980 results match your criteria: "One Medical Center Drive[Affiliation]"
Co-crystal structure of Helicobacter pylori biotin protein ligase with biotinyl-5-ATP.
Acta Crystallogr F Struct Biol Commun
January 2025
Dartmouth Cancer Center, One Medical Center Drive, Lebanon, NH 03756, USA.
Helicobacter pylori, a type 1 carcinogen that causes human gastric ulcers and cancer, is a priority target of the Seattle Structural Genomics Center for Infectious Disease (SSGCID). These efforts include determining the structures of potential H. pylori therapeutic targets.
View Article and Find Full Text PDFStructure of Plasmodium vivaxN-myristoyltransferase with inhibitor IMP-1088: exploring an NMT inhibitor for antimalarial therapy.
Acta Crystallogr F Struct Biol Commun
January 2025
Chemistry and Biochemistry Department, Hampton University, 200 William R. Harvey Way, Hampton, VA 23668, USA.
Plasmodium vivax, a significant contributor to global malaria cases, poses an escalating health burden on a substantial portion of the world's population. The increasing spread of P. vivax because of climate change underscores the development of new and rational drug-discovery approaches.
View Article and Find Full Text PDFExtensive epigenomic dysregulation is a hallmark of homologous recombination deficiency in triple-negative breast cancer.
Int J Cancer
December 2024
Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College, One Medical Center Drive, Lebanon, New Hampshire, USA.
Article Synopsis
- Triple-negative breast cancer (TNBC) is a highly aggressive subtype with varied characteristics, limited treatment choices, and poor clinical outcomes, particularly when associated with homologous recombination deficiency (HRD).
- The study analyzed TNBC tumors from two groups (n=32 and n=58), revealing significant differences in genome-wide copy number and methylation alterations linked to HRD, including lower methylation in specific genomic regions.
- Findings indicate that HRD in TNBC is associated with key biological pathways, and using machine learning can aid in classifying tumors based on HRD and methylation patterns, offering potential for improved treatment strategies.
Implementation of a Trauma-Informed Care Approach in a Gastroenterology Setting.
Dig Dis Sci
November 2024
Department of Psychiatry, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH, USA.
Article Synopsis
- Many individuals in healthcare settings, particularly those with gastrointestinal (GI) issues, have histories of trauma that can affect their health and interactions with medical professionals.* -
- The study aimed to improve understanding of trauma's impact on GI patients and to develop effective strategies for healthcare providers to respond to trauma-related distress.* -
- Innovative programs were created to help healthcare personnel recognize trauma effects, respond appropriately during patient interactions, and ultimately enhance the overall healthcare experience for GI patients.*
Structures of Trichomonas vaginalis macrophage migratory inhibitory factor.
Acta Crystallogr F Struct Biol Commun
December 2024
Department of Biology, University of Fribourg, Chemin du Musée 10, 1700 Fribourg, Switzerland.
Article Synopsis
- Trichomonas vaginalis is a one-celled parasite that causes trichomoniasis, the most common nonviral STD worldwide, and it uses mimicry of human proteins to evade the immune system.
- The parasite produces a protein called TvMIF, which helps it survive stress, boosts prostate cell growth, and triggers inflammation, paralleling the effects of human MIF.
- Recent studies have revealed the structure of TvMIF, showing it has a similar shape to human versions, suggesting that understanding this protein can aid in developing new drugs.
Crystal structure of glutamyl-tRNA synthetase from Helicobacter pylori.
Acta Crystallogr F Struct Biol Commun
December 2024
Dartmouth Cancer Center, One Medical Center Drive, Lebanon, NH 03756, USA.
Article Synopsis
- * There is a growing need for alternative treatments due to drug resistance in H. pylori, leading to research at the Seattle Structural Genomics Center for Infectious Disease (SSGCID) into potential drug targets, specifically Glutamyl-tRNA synthetase (GluRS).
- * The SSGCID has successfully determined the structure of H. pylori GluRS, which shares significant similarities with other bacterial GluRS, presenting opportunities for drug discovery aimed at developing new antibacterials to combat H. pylori infections.
