3 results match your criteria: "One Amgen Center Dr. Thousand Oaks[Affiliation]"
Cardiovascular event rates in a high atherosclerotic cardiovascular disease risk population: estimates from Swedish population-based register data.
Eur Heart J Qual Care Clin Outcomes
July 2019
Department of Global Health Economics, One Amgen center dr. Thousand Oaks, CA, USA.
Aims: This study aimed to estimate the rate of cardiovascular (CV) events in the real world in patients at high risk of recurrent CV events similar to the FOURIER trial population.
Methods And Results: A retrospective population-based cohort study was conducted using Swedish national registers from 1 July 2001 to 31 December 2015. Patients in the atherosclerotic cardiovascular disease (ASCVD) prevalent cohort met the FOURIER-like inclusion criteria, including treatment with high/moderate-intensity statins, on 1 July 2006.
Prostaglandin D₂ receptor CRTH2 antagonists for the treatment of inflammatory diseases.
Prog Med Chem
October 2011
Chemistry Research and Discovery, Amgen Inc., One Amgen Center Dr. Thousand Oaks, CA 91320, USA.
Rheumatoid factor interference in immunogenicity assays for human monoclonal antibody therapeutics.
J Immunol Methods
May 2010
Dept. of Clinical Immunology Amgen Inc., One Amgen Center Dr. Thousand Oaks, CA 91320, United States.
Article Synopsis
- Rheumatoid factors (RFs) are natural human antibodies that bind to other antibodies, particularly in the context of immune complexes, which can lead to misleading results in immunoassays for anti-human antibodies after monoclonal therapy.
- In patients with rheumatoid arthritis, there was a significantly higher baseline reactivity in blood samples compared to healthy individuals when tested with a sensitive electrochemiluminescent (ECL) assay.
- The presence of high molecular weight aggregates (as little as 0.55%) in therapeutic antibodies can increase false reactivity, but careful monitoring of storage conditions through size exclusion high-performance liquid chromatography (SE-HPLC) can help reduce this issue.