3,796 results match your criteria: "Oncology Centre.[Affiliation]"

The Ovarian Cancer Retrospective European (O'CaRE) study assessed the cumulative impact of high-risk factors on progression-free survival (PFS) and overall survival (OS) following first-line treatment in patients diagnosed with advanced ovarian cancer. Medical records were collected from five European countries (2014 and 2015). Patients were grouped by number of high-risk factors: stage IV diagnosis, no known , interval debulking surgery or no surgery, or visible residual disease.

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The role of radiosurgery in preventing haemorrhage in brainstem cavernous malformations remains a subject of debate. This study aims to evaluate whether radiosurgery provides a protective benefit against haemorrhage in these patients. This multicentre, prospective observational study was conducted in 17 centres and enrolled eligible patients with brainstem cavernous malformations consecutively.

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Potential Role of Gene Methylation in Diagnosis of Patients With Breast Cancer.

Clin Med Insights Oncol

October 2024

Biochemistry Department, Biotechnology Research Institute, High Throughput Molecular and Genetic Laboratory, Central Laboratories Network and the Centers of Excellence, National Research Centre, Giza, Egypt.

Article Synopsis
  • This study investigates the role of aldo-keto reductase family 1 member B1 (AKR1B1) methylation as a noninvasive biomarker for early diagnosis of breast cancer (BC).
  • The research involved 200 Egyptian women, finding that hypermethylation levels were significantly higher in BC cases (93.2%) compared to benign conditions (23.9%) and healthy controls (15.5%).
  • Results indicate that hypermethylation is a strong indicator of BC, correlating with tumor severity and early detection, thus highlighting its potential as a valuable diagnostic and prognostic tool in breast cancer management.
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-RAMP3 promotes hepatocellular carcinoma tumor cell-mediated CCL2 degradation by supporting membrane distribution of ACKR2.

Int Immunopharmacol

December 2024

Department of Oncology Centre, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China. Electronic address:

This study aimed to explore the potential bind of Receptor Activity-Modifying Protein 3 (RAMP3) with atypical chemokine receptor 2 (ACKR2), and their cooperative regulation on the degradation of the immunosuppressive chemokine CCL2 in the tumor microenvironment of HCC. Bioinformatic analysis was conducted using available bulk-tissue RNA-seq, single-cell RNA-seq, and protein-protein interaction datasets. Human HCC cell line Huh7 and HepG2 and mouse HCC cell line Hepa1-6 were utilized for experiments.

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Background: Only 10-40% of patients with cancer in low-income and middle-income countries were able to access curative or palliative radiotherapy in 2015. We aimed to assess the current status of diagnostic imaging and radiotherapy services in the Baltic countries, eastern Europe, central Asia, and the Caucasus by collecting and analysing local data.

Methods: This Access to Radiotherapy (ART) comprehensive analysis used data from 12 countries: the three Baltic countries (Estonia, Latvia, and Lithuania), two countries in eastern Europe (Moldova and Ukraine), four countries in central Asia (Kazakhstan, Kyrgyzstan, Tajikistan, and Uzbekistan), and three countries in the Caucasus (Armenia, Azerbaijan, and Georgia), referred to here as the ART countries.

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Purpose: To determine new-onset or worsening T2DM risk in patients with metastatic castration-resistant prostate cancer (mCRPC) receiving abiraterone acetate (AA) vs. enzalutamide (ENZA) in England.

Methods: Records of patients on AA and/or ENZA (2015-2021) were analysed retrospectively from UK- or England-wide databases and data sets.

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Article Synopsis
  • The study focuses on the management of advanced ovarian cancer, highlighting the gold standard of complete removal of visible tumors, and exploring the implications of delayed cytoreductive surgery for patients who cannot undergo initial or interval surgery.
  • It is a retrospective analysis of patients with stage IIIC or higher ovarian cancer at the Northern Gynaecological Oncology Centre over six years, comparing survival outcomes between two groups: those who received only chemotherapy and those who had delayed surgery after six cycles.
  • Of the 89 patients evaluated, most completed six cycles of chemotherapy without surgery, while a smaller group underwent delayed surgery, suggesting a potential benefit from this approach in specific cases where initial surgery was not feasible.
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High-dose melphalan followed by stem cell rescue is the standard consolidative therapy for transplant-eligible patients with multiple myeloma (MM) in the United Kingdom. A melphalan dose of 200 mg/m (Mel200) is considered the "gold standard" for autologous stem cell transplant (ASCT) conditioning for fit patients ≤70 years old; however, with a peak diagnosis incidence at 80-89 years old in the UK dose adjustments will be inevitable to limit toxicities. In this single-centre UK-based retrospective analysis, data was collected from patients with plasma cell dyscrasias who underwent a first reduced-intensity, Mel140, ASCT from 2006 to 2019, a total of 81 patients.

