A CASE OF KAWASAKI DISEASE IN AN EIGHT-YEAR-OLD BOY.

Kawasaki disease is an acute systemic disease characterized by the predominant lesions of middle and small arteries, alongside destructive and proliferative vasculitis development. The aetiology is currently being discussed. Infectious factors are mostly preferred, in addition, autoimmune mechanisms and genetic heredity are considered.

STATE OF AUTONOMIC REGULATION AND CEREBROVASCULAR REACTIVITY IN PATIENTS WITH HEADACHE WITH ARTERIAL HYPERTENSION.

Objective: The aim: A comprehensive assessment of the state of the autonomic nervous system and cerebrovascular reactivity of the cerebral blood flow in the patients with the headache accompanied by arterial hypertension (AH) and somatoform autonomic dysfunction (SAD).

Patients And Methods: Materials and methods: We conducted the clinical, autonomic regulation and Doppler sonography examination of 124 young patients (18-45 years old), including 51 men and 73 women in the conditions of the clinical base of the Kharkiv Medical Academy of Postgraduate Education in 2018-2021. All patients with cephalgias were divided into three groups: with AH stage II (Group I - 41 patients), AH stage I (Group II - 40 patients), SAD (Group III - 43 patients).

PREVALENCE OF HEALTHCARE-ASSOCIATED CERVICITIS AND ANTIMICROBIAL RESISTANCE OF THE RESPONSIBLE PATHOGENS IN UKRAINE: RESULTS OF A MULTICENTER STUDY (2019-2021).

Objective: The aim: To obtain the first estimates of the current prevalence of healthcare-associated cervicitis (HACs) and antimicrobial resistance of responsible pathogens in Ukraine.

Patients And Methods: Materials and methods: We conducted a retrospective multicentre cohort study was based on surveillance data from January 1st, 2019 to December 31st, 2021 in Ukraine. Antibiotic susceptibility testing was determined by Kirby-Bauer disc diffusion test according to the protocol of the European Committee on Antimicrobial Susceptibility Testing.

SENTINEL LYMPH NODES DETECTION METHOD IN BREAST CANCER.

In 2020 more than 2.2 million cases of breast cancer were registered, and these figures indicate that this disease is very widespread. Lymphatic metastasis is one of the most important causes of local recurrence of breast cancer and is unfavorable factor of prognosis.

INFECTIONS ASSOCIATED WITH OBSTETRIC AND GYNECOLOGICAL SURGERIES AS A CAUSE OF FEMALE INFERTILITY IN UKRAINE.

Objective: The aim: To assess the role of surgical site infections types associated with obstetric and gynecological surgeries as a cause of infertility among women reproductive age in Ukraine.

Patients And Methods: Materials and methods: We conducted a retrospective multicentre cohort study was based on reproductive health surveillance data among women reproductive age from 2019 to 2021. Definitions of infertility were used from the WHO and surgical site infections were used CDC/ NHSN.

PREVALENCE AND RISK FACTORS OF INFERTILITY IN UKRAINE: RESULTS A MULTICENTER STUDY (2019-2021).

Objective: The aim: To assess the current prevalence and identify the risk factors for infertility among couples of reproductive age in Ukraine.

Patients And Methods: Materials and methods: We conducted a retrospective multicentre cohort study was based on reproductive health surveillance data among married populations from January 1st, 2019 to December 31st, 2021 in Ukraine. Definitions of infertility were used from the WHO.

The diagnostic and prognostic value of copeptin in patients with acute ischemic stroke and transient ischemic attack: A systematic review and meta-analysis.

Background: Stroke is the second main cause of mortality and the third leading cause of mortality and permanent disability combined. Many potential biomarkers have been described to contribute to the diagnosis, prognosis of outcomes, and risk stratification after stroke. Copeptin is an inactive peptide that is produced in an equimolar ratio to arginine vasopressin (AVP) in response to the activation of the endogenous stress system.

REHABILITATION OF PATIENTS WITH LONG-TERM AFTEREFFECTS OF MILD COMBAT TRAUMATIC BRAIN INJURY.

Objective: The aim: To analyze the effect of Korean red ginseng on status of the vegetative nervous system and well-being of patients with asthenic syndrome assotiated with mild combat traumatic brain injury.

Patients And Methods: Materials and methods: We have examined 42 patients. Duration of their injury was from 4 to 6 years.

MULTIPLE INTERVAL DEBULKING SURGERY IN RECURRENT UTERINE SARCOMA (CASE REPORT).

