5,186 results match your criteria: "Okmeydanı Research and Training Hospital[Affiliation]"

Background: Maintaining and improving infant health and continuing care at home are very important for the health system. According to the coronavirus disease 2019 (COVID-19) pandemic and its effects on the health system capacity and medical staff's physical-mental health, this study investigated the health staff's attitude on the implementation of an infant home care plan.

Materials And Methods: This descriptive-analytical cross-sectional study was conducted on 130 nurses, midwives, and doctors working in the newborn care department in Isfahan health-therapeutic centers, with at least 6 months of work experience.

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Does Omalizumab Cause Atopic Dermatitis Flare-Ups?

Cutis

September 2024

Division of Allergy and Immunology, Department of Pediatrics, Sakarya University, Faculty of Medicine, Research and Training Hospital of Sakarya, Adapazarı, Türkiye.

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Extracorporeal membrane oxygenation: unmet needs and perspectives.

Rheumatol Int

December 2024

Department of Physical Medicine and Rehabilitation, University of Health Sciences, Adana City Research and Training Hospital, Adana, Türkiye.

Article Synopsis
  • ECMO is a critical lifesaving treatment for severe cardiovascular and respiratory failure, with an increasing range of applications, especially during the COVID-19 pandemic where it has been vital for patients with ARDS.
  • In pregnant women, ECMO can be used similarly to the general population, but healthcare providers must consider the health of both the mother and the fetus due to complicating factors of pregnancy.
  • The article discusses the importance of careful anticoagulation management in ECMO patients, summarizes how ECMO affects drug metabolism, and evaluates global practices, training, and rehabilitation needs for ECMO survivors to enhance their recovery and quality of life.
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Following the results of the phase 3 KEYNOTE-522 trial, the U.S. Food and Drug Administration approved pembrolizumab, a humanized IgG4 kappa monoclonal antibody, in combination with neoadjuvant chemotherapy as a new standard of care for high-risk early-stage triple-negative breast cancer (TNBC).

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The Effects of Having a Child with Cancer on Parental Psychology: A Cross-Sectional Study.

J Clin Med

October 2024

Department of Pediatric Hematology and Oncology, Umraniye Research and Training Hospital, University of Health Sciences, 34764 Istanbul, Turkey.

: In childhood cancers, parents are affected psychologically as well as children. We aimed to evaluate the effect of childhood cancer type and stage, as well as elapsed time from diagnosis, on the anxiety and stress indicators among parents. : Patients aged between 0-18 years and diagnosed with cancer who were receiving chemotherapy (0-1 month, 1-6 month, 6-12 month) and completed treatment were included.

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Introduction: Cyclin Dependent Kinase (CDK) 4-6 inhibitors are the recommended first-line treatment option for hormone-positive metastatic breast cancer (MBC). They show their effects by causing cell cycle arrest in G1-S phase. Neutropenia is the most common haematological side effect.

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Background: Echocardiographic right ventricular (RV) dysfunction is a strong risk determinant for prognosis in patients with heart failure (HF). Although parameters of RV systolic function are widely used to define RV dysfunction, there is scarce data to suggest these parameters are best suited to predict HF-related outcomes.

Aims: We aimed to understand which morphologic or functional parameters are most closely associated with short-term mortality and HF-related hospitalization in patients with HF.

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Article Synopsis
  • The study investigated the role of sonic hedgehog (SHH) protein in the development of bladder and ureter smooth muscle in children with vesicoureteral reflux (VUR) after ureteroneocystostomy operations.
  • Researchers analyzed 28 ureterovesical junction segments from 19 children using Western Blot to measure SHH protein expression levels against β-Actin as a control.
  • Results indicated that while SHH was present, there was no significant correlation between SHH levels and the severity of VUR, suggesting that SHH may play a role in the condition's development rather than its severity.
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  • A gram-negative bacterium typically does not cause infective endocarditis, but a rare case has been documented.
  • In this case, after an eight-year period following the Benthall-DeBono procedure, there was late dehiscence of an aortic valve conduit due to leakage.
  • This led to the development of a large pseudoaneurysm and severe paravalvular aortic insufficiency, ultimately linked to the infective endocarditis infection.
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  • The ARTEMIS registry investigates Peripartum Cardiomyopathy (PPCM), a serious condition occurring during late pregnancy or shortly after childbirth, focusing on clinical characteristics and outcomes in Turkish patients.
  • The study observed 293 women primarily aged 25-35 diagnosed with PPCM, mostly presenting symptoms like shortness of breath, and found a low usage of advanced imaging techniques, relying mainly on echocardiography.
  • Results indicated a 5.1% mortality rate among patients, emphasizing the need for better education for healthcare practitioners and the critical role of national registries in managing rare diseases like PPCM.
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  • Awake video-assisted thoracoscopic surgery (VATS) allows for lung resections without general anesthesia, primarily using thoracic paravertebral blocks (TPB) for pain management.
  • A study involving 24 patients demonstrated that TPB can be safely used for non-anatomical lung surgeries, with a low morbidity rate and no in-hospital mortality.
  • While outcomes with TPB are similar to those achieved with other anesthesia methods, using TPB may help reduce potential complications associated with thoracic epidural analgesia.
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Purpose: This study aimed to examine the effect of mechanical vibration and the ShotBlocker® device on pain level, crying time, and procedure time during a heel lance in healthy term neonates.