Electronic Monitoring of Mom's Schedule (eMOMS™): A Feasibility Randomized Controlled Trial Targeting Postpartum Weight Retention and Breastfeeding Duration Among Populations With Overweight/Obesity.
J Hum Lact
November 2024
University of Kansas School of Medicine-Wichita, Department of Obstetrics and Gynecology, Wichita, Kansas, USA.
Article Synopsis
The risk of shortcutting in deep learning algorithms for medical imaging research.
Sci Rep
November 2024
Department of Orthopaedic Surgery, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH, 03756, USA.
Article Synopsis
- Deep learning (DL) can recognize intricate patterns in data that humans might miss, but it often leads to misleading results due to its black-box nature and a problem known as algorithmic shortcutting.
- In a case study, simple convolutional neural networks (CNNs) were able to predict patient behaviors like avoiding refried beans or beer just by analyzing knee X-rays, showcasing the dangers of relying on shortcuts in data interpretation.
- The findings highlight that the models' predictions are influenced by confounding factors in the images that cannot be easily eliminated, indicating a need for stricter criteria when assessing research involving medical imaging.
The Comorbidity Between Eating Disorders and Alcohol Misuse: Biological and Psychological Perspectives Illustrated by a Case Report.
Prim Care Companion CNS Disord
November 2024
Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire.
Superficial Neurocristic FET::ETS Fusion Tumor: Expanding the Clinicopathological and Molecular Genetic Spectrum of a Recently Described Entity.
Mod Pathol
November 2024
Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota.
Article Synopsis
- * Recent cases of the tumor were reported in five patients (from ages 8 to 69) who presented with solitary masses on various body parts, with all undergoing surgical excision and showing no disease upon follow-up.
- * The study reveals unique morphological and molecular characteristics of these tumors and suggests rebranding the tumor as "superficial neurocristic FET::ETS fusion tumor" to better reflect its distinct nature.
Feasibility and acceptability of the brief patient-reported experience measure consideRATE within the hospital setting for patients with palliative care needs, their families/carers and clinicians.
Palliat Med
November 2024
Improving Palliative, Aged and Chronic Care through Clinical Research and Translation (IMPACCT), Faculty of Health, University of Technology Sydney (UTS), Ultimo, New South Wales, Australia.
Article Synopsis
- Supporting clinical teams to enhance care for palliative patients and their caregivers is a top priority, and patient-reported experience measures (PREMs) like consideRATE can help identify areas for improvement.
- A study in an Australian hospital showed a 71% response rate from eligible patients and their caregivers, with a majority preferring to complete the measure electronically, and many needing assistance.
- The findings suggest that using consideRATE is feasible and provides valuable feedback to clinicians, who noted the importance of having accessible and context-sensitive data for quality improvement.
The power of three: Retatrutide's role in modern obesity and diabetes therapy.
Eur J Pharmacol
December 2024
Department of Medicine, The Wright Center for Graduate Medical Education, Scranton, PA, USA. Electronic address:
Article Synopsis
Crystal structure of N-terminally hexahistidine-tagged Onchocerca volvulus macrophage migration inhibitory factor-1.
Acta Crystallogr F Struct Biol Commun
December 2024
Dartmouth Cancer Center, One Medical Center Drive, Lebanon, NH 03756, USA.
Article Synopsis
- Onchocerca volvulus is responsible for serious health issues, including blindness and neurological diseases, and current treatments like ivermectin can't be safely used in pregnant women or those co-infected with Loa loa.
- Researchers at the Seattle Structural Genomics Center for Infectious Disease have successfully produced and crystallized a potential drug target called OvMIF-1, which has a unique jellyfish-like structure.
- The study suggests that deleting its N-terminal tag could reveal a larger cavity for drug targeting, indicating the need for further analysis to confirm the true biological structure of OvMIF-1.
Sinonasal Specific Bone Lesions, Including Fibro-Osseous and Select Odontogenic Lesions.
Surg Pathol Clin
December 2024
Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA; Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA. Electronic address:
Article Synopsis
Cost-effectiveness Improves for Operative vs Nonoperative Treatment of Adult Symptomatic Lumbar Scoliosis at Eight-Year Follow-up.
