Differing coronavirus genres alter shared host signaling pathways upon viral infection.

Coronaviruses are important viral pathogens across a range of animal species including humans. They have a high potential for cross-species transmission as evidenced by the emergence of COVID-19 and may be the origin of future pandemics. There is therefore an urgent need to study coronaviruses in depth and to identify new therapeutic targets.

Comparative Transcriptome Profiling of Human and Pig Intestinal Epithelial Cells after Porcine Deltacoronavirus Infection.

Porcine deltacoronavirus (PDCoV) is an emerging infectious disease of swine with zoonotic potential. Phylogenetic analysis suggests that PDCoV originated recently from a host-switching event between birds and mammals. Little is known about how PDCoV interacts with its differing hosts.

Interactive medical data on demand: a high-performance imaged-based approach across heterogeneous environments.

Medical data in image format continues to increase in both size and complexity. We have integrated advanced techniques in visualization, networked computing, and interface design to improve methods for accessing medical data comprising high-resolution images for reconstructions into three-dimensional volumetric representations. We present two approaches to handle the range of low to high-end client platforms, support visualization functionality, and provide the ability to manipulate very large data over heterogeneous computing and networking environments.