PREVALENCE OF AEROBIC VAGINITIS AFTER GYNECOLOGICAL SURGERIES AND ASSOCIATED ADVERSE PREGNANCY OUTCOME IN UKRAINE.

Objective: Aim: To determine prevalence of Aerobic Vaginitis (AV) after gynecologic surgery, risk factors and antimicrobial resistance of responsible pathogens, and adverse pregnancy outcomes in Ukraine.

Patients And Methods: Materials and Methods: Multicenter retrospective cohort study was conducted from January 2020 to December 2022 in fifteen medical clinics from eight regions of Ukraine. Smears were analyzed using Donders' classification method and Dong's modified AV diagnosis for Gram stains.

Common clinical laboratory features among women with polycystic ovary syndrome and metabolic syndrome.

Women with polycystic ovary syndrome (PCOS) have a high prevalence of metabolic syndrome (MS), with rates up to 33%. This is associated with long-term consequences such as cardiovascular diseases, type 2 diabetes mellitus (T2DM), cancer, sleep apnea, and psychological issues. The prevalence of MS worldwide is often associated with obesity and T2DM, yet regional variations are reported.

HEALTHCARE-ASSOCIATED BACTERIAL VAGINOSIS AFTER GYNECOLOGICAL SURGERIES AND ASSOCIATED ADVERSE PREGNANCY OUTCOME IN UKRAINE.

Objective: The aim: To determine the prevalence of healthcare-associated bacterial vaginosis after gynecological surgeries and associated adverse pregnancy outcomes in Ukraine.

Patients And Methods: Materials and methods: Multicenter retrospective cohort study was conducted from January 2019 to December 2021 in eleven medical centers from eight regions of Ukraine. Vaginal cultures were obtained preoperatively from 3,502 women undergoing gynecologic surgery.

THE IMPACT OF HORMONE-VITAMIN COMPLEX ON FUNCTIONAL ACTIVITY OF THE MUSCLE TISSUE OF DESCENDANTS OF IRRADIATED ANIMALS.

Objective: The aim: To determine the hormone-vitamin complex impact on the terminal links of glycolysis, the tricarboxylic acids cycle, and the initial stage of glucone¬ogenesis in the muscle tissue in descendants of irradiated animals.

Patients And Methods: Materials and methods: Pyruvate kinase, lactate dehydrogenase, malate dehydrogenase, NADP-dependent malate dehydrogenasee and phosphoenolpyruvate carboxykinase activities, the content of lactate, pyruvate, malate and oxaloacetate were determined in the blood, myocardium and thigh muscles of 66 rats after exposure to ionizing gamma-radiation. Rats were injected by a hormone-vitamin complex which efficacy was determined using the abovementioned indexes.

Hyperthyroidism Masquerading as an Anxiety Disorder: A Report on a Misdiagnosed Case.

Hyperthyroidism is an endocrine disorder characterized by excess thyroid hormone production. Its classic symptoms include weight loss, palpitations, tremors, and anxiety. We present a case of a 33-year-old female who initially presented with anxiety-like symptoms, leading to a misdiagnosis of generalized anxiety disorder.

URINARY TRACT INFECTIONS IN PREGNANT WOMEN IN UKRAINE: RESULTS OF A MULTICENTER STUDY (2020-2022).

Objective: The aim: To obtain the first national estimates of the current prevalence rate of urinary tract infections (UTIs) in pregnant women and antimicrobial resistance of causing pathogens in Ukraine.

Patients And Methods: Materials and methods: Prospective multicentre cohort study was conducted from January 2020 to December 2022. The study population consisted of 36,876 pregnant women from 17 regions of Ukraine.

A Rare Case of Chronic Photophobia Associated With Oral Vancomycin Therapy: Exploring the Relationship.

Vancomycin is a widely used tricyclic glycopeptide antibiotic for treating various Gram-positive infections, including colitis. Although considered generally safe, it has been associated with several side effects. In this case report, we highlight a rare adverse effect in which a patient experienced chronic photophobia following treatment with oral vancomycin.

MINE-BLAST TRAUMA AS A FACTOR IN THE EARLY DEVELOPMENT OF VASCULAR DISEASES OF THE BRAIN.

Objective: The aim of this study is to investigate the state of bulbar conjunctival vessels, rheological properties of blood, catecholamines (adrenaline, norepinephrine), lipid metabolism, alkaline proteins of blood serum in patients with consequences of mild combat traumatic brain injury.

Patients And Methods: Materials and methods: 76 individuals aged 28 to 41 years were examined. The duration of the injury lasted from 2 to 4 years.

CATHETER-ASSOCIATED URINARY TRACT INFECTIONS AFTER CAESAREAN SECTION IN UKRAINE: RESULTS A MULTICENTER STUDY (2020-2022).

Objective: The aim: To obtain the first national estimates of the current prevalence rate of catheter-associated urinary tract infections (CAUTIs) after caesarean section (CSEC) and antimicrobial resistance of causing pathogens in Ukraine.

Patients And Methods: Materials and methods: Prospective multicentre surveillance was conducted from January 2020 to December 2022 in 15 women hospitals of Ukraine. Definitions of CAUTIs were adapted from the CDC/NHSN.

Hepatitis C Virus in people with experience of injection drug use following their displacement to Southern Ukraine before 2020.

Background: Due to practical challenges associated with genetic sequencing in low-resource environments, the burden of hepatitis C virus (HCV) in forcibly displaced people is understudied. We examined the use of field applicable HCV sequencing methods and phylogenetic analysis to determine HCV transmission dynamics in internally displaced people who inject drugs (IDPWID) in Ukraine.

Methods: In this cross-sectional study, we used modified respondent-driven sampling to recruit IDPWID who were displaced to Odesa, Ukraine, before 2020.

The advantages of drinking mineral water in the rehabilitation of patients with viral hepatitis C with accompanying non-alcoholic fatty liver disease after suffering from COVID-19.

Introduction And Objective: Past COVID-19 significantly worsens Chronic viral hepatitis C patients with concomitant NAFLD. The aim of the study was to assess effectiveness of including mineral water in the rehabilitation complex in patients with chronic hepatitis C with concomitant non-alcoholic fatty liver disease who contracted COVID-19.

Material And Methods: 71 patients with chronic hepatitis C with concomitant NAFLD wo contracted COVID-19 were examined.

PREGNANCY AND BIRTH OUTCOMES IN FEMALE WITH AND WITHOUT ASSISTED REPRODUCTIVE TECHNOLOGY IN UKRAINE.

Objective: The aim: To assess and compare the risk of maternal/perinatal complications and adverse outcomes in pregnancy and childbirth conceived by ART with those conceived naturally in Ukraine.

Patients And Methods: Materials and Methods: We conducted a retrospective multicenter cohort study from January 1st, 2019 to December 31st, 2021. This study included pregnant women who delivered at 14 Women's Hospitals from 8 regions of Ukraine.

VESTIBULAR DYSFUNCTIONS IN CHRONIC BRAIN ISCHEMIA IN THE POST COVID PERIOD.

Objective: The aim: The aim of the study is the clinical-pathogenetic reasoning of vestibular dysfunctions (VD) development against the background of chronic brain ischemia in the presence of degenerative changes in the cervical spine (CS) in the post COVID period.

Patients And Methods: Materials and methods: 82 patients, in the conditions of the clinical base of the Odessa National Medical University in 2019-2021 were examined. Group I with VD against the background of chronic brain ischemia (CBI) at the compensated phase; Group II with VD against the background of CBI at the subcom¬pensated phase (33 men; 49 women), aged from 18 to 55 years.

PECULIARITIES OF EATING BEHAVIOR IN CHILDREN WITH AUTISTIC SPECTRUM DISORDERS.

Objective: The aim: To determine of the nutrition peculiarities in children with ASD.

Patients And Methods: Materials and methods: The study involved 37 children with ASD from 2 -12 years and thier mothers, in according to reveal its disorder effect on the clinical course of ASD in children.

Results: Results: It was shown role of irrational nutrition of the mother during pregnancy, peculiarities of family food traditions, problems of breastfeeding and com-plementary feeding.

HYPERPLASIA OF THE FEMALE REPRODUCTIVE ORGANS IN UKRAINE.

Objective: The aim: To determine the role of infectious diseases as the cause of the Cervical, Ovarian and Breast hyperplasia in Ukraine.

Patients And Methods: Materials and methods: We conducted a retrospective multicenter cohort study from January 1st, 2020 to December 31st, 2022. This study included patients aged 20-59 years with a diagnosis of hyperproliferative pathology of the women reproductive organs without atypia, who sought medical care for hyperplastic processes admitted to the 12 hospitals from 9 regions of Ukraine.

CONDITION OF PERIODONTAL TISSUES ON THE BACKGROUND OF HELICOBACTER INVASION: THE CONCEPT OF PATHOGENESIS.

