107 results match your criteria: "Oklahoma University Health Science Center[Affiliation]"

Multivalent interaction of ESCO2 with the replication machinery is required for sister chromatid cohesion in vertebrates.

Proc Natl Acad Sci U S A

January 2020

Program in Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104;

The tethering together of sister chromatids by the cohesin complex ensures their accurate alignment and segregation during cell division. In vertebrates, sister chromatid cohesion requires the activity of the ESCO2 acetyltransferase, which modifies the Smc3 subunit of cohesin. It was shown recently that ESCO2 promotes cohesion through interaction with the MCM replicative helicase.

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Importance: Despite standard chemoradiotherapy (CRT), most women with lymph node (LN)-positive cervical cancer experience disease recurrence. Immunotherapy is being investigated in the up-front treatment setting.

Objectives: To assess the safety of sequential immunotherapy after CRT and to investigate human papillomavirus (HPV) genotype and HLA allele status on survival and programmed cell death 1 (PD-1) expression before and after CRT and sequential immunotherapy.

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B cell function impacts the efficacy of IFN-β therapy in EAE.

J Neuroimmunol

January 2020

Department of Microbiology and Immunology, Oklahoma University Health Science Center, Oklahoma City, OK, USA. Electronic address:

Recent studies identified that interferon beta (IFN-β) treatment skews B-cells towards a regulatory phenotype in multiple sclerosis. To assess B cell involvement during IFN-β therapy, we compared IFN-β treatment in a B cell-independent model and a B cell-dependent model of experimental autoimmune encephalomyelitis (EAE). We show that in B cell-independent EAE, IFN-β ameliorates neuroinflammation.

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The optimal treatment strategy for coronary chronic total occlusion (CTO) has not been well established. The benefit of percutaneous coronary intervention (PCI) was inferred mainly from observational studies comparing successful versus failed PCI without a control group receiving optimal medical therapy (OMT). We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) and observational studies comparing PCI using drug-eluting stent (DES) versus OMT alone in patients with CTO.

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Accelerated sarcopenia in Cu/Zn superoxide dismutase knockout mice.

Free Radic Biol Med

February 2019

Department of Geriatric Medicine and the Reynolds Oklahoma Center on Aging, Oklahoma University Health Science Center, Oklahoma City, OK, USA; Oklahoma City VA Medical Center, Oklahoma City, OK, USA. Electronic address:

Mice lacking Cu/Zn-superoxide dismutase (Sod1 or Sod1KO mice) show high levels of oxidative stress/damage and a 30% decrease in lifespan. The Sod1KO mice also show many phenotypes of accelerated aging with the loss of muscle mass and function being one of the most prominent aging phenotypes. Using various genetic models targeting the expression of Cu/Zn-superoxide dismutase to specific tissues, we evaluated the role of motor neurons and skeletal muscle in the accelerated loss of muscle mass and function in Sod1KO mice.

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Background: Use of atherectomy for the treatment of peripheral arterial disease (PAD) is increasing as an adjunctive treatment to either conventional or drug-coated balloon angioplasty. There is limited data on atherectomy outcomes in below-the-knee (BTK) endovascular interventions.

Methods: Data from the multicenter Excellence in Peripheral Artery Disease (XLPAD) registry (NCT01904851) were analyzed to examine predictors of atherectomy use and its associated 1-year patency rate.

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Oxidative stress-induced dysregulation of excitation-contraction coupling contributes to muscle weakness.

J Cachexia Sarcopenia Muscle

October 2018

Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.

Background: We have previously shown that the deletion of the superoxide scavenger, CuZn superoxide dismutase, in mice (Sod1 mice) results in increased oxidative stress and an accelerated loss of skeletal muscle mass and force that mirror the changes seen in old control mice. The goal of this study is to define the effect of oxidative stress and ageing on muscle weakness and the Excitation Contraction (EC) coupling machinery in age-matched adult (8-10 months) wild-type (WT) and Sod1 mice in comparison with old (25-28 months) WT mice.

Methods: In vitro contractile assays were used to measure muscle contractile parameters.