We report a case of a 61-year-old woman, who had been suffering from multiple relapses of uterine sarcoma treated by multiple cytoreduction operations. During the observation period there were performed 13 surgical interventions. As a result of operations, together with the removal of more than 60 liters of tumor volume, the following were performed: extirpation of the uterus with ovaries, right colectomy, resection of the small intestine four times, resection of the sigmoid colon, resection of the duodenum, peritonectomy, cholecystectomy, appendectomy, 2 cycles of adjuvant chemotherapy and Hyperthermic intraperitoneal chemotherapy procedure.

FEATURES OF HEMODYNAMICS IN HEAD MAGISTRAL AND CEREBRAL ARTERIES IN THE PATIENTS WITH MIGRAINE.

Objective: The aim of the study was to Doppler sonography study of the structural and functional state of head magistral arteries (HMA) and cerebral arteries in the patients with various forms of migraine.

Patients And Methods: Materials and methods: We conducted the clinical Doppler examination of 124 young patients (18-45 years old), including 55 men and 69 women in the conditions of the clinical base of the Kharkiv Medical Academy of Postgraduate Education in 2017-2019. The criteria for involvement of patients in the study were: migraine without aura (group 1 - 63 patients), migraine with aura (group 2 - 61 patients) The control group consisted of 45 patients of the corresponding gender and age.

PERINATAL INFECTIONS IN UKRAINE: RESULTS OF A MULTICENTER STUDY.

Objective: The aim: To obtain the estimates of the сurrent incidence rate of perinatal infections, risk factors, as well as their associated impact on mortality and determine the antimicrobial resistance of responsible pathogens in Ukraine.

Patients And Methods: Materials and methods: We performed a multicentre retrospective cohort study was based on surveillance data. This study included infants aged 0 to 6 days delivered in 2017-2019 at 11 Ukrainian regional perinatal centers.

The Impact of IgG administration on the cellular immunity status in the patients with multidrug-resistant tuberculosis/HIV with CD4 + lymphocyte cells below 50 cells/ μl.

Background: Treatment of the patients with multidrug-resistant tuberculosis (MDR-TB)/HIV coinfection in a state of severely suppressed immune system remains unsatisfactory.

Methods: The study involved 52 HIV-positive patients with MDR-TB and CD4+ lymphocyte cells below 50 cells/μCL. Patients in control group (Group 1) and in basic group (Group 2) received standard treatment with second-line antituberculosis agents and antiretroviral agents.

DETERMINATION OF SAFETY PROFILE OF REPARATIVE ACTIVITY OF THE NEW HYGIENIC PRODUCT "APIPROL".

Objective: The aim: To prove safety of the new elixir and determine the effect on regenerative processes under conditions of the experimental trauma.

Patients And Methods: Materials and methods: The formula of the new dental elixir "Apiprol" includes biologically active components of bee products (propolis, comb capping wax), plant origin compounds. The elixir was single administered, intragastrally to white nonlinear mice weighing (22±2) g at doses at 50 mg/kg, 500 mg/kg, 5000 mg/kg.

SELF-ESTEEM OF THE EATING BEHAVIOR BY THE STUDENT PHARMACEUTICAL YOUTH FROM THE VIEW OFTHE EXCESS BODY WEIGHT AND OBESITY.

Objective: The aim: The purpose of the research is to study the understanding of student pharmaceutical youth the eating behavior in the context of the EBW and obesity.

Patients And Methods: Materials and methods: The material of the study was anonymous questionnaire survey the students of the pharmaceutical faculties from Ukraine.

Results: Results: The results of the questionnaire were analyzed using methods of statistics, comparison and generalization.

HEALTHCARE ASSOCIATED INFECTION AFTER LEGAL INDUCED ABORTIONS IN UKRAINE: RESULTS A MULTICENTER STUDY.

Objective: The aim: To determine trend of legal induced surgical abortion and to assess the frequency of infection complications after termination of pregnancy in Ukraine.

Patients And Methods: Materials and methods: We conducted a prospective multicentre cohort study was based on surveillance data of healthcare-associated infection (HAI) after legal induced surgical abortion in women's from January 2017 to 2019 in Ukraine. Definitions of HAI after induced abortion were used from the CDC/ NHSN.

Cerebellar contribution to absence epilepsy.

The new aggregate data analyses revealed the earlier missing role of cerebellum long-term electrical stimulation in the absence epilepsy. Neurophysiologic data gained by authors favor that cerebellar serial deep brain stimulation (DBS) (100 Hz) causes the transformation of penicillin-induced cortical focal discharges into prolonged 3,5-3,75 sec oscillations resembling spike-wave discharges (SWD) in cats. Such SWDs were not organized in the form of bursts and persisted continuously after stimulation.

Organizational, regulatory and legal aspects of european integration of higher medical education in ukraine: a critical review.

