Patent review of novel compounds targeting opioid use disorder (2018-2024).

Introduction: Opioids have served as a cornerstone in pain management for decades. However, the emergence of increasingly potent synthetic analogs brings forth a range of side effects, including respiratory depression, tolerance, dependence, constipation, and, more importantly, the development of severe and debilitating opioid use disorder (OUD). Search for therapeutics to mitigate OUD has been challenging and this has called for novel approaches that include design of small molecules targeting neuronal circuits involved in addiction (opioid, dopamine, serotonin, norepinephrine, and glutamate receptors, etc.

Generating Virtual Bone Scans for the Purpose of Investigating the Effects of Cortical Microstructure.

Evaluating the contribution of microstructure to overall bone strength is tricky since it is difficult to control changes to pore structure in human or animal samples. We developed an open-source program that can generate three-dimensional models of micron-scale cortical bone. These models can be highly customized with a wide array of variable input parameters to allow for generation of samples with high similarity to CT scans of cortical bone or with specific geometric features.

Opinions about climate change, health, and pharmacy education among pharmacy faculty and administrators in the United States: A cross-sectional survey.

Background: The pharmacy profession must address climate change and its impact on health. Student pharmacists should be made aware of roles in sustainability, education, patient care, and advocacy; yet, pharmacy educators' perceptions of climate change and health may impact the extent and quality of education provided.

Objective: The primary objective was to assess pharmacy educators' beliefs regarding climate change and whether its effects on health should be included in Doctor of Pharmacy curricula.

Functional large-conductance calcium and voltage-gated potassium channels in extracellular vesicles act as gatekeepers of structural and functional integrity.

Extracellular vesicles (EVs) are associated with intercellular communications, immune responses, viral pathogenicity, cardiovascular diseases, neurological disorders, and cancer progression. EVs deliver proteins, metabolites, and nucleic acids into recipient cells to effectively alter their physiological and biological response. During their transportation from the donor to the recipient cell EVs face differential ionic concentrations, which can be detrimental to their integrity and impact their cargo content.

Gene model for the ortholog of in .

Gene model for the ortholog of Downstream of raf1 ( ) in the May 2011 (Broad dper_caf1/DperCAF1) Genome Assembly (GenBank Accession: GCA_000005195.1 ) of . This ortholog was characterized as part of a developing dataset to study the evolution of the Insulin/insulin-like growth factor signaling pathway (IIS) across the genus using the Genomics Education Partnership gene annotation protocol for Course-based Undergraduate Research Experiences.

Advanced Segmentation of Gastrointestinal (GI) Cancer Disease Using a Novel U-MaskNet Model.

The purpose of this research is to contribute to the development of approaches for the classification and segmentation of various gastrointestinal (GI) cancer diseases, such as dyed lifted polyps, dyed resection margins, esophagitis, normal cecum, normal pylorus, normal Z line, polyps, and ulcerative colitis. This research is relevant and essential because of the current challenges related to the absence of efficient diagnostic tools for early diagnostics of GI cancers, which are fundamental for improving the diagnosis of these common diseases. To address the above challenges, we propose a new hybrid segmentation model, U-MaskNet, which is a combination of U-Net and Mask R-CNN models.

Development and Applications of an Amide Linchpin Reagent.

Linchpin reagents are building blocks that can be chemoselectively functionalized to afford products with a common, useful functional group. In this work, we describe the development and validation of the first amide linchpin reagent and demonstrate its use as a doubly electrophilic building block for the synthesis of a variety of amides, including challenging classes. The linchpin reagent was first functionalized via rhodium-catalyzed electrophilic amination.

Practice transformation starts in the classroom: Mapping practice change learning in a PharmD program.

Objective: As the profession of pharmacy continues to evolve, it is important to integrate pharmacy practice change learning into the Doctor of Pharmacy (PharmD) curriculum. The objective of this project was to evaluate how pharmacy practice change was being taught within a PharmD curriculum and to identify strategies for improvement.

Methods: The College of Pharmacy's PharmD Curricular Leadership Committee (PDCLC) developed a definition for practice change learning and assembled a team of faculty experts to map practice change to the PharmD curriculum.

Student-to-faculty ratios and NAPLEX pass rates.

Objective: ACPE newly approved standards for PharmD programs (Standards 2025) indicates that colleges should maintain a student-to-faculty ratio of no greater than 10:1. This may have significant implications for colleges that are currently above the 10:1 ratio; yet, little published evidence exists for using 10:1 as the threshold for determining whether a college has sufficient faculty. This study examines the relationship of student-to-faculty ratio with NAPLEX first-attempt pass rate.

Acid suppressive therapy for gastroesophageal reflux disease.

