1 results match your criteria: "Oakland dUniversity of California[Affiliation]"
Dysfunctional high-density lipoprotein from HIV+ individuals promotes monocyte-derived foam cell formation in vitro.
AIDS
November 2017
aCentre for Biomedical Research, Burnet Institute bDepartment of Infectious Diseases, Monash University, Melbourne, Victoria, Australia cChildren's Hospital Oakland Research Institute, Oakland dUniversity of California, Los Angeles, Los Angeles, California, USA. *Thomas A. Angelovich, Anna C. Hearps, Anthony Jaworowski, and Theodoros Kelesidis contributed equally to this article.
Objective: The role of high-density lipoprotein (HDL) function in HIV-related atherosclerotic cardiovascular disease (CVD) is unclear. HDLs isolated from HIV [HIV(+)HDL] and HIV-uninfected individuals [HIV(-)HDL] were assessed for HDL function and ability to promote monocyte-derived foam cell formation (MDFCF; a key event in HIV-related CVD) ex vivo.
Design/methods: Using an established in-vitro model of atherogenesis and plasma samples from an established cross-sectional study of virologically suppressed HIV men on stable effective antiretroviral therapy and with low CVD risk (median age: 42 years; n = 10), we explored the impact of native HDL [HIV(+)HDL] on MDFCF.