Characterizing the within-person variability of food insecurity in everyday life.

Food insecurity (FI), the lack of access to adequate food, is linked with negative health and psychological outcomes. FI is typically measured retrospectively over the last year; although this measurement is useful to understand FI prevalence to inform broad policy, it leaves the experience of FI in everyday life poorly understood. Understanding how FI varies across shorter periods of time (days or weeks) can help inform FI prevention and/or intervention.

The Effects of Practice on Graduate Nursing Students' Objective Structured Clinical Examination Scores.

Background: Objective structured clinical examinations (OSCEs) are an important part of the graduate nursing curriculum at The Ohio State University, including in the psychiatric mental health nurse practitioner (PMHNP) program. Despite positive feedback from the OSCE assignments, students often reported experiencing anxiety before the assignments. In 2023, the PMHNP faculty implemented a pre-OSCE practice assignment designed for students to review an initial psychiatric evaluation by interviewing a peer.

Brain Transcriptome Changes Associated With an Acute Increase of Protein O-GlcNAcylation and Implications for Neurodegenerative Disease.

Enhancing protein O-GlcNAcylation by pharmacological inhibition of the enzyme O-GlcNAcase (OGA) has been considered as a strategy to decrease tau and amyloid-beta phosphorylation, aggregation, and pathology in Alzheimer's disease (AD). There is still more to be learned about the impact of enhancing global protein O-GlcNAcylation, which is important for understanding the potential of using OGA inhibition to treat neurodegenerative diseases. In this study, we investigated the acute effect of pharmacologically increasing O-GlcNAc levels, using the OGA inhibitor Thiamet G (TG), in normal mouse brains.

Monitoring Treatment Fidelity in a Pragmatic Pediatric Rehabilitation Trial Comparing Two Physical Therapy Schedules: Analysis and Unexpected Findings.

Objective: This study aimed to describe the monitoring of treatment fidelity in a pragmatic pediatric rehabilitation trial using the National Institutes of Health Behavior Change Consortium framework, and to identify child and therapist factors that influence treatment fidelity.

Methods: Therapists (n = 28) were trained in the key ingredients (1-on-1, functional, goal-directed, motor learning intervention) and study protocol for a comparative effectiveness trial titled: A Comparison: High Intensity periodic vs. Every week therapy in children with cerebral palsy (ACHIEVE) for children ages 2 to 8 years with cerebral palsy.

Illuminating the dark mess of fibers: Application of circular cross polarized light in unravelling the bone tissue structure of the dermal pectoral girdle of Metoposaurus krasiejowensis.

Current understanding of the histology of the dermoskeleton of tetrapods comes from fossilized and recent remains of skulls, osteoderms, carapace, plastron and other postcranial material which were always investigated using linear cross polarized light (LCPL) microscopy. The pectoral girdle of vast majority of non-amniote tetrapods, including temnospondyls evolved large ventrally located dermal bones- the interclavicle and a pair of clavicles. Despite that, there is a lack of information about the bone tissue structure from these postcranial dermal bones.

Inpatient Audiologic Services Facilitate Early Hearing Detection.

Purpose: Infants needing neonatal intensive care unit (NICU) intervention have protracted timelines for diagnosis after not passing their newborn hearing screening despite being at higher risk for congenital hearing loss. The primary aim of this study was to evaluate the outcomes of early hearing detection for infants with a history of NICU admission. The secondary aim was to determine if diagnostic audiology services within the NICU setting accelerated diagnosis and intervention.

Transforming Medicine: Cutting-Edge Applications of Nanoscale Materials in Drug Delivery.

Since their inception in the early 1960s, the development and use of nanoscale materials have progressed tremendously, and their roles in diverse fields ranging from human health to energy and electronics are undeniable. The application of nanotechnology inventions has revolutionized many aspects of everyday life including various medical applications and specifically drug delivery systems, maximizing the therapeutic efficacy of the contained drugs by means of bioavailability enhancement or minimization of adverse effects. In this review, we utilize the CAS Content Collection, a vast repository of scientific information extracted from journal and patent publications, to analyze trends in nanoscience research relevant to drug delivery in an effort to provide a comprehensive and detailed picture of the use of nanotechnology in this field.

Matching Into Integrated Plastic Surgery: The Impact of USMLE Step 1 Transition to Pass/Fail: Did the 2019 Predictions Come True in 2024?

Background: The first class of integrated plastic surgery residency applicants with pass/fail (P/F) step 1 assessments occurred during the 2023-2024 Match cycle. This study analyzes the results of a 2024 postmatch survey to program directors (PDs) regarding the impact of the conversion to P/F step 1 scoring and compares the results to the 2019 survey that attempted to predict how this conversion would influence decision-making when it was initially announced.

Methods: A 26-item survey evaluating PDs' perspectives on applicant characteristics and the application process following P/F step 1 scoring was distributed March 2024.

High-Specific Power Flexible Photovoltaics from Large-Area MoS for Space Applications.

Two-dimensional (2D) transition metal dichalcogenides (TMDCs) such as MoS and WSe are excellent candidates for photovoltaic (PV) applications. Here, we present the modeling, fabrication, and characterization of large-area CVD-grown MoS-based flexible PV on an off-the-shelf, 3 μm-thick flexible colorless polyimide with polyimide encapsulation designed for space structures. The devices are characterized under 1 sun AM0 illumination and show a of 0.

