52 results match your criteria: "OPALE Carnot Institute[Affiliation]"
Venetoclax combination therapy induces deep AML remission with eradication of leukemic stem cells and remodeling of clonal haematopoiesis.
Blood Cancer J
March 2021
Assistance Publique-Hôpitaux de Paris, Centre-Université de Paris, Service d'Hématologie Biologique, Hôpital Cochin, Paris, France.
Hematologic disorder-associated Cxcr4 gain-of-function mutation leads to uncontrolled extrafollicular immune response.
Blood
June 2021
Ecotaxie, Microenvironnement et Developpement Lymphocytaire (EMiLy), INSERM U1160, Institut de Recherche Saint Louis, Université de Paris, Paris, France.
The extrafollicular immune response is essential to generate a rapid but transient wave of protective antibodies during infection. Despite its importance, the molecular mechanisms controlling this first response are poorly understood. Here, we demonstrate that enhanced Cxcr4 signaling caused by defective receptor desