123 results match your criteria: "Oklahoma Children's Hospital[Affiliation]"

Background: Glossopharyngeal neuralgia (GPN) is a rare condition typically manifesting as paroxysms of sharp, lancinating pain localized to the middle ear and auditory canal, base of the tongue, tonsillar fossa, and region just inferior to the angle of the mandible. Vascular compression is a common etiology, and microvascular decompression (MVD) has been established as a safe and efficacious treatment in adults. With the exception of one report of an adult patient undergoing the procedure for symptomatology that began in adolescence, there are no published cases of MVD for GPN in pediatric patients to the author's knowledge.

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Background: Camurati-Engelmann disease (CED) is an extremely rare autosomal dominant genetic disorder that can cause increased intracranial pressure (ICP) secondary to cranial hyperostosis, which decreases intracranial volume. Surgical procedures to reduce ICP in medically refractory cases include intracranial volume expansion and ventriculoperitoneal shunting.

Observations: The authors present the case of a pediatric patient with CED and medically refractory increased ICP who underwent unilateral hemicraniectomy with titanium cranioplasty, resulting in a complete long-term resolution of symptoms.

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Using the Expertise of a Clinical Nurse Specialist to Lead a Neonatal Peripherally Inserted Central Catheter Team to Central Line-Associated Bloodstream Infection Reduction and Cost-Efficiency Through Quality Improvement.

J Nurs Adm

October 2024

Author Affiliations: Assistant Professor (Dr Bedwell), University of Oklahoma Fran and Earl Ziegler College of Nursing; and Director of Quality (Dr Bedwell), Director of Neonatal Nursing (Oberlechner), and Neonatologist (Drs Pogribna and Sekar), Oklahoma Children's Hospital, Oklahoma City.

Objective: This quality improvement project aimed to reduce central line bacteremias (central line-associated bloodstream infections [CLABSIs]) in a neonatal ICU (NICU) to a CLABSI rate of zero using a clinical nurse specialist (CNS)-led neonatal peripherally inserted central catheter (PICC) team.

Background: The NICU at the study site was experiencing more than twice the National Healthcare Safety Network average CLABSI rate at 2.2 per 1000 line-days with an estimated cost of $2 072 806 to the organization.

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Purpose: Povidone-iodine, or Betadine® (Atlantis Consumer Healthcare Inc., Bridgewater, NJ), is a commonly used agent for surgical site preparation. Although commonly used, it carries the risk of skin reactions, and multiple cases of intra-operative contact dermatitis and chemical burns have been reported.

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We report a 7-year-old girl born with pyloric atresia but without congenital epidermolysis bullosa or skin fragility. Nail dysplasia developed at age 8 months and throughout childhood she suffered from onycholysis and mild nail hypertrophy. Whole-exome sequencing demonstrated biallelic mutations in alpha6 integrin (ITGA6): p.

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Article Synopsis
  • The study investigates the effectiveness of enoxaparin, a medication for preventing blood clots, in critically ill children, focusing on differences in response based on age, particularly between older children and infants.
  • It consists of two simultaneous clinical trials: one for older children aged 1-17 years, and another for infants under 1 year, with specific dosing protocols for each group.
  • The trials are set in multiple pediatric intensive care units across the U.S., using methods like randomization, ultrasonography, and blood analysis to assess outcomes and monitor safety.
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Contemporary Ethical Considerations for Pediatric Metabolic and Bariatric Surgery.

J Pediatr Surg

October 2024

Section of Pediatric Surgery, Department of Surgery, The University of Chicago, Chicago, IL, USA; The MacLean Center for Clinical Medical Ethics, The University of Chicago, Chicago, IL, USA. Electronic address:

Background: The prevalence of pediatric obesity continues to increase dramatically. Though metabolic and bariatric surgery (MBS) is efficacious and is supported by high-quality data in this population, it remains underutilized. This paper aims to discuss current ethical concerns, considerations, and controversies of pediatric MBS.

