, nurses' resilience, ability to cope with stress and disaster competence play a significant role in disasters.

Objective: The objective of this study is to establish the intermediary role of resilience in the relation between nurses' competencies in disaster management and perceived stress.

Method: The sampling of this descriptive and cross-sectional study included 240 nurses from across Türkiye.

Gold Nanoparticles in Nanomedicine: Unique Properties and Therapeutic Potential.

Gold nanoparticles (NPs) have demonstrated significance in several important fields, including drug delivery and anticancer research, due to their unique properties. Gold NPs possess significant optical characteristics that enhance their application in biosensor development for diagnosis, in photothermal and photodynamic therapies for anticancer treatment, and in targeted drug delivery and bioimaging. The broad surface modification possibilities of gold NPs have been utilized in the delivery of various molecules, including nucleic acids, drugs, and proteins.

Gold Nanoparticles: Multifunctional Properties, Synthesis, and Future Prospects.

Gold nanoparticles (NPs) are among the most commonly employed metal NPs in biological applications, with distinctive physicochemical features. Their extraordinary optical properties, stemming from strong localized surface plasmon resonance (LSPR), contribute to the development of novel approaches in the areas of bioimaging, biosensing, and cancer research, especially for photothermal and photodynamic therapy. The ease of functionalization with various ligands provides a novel approach to the precise delivery of these molecules to targeted areas.

Cognitive performance, psychiatric comorbidities, and quality of life in pediatric patients with juvenile idiopathic arthritis: a comparative analysis with healthy controls.

This study aimed to assess the extent of cognitive impairment in children and adolescents with Juvenile Idiopathic Arthritis (JIA). While cognitive deficits are recognized in other systemic rheumatic diseases, exploration within the pediatric JIA population remains limited. The investigation utilized a comprehensive approach to examine neuropsychological test performance.

Breastfeeding and secretory factors in idiopathic granulomatous mastitis: Unveiling etiological insights.

Background: Idiopathic granulomatous mastitis (IGM) is a rare, chronic inflammatory, and benign breast disease. Its unclear etiology may involve autoimmune reactions, secretion-related factors, and microorganisms.

Aim: To analyze data from our IGM patient series and compare potential etiological factors.

The role of mineralogical and textural complexity in the damage evolution of brittle rocks.

In brittle rocks, deformation is characterized by the initiation and propagation of cracks at both microscale and mesoscale levels. This study explores how rock texture influences the evolution of cracking networks and progressive rock damage results under uniaxial compression. 3D discrete analyses were employed to identify the critical stresses of three different rock types.