A systematic review of microbiome composition in osteoarthritis subjects.

Objective: Osteoarthritis (OA) started to be associated to shifted microbiota composition recently. This systematic review aims to elucidate if there is a common microbiota composition linked with OA between different studies.

Methods: We screened PubMed, Scopus, Web of Science and Cochrane databases up to July 26 2021 to identify original studies in which microbiome was assessed from OA individuals, both in human and laboratory animals' studies.

Supporting government policies to embed and expand rehabilitation in health systems in Europe: A framework for action.

Investment in action is vital to confront the challenges associated with chronic diseases and disability facing European health systems. Although relevant policy responses are being increasingly developed, most of them fail to recognize the role of rehabilitation services in achieving public health and social goals. Comprehensive guidance is thus urgently needed to support rehabilitation policy development and expand access to rehabilitation care to meet population needs effectively.

Violists and Violinists Report More Intense Hand Pain on NRS Than Other Orchestra Musicians.

Aims: Among musicians, string players have the highest prevalence for musculoskeletal overuse. Playing a violin or viola requires rapid, repetitive, and complicated movements of the hands and fingers. This cross-sectional study aimed to examine whether violin/viola, violin/cello, and violin/French horn players experience more intense musculoskeletal pain than other instrumentalists.

Musculoskeletal pain among Finnish orchestra musicians versus core workforce.

Background: Professional musicians show a high prevalence of musculoskeletal pain, but information is limited about prevalence of pain compared to the general populations.

Aims: Our cross-sectional epidemiological study compared the prevalence of musculoskeletal pain between professional orchestra musicians and the working population in Finland.

Methods: Musicians with a permanent contract with all domestic professional symphony and philharmonic orchestras and a population sample of the workforce in Finland completed questionnaires including the same questions on musculoskeletal pain and on various other issues.

Osteoarthritis and Toll-Like Receptors: When Innate Immunity Meets Chondrocyte Apoptosis.

Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In particular, chondrocyte-mediated inflammatory responses triggered by the activation of innate immune receptors by alarmins (also known as danger signals) are thought to be involved. Thus, toll-like receptors (TLRs) and their signaling pathways are of particular interest.

Decreasing trend in the incidence of serious pneumonias in Finnish children with juvenile idiopathic arthritis.

Objectives: Children with juvenile idiopathic arthritis (JIA) may be predisposed to serious pneumonia due to modern disease-modifying anti-rheumatic treatment. In this nationwide retrospective study with clinical data, we describe the pneumonia episodes among children with JIA.

Methods: Patients under 18 years of age with JIA and pneumonia during 1998-2014 were identified in the National Hospital Discharge Register in Finland.

Validity and internal consistency of the thoracic outlet syndrome index for patients with thoracic outlet syndrome.

Background: No validated scales exist specifically for measuring quality of life (QoL) and functioning level in patients with thoracic outlet syndrome (TOS). This cross-sectional survey examined whether some items adopted from validated QoL scales could be suitable for patients with TOS.

Methods: To find an optimal thoracic outlet syndrome index (TOSI), a panel of 14 specialists experienced in treating TOS independently evaluated the relevance of 19 items adopted from scales used in other upper-extremity syndromes.

Correction of leg-length discrepancy among meat cutters with low back pain: a randomized controlled trial.

Background: The etiology of non-specific low back pain (LBP) is complex and not well understood. LBP is common and causes a remarkable health burden worldwide. Leg-length discrepancy (LLD) is potentially a risk factor for development of LBP, although this relationship has been questioned.

Pure intervention effect or effect in routine health care - blinded or non-blinded randomized controlled trial.

Background: Randomized trials provide the most valid evidence of effectiveness of interventions. The study aims to determine the primary study question for randomized controlled trials; to evaluate the study questions in trials on effectiveness of arthroscopic meniscectomy for meniscal rupture of the knee; and to explore the clinical and research implications.

Methods: Previous studies on benchmarking controlled trials were utilized.

Treatment after traumatic shoulder dislocation: a systematic review with a network meta-analysis.

Objective: To review and compare treatments (1) after primary traumatic shoulder dislocation aimed at minimising the risk of chronic shoulder instability and (2) for chronic post-traumatic shoulder instability.

Design: Intervention systematic review with random effects network meta-analysis and direct comparison meta-analyses.

Data Sources: Electronic databases (Ovid MEDLINE, Cochrane Clinical Trials Register, Cochrane Database of Systematic Reviews, Embase, Scopus, CINAHL, Ovid MEDLINE Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE Daily, DARE, HTA, NHSEED, Web of Science) and reference lists were searched from inception to 15 January 2018.

The importance of radiological results in distal radius fracture operations: Functional outcome after long-term (6.5 years) follow-up.

Background And Aims: Whether or not radiological results correlate with functional outcome after operative treatment of distal radius fractures still remains controversial. We carried out a retrospective study to analyse the long-term (6.5 year) outcome of radius fractures treated by means of surgery in our hospital.

Validity and generalizability of findings of randomized controlled trials on arthroscopic partial meniscectomy of the knee.

The validity and generalizability of evidence from trials on arthroscopic partial meniscectomy (APM) for a ruptured meniscus of the knee has been debated in scientific journals. The aim of this paper was to assess the validity and generalizability of evidence for trials on effectiveness of APM by a novel Benchmarking method; to compare this assessment with established assessment methods; and to make an overall assessment of the current evidence on validity and generalizability of findings. Literature search was undertaken to find all randomized controlled trials.