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Article Synopsis
  • * Residency programs offer structured research support, but many new practitioners still find it intimidating to start research independently.
  • * The article outlines strategies for integrating research into practice, including collaboration, professional opportunities, and planning, to help new pharmacists successfully incorporate scholarly activities early in their careers.
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Article Synopsis
  • A multicenter study involving 13 pediatric trauma centers examined the effects of a standardized non-operative management (NOM) approach for children with blunt traumatic pancreatic laceration and ductal injury between 2018-2022.
  • Results showed that most patients recovered quickly with a low-fat diet starting after a median of 4 days, and hospital stays averaging 8 days, while complications like cyst development were significantly reduced compared to a historical variable management cohort.
  • The findings suggest that using a consistent NOM protocol can improve patient outcomes and that pancreatic ascites at presentation might indicate a higher risk of developing pseudocysts in these cases.
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Objectives: Vasopressin is used for shock and acute pulmonary hypertension in the neonatal intensive care unit (NICU) and is associated with hyponatremia. The purpose of this study was to determine the incidence, severity, contributing risk factors associated with vasopressin-induced hyponatremia in neonates and infants <3 months of age in the NICU. The primary objective was to determine the incidence of hyponatremia (<130 mEq/L) and severe hyponatremia (<125 mEq/L).

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Gabapentin for Delirium in Infants in the Neonatal Intensive Care Unit.

J Pediatr Pharmacol Ther

October 2024

Department of Pharmacy: Clinical and Administrative Sciences (JLM, SBN, PNJ, AP), College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK.

Objective: A protocol was developed for neonatal intensive care unit (NICU) delirium: Step 1, gabapentin for pain or melatonin for sleep; Step 2, add on other Step 1 agent; Step 3, antipsychotics. The purpose of this study was to describe the utility and dosing of gabapentin for NICU delirium.

Methods: Retrospective evaluation of NICU patients from January 1, 2021-December 31, 2022 who received >1 dose of gabapentin based on the delirium protocol.

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Article Synopsis
  • Intravenous lipids are important for very premature babies to get the nutrition they need safely.
  • The study compared two kinds of intravenous fats: one made with fish oil (CO-ILE) and another made with only soybean oil (SOLE), to see which was better for babies needing long-term nutrition.
  • Results showed that CO-ILE had a lower chance of causing liver problems and less yellowing of the skin compared to SOLE, suggesting CO-ILE might be a safer choice for these babies.
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Pediatric gastrointestinal bleeding: identification and management in the emergency department.

Pediatr Emerg Med Pract

September 2024

Clinical Assistant Professor, Department of Pediatrics, Division of Pediatric Emergency Medicine, Oklahoma University Health Science Center, Oklahoma City, OK.

Pediatric gastrointestinal (GI) bleeding ranges from mild and self-limited cases to severe episodes of hemorrhagic shock. A structured, age-specific approach is essential for the correct diagnostic workup and effective management. Collaboration with a multidisciplinary team, including pediatric surgery and gastroenterology specialists, may be necessary.

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Redox Chemistry: Implications for Necrotizing Enterocolitis.

Int J Mol Sci

August 2024

Division of Pediatric Surgery, Oklahoma Children's Hospital, 1200 Everett Drive, ET NP 2320, Oklahoma City, OK 73104, USA.

Reduction-oxidation (redox) chemistry plays a vital role in human homeostasis. These reactions play critical roles in energy generation, as part of innate immunity, and in the generation of secondary messengers with various functions such as cell cycle progression or the release of neurotransmitters. Despite this cornerstone role, if left unchecked, the body can overproduce reactive oxygen species (ROS) or reactive nitrogen species (RNS).

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Objective: The objective of this study was to determine the incidence of hydrocortisone-associated gastrointestinal bleeding (GIB) in infants <3 months and compare rates with or without stress ulcer prophylaxis.

Study Design: Retrospective cohort study of NICU patients <3 months who received hydrocortisone for hypotension. Three logistic regressions were conducted for adjusted associations between GIB, necrotizing enterocolitis (NEC), or infection and clinical characteristics.

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Effect of Ablation Energy Source on Outcomes of Slow Pathway Modification for AVNRT in Children.