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Time to stroke: A Western Trauma Association multicenter study of blunt cerebrovascular injuries.

J Trauma Acute Care Surg

November 2018

From the Department of Surgery (C.C.B., J.J.S., C.D.B., M.J.C.), Denver Health Medical Center, Denver, Colorado; Department of Surgery (M.K.M., J.M.), McGovern Medical School, University of Texas Health Science Center, Houston, Texas; Department of Surgery (J.P.S., M.A.C.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Surgery (M.B., J.K.), Hadassah Hebrew University Medical Center, Jerusalem, Israel; Department of Surgery (M.B., J.K.), Assia Medical Group/Tel Aviv University School of Medicine, Tel Aviv, Israel; Department of Surgery (M.C.S., P.R.B.), Grant Medical Center, Columbus, Ohio; Department of Surgery (S.J., D.J.H.), Erlanger Health System, Chattanooga, Utah; Department of Surgery (L.H., D.M.S.), R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, Maryland; Department of Surgery (R.C., C.W.), University of California, San Francisco, San Francisco, California; Department of Surgery (J.S., V.A.), University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Surgery (J.D.), University of Colorado Health North Medical Center of the Rockies, Loveland, Colorado; Department of Surgery (J.P.V., C.V.R.B.), Dell Medical School, University of Texas at Austin, Austin, Texas; Department of Surgery (A.C., T.L.Z.), Oklahoma University Health Science Center, Oklahoma City, Oklahoma; Department of Surgery (R.C., A.E.B.), University of California, San Diego, La Jolla, California; Department of Surgery (T.Z.M., A.K.M.), University of Vermont Medical Center, Burlington, Vermont; Department of Surgery (J.P.H., K.L.), Cooper University Hospital, Camden, New Jersey; Department of Surgery (M.W.), North Memorial Health, Robbinsdale, Minnesota; Department of Surgery (H.B.A., A.M.W.), University of Michigan, Ann Arbor, Michigan; Department of Surgery (J.K., K.I.), University of Southern California, Los Angeles, California; Department of Surgery (S.M., Y.M.C.), Children's Hospital Colorado, Aurora, Colorado; Department of Surgery (H.L.W., B.C.), Virginia Tech Carilion School of Medicine, Roanoke, Virginia; Department of Surgery (C.G.D.), University of Calgary, Calgary, Alberta, Canada; Department of Surgery (S.S., J.L.H.), Indiana University School of Medicine, Indianapolis, Indiana; Department of Surgery (D.C.C.), Marshfield Clinic, University of Wisconsin School of Medicine, Madison, Wisconsin; Department of Surgery (M.D.Z., M.D.R.-Z.), Mayo Clinic, Rochester, Minnesota; Department of Surgery (B.C.M.), Grady Memorial Hospital, Chickasha Oklahoma; Department of Surgery (E.J.R., P.U.), WakeMed Health & Hospitals, Raleigh, North Carolina; Department of Surgery (C.R., E.T.), East Carolina University, Greenville, North Carolina; Department of Surgery (S.G., T.J.), George Washington University Hospital, Washington, District of Columbia; Department of Surgery (J.M.H., K.L.L.), Via Christi Hospital, Wichita, Kansas; Department of Surgery (N.K., B.C.), Banner-University of Arizona Tucson, Tucson, Arizona; Department of Surgery (A.F.K., S.R.T.), Baylor College of Medicine/Ben Taub Hospital, Houston, Texas; Department of Surgery (B.Z.), Eskenazi Health, Indianapolis, Indiana; Department of Surgery (C.J.W., K.J.K.), Gundersen Health System, La Crosse, Wisconsin; Department of Surgery (T.N., S.B.Z.E.), Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Surgery (K.A.P., C.E.D.), Scripps Mercy Hospital, San Diego, California; Department of Surgery (K.K., F.B.), John H. Stroger, Jr. Hospital of Cook County, Chicago, Illinois; Department of Surgery (T.S.D., J.M.G.), and University of California, Davis, Davis, California.

Background: Screening for blunt cerebrovascular injuries (BCVIs) in asymptomatic high-risk patients has become routine. To date, the length of this asymptomatic period has not been defined. Determining the time to stroke could impact therapy including earlier initiation of antithrombotics in multiply injured patients.

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Blunt traumatic scapular fractures are associated with great vessel injuries in children.

J Trauma Acute Care Surg

November 2018

From the Pediatric Trauma Center, Cohen Children's Medical Center, the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York (I.A.e., J.M.P., N.G.R.); Feinstein Institute for Medical Research, Manhasset, New York (I.A.e., L.M.R., J.M.P., N.G.R.); Maimonides Medical Center, Brooklyn New York (I.A.e.); and Oklahoma University Health Science Center, Oklahoma City, Oklahoma (R.W.L.).

Background: Patients with stable blunt great vessel injury (GVI) can have poor outcomes if the injury is not identified early. With current pediatric trauma radiation reduction efforts, these injuries may be missed. As a known association between scapular fracture and GVI exists in adult blunt trauma patients, we examined whether that same association existed in pediatric blunt trauma patients.

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Necroptosis is a newly identified programmed cell death pathway that is highly proinflammatory due to the release of cellular components that promote inflammation. To determine whether necroptosis might play a role in inflammaging, we studied the effect of age and dietary restriction (DR) on necroptosis in the epididymal white adipose tissue (eWAT), a major source of proinflammatory cytokines. Phosphorylated MLKL and RIPK3, markers of necroptosis, were increased 2.

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Importance: Ovarian cancer is the leading cause of gynecologic cancer deaths in the United States. Pazopanib is an oral, multitarget kinase inhibitor of vascular endothelial growth factor receptors 1, 2, and 3; platelet-derived growth factor receptors α and β; and proto-oncogene receptor tyrosine kinase (c-KIT).

Objective: To estimate the progression-free survival (PFS) hazard ratio (HR) of weekly paclitaxel and pazopanib compared with weekly paclitaxel and placebo in women with recurrent ovarian cancer.

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Introduction: Diffuse leptomeningeal glioneuronal tumors (DLGT) have been recognized in the most recent WHO classification as a distinct entity.

Objective: We describe seven pediatric cases of DLGT and the responses to therapy and outcome.

Methods: We conducted a retrospective review of charts from 1985 to 2013.

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Role of nerve-muscle interactions and reactive oxygen species in regulation of muscle proteostasis with ageing.

J Physiol

October 2017

Department of Musculoskeletal Biology, MRC Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.

Skeletal muscle ageing is characterised by atrophy, a deficit in specific force generation, increased susceptibility to injury, and incomplete recovery after severe damage. The hypothesis that increased generation of reactive oxygen species (ROS) in vivo plays a key role in the ageing process has been extensively studied, but remains controversial. Skeletal muscle generates ROS at rest and during exercise.

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Objetive: To evaluate the performance of resident physicians in diagnosing and treating a case of anaphylaxis, six months after participating in simulation training exercises.

Methods: Initially, a group of pediatric residents were trained using simulation techniques in the management of critical pediatric cases. Based on their performance in this exercise, participants were assigned to one of 3 groups.

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Introduction: The probability of making mistakes in the prescription of medicines is high in pediatrics, and substantially increases in emergency situations.

Material And Methods: This prospective observational study analyzed the prescriptions issued by physicians during 23 cardiopulmonary resuscitation pediatric emergency training sessions.

Results: During 94 simulated cases, 96 physicians participated.

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VPS45-associated severe congenital neutropenia (SCN) is a rare disorder characterized by life-threating infections, neutropenia, neutrophil and platelet dysfunction, poor response to filgrastim, and myelofibrosis with extramedullary hematopoiesis. We present a patient with SCN due to a homozygous c.1403C>T (p.

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Development of new therapeutic products requires efficacy testing in an animal model. The pulmonary route of administration can be utilized to deliver drugs locally and systemically. Evaluation of dry powder aerosols necessitates an efficient dispersion mechanism to maintain high concentrations in an exposure chamber or for direct endotracheal administration.

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Adequacy and accuracy of nontrauma center computed tomography: What are we missing?

