Overcoming immune evasion in T cell therapy of cancer: lessons from animal models.

Cancer antigen-specific cytotoxic T lymphocytes (CTL) are the major effectors against cancer cells. However, large established tumors are usually not fully controlled by CTL for at least two reasons. First, large established tumors have immune suppressive networks that not only suppress CTL effector function but also permit tumor progression.

Sticking together! A creative approach to documenting insulin double checks.

Patient care and family teaching are the heart of the rehabilitation staff nurse's role. Documentation of the various aspects of patient care and family teaching is a necessary but time-consuming process. In this article you will learn how the nurses of one rehabilitation center welcomed a creative time-saving method of working together to improve documentation compliance for double checking insulin administration.

Neuroendocrine carcinomas of the pancreas with 'Rhabdoid' features.

Neuroendocrine carcinomas of the pancreas are rare neoplasms whose morphologic features generally mirror those seen in neuroendocrine tumors in other organs. Rarely, however, they may display unusual morphologic appearances that can introduce difficulties for diagnosis. We report four cases of primary neuroendocrine carcinomas of the pancreas (islet cell tumors) that were characterized by prominent "rhabdoid" features of the tumor cells.