6 results match your criteria: "Ochsner Clinical School-University of Queensland School of Medicine New Orleans[Affiliation]"

Mechanical circulatory support devices in advanced heart failure: 2020 and beyond.

Prog Cardiovasc Dis

December 2020

Heart and Vascular Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States of America. Electronic address:

Substantial progress in the field of mechanical circulatory support (MCS) has expanded the treatment options for patients with advanced-stage heart failure (HF). Currently available MCS devices can be implanted percutaneously or surgically. They can also be configured to support the left, right, or both ventricles, offering varying levels of circulatory support.

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Article Synopsis
  • Transthyretin amyloidosis (ATTR) is a complex disorder affecting multiple organs, with both genetic and non-genetic causes; this study aimed to describe its characteristics in the U.S. using data from the THAOS registry.
  • Analysis revealed that U.S. patients are generally older (average age of 70) and predominantly male (85.4%), with a notable incidence of the Val122Ile mutation and a greater prevalence of wild-type disease compared to patients in other regions.
  • Patients with the Val122Ile mutation showed a higher burden of neurological symptoms and worse quality of life, while survival analysis indicated that advancing age and lower mean arterial pressure are key factors linked to increased mortality, rather than specific
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Heart failure and diabetes mellitus contribute significantly to the morbidity and mortality of the US population. The combined economic impact on the US health care system reaches nearly $300 billion. Much of this cost stems from the frequent hospital admissions and direct cost of managing the two diseases.

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