JACC Clin Electrophysiol

October 2024

Division of Cardiology, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address:

Article Synopsis
  • A study was conducted to compare the effectiveness of radiofrequency ablation (RF) and cryoablation (Cryo) in treating atrioventricular nodal re-entrant tachycardia (AVNRT) in children, as previous studies have lacked contemporary comparisons.
  • Data from the National Cardiovascular Data Registry was analyzed for 2,448 pediatric patients aged 1 to 21 who underwent their first ablation for AVNRT from 2016 to 2019, examining outcomes based on ablation energy type.
  • The results showed that both RF and Cryo had similar success rates for acute ablation failure and very few complications, indicating that both methods are effective and safe for this procedure in children.
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Electronic Heart (ECG) Monitoring at Birth and Newborn Resuscitation.

Children (Basel)

June 2024

Department of Pediatrics, College of Medicine, University of Oklahoma (OU), Oklahoma City, OK 73104, USA.

Background: Approximately 10% of newborns require assistance at delivery, and heart rate (HR) is the primary vital sign providers use to guide resuscitation methods. In 2016, the American Heart Association (AHA) suggested electrocardiogram in the delivery room (DR-ECG) to measure heart rate during resuscitation. This study aimed to compare the frequency of resuscitation methods used before and after implementation of the AHA recommendations.

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Article Synopsis
  • Neurological issues are prevalent in children hospitalized with SARS-CoV-2-related multisystem inflammatory syndrome (MIS-C), potentially leading to lasting cognitive and functional problems.
  • This study investigates how severe neurological symptoms during hospitalization relate to new cognitive and functional impairments upon discharge among children under 18.
  • Over 3,500 patients were examined, revealing that those with severe neurological manifestations had a higher likelihood of experiencing new morbidities at discharge compared to those without such issues.
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Objective: The goal of this study was to evaluate the impact of endoscopic third ventriculostomy (ETV) failure on subsequent risk of ventriculoperitoneal shunt (VPS) placement.

Methods: A retrospective chart review was performed to identify pediatric patients receiving ETV followed by a VPS at Oklahoma Children's Hospital between January 1, 2016, and December 31, 2021. A control group of patients receiving a VPS alone was also gathered.

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Refeeding syndrome is characterized by electrolyte imbalances that occur during nutritional replenishment in malnourished patients. Hypomagnesemia is a potential complication.  We present a unique case of a female, young adult patient with anorexia nervosa who experienced persistent hypomagnesemia during inpatient refeeding that did not resolve with magnesium supplementation.

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Extremely preterm infants are often treated with supraphysiological oxygen, which contributes to the development of bronchopulmonary dysplasia (BPD). These same infants exhibit compromised antioxidant capacities due in part to selenium (Se) deficiency. Se is essential for basal and inducible antioxidant responses.

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Article Synopsis
  • The study focuses on children who have surgery to remove spine tumors and whether they also need a second surgery to fix their spine afterwards.
  • It explains that many kids experience problems after surgery, and that there isn’t much information on doing both the tumor removal and spine fixing at the same time.
  • The researchers gathered results from several studies and found nine kids who had both surgeries together, mostly because they had major issues with their spine before the operation.
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Nationwide abortion restrictions resulting from the Dobbs v Jackson Women's Health Organization (2022) decision have generated confusion and uncertainty among healthcare professionals, with concerns for liability impacting clinical decision-making and outcomes. The impact on pediatric surgery can be seen in prenatal counseling for fetal anomaly cases, counseling for fetal intervention, and recommendations for pregnant children and adolescents who seek termination. It is essential that all physicians and healthcare team members understand the legal implications on their clinical practices, engage with resources and organizations that can help navigate these circumstances, and consider advocating for patients and themselves.

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Background: Surgical residencies act as an apprenticeship to train new surgeons, ideally with increasing trainee autonomy and competency. Objective methods of measuring these two qualities are needed.

Methods: The objective of this pilot study is to use the Surgical Autonomy Program to compare resident and attending perception of competency, via Zones of Proximal Development (ZPDs), and autonomy, via Teach, Advise, Guide, Solo (TAGS) scale for a common pediatric neurosurgical procedure.

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