Objective: The aim: To analyze the state of periodontal tissues against the background of Helicobacter pylori invasion in dynamics and to propose a possible mechanism of development of inflammatory periodontal diseases in patients with Helicobacter pylori-associated pathology of the gastrointestinal tract.

Patients And Methods: Materials and methods: We examined 43 patients with Helicobacter pylori-associated gastrointestinal pathology and 42 patients of the same age without somatic pathology, including without gastrointestinal pathology associated with Helicobacter pylori. Clinical and laboratory research methods (clinical, instru-mental, biochemical, histological methods) were used.

DIGITAL IMAGES CLASSIFICATION IN AUTOMATIC LAPAROSCOPIC DIAGNOSTICS.

Objective: The aim: To evaluate the automatic computer diagnostic (ACD) systems, which were developed, based on two classifiers-HAAR features cascade and AdaBoost for the laparoscopic diagnostics of appendicitis and ovarian cysts in women with chronic pelvic pain.

Patients And Methods: Materials and methods: The training of HAAR features cascade, and AdaBoost classifiers were performed with images/ frames of laparoscopic diagnostics. Both gamma-corrected RGB and RGB converted into HSV frames were used for training.

Determining the level of stromal and epithelial cells activity in normal and hyperplastic endometrium of late reproductive and perimenopausal women.

Hyperplastic processes of the endometrium (HPE) are a group of benign endometrial and stromal cells that have undergone altered growth. This study aimed to investigate the potential role of hypoxia (as indicated by Hif-1α) and apoptosis markers (p53 and BCL-2) in the development of hyperplastic processes of the endometrium (HPE). Results showed that endometrial cells with atypical hyperplasia had increased levels of Hif-1ɑ, which indicates the presence of endometrial hypoxia and may trigger pathological manifestations.

The influence of psychological characteristics on managers efficiency within medical institutions during the COVID-19 pandemic.

This article examines the theoretical and practical aspects of the activity of medical managers, the social and psychological climate within teams, and interpersonal relations. The goal of the study was to investigate the interpersonal interaction styles and intragroup relations between team members and managers, as well as to determine the impact of managers' psycho-emotional characteristics on their effectiveness during the COVID-19 pandemic. A total of 158 medical workers participated in the study, which was conducted in 2021 using a self-developed questionnaire.

NAVIGATION SURGERY FOR INTRAOPERATIVE SENTINEL LYMPH NODE DETECTION USING ICG IN BREAST CANCER PATIENTS.

In 2020 more than 2.2 million cases of breast cancer were registered, and these figures indicate that this disease is very widespread. Lymphatic metastasis is one of the most important causes of local recurrence of breast cancer and is unfavorable factor of prognosis.

EFFECT OF HIGH-FREQUENCY CHEST WALL OSCILLATION ON CLINICAL INDICES OF COMMUNITY-ACQUIRED PNEUMONIA IN CHILDREN.

Objective: The aim: To study the effect of high-frequency chest wall oscillation (HFCWO) on clinical indices of community-acquired pneumonia (CAP) in children.

Patients And Methods: Materials and methods: The main clinical symptoms were assessed in 107 children (girls - 45.79% and boys - 54.

CERVICITIS AS A CAUSE OF PRETERM BIRTH IN WOMEN.

Objective: The aim: To evaluate the prevalence of preterm birth and to determine the role of cervicitis as a cause of preterm birth in women in Ukraine.

Patients And Methods: Materials and methods: We conducted a retrospective multicentre cohort study from January 1st, 2019 to December 31st, 2021. This study included pregnant women aged 17-50 years admitted to the labor ward at the 13 hospitals from 10 regions of Ukraine.

Haematological changes in sailors who had COVID-19.

Background: Follow-up of patients who had coronavirus disease 2019 (COVID-19) proves that clinical symptoms persist for months after recovery. A complex of such persistent manifestations is defined as the post-COVID-19 syndrome. One of the criteria for post-COVID-19 syndrome may be typical changes in white blood cell count and white blood cell (WBC) differential.

A CASE OF KAWASAKI DISEASE IN AN EIGHT-YEAR-OLD BOY.

Kawasaki disease is an acute systemic disease characterized by the predominant lesions of middle and small arteries, alongside destructive and proliferative vasculitis development. The aetiology is currently being discussed. Infectious factors are mostly preferred, in addition, autoimmune mechanisms and genetic heredity are considered.