441 results match your criteria: "Okayama Saiseikai General Hospital.[Affiliation]"

Introduction: Osteogenesis imperfecta (OI) is a congenital skeletal disorder characterized by bone fragility. Bisphosphonates (BISs) have become the mainstream treatment in children with OI. However, an optimal treatment protocol has not yet been established, while BIS treatment tends to be administered to normalize bone mineral density (BMD).

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Several reports revealed that oxidative stress was involved in the mouse model of nonsteroidal anti-inflammatory drug (NSAIDs)-induced small intestinal mucosal injuries. Thus, we aimed to investigate in the prospective clinical study, that the relevance of oxidative stress balance in small intestinal mucosal injury in NSAIDs users. We prospectively included 60 patients who had been taking NSAIDs continuously for more than 3 months and exhibited obscure gastrointestinal bleeding (number UMIN 000011775).

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Limited data are available on the frequency and significance of body weight loss during cancer therapy. This study investigated the frequency of patients who experienced body weight loss during immune checkpoint inhibitor (ICI) plus chemotherapy for advanced non-small cell lung cancer (NSCLC) and the impact of weight loss on treatment outcomes. Using the clinical data of 370 patients with NSCLC who received a combination of ICI and chemotherapy at 13 institutions, this study investigated the frequency of body weight loss > 5% during treatment and determined the impact of body weight loss on patient outcomes.

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Purpose: Following the COVID-19 pandemic, group A Streptococcus (GAS) infection has been surging worldwide. We aimed to compare the disease burden between notified cases of streptococcal toxic shock syndrome (STSS) and unreported GAS infections.

Methods: This is a multicentral observational study, retrospectively performed at seven hospitals in Okayama prefecture in Japan from January 2022, to June 2024.

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  • The study analyzed data from 93 participants with type 1 diabetes to explore how the frequency of scanning with intermittent-scanning continuous glucose monitoring (isCGM) affects time in range (TIR), time above range (TAR), and time below range (TBR) throughout the day.
  • Increased scanning frequency was linked to higher TIR, particularly in the afternoon, evening, and night, and was associated with lower TAR and TBR during these times.
  • Psychological factors, such as concerns about blood glucose levels affecting social interactions and feelings of loneliness, were found to influence how often participants scanned their glucose levels.
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Colorectal villous tumors secrete large amounts of mucus that can cause electrolyte abnormalities and dehydration, a condition known as electrolyte depletion syndrome. A woman in her 70s, who had been underweight for 10 years with a body mass index(BMI)of 16, was admitted to our hospital with electrolyte abnormalities, renal disorders, and rectal tumors. The electrolyte abnormalities and renal disorders were corrected relatively quickly with supplemental fluid therapy.

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  • Type 2 diabetes mellitus (T2DM) significantly increases the risk of developing hepatocellular carcinoma (HCC), which is typically diagnosed late in diabetes patients due to insufficient surveillance criteria.
  • This study involved 330 T2DM patients with nonviral chronic liver disease diagnosed using imaging techniques, comparing clinical parameters between those with and without HCC.
  • Key risk factors for HCC included age over 65, alcohol consumption, and specific laboratory results, highlighting the need for adapted HCC surveillance strategies tailored to both younger and older T2DM patients.
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  • A study looked at the safety of continuing blood thinners (warfarin and DOACs) in patients needing a stomach procedure for early cancer.
  • It found that people taking warfarin didn't have any bleeding after the procedure, while some people taking DOACs did.
  • The researchers suggest that it's safer to keep using warfarin and that stopping DOACs too close to the procedure can lead to more bleeding problems.
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Purpose: The effects of first-generation antihistamines in preventing postoperative emergence agitation or delirium are unclear. Determining the postoperative effects of first-generation antihistamines may provide important insights into the management of patient safety. Therefore, we performed a systematic review of randomized controlled trials (RCTs) evaluating the efficacy and safety of postoperative first-generation antihistamines.