Spine (Phila Pa 1976)
October 2024
Department of Orthopedic Surgery, Washington University School of Medicine, Campus Box 8233, 600 South Euclid Ave, Box 8233, St Louis, MO, 63110, USA.
Article Synopsis
- - The study is a secondary data analysis of an NIH-sponsored research focusing on cost-effectiveness between surgical and non-surgical treatments for Adult Symptomatic Lumbar Scoliosis (ASLS) eight years post-enrollment.
- - Previous analyses at the five-year mark showed a cost-effectiveness ratio (ICER) of $44,033 (As-Treated) and $27,480 (Intent-to-treat), while the current eight-year data suggests that surgical treatment is more economically favorable, with an ICER of $20,569 per Quality Adjusted Life Year (QALY) gained.
- - The conclusion highlights that operative treatment for ASLS presents a more cost-effective option compared to non-operative treatment, as indicated
Continuous adaptation of conversation aids for uterine fibroids treatment options in a four-year multi-center implementation project.
BMC Med Inform Decis Mak
September 2024
The Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine at Dartmouth College, One Medical Center Drive, Williamson Translational Research Building Level 5, Lebanon, NH, 03756, USA.
Article Synopsis
- Fibroids are non-cancerous growths in the uterus that can negatively affect quality of life, prompting the need for personalized treatment options and better communication tools for shared decision-making among patients and healthcare providers.* -
- A user-centered approach was used to develop two conversation aids—one text-based and one picture-enhanced—through stakeholder focus groups and user-testing interviews, with efforts made to translate them into Spanish simultaneously.* -
- Initial feedback from focus groups and user-testing showed the conversation aids were well-received, but ongoing implementation revealed the need for significant updates to reflect new treatment information and accommodate stakeholder suggestions.*
Ternary structure of Plasmodium vivaxN-myristoyltransferase with myristoyl-CoA and inhibitor IMP-0001173.
Acta Crystallogr F Struct Biol Commun
October 2024
Chemistry and Biochemistry Department, Hampton University, 200 William R. Harvey Way, Hampton, VA 23668, USA.
Article Synopsis
- Plasmodium vivax causes malaria, affecting about a third of the world's population, and primaquine treatment is unsafe for those with G6PD deficiency, which impacts a significant portion of people in endemic areas.
- The Seattle Structural Genomics Center for Infectious Disease studied PvNMT (N-myristoyltransferase) to find alternative drug targets since it's essential for P. vivax survival by facilitating protein modification.
- The newly solved crystal structure of PvNMT, showing its interaction with myristoyl-CoA and a novel inhibitor, reveals differences from human enzymes, providing insights for creating effective antimalarial drugs.
Utilizing innovative implementation strategies for familial hypercholesterolemia: Implementation outcomes from the IMPACT-FH study.
J Clin Lipidol
November 2024
Department of Genomic Health, Research Institute, Geisinger, Danville, PA, 17822, USA (Drs Campbell-Salome, Morgan, Gabriel, Walters, Brangan, Rahm and Jones); Heart and Vascular Institute, Geisinger, Danville, PA, 17822, USA (Dr Jones).
Article Synopsis
- Cascade testing is useful for identifying familial hypercholesterolemia (FH) and reducing the risk of cardiovascular disease; the IMPACT-FH program aimed to increase participation in this process with improved strategies.
- A mix of qualitative and quantitative methods was used to assess the program, involving interviews with program participants, including individuals with FH and healthcare professionals, to analyze their experiences and outcomes.
- Overall, participants found the IMPACT-FH program to be valuable and effective but noted several barriers that could be improved, such as the complexities of communication and the use of technology, to boost participation in FH cascade testing.
Applying cognitive walkthrough methodology to improve the usability of an equity-focused implementation strategy.
Implement Sci Commun
September 2024
Massachusetts General Hospital, 125 Nashua St, Boston, MA, 02114, USA.
Article Synopsis
- The study aimed to improve the implementation of evidence-based interventions in community health centers, focusing on cancer screening, by using a structured approach called PEDDI.
- Researchers conducted usability sessions, known as Cognitive Walkthrough for Implementation Strategies (CWIS), with healthcare staff to identify problems and gather feedback on the PEDDI tool.