Long-Term Clinical Outcome After Titanium Lunate Arthroplasty for Kienböck Disease.

Purpose: Titanium lunate arthroplasty (TLA) for Kienböck disease was introduced in 1984 to address the silicone-wear particle problem common to silicone lunate implants. We sought to study the outcome of TLA.

Methods: We identified 11 patients from our hospital database who had undergone TLA between 2001 and 2010.

The Finnish version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR).

The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient-reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patient versions of the JAMAR in the Finnish language. The reading comprehension of the questionnaire was tested in ten JIA parents and patients.

Initial Electromyography Fails to Predict Long-Term Outcome of Isolated Serratus Palsy.

Background And Aims:: The course of isolated serratus palsy is difficult to predict, especially if, in initial electromyographic examination, long thoracic nerve function is totally absent. How initial electromyography correlates with long-term outcome of isolated serratus palsy is unknown. We evaluated initial electromyographic examinations of isolated serratus palsy patients and compared these to their long-term outcome.

Fear of Injections and Needle Phobia Among Children and Adolescents: An Overview of Psychological, Behavioral, and Contextual Factors.

The purpose of this clinical update is to provide an overview of the fear of needles and needle phobia in children and adolescents including characteristics and diagnosis, prevalence and epidemiology, etiological factors, and treatment options. Needle-related fear and needle phobia present as significant needle-related distress and avoidance behavior. The etiology is biopsychosocial.

Validity and internal consistency of the Helsinki Serratus Palsy Index for patients with serratus palsy.

Background: To our knowledge, no validated scales exist as yet for measuring quality of life and functioning level in patients with serratus palsy. This cross-sectional survey study examined whether a broadly validated Western Ontario Rotator Cuff Index (WORC) could be partially adapted for patients with serratus palsy.

Methods: The relevancy of WORC, 21 items, along with 4 additional new items, was tested by 95 patients with serratus palsy and a panel of 9 medical experts.

Pneumonia in children with juvenile idiopathic arthritis in Finland 1999-2014: a nationwide retrospective register linkage study.

Objectives: To compare the incidence of pneumonia in children with juvenile idiopathic arthritis (JIA) to the aged-matched general population and to evaluate the use of anti-rheumatic medication among children with JIA and pneumonia.

Methods: The National Hospital Discharge Register collects data on ICD-diagnoses of hospital patients in Finland. From this register, patients with JIA under 18 years of age with pneumonia from 1999 through 2014 were identified.

Confirmatory Factor Analysis of the Finnish Job Content Questionnaire (JCQ) in 590 Professional Musicians.

Background: Poorly functioning work environments may lead to dissatisfaction for the employees and financial loss for the employers. The Job Content Questionnaire (JCQ) was designed to measure social and psychological characteristics of work environments.

Objective: To investigate the factor construct of the Finnish 14-item version of JCQ when applied to professional orchestra musicians.

Reliability of Measuring Lower-Limb-Muscle Electromyography Activity Ratio in Activities of Daily Living With Electrodes Embedded in the Clothing.

Context: Using technical clothes with electrodes embedded in the clothing makes it possible to record the electrical activity produced by the activity of the skeletal muscles in activities of daily living.

Objective: To investigate the reliability of measuring lower-limb left-right electromyography (EMG) activity ratio with smart shorts during stair descent, stair ascent, and repeated unloaded squats among healthy working-aged subjects.

Methods: Seventeen females (mean age 25.

Progression of untreated mild thoracic Scheuermann's kyphosis - Radiographic and functional assessment after mean follow-up of 46 years.

Background: There is no data available on the radiographic development of the Scheuermann's deformity. Our purpose was to investigate radiographic deformity progression and the relation between kyphosis progression and clinical outcome in patients with untreated Scheuermann's kyphosis.

Methods: Thoracic kyphosis (Th4-Th12) was measured from standing lateral radiographs in 19 patients at baseline and after mean 46-year follow-up.

Prevention of Biomaterial Infection by Pre-Operative Incubation with Human Cells.

Background: Cells of tissues and biofilm forming bacteria compete for the living space on the surface of an implant. We hypothesized the incubation of the implant (titanium, polydimethylsiloxane, and polystyrene surface) with human cells before implantation as a strategy to prevent bacterial adhesion and biofilm formation.

Methods: After 24 hours of incubation with human osteogenic sarcoma SaOS-2 cells (1 × 10 cells/mL), the materials were incubated for 4.

Psychometric Properties of the Pain Numeric Rating Scale When Applied to Multiple Body Regions among Professional Musicians.

Background: Despite the broad popularity of a numeric rating scale (NRS) its psychometric properties are not well known. The objective was to determine if there is any difference in the discrimination ability of the NRS when used for measuring pain severity separately in different body regions.

Methods: Cross-sectional survey study of 630 professional musicians.

Competitive colonization of prosthetic surfaces by staphylococcus aureus and human cells.

Implantation of a biomaterial provides an adhesion substratum both to host cell integration and to contaminating bacteria. We studied simultaneous competitive adhesion of Staphylococcus aureus in serial 1:10 dilutions of 10 colony forming units (CFU)/mL and human osteogenic sarcoma (SaOS-2) or primary osteoblast (hOB) cells, both 1x10 cells/mL, to the surfaces of titanium, polydimethylsiloxane and polystyrene. The bacterial adherence and human cell proliferation, cytotoxicity and production of reactive oxygen species (ROS) were studied using fluorometric (fluorescent microscopy and flow cytometry) and colorimetric methods (MTT, LDH and crystal violet).