J Trauma Acute Care Surg

July 2017

From the Department of Surgery (M.M.B., S.H., T.G., S.J., A.A., J.L., W.H.); Department of Biostatistics and Epidemiology (T.G.), Department of Radiology (R.F.) and University of Oklahoma College of Medicine (C.K.), Oklahoma University Health Science Center, Oklahoma City, Oklahoma.

Background: Timely and appropriate use of computed tomography (CT) scans is critical to the evaluation of traumatic injuries. The objective of this study was to assess the adequacy of CT scans performed at nontrauma centers (NTCs) as they pertain to the management of trauma patients.

Methods: Adult patients transferred to our ACS-verified Level I trauma center from any NTC between May and December 2012 were enrolled prospectively.

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A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse.

Geroscience

April 2017

Department of Geriatric Medicine and the Reynolds Oklahoma Center on Aging, Oklahoma University Health Science Center, Oklahoma City, OK, USA.

Frailty is a geriatric syndrome that is an important public health problem for the older adults living in the USA. Although several methods have been developed to measure frailty in humans, we have very little understanding of its etiology. Because the molecular basis of frailty is poorly understood, mouse models would be of great value in determining which pathways contribute to the development of frailty.

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Professional Practice Evaluation for Pathologists: The Development, Life, and Death of the Evalumetrics Program.

Arch Pathol Lab Med

April 2017

From the Department of Pathology, Rex Pathology Associates, Raleigh, North Carolina (Dr Volmar); the Department of Pathology, Duke University Medical Center, Durham, North Carolina (Dr McCall); the Department of Pathology, Southern Arizona VA Healthcare System, Tucson (Dr Schifman); the Department of Pathology, Oklahoma University Health Science Center, Oklahoma City (Dr Talbert); the Department of Pathology, St. Joseph Mercy Hospital, Ann Arbor, Michigan (Dr Tworek); Structured Data Team (Dr Hulkower), Department of Biostatistics (Ms Souers), Department of Laboratory Improvement-Surveys (Ms Bashleben), Department of Laboratory Improvement-Biostatistics (Ms Blond), College of American Pathologists, Northfield, Illinois; the Department of Pathology, Newton-Wellesley Hospital, Newton, Massachusetts (Dr Guidi); and the Department of Pathology, Mayo Clinic Jacksonville, Jacksonville, Florida (Dr Nakhleh).

Context: - In 2008, the Joint Commission (JC) implemented a standard mandating formal monitoring of physician professional performance as part of the process of granting and maintaining practice privileges.

Objective: - To create a pathology-specific management tool to aid pathologists in constructing a professional practice-monitoring program, thereby meeting the JC mandate.

Design: - A total of 105 College of American Pathologists (CAP)-defined metrics were created.

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A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1 mice is correlated to increased cellular senescence.

Redox Biol

April 2017

Department of Geriatric Medicine and the Reynolds Oklahoma Center on Aging, Oklahoma University Health Science Center, Oklahoma City, OK, USA; Oklahoma City VA Medical Center, Oklahoma City, OK, USA. Electronic address:

In contrast to other mouse models that are deficient in antioxidant enzymes, mice null for Cu/Zn-superoxide dismutase (Sod1 mice) show a major decrease in lifespan and several accelerated aging phenotypes. The goal of this study was to determine if cell senescence might be a contributing factor in the accelerated aging phenotype observed in the Sod1 mice. We focused on kidney because it is a tissue that has been shown to a significant increase in senescent cells with age.

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Objectives: The aim of this study was to assess actual procedural costs and outcomes comparing wire-catheter and dedicated chronic total occlusion (CTO) device strategies to cross peripheral artery CTOs.

Background: Peripheral artery CTO interventions are frequently performed, but there are limited data on actual procedural costs and outcomes comparing wire-catheter and dedicated CTO devices.

Methods: The XLPAD (Excellence in Peripheral Artery Disease Intervention) registry (NCT01904851) was accessed to retrospectively compare cost and 30-day and 12-month outcomes of wire-catheter and crossing device strategies for treatment of infrainguinal peripheral artery CTO.

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