Basic Science and Pathogenesis.

Background: Worldwide, the actual number of 55 million people diagnosed with dementia is estimated to increase to 139 million people affected by dementia in 2050. 61% of these individuals resided in low and middle-income countries (LMIC). Genetic risk factors account for up to 80% of the attributable risk of Alzheimer's disease (AD), the leading cause of dementia.

Clinical Manifestations.

Background: The Cognitive Domains and Functional Assessment Questionnaire (CDFAQ) assess cognitive and functional decline for Neurocognitive Disorders based on the DSM-5 criteria (1). It's accuracy to the Informant Questionnaire on Cognitive Decline in the Elderly - Long Version (IQCODE-LV) has been assessed (2), and was translated and validated into English. The informant version (CDFAQ-IV) assess: Complex Attention (CA), Executive Functions (EF), Learning and Memory (LM), Language (L), Perceptual-Motor (PM) and Social Cognition.

Clinical Manifestations.

Background: The Cognitive Domains and Functional Assessment Questionnaire (CDFAQ) assess cognitive and functional decline for Neurocognitive Disorders based on the DSM-5 criteria (1). It's accuracy to the Informant Questionnaire on Cognitive Decline in the Elderly - Long Version (IQCODE-LV) has been assessed (2), and was translated and validated into English (3). The informant version (CDFAQ-IV) assess: Complex Attention (CA), Executive Functions (EF), Learning and Memory (LM), Language (L), Perceptual-Motor (PM) and Social Cognition.