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Background: Grey-white matter ratio (GWR) measured by head computed tomography (CT) scan is known as a neurological prognostication tool for out-of-hospital cardiac arrest (OHCA) survivors. The prognostic value of GWR obtained early (within two hours after return of spontaneous circulation [ROSC]) remains a matter of debate.

Methods: We conducted a multicenter, retrospective, observational study at five hospitals.

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  • The CANPIONE study aimed to evaluate the effectiveness of canagliflozin, an SGLT2 inhibitor, in slowing the progression of chronic kidney disease (CKD) in participants with early-stage CKD and type 2 diabetes.
  • In a trial involving 98 participants, those taking canagliflozin showed a significant reduction in urinary albumin levels and a slower decline in their estimated glomerular filtration rate (eGFR) compared to those receiving standard treatment.
  • The study suggests that monitoring individual changes in eGFR slope could be a promising method for assessing the kidney-protective effects of new treatments in early CKD.
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Objectives: This study investigated the incidence of lymph node metastasis and long-term outcomes in patients with T1 colorectal cancer where endoscopic submucosal dissection (ESD) resulted in noncurative treatment. It is focused on those with deep submucosal invasion, a factor considered a weak predictor of lymph node metastasis in the absence of other risk factors.

Methods: This nationwide, multicenter, prospective study conducted a post-hoc analysis of 141 patients with T1 colorectal cancer ≥20 mm where ESD of the lesion resulted in noncurative outcomes, characterized by poor differentiation, deep submucosal invasion (≥1000 μm), lymphovascular invasion, high-grade tumor budding, or positive vertical margins.

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Objective: The aim of this study was to evaluate the effects of the single-photon emission computed tomography (SPECT) acquisition method and sampling angles on the qualitative and quantitative interpretations of xSPECT-reconstructed images.

Methods: The spatial resolution was evaluated using a JSP phantom, and the uniformity and quantitative accuracy were verified with a NEMA IEC Body Phantom using an SIEMENS Symbia Intevo SPECT/computed tomography system. SPECT was performed using three acquisition methods (step-and-shoot, continuous, and acquire during the step), and the sampling angles were set to 2, 3, 4, 5, and 6°.

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Predictors of the effectiveness of isCGM usage in adults with type 1 diabetes mellitus: post-hoc analysis of the ISCHIA study.

Diabetol Int

July 2024

Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan.

Aim: The Effect of Intermittent-Scanning Continuous Glucose Monitoring to Glycemic Control Including Hypoglycemia and Quality of Life of Patients with Type 1 Diabetes Mellitus (ISCHIA) study was a randomized, crossover trial that reported the decrease in time below range (TBR) by the use of intermittent-scanning continuous glucose monitoring (isCGM) combined with structured education in adults with type 1 diabetes (T1D) treated by multiple daily injections. The participants were instructed to perform frequent scanning of the isCGM sensor (10 times a day or more) and ingest sugar when impending hypoglycemia is suspected by tracking the sensor glucose levels and the trend arrow. We conducted post-hoc analysis to identify factors affecting difference in TBR (∆TBR), in time in range (∆TIR), and in time above range (∆TAR).

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  • A study on hepatitis E virus (HEV) infection in wild boars in Japan analyzed samples from 968 boars across 16 prefectures between 2018 and 2023 to assess infection rates and genetic diversity.
  • The prevalence of anti-HEV IgG antibodies varied from 0% to 35%, while HEV RNA was detected in 3.6% of the boars, with genotype 3 being the most common.
  • The study found a significant decrease in HEV infection rates over time, likely due to control measures like fencing to prevent wild boar intrusion into pig farms, implemented in response to a related outbreak of classical swine fever virus.
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Introduction: ACE cleaves angiotensin I (Ang I) to angiotensin II (Ang II) inducing vasoconstriction via Ang II type 1 (AT1) receptor, while ACE2 cleaves Ang II to Ang (1-7) causing vasodilatation by acting on the Mas receptor. In diabetic kidney disease (DKD), it is still unclear whether plasma or urine ACE2 levels predict renal outcomes or not.

Research Design And Methods: Among 777 participants with diabetes enrolled in the Urinary biomarker for Continuous And Rapid progression of diabetic nEphropathy study, the 296 patients followed up for 9 years were investigated.