Objective: The aim: The main purpose of this research is to conduct the theoretical and applied study of the legal profile enforcement for state attestation of medical graduates, the relevant legislative system, and its effectiveness; to identify the issues of special legislative requirements, as well as the search for ways to resolve it.

Patients And Methods: Materials and methods: Basic methods: analysis, synthesis and comparison. Object of research: system of state certification of graduates of medical sciences.

Prevalence of postpartum endometritis and antimicrobial resistance of responsible pathogens in ukraine: results a multicenter study (2015-2017).

Objective: The aim: To obtain the prevalence of postpartum endometritis women and antimicrobial resistance of responsible pathogens in Ukraine.

Patients And Methods: Materials and methods: We performed a retrospective multicenter cohort study. The study population consisted of all women who had a vaginal delivery or cesarean section in 14 Regional Women's Hospitals of Ukraine.

Postpartum mastitis in the breastfeeding women and antimicrobial resistance of responsible pathogens in ukraine: results a multicenter study.

Objective: The aim: To obtain the prevalence of mastitis in the breastfeeding women and antimicrobial resistance of responsible pathogens in Ukraine.

Patients And Methods: Materials and methods: A retrospective multicenter cohort study was based on surveillance data for Postpartum Mastitis and included 18,427 breastfeeding women's who gave birth in 11 regional hospitals of Ukraine.

Results: Results: 22.

A responsible patient: from theory to practice on a model of a patient with bronchial asthma.

Objective: Introduction: The medicine of today is focused on personalized aid to a patient, which involves partnership and mutual responsibility between the patient and the doctor. In our reality, the patient believes that the responsibility for the treatment and outcome depends on the doctor in most cases. The aim: Induce the patient to develop responsibility for the course of asthma against the background of EBW or obesity and introducing this program into the practice of family physicians.

Application of cognitive-behavioral therapy in patients with uncontrolled bronchial asthma due to excess body weight and obesity.

Objective: The aim: The aim of our study was to determine the effect of CBT in patients with uncontrolled BA against the background of excess body weight and obesity.

Patients And Methods: Materials and methods: By the study design there were examined 78 patients who had a primary diagnosis of uncontrolled BA.

Results: Results: The patients in the main group had significant positive dynamics regarding a number of AQLQ questionnaires, namely emotions, activity, overall quality of life (p≤0.

Biochemical value dynamics in patients with multidrug-resistant tuberculosis/hiv with CD4+ lymphocyte cells below 50 cells/μCL and its variability in the application of adjuvant immunoglobulin therapy.

Context: Treatment of the patients with multidrug-resistant tuberculosis (MDR-TB)/HIV coinfection in a state of severely suppressed immune system remains under efficient.

Aims: The aim of this study was to assess the effectiveness of adjuvant immunoglobulin therapy in TB/HIV patients.

Settings And Design: The relationship between biochemical indexes in the patients with MDR-TB/HIV co-infection and adjuvant immunoglobulin therapy.

Phenomenon of self-destructive behavior in female sex workers: discriptors, predictors, typology, psychological correction.

Objective: Introduction: Engaging in sex, which is obligatory associated with the extraordinary risks of harm to their own safety and physical health, can be considered as one of the variants of self-destruction. The aim is to analyze the leading descriptors and predictors of self-destructive behavior among female sex workers, on the basis of which to propose measures for their psycho-correction.

Patients And Methods: Materials and methods: The main group of the study was 135 women - female sex workers, a comparative group of 50 women who had no relation to such activities.

Anaplasmosis: experimental immunodeficient state model.

Objective: Introduction: The recently described anaplasmosis infection is widespread but concerns to the insufficiently known group of diseases. The aim of our research is the development of uniform biological model for reproducing of artificial immunodeficient state by experimental anaplasmosis.

Patients And Methods: Materials and methods: Algorithm of experimental anaplasmosis reproducing, consisted of such consecutive stages: 1) artificial forming of the immunodeficient state at nonlinear white mise (Mus musculus L.

Administrative and legal enforcement of health care: conceptual frameworks.

The analysis of the administrative and legal enforcement of health care in Ukraine indicates the lack of sufficient regulatory and legal acts due to the lack of and deficiencies in conceptual documents, doctrinal developments, strategic planning in this area. The modern administrative-legal management is historically due, since during the Soviet period health care regulation was determined by the high centralization of governance, the imperative of decision-making, the precise regulation of the activities of its subjects, the lack of overall control and supervision. The Conceptual Frameworks in this area, as shown by the analysis of scientific literature and legal documents, should include general provisions, goals, objectives, principles, legal framework, subject and object, priority areas of implementation, phases and stages, terms, amount of financial, material and technical resources, expected results.