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To assess the concordance of the preoperative application of the #ENZIAN classification (#ENZIANi) with the postoperative result (#ENZIANs) using surgical findings as the reference standard. This retrospective study included 282 consecutive patients with deep endometriosis undergoing surgical treatment. Preoperative assessment with transvaginal sonography and magnetic resonance imaging was compared with postoperative assessment.

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Background: In prior randomised controlled trials, lung cancer screening using low-dose computed tomography (LDCT) has been shown to reduce lung cancer mortality and overall mortality. Despite these results, organised screening in France remains a challenge. This study assessed the feasibility and efficacy of lung cancer screening within a real-life context in a French administrative territory.

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Article Synopsis
  • The guidelines are created by the British Gynaecological Cancer Society and British Menopause Society to help healthcare professionals support women treated for gynaecological cancer, especially regarding menopausal symptoms that can affect life quality.* -
  • Cancer treatments like surgery, radiotherapy, and chemotherapy can impact hormonal function, and the guidelines discuss the use of hormone replacement therapy (HRT) based on cancer type and when it should start post-treatment.* -
  • The document also highlights the effectiveness and safety of vaginal estrogens for urogenital symptoms and reviews alternative treatments to HRT, including both medication and lifestyle approaches.*
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Background: The aim was to evaluate the performance of the Peritoneal Cancer Index (PCI) using imaging (ultrasound, contrast-enhanced computed tomography (CT), and whole-body diffusion-weighted magnetic resonance imaging (WB-DWI/MRI) in assessing peritoneal carcinomatosis and predicting non-resectability in tubo-ovarian carcinoma patients.

Methods: This was a prospective multicenter observational study. We considered all patients with suspected primary ovarian/tubal/peritoneal cancer who underwent preoperative ultrasound, CT, and WB-DWI/MRI (if available).

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Treatment of Late-onset Acute Graft-versus-host Disease Following Double Lung Transplantation Using a JAK2 Inhibitor.

Transplantation

October 2024

Hans Messner Allogeneic Blood and Marrow Transplant Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

Article Synopsis
  • Acute graft-versus-host disease (aGVHD) is a serious, rare complication that can occur after solid organ transplants, especially in organs with a lot of lymphoid tissue like the liver and intestines, and is becoming more relevant in lung transplants due to increasing numbers of procedures.
  • The understanding of aGVHD’s causes, risk factors, and treatment strategies is limited, leading to potential delays in diagnosis and inferior patient outcomes, as there’s currently no standardized management approach.
  • This report highlights a unique case of aGVHD that developed nearly a year post-lung transplant and was effectively treated with ruxolitinib, suggesting a potential new approach to managing this condition similar to treatments used for aGVHD
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Background: 18F-prostate specific membrane antigen (PSMA) PET is fast becoming the gold-standard in prostate cancer, both in staging of intermediate-/high-risk patients and in re-staging patients with biochemical failure. Several pitfalls of 18F-PSMA PET have been reported, and we report, to our best of knowledge, for the first time, a case which could have been falsely diagnosed as peritoneal spread.

Case Presentation: A 67-year-old patient with high-risk prostate cancer underwent staging with 18F-PSMA-1007 PET/CT (PSMA-PET/CT).

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Quality of life issues in patients with ductal carcinoma in situ: a systematic review.

Support Care Cancer

October 2024

Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

Purpose: Ductal carcinoma in situ (DCIS) of the breast is one of the most common pre-invasive cancers diagnosed in women. Quality of life (QoL) is extremely important to assess in studies including these patients due to the favorable prognosis of the disease. The primary objective of this systematic review was to compile a comprehensive list of QoL issues, all existing QoL assessment tools, and patient-reported outcome measures used to assess DCIS.

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Objective: The empty pelvis syndrome (EPS) is common after pelvic exenteration (PE), causing fluid collections, bowel obstruction, perineal sinuses, and fistulas. The best approach to fill the pelvis to mitigate this remains controversial, and the impact of EPS on health-related quality of life (HrQoL) is unknown. This study is the first to begin to explore lived-experiences of EPS complications.

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Article Synopsis
  • The study investigates the impact of chemotherapy on cardiovascular health in women with breast cancer, specifically looking at indicators like cardio-ankle vascular index (CAVI), global longitudinal strain (GLS), and ventricular-arterial coupling (VAC).
  • It involved 78 women undergoing anthracycline-based chemotherapy, comparing their cardiovascular metrics with those of 41 healthy women over time (baseline, 3 months, 6 months).
  • Results showed that chemotherapy patients had abnormal CAVI, GLS, and VAC levels, with these changes being more pronounced in those with cancer therapy-related cardiovascular dysfunction (CTRCD), suggesting these metrics could help improve screening and treatment for affected patients.
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Loop ileostomy is commonly performed by colorectal and general surgeons to protect newly created large bowel anastomoses. The optimal timing for ileostomy closure remains debatable. Defining the timing associated with the best postoperative outcomes can significantly improve the clinical results for patients undergoing ileostomy closure.

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Correlating Ultrastructural Changes in the Invasion Area of Colorectal Cancer with CT and MRI Imaging.

Int J Mol Sci

September 2024

Department of Human Histology and Embryology, Faculty of Medical Sciences, University of Warmia and Mazury, 10082 Olsztyn, Poland.

The cancer invasion of the large intestine, a destructive process that begins within the mucous membrane, causes cancer cells to gradually erode specific layers of the intestinal wall. The normal tissues of the intestine are progressively replaced by a tumour mass, leading to the impairment of the large intestine's proper morphology and function. At the ultrastructural level, the disintegration of the extracellular matrix (ECM) by cancer cells triggers the activation of inflammatory cells (macrophages) and connective tissue cells (myofibroblasts) in this area.

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: The anti-neoplastic activity of metformin is a subject of current debate. Preclinical data have suggested that metformin enhances PD-L1 anti-tumor effects in various cancer entities by decreasing insulin levels and inducing energetic stress. However, its impact on PD-L1 expression remains unclear in a clinical setting.

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In advanced-stage colorectal cancer (CRC), a strategy based on a sequence of systemic therapies brings survival benefits in most patients. Trifluridine and tipiracil hydrochloride (TT) is a chemotherapy drug effective in patients in the third- or later line setting. No highly specific biomarkers have been established for TT therapy so far.

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Real-World Survival Outcomes of First-Line Therapies in Patients with Metastatic Clear Cell Renal Cell Carcinoma: A Retrospective Analysis from Two Centres in Saudi Arabia.

Cancers (Basel)

September 2024

Adult Medical Oncology Department, Ministry of National Guard Health Affairs-Central Region (MNGHA-CR), King Abdullah International Medical Research Centre (KAIMRC), King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), King Abdulaziz Medical City, Riyadh 11481, Saudi Arabia.

Article Synopsis
  • This study focused on metastatic renal cell carcinoma (mRCC), examining the survival outcomes of first-line immuno-oncological (ICI) regimens compared to single-agent tyrosine kinase inhibitors (TKIs) in Saudi Arabian patients.
  • A total of 84 patients diagnosed with clear cell mRCC were analyzed, showing a median progression-free survival (PFS) of 9.7 months and an overall survival (OS) of 42.0 months, with no significant difference between treatment groups.
  • The results indicated that first-line single-agent ICI therapy demonstrated promising anti-tumor activity and survival outcomes similar to both ICI-based combinations and TKIs, with liver metastasis and lower performance status being significant
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Introduction: Sacituzumab govitecan (SG) is approved for patients with previously treated metastatic or locally advanced triple-negative breast cancer (TNBC), as per the ASCENT trial results. Real-world studies (RWSs) cover more diverse patients than clinical trials, offering crucial data for healthcare policies. This study aimed to investigate the safety and efficacy of SG in real-world Polish patients with previously treated metastatic TNBC.

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The frontier of neoadjuvant therapy in non-small cell lung cancer beyond PD-(L)1 agents.

Expert Opin Biol Ther

October 2024

Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University Hospital Trust, Verona, Italy.

Introduction: While surgical resection is the cornerstone of treatment for resectable lung cancer, neoadjuvant/adjuvant chemotherapy has shown limited improvement in survival rates over the past decades. With the success of immune checkpoint inhibitors (ICIs) in advanced NSCLC, there is growing interest in their application in earlier stages of the disease. Recent approvals for neoadjuvant/adjuvant ICIs in stage II-IIIA NSCLC highlight this shift in treatment paradigms.

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Discontinuation of Tyrosine Kinase Inhibitor Therapy and Treatment Free Remission (TFR) in Chronic Myeloid Leukemia: Successful Achievement of TFR in More Than Two-Third of Patients in a Real-World Practice.

Clin Lymphoma Myeloma Leuk

January 2025

King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; King Abdulaziz Medical City, Ministry of the National Guard Health Affairs, Riyadh, Saudi Arabia; Saudi Society of Blood and Marrow Transplantation; College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Al-Ahsa, Saudi Arabia.

Background: Discontinuation of TKI therapy and treatment-free remission (TFR) have become new goals for chronic-phase chronic myeloid leukemia (CP-CML). The aim of this study was to estimate the TFR post discontinuation of TKI therapy at 3 tertiary-care centers.

Patients And Methods: CP-CML patients aged ≥16 years who had an attempt to discontinue TKI therapy till June 2022, were eligible.

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