Gastrointestinal (GI) disorders range from intermittent heartburn to life-threatening GI hemorrhage. One of the most common GI disorders is gastroesophageal reflux disease (GERD), which affects an estimated 19% of adults in North America. This article discusses the advantages and disadvantages of acid-suppressive therapy for patients with GERD as well as relevant nursing considerations.

Transforming education for rural health equity: Lessons from a rural and underserved health scholars program.

Background And Purpose: Rural and underserved areas are in desperate need of improved access to healthcare services to enhance the well-being of patients. In an effort to increase students' healthcare access and exposure to the knowledge and skills of healthcare professionals in this area, a specialized certificate program on the care of rural and underserved patients was created. The purpose of this article is to describe the design, implementation, and assessment of this program.

In Silico Design of Novel RGS2-G Interaction Inhibitors with Anticancer Activity.

Regulators of G-protein signaling (RGS) are a family of approximately 30 proteins that bind to and deactivate the alpha subunits of G-proteins (G) by accelerating their GTP hydrolysis rates, which terminates G-protein coupled receptor (GPCR) signaling. Thus, RGS proteins are essential in regulating GPCR signaling, and most members are implicated as critical nodes in human diseases such as hypertension, depression, and others. Regulator of G-protein signaling 2 (RGS2), a member of the R4 family of RGS proteins, is overexpressed in many solid breast cancers, and its levels in prostate cancer significantly correlate with the metastatic stage and poor prognosis.

is a novel allele of the gene ( ) in .

Genetic screens in have long been used to identify genes found in a variety of developmental, cellular, and behavioral processes. Here we describe the characterization and mapping of a mutation identified in a conditional screen for genetic regulators of cell growth and cell division. Within a Flp/FRT system, mutant results in a reduction of mutant tissue and a rough eye phenotype.

Pearls and pitfalls of over-the-counter nasal sprays for seasonal allergy.

Allergic rhinitis (AR), commonly called hay fever, is primarily caused by the release of histamine after exposure to an allergen. This article reviews over-the-counter nasal spray options for the prevention and treatment of AR, including mechanisms of action, risks and benefits, and patient education.

Evaluating the potential for psilocybin as a treatment for post-traumatic stress disorder.

Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition that develops following exposure to a traumatic event. Individuals with this condition experience numerous physiological and behavioral alterations, including intrusive memories, avoidance of trauma-related stimuli, heightened anxiety, hypervigilance, impaired cognition, elevated resting heart rate and blood pressure, and altered neuroendocrine function, to name a few. In most patients, currently available pharmacological and psychological treatments are insufficient to alleviate the array of symptoms associated with the disorder.

Design, synthesis, and antiproliferative activity of new indole/1,2,4-triazole/chalcone hybrids as EGFR and/or c-MET inhibitors.

A novel group of indolyl-1,2,4-triazole-chalcone hybrids was designed, synthesized, and assessed for their anticancer activity. The synthesized compounds exhibited significant antiproliferative activity. Compounds 9a and 9e exhibited significant cancer inhibition with GI ranging from 3.

The Risk of Venous Thromboembolism Events Resulting in Hospitalization following Exposure to Antipsychotic Medication in Pre-Disposed Adult Patients.

: The primary objective of this study was to compare the incidence of antipsychotic use in those with venous thromboembolism (VTE) resulting in hospital admission. This study expands upon current knowledge regarding VTE risk and antipsychotic use and investigates potential risk factors and lab values that may precede antipsychotic-induced coagulopathy. : This retrospective, case-control, chart review investigated patients admitted to an acute care hospital with either a VTE or non-VTE diagnosis.

Pharmacy Interns' Perception of Climate Change and Its Impact on Health.

: The effects of climate change are major threats to health and well-being. While the profession of pharmacy can make a difference through patient care activities, sustainability, and advocacy, literature detailing U.S.

Effects of amphibian genetic diversity on ecological communities.

The amount of genetic diversity within a population can affect ecological processes at population, community, and ecosystem levels. However, the magnitude, consistency, and scope of these effects are largely unknown. To investigate these issues, we conducted two experiments manipulating the amount of genetic diversity and environmental factors in larval amphibians.

Pearls and pitfalls of OTC medications for seasonal allergies.

Seasonal allergies have a negative impact on patients' quality of life. Nurses must be aware of the different treatment options and lifestyle modifications to help patients manage their symptoms. This article discusses the benefits and risks of over-the-counter medications for seasonal allergies and other implications for nurses.

Benzimidazole scaffold as a potent anticancer agent with different mechanisms of action (2016-2023).

Benzimidazole scaffolds have potent anticancer activity due to their structure similarity to nucleoside. In addition, benzimidazoles could function as hydrogen donors or acceptors and bind to different drug targets that participate in cancer progression. The literature had many anticancer agents containing benzimidazole cores that gained much interest.