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Genetics in Sjögren's syndrome: where we are and where we go.
Clin Exp Rheumatol
October 2019
Arthritis & Clin. Immunology Program, Oklahoma Med. Research Foundation; Depts. of Medicine and Pathology, College of Medicine, Univ. of Oklahoma Health Sciences Center; Research & Medical Services, Oklahoma City US Dept. of Veterans Affairs Center, USA.
Sjögren's syndrome is a complex autoimmune disease that involves dysregulation of immune responses that preferentially target exocrine glands. Systemic manifestations vary and may involve nearly every organ system. Genetic studies to date are in their infancy relative to other autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis, each with more than 100 genetic associations now established.
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