Design And Methods: A total of 105 healthy-term neonates were randomized into three groups: control (n = 36), mechanical vibration (n = 33), and ShotBlocker® (n = 36). The control group underwent a routine heel lance procedure.

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Effect of Stromal Vascular Fraction in the Rat Model of Pharyngocutaneous Fistulas.

Cureus

September 2024

Molecular Biology and Genetics, Iontek Molecular Diagnostics, İstanbul, TUR.

Article Synopsis
  • - The study aimed to explore the impact of adipose tissue-derived stromal vascular fraction on healing pharyngocutaneous fistulas in rats after laryngeal surgery.
  • - Eleven rats were divided into study and control groups, with the study group receiving an injection of the stromal vascular fraction post-surgery.
  • - While epithelialization was greater in the study group, the differences weren’t statistically significant; however, there was less mucosal injury and cell infiltration in the study group compared to controls, suggesting some potential benefits.
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Article Synopsis
  • * A new screening tool, the obstructive sleep apnea morphologic scale (OSAMS), was developed using five anatomical features to better assess the severity of OSA in 149 patients without additional health issues.
  • * The OSAMS showed a moderate positive correlation with the apnea-hypopnea index (AHI) from PSG, achieving 80.3% sensitivity and 53.9% specificity for identifying severe OSA, outperforming traditional questionnaires.
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A 67-year-old woman presented with a palpable breast mass. A biopsy was taken, and the diagnosis was squamous cell carcinoma. Primary squamous cell carcinoma of breast is an extremely rare subtype of invasive breast cancer.

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  • The study examines how urine pH and specific gravity affect the energy used during Extracorporeal Shock Wave Lithotripsy (ESWL), a treatment for kidney stones.
  • A total of 129 patients were analyzed, focusing on stone-free rates, complications, and various patient characteristics while evaluating the relationship between energy use and these factors.
  • Findings indicate that higher urine pH (more alkaline) correlates with less energy needed for treatment, but no significant links were found with other factors like age or stone size.
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  • Abdominal actinomycosis is a rare infection, often misdiagnosed, caused by bacteria normally found in the oral cavity and gut, which can lead to conditions that mimic serious abdominal issues, including cancers.
  • A case study of a 59-year-old male with existing health problems showed how he was initially misdiagnosed with appendicitis but was later found to have actinomycosis during surgery.
  • The patient received successful treatment through surgery and penicillin, illustrating the need for healthcare providers to consider abdominal actinomycosis when diagnosing abdominal pain and masses.
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Objective: The objective of this study was to evaluate the efficacy and safety of isotonic and hypotonic intravenous fluids in maintenance fluid therapy for term infants.

Methods: This was a multi-centre, prospective, observational study conducted in 21 participating centres from December 30, 2020, to June 30, 2023. The study included term newborns requiring parenteral fluid therapy for maintenance (NCT04781361).

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Article Synopsis
  • - Nurses make up about 50% of the global health workforce, and the World Health Organization is pushing for broader roles to meet the increasing healthcare demands, emphasizing the need for evidence-based practices and robust academic training like PhD programs for nurses.
  • - The article stresses the importance of nurses actively participating in creating practical evidence-based guidelines, utilizing their clinical experience to ensure relevance and effectiveness.
  • - To improve nursing research and publication quality, strategies include enhancing writing skills through targeted education, promoting open-access publishing, and leveraging social media for wider reach, ultimately aiming to strengthen nursing's influence in health policy and patient care.
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Background: The aim of this study is to determine whether there are any changes in hemorheological parameters, including whole blood viscosity (WBV), plasma viscosity, erythrocyte aggregation, and erythrocyte deformability, in acute ischemic stroke patients, and to establish their relationship with stroke etiology. The study also aims to observe the changes in these parameters, if any, over time and after treatment, and to assess the correlation between risk factors for ischemic stroke and neuroimaging findings.

Methods: This was a prospective observational study including 70 patients diagnosed with acute ischemic stroke within the first 3 days of the onset of symptoms and 96 healthy controls.

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  • The study investigates how papaverine affects myringosclerosis (MS) in rats, focusing on its impact on hearing issues caused by the condition.
  • Twenty Wistar albino rats were divided into four groups to test different treatments, including myringotomy, saline application, and both systemic and topical papaverine.
  • Results indicated that papaverine increased the severity of MS, possibly due to its vasodilating effects that lead to higher levels of oxygen-derived free radicals, warranting further evaluation of its implications on MS.
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Intravascular lobular capillary hemangioma (ILCH), also known as intravenous pyogenic granuloma, is a benign vascular lesion with a distinctive lobular arrangement of capillaries. It is typically confined to the head, neck, and upper extremities, and its occurrence in the testicular region is exceedingly rare. Here, we present a case of a 68-year-old male who was initially diagnosed with a testicular tumor based on imaging studies but was later found to have an ILCH located in the epididymis.

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Purpose: Tamoxifen, a widely used drug for breast cancer treatment, is associated with adverse effects on the liver, including the development of fatty liver. This study aimed to investigate the potential protective effect of caffeine against tamoxifen-induced fatty liver in Wistar rats.

Methods: Rats were divided into normal control, tamoxifen + saline, and tamoxifen + caffeine.

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