Mitigating adversarial manipulation in LLMs: a prompt-based approach to counter Jailbreak attacks (Prompt-G).

Large language models (LLMs) have become transformative tools in areas like text generation, natural language processing, and conversational AI. However, their widespread use introduces security risks, such as jailbreak attacks, which exploit LLM's vulnerabilities to manipulate outputs or extract sensitive information. Malicious actors can use LLMs to spread misinformation, manipulate public opinion, and promote harmful ideologies, raising ethical concerns.

Effect of myogenic tone on agonist-mediated vasoconstriction in isolated arteries: A computational study.

Background And Objective: Vasoconstriction of the resistance artery is mainly determined by an integrated action of multiple local stimuli acting on the vascular smooth muscle cells, which include neuronal delivery of α-adrenoceptor agonists and intraluminal pressure. The contractile activity of the arterial wall has been extensively studied ex vivo using isolated arterial preparations and myography techniques. However, agonist-mediated vasoconstriction response is often confounded by local effects of other stimuli (e.

5-Fluorouracil-loaded green chitosan nanoparticles/ guar gum nanocomposite hydrogel in controlled drug delivery.

In recent years nanotechnologies have been applied to human health with promising results, especially in the field of drug delivery. Polymeric nanoparticles (NPs) have garnered much importance in controlled drug delivery owing to their size. Chitosan (Cs) is a well-recognized biopolymer and Cs NPs have been widely explored in drug delivery.

Multi-component forms of the 2nd generation H1 receptor antagonist drug, Bilastine and its enhanced physicochemical characteristics.

Bilastine (BIL) is a novel 2nd generation antihistamine medication is used to treat symptoms of chronic urticaria and allergic rhinitis. However, its poor solubility limits its therapeutic efficacy. In order to enhance the physicochemical characteristics of BIL, various molecular adducts of BIL (Salt, hydrate and co-crystal) were discovered in this study using two distinct salt-formers: Terephthalic acid (TA), 2,4-Dihydroxybenzoic acid (2,4-DHBA), and three nutraceuticals (Vanillic Acid (VA), Hydroquinone (HQN) and Hippuric acid (HA)).

Chitosan-sunflower meal biochar hydrogel incorporated with green synthesized NiO nanoparticles for enhanced catalytic reduction of anthropogenic water pollutants.

Anthropogenic activities have been one of the crucial driving factors for water pollution globally, thereby warranting a sustainable strategy for its redressal. In this study, we have developed a hydrogel-biochar nanocomposite for catalytic reduction of water pollutants. To begin with, green synthesis of nickel oxide nanoparticles (NiO NPs) was accomplished from waste kinnow peel extract via the environmentally benign microwave method.

Green NiO nanoparticle-integrated PVA-alginate hydrogel: potent nanocatalyst for efficient reduction of anthropogenic water pollutants.

Hydrogel nanocatalyst composed of nickel oxide (NiO) nanoparticles embedded in PVA-alginate hydrogels were potentially explored toward the reduction of anthropogenic water pollutants. The NiO nanoparticles was accomplished via green method using waste pineapple peel extract. The formation of the nanoparticles was affirmed from different analytical techniques such as UV-Vis, FTIR, XRD, TGA, FESEM, and EDS.

Predicting cervical cancer risk probabilities using advanced H20 AutoML and local interpretable model-agnostic explanation techniques.

Background: Cancer is positioned as a major disease, particularly for middle-aged people, which remains a global concern that can develop in the form of abnormal growth of body cells at any place in the human body. Cervical cancer, often known as cervix cancer, is cancer present in the female cervix. In the area where the endocervix (upper two-thirds of the cervix) and ectocervix (lower third of the cervix) meet, the majority of cervical cancers begin.

Fundamentals and Applications of Surface Wetting.

In an era defined by an insatiable thirst for sustainable energy solutions, responsible water management, and cutting-edge lab-on-a-chip diagnostics, surface wettability plays a pivotal role in these fields. The seamless integration of fundamental research and the following demonstration of applications on these groundbreaking technologies hinges on manipulating fluid through surface wettability, significantly optimizing performance, enhancing efficiency, and advancing overall sustainability. This Review explores the behavior of liquids when they engage with engineered surfaces, delving into the far-reaching implications of these interactions in various applications.

Exploration of Photoluminescence, Colorimetric, and Decay Performance of Sm-activated CaWO Ceramic.

This paper represents structure, photoluminescence, and colorimetric investigations of Sm-activated CaWO ceramic made with the help of a solid-state reaction process. Structures of the ceramics are examined through X-ray diffraction spectroscopy. It indicates that these materials have a tetragonal structure and I4/a space group without having any other secondary phase.

Bio-valorization of Tagetes floral waste extract in fabrication of self-healing Schiff-base nanocomposite hydrogels for colon cancer remedy.

The drastic boom in floriculture and social events in religious and recreational places has inevitably led to generation of tremendous floral waste across the globe. Marigold (Tagetes erecta) is one of the most common loose flowers offered for the same. Generally discarded, these Tagetes floral wastes could be valorized for biogenic syntheses.

In situ forming dialdehyde xanthan gum-gelatin Schiff-base hydrogels as potent controlled release fertilizers.

Controlled release fertilizer (CRF) hydrogels have blossomed into promising materials in agriculture owing to the sustained release of the fertilizer and also as soil conditioner. Apart from the traditional CRF hydrogels; Schiff-base hydrogels have garnered significant thrust that release nitrogen slowly in addition to reducing the environmental pollution. Herein, we have fabricated Schiff-base CRF hydrogels composed of dialdehyde xanthan gum (DAXG) and gelatin.

Energy-Efficient Object Detection and Tracking Framework for Wireless Sensor Network.

Object detection and tracking is one of the key applications of wireless sensor networks (WSNs). The key issues associated with this application include network lifetime, object detection and localization accuracy. To ensure the high quality of the service, there should be a trade-off between energy efficiency and detection accuracy, which is challenging in a resource-constrained WSN.

Current status of COVID-19 vaccination: safety and liability concern for children, pregnant and lactating women.

Introduction: Since its inception, Coronavirus disease-19 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has claimed a significant number of lives around the world.

Area Covered: COVID-19 vaccine development involves several vaccine platforms, including traditional live-attenuated or killed viral particles, viral vectors or DNA, and mRNA-based vaccines. The efficacy and effectiveness (EV) of these vaccines must be assessed in order to determine the extent to which they can protect us against infection.

Harnessing the potential of dialdehyde alginate-xanthan gum hydrogels as niche bioscaffolds for tissue engineering.

Biomimetic hydrogels composed of natural polysaccharides have invariably blossomed as niche biomaterials in tissue engineering applications. The prospects of creating an extracellular matrix (ECM)-like milieu from such hydrogels has garnered considerable importance. In this study, we have fabricated bioscaffolds comprising dialdehyde alginate and xanthan gum and explored their potential use in tissue regeneration.

Structural, Morphological, Optical and Electrical Characterization of Gahnite Ferroan Nano Composite Derived from Fly Ash Silica and ZnO Mixture.

The synthesis of a high value-added product, gahnite ferroan nano composite, from a mixture of fly ash silica and ZnO is a low-cost and non-expensive technique. The XRD pattern clearly reveals the synthesized product from fly ash after leaching is a product of high-purity gahnite ferroan composite. The grains are mostly cubical in shape.