- Post-session, usability ratings for PEDDI improved significantly, indicating that the tool became more user-friendly after addressing ten identified issues and incorporating suggested redesign solutions.*
Structures of Brucella ovis leucine-, isoleucine-, valine-, threonine- and alanine-binding protein reveal a conformationally flexible peptide-binding cavity.
Acta Crystallogr F Struct Biol Commun
September 2024
Dartmouth Cancer Center, Dartmouth College, One Medical Center Drive, Lebanon, NH 03756, USA.
Article Synopsis
- Brucella ovis is a major cause of reproductive diseases in sheep and other animals, with no effective global eradication methods for ovine brucellosis currently available.
- Research at the Seattle Structural Genomics Center is focusing on analyzing B. ovis and other Brucella proteins to discover new therapeutic targets while also aiding in education about structural science and biochemistry.
- The study highlights the unique structure of BoLBP, a protein that binds amino acids, which could help in the development of new drugs by revealing insights into its flexibility and potential for drug repurposing.
Tensionable lesser tuberosity osteotomy repair for anatomic total shoulder arthroplasty.
JSES Rev Rep Tech
August 2024
Department of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Article Synopsis
Artificial Intelligence Applications in Cytopathology: Current State of the Art.
Surg Pathol Clin
September 2024
Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA; Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
Article Synopsis
- - Recent advancements in cytopathology involve developing consensus rules for diagnosing specimens, improving accuracy and consistency in diagnoses.
- - These diagnostic systems aim to minimize variability among observers, eliminate vague categories, reduce "atypical" diagnoses, and standardize communication through quantitative scoring.
- - Computational pathology emerges from these improvements, offering standardized and reproducible diagnoses using quantitative methods, thereby reducing human bias.
Thyroid Fine-Needle Aspiration: The Current and Future Landscape of Cytopathology.
Surg Pathol Clin
September 2024
Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA; Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA. Electronic address:
Article Synopsis
- Thyroid cytology focuses on diagnosing thyroid nodules, distinguishing between benign and malignant growths, and assessing risk when a clear diagnosis can't be made.
- Fine-needle aspiration and standardized reporting systems like the Bethesda System streamline the diagnosis process for these nodules.
- Recent advancements in molecular testing have become important for categorizing patients' risks of malignancy, aiding in the decision-making for treatment.
Aberrant lipid accumulation and retinal pigment epithelium dysfunction in PRCD-deficient mice.
Exp Eye Res
September 2024
Department of Ophthalmology and Visual Sciences, One Medical Center Drive, ERMA 2nd Floor, West Virginia University, Morgantown, WV, 26505-9193, USA; Department of Biochemistry and Molecular Medicine, 64 Medical Center Drive, West Virginia University, Morgantown, WV, 26505-9193, USA. Electronic address:
Article Synopsis
- Progressive Rod-Cone Degeneration (PRCD) is linked to retinitis pigmentosa in humans and dogs, and its absence leads to altered cholesterol levels in the retina and impaired function of the retinal pigment epithelium (RPE).
- In PRCD-deficient mouse models, lipid analysis revealed a significant increase in cholesteryl esters and lipid deposits, along with an increased expression of the lipid transporter gene Abca1 in the RPE.
- The study identifies age-related damage in the RPE, including lipofuscin accumulation and other deposits, suggesting that impaired phagocytosis and disrupted cholesterol balance contribute to vision loss in PRCD mice, resembling features of age-related macular degeneration (AMD).
Cerebral venous sinus thrombosis and SCN1A, a novel association?
Mol Biol Rep
August 2024
Division of Genetics, Department of Pediatrics, West Virginia University Medicine, One Medical Center Drive, Morgantown, WV, 26506, USA.
Article Synopsis
- Cerebral venous sinus thrombosis (CVST) is a rare type of stroke primarily linked to genetic and acquired factors that increase the risk of blood clots.
- A study of an adolescent patient with CVST found high levels of homocysteine due to a specific genetic mutation in the MTHFR gene, while his unaffected brother showed similar genetic traits but no symptoms.
- Despite the connection between high homocysteine and CVST through MTHFR polymorphisms, the study suggests that other factors, like abnormalities in blood flow linked to the SCN1A gene, may also play a crucial role in developing thrombosis.