3 results match your criteria: "Oncology and Stem Cell Transplant - Cohen Children's Medical Center[Affiliation]"
Inherited Disorders of the Fibrinolytic Pathway: Pathogenic Phenotypes and Diagnostic Considerations of Extremely Rare Disorders.
Semin Thromb Hemost
September 2024
Division of Pediatric Hematology, Oncology and Stem Cell Transplant - Cohen Children's Medical Center, New Hyde Park, New York.
Article Synopsis
- Fibrinolysis is the process of breaking down fibrin in blood clots, initiated by plasminogen activation through tPA and uPA, while antifibrinolytics like PAI-1 and αAP help regulate this process.
- Rare inherited disorders of the fibrinolytic pathway often lead to excessive bleeding, with conditions such as PAI-1 deficiency being treated with antifibrinolytic medications like aminocaproic acid during surgeries.
- Diagnosing these disorders is challenging, often requiring specialized testing for protein activity and genetic mutations, as routine tests typically lack specificity and sensitivity for such conditions.
Exploration of rotational thromboelastometry (ROTEM) to characterize the coagulation profiles of newly diagnosed pediatric leukemia patients.
Thromb Res
January 2024
Division of Pediatric Hematology, Oncology and Stem Cell Transplant - Cohen Children's Medical Center, New Hyde Park, New York, United States of America; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, United States of America. Electronic address:
Background: Viscoelastic testing has been used in adult hematologic malignancies in conjunction with conventional coagulation tests (CCTs) to predict coagulopathies and tailor blood product replacement. However, there is a paucity of similar pediatric studies.
Objectives: Analyze and correlate leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCT's and Rotational Thromboelastometry (ROTEM).
Prolonged prothrombin time does not correlate with clinical bleeding symptoms in newly diagnosed paediatric leukaemia patients.
Blood Coagul Fibrinolysis
April 2023
Division of Pediatric Hematology, Oncology and Stem Cell Transplant - Cohen Children's Medical Center, New Hyde Park.
Prolonged prothrombin time (PT) and/or activated partial thromboplastin time (aPTT) are frequently seen in newly diagnosed paediatric leukaemia patients (NDPLP), which can lead to delayed diagnostic and therapeutic procedures due to concern for bleeding. A single-centre retrospective chart review of NDPLP between 2015 and 2018 aged 1-21 years. We analysed 93 NDPLP of whom 33.
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