System-failing creativity in health care.

Introduction: Health care professionals often generate novel solutions to solve problems during day-to-day patient care. However, less is known about generating novel and useful (i.e.

Obstructive Thrombosis of Transcatheter Pulmonary Valve-in-Valve Prosthesis.

A 79-year-old woman, previously treated for congenital pulmonary valve stenosis through surgical and transcatheter procedures, presented with worsening dyspnea. This led to the identification of valve thrombosis in her bioprosthetic pulmonary valve. This report delves into the clinical importance of obstructive valve thrombosis, its diagnostic assessment, and potential therapeutic strategies.

Unveiling Cardiac Mysteries: The Role of Endomyocardial Biopsy in Diagnosing Heart Masses.

This case series highlights the role of endomyocardial biopsy (EMB) in diagnosing cardiac tumors instead of tumor resection. EMB provided critical diagnostic clarity and influenced therapeutic decisions, demonstrating its utility in complex cardiovascular cases while preventing unnecessary surgery. Furthermore, EMB provides vital information that can be used for a multidisciplinary approach to cardiac tumors.

Clinical and Radiological Outcomes After Lateral Meniscal Allograft Transplantation Through a Medial Arthrotomy: A Minimum 4-Year Follow-up.

Background: Previous studies have demonstrated that lateral meniscal allograft transplantation (MAT) through medial arthrotomy showed less extrusion than that of the lateral arthrotomy. However, there is a paucity of literature reporting clinical and radiological outcomes after lateral MAT through the medial arthrotomy.

Hypothesis: Lateral MAT through a medial arthrotomy would show significantly improved clinical scores and minimal joint space narrowing compared with preoperative status.

Diagnosing Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia Syndrome and a Novel Variant.

Hypoparathyroidism (hypoPTH), sensorineural deafness, and renal dysplasia (HDR) syndrome is a rare autosomal dominant condition with approximately 200 cases published. HDR syndrome is caused by variants of GATA binding protein 3 gene (), which encodes a transcription factor, with multiple types of variants reported. We present the case of a 76-year-old woman who was diagnosed with hypoPTH when she was aged 40 years and transferred care to our institution.

is overexpressed in keloid keratinocytes and its inhibition alters profibrotic gene expression.

Background: Keloids are disfiguring, fibrotic scar-like lesions that are challenging to treat and commonly recur after therapy. A deeper understanding of the mechanisms driving keloid formation is necessary for the development of more effective therapies. Reduced vitamin D receptor (VDR) expression has been observed in keloids, implicating vitamin D signaling in keloid pathology.

Renal Physiology Education via Podcast: Channel Your Enthusiasm.

Renal physiology is considered one of the most challenging medical disciplines to understand and to teach. Eight academic nephrologists have come together to produce a podcast devoted to helping learners at any level improve their understanding of this difficult topic. Using Dr Burton D.

Association between choroidal microvasculature in the eye and Alzheimer's disease risk in cognitively healthy mid-life adults: A pilot study.

Introduction: We explored associations between measurements of the ocular choroid microvasculature and Alzheimer's disease (AD) risk.

Methods: We measured the choroidal vasculature appearing in optical coherence tomography (OCT) scans of 69 healthy, mid-life individuals in the PREVENT Dementia cohort. The cohort was prospectively split into low-, medium-, and high-risk groups based on the presence of known risk factors (apolipoprotein E [] ε4 genotype and family history of dementia [FH]).

Factors that Influence Applicant Choice of In-Person versus Virtual Interview Format.

Background: Governing bodies of graduate medical education recommend conducting interviews virtually. Although most programs remain compliant with this guidance, it is unclear if this is broadly supported by interviewees. Virtual interview (VI), in-person interview (IPI), and virtual interview with an optional in-person visit (VI+) formats have unique strengths and weaknesses.

Highlights From the 2nd Turin International Workshop on Liver Machine Perfusion.

The 2nd Turin International Workshop on Liver Machine Perfusion took place in Turin, Italy, on November 22, 2024. Leading experts came together to discuss the current applications, limitations, and future directions of this technology, with a primary focus on but not limited to liver transplantation. This report provides a summary of the evidence, insights, and debates shared during the meeting.

Therapeutic Errors Associated With Antithrombotic Medications Reported to United States Poison Centers.

The objective of this study was to investigate the characteristics and trends of therapeutic errors in non-healthcare facility settings associated with antithrombotic medications reported to United States Poison Centers by analyzing data from the National Poison Data System from 2000 to 2021. There were 57 288 reported therapeutic error-related exposures involving antithrombotic medications as the primary substance. The rate of therapeutic errors increased by 590.

Breeding bird sensitivity to urban habitat quality is multi-scale and strongly dependent on migratory behavior.

Human-caused conversion of natural habitat areas to developed land cover represents a major driver of habitat loss and fragmentation, leading to reorganization of biological communities. Although protected areas and urban greenspaces can preserve natural systems in fragmented landscapes, their efficacy has been stymied by the complexity and scale-dependency underlying biological communities. While migratory bird communities are easy to-study and particularly responsive to anthropogenic habitat alterations, prior studies have documented substantial variation in habitat sensitivity across species and migratory groups.

Pareto in Prison.

The Pareto principle is based on the concept that roughly 80% of outcomes are generated by 20% of inputs, efforts, or contributors within a group. Using a national sample of U.S.