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Aim: To conduct a post hoc subgroup analysis of patients with type 2 diabetes (T2D) from the RECAP study, who were treated with sodium-glucose cotransporter-2 (SGLT2) inhibitor and glucagon-like peptide 1 receptor agonist (GLP-1RA) combination therapy, focusing only on those patients who had chronic kidney disease (CKD), to examine whether the composite renal outcome differed between those who received SGLT2 inhibitor treatment first and those who received a GLP-1RA first.

Methods: We included 438 patients with CKD (GLP-1RA-first group, n = 223; SGLT2 inhibitor-first group, n = 215) from the 643 T2D patients in the RECAP study. The incidence of the composite renal outcome, defined as progression to macroalbuminuria and/or a ≥50% decrease in estimated glomerular filtration rate (eGFR), was analysed using a propensity score (PS)-matched model.

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This network meta-analysis of randomized controlled trials aimed to determine whether any individual dipeptidyl peptidase-4 (DPP-4) inhibitors increase the risk of acute kidney injury (AKI). The Medical Literature Analysis and Retrieval System Online via PubMed, the Cochrane Central Register of Controlled Trials and ClinicalTrials.gov were systematically searched to identify relevant studies.

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In a randomized, open-label phase 3 study of 61 children aged 1-12 years old with X-linked hypophosphatemia (XLH) previously treated with conventional therapy, changing to burosumab every 2 weeks (Q2W) for 64 weeks improved the phosphate metabolism, radiographic rickets, and growth compared with conventional therapy. In this open-label extension period (weeks 64-88), 21 children continued burosumab Q2W at the previous dose or crossed over from conventional therapy to burosumab starting at 0.8 mg/kg Q2W with continued clinical radiographic assessments through week 88.

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  • The study evaluated the effectiveness and safety of selective laser trabeculoplasty (SLT) as both a first-line and second-line treatment for normal-tension glaucoma (NTG) in Japanese patients.
  • 99 patients were treated with SLT, showing significant reductions in intraocular pressure (IOP) after one year, with the first-line group demonstrating a higher success rate than the second-line group.
  • Most complications observed were minor and temporary, indicating that SLT is a reliable treatment option for NTG regardless of its line of use.
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  • SGLT2 inhibitors (SGLT2i) and GLP-1 receptor agonists (GLP1Ra) both show protective effects for patients with diabetic kidney disease, often used in combination for type 2 diabetes (T2D).
  • A study involving 643 T2D patients examined differences in annual eGFR decline based on whether patients started with SGLT2i or GLP1Ra.
  • Results indicated that those starting with SGLT2i had a significantly smaller decline in eGFR after adding GLP1Ra, while the reverse pairing showed no significant change, suggesting the preceding drug influences the renal benefits of the combination therapy.
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Enhancing Diagnostic Precision: Evaluation of Preprocessing Filters in Simple Diffusion Kurtosis Imaging for Head and Neck Tumors.

J Clin Med

March 2024

Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.

Our initial clinical study using simple diffusion kurtosis imaging (SDI), which simultaneously produces a diffusion kurtosis image (DKI) and an apparent diffusion coefficient map, confirmed the usefulness of SDI for tumor diagnosis. However, the obtained DKI had noticeable variability in the mean kurtosis (MK) values, which is inherent to SDI. We aimed to improve this variability in SDI by preprocessing with three different filters (Gaussian [G], median [M], and nonlocal mean) of the diffusion-weighted images used for SDI.

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Background And Aims: Cholecystitis can occur after self-expandable metallic stent (SEMS) placement for malignant biliary obstruction (MBO), but the best treatment option for cholecystitis has not been determined. Here, we aimed to identify the risk factors of cholecystitis after SEMS placement and determine the best treatment option.

Methods: Incidence, treatments, and predictive factors of cholecystitis were retrospectively evaluated in 1084 patients with distal MBO (DMBO) and 353 patients with hilar MBO (HMBO) who underwent SEMS placement at 12 institutions from January 2012 to March 2021.

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