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Genomic epidemiology of the rotavirus G2P[4] strains in coastal Kenya pre- and post-rotavirus vaccine introduction, 2012-8.

Virus Evol

April 2023

Epidemiology and Demography Department Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Off Hospital Road, P.O BOX 230-80108, Kilifi, Kenya.

The introduction of rotavirus vaccines into the national immunization programme in many countries has led to a decline in childhood diarrhoea disease burden. Coincidentally, the incidence of some rotavirus group A (RVA) genotypes has increased, which may result from non-vaccine-type replacement. Here, we investigate the evolutionary genomics of rotavirus G2P[4] which has shown an increase in countries that introduced the monovalent Rotarix® vaccine.

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Article Synopsis
  • Rotavirus group A remains a leading cause of severe diarrhea in children, even with vaccines used in over 100 countries.
  • In a study in Kilifi County, Kenya, 248 stool samples were collected from children under 13, revealing a 22.2% prevalence of rotavirus.
  • Phylogenetic analysis identified seven genetic clusters of rotavirus strains, with G3P[8] being the most common, emphasizing the need for better global vaccine coverage due to the wide transmission of this virus.
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Background: The utilization of routine health information systems (HIS) for surveillance of assisted partner services (aPS) for HIV in sub-Saharan is sub-optimal, in part due to poor data quality and limited use of information technology. Consequently, little is known about coverage, scope and quality of HIV aPS. Yet, affordable electronic data tools, software and data transmission infrastructure are now widely accessible in sub-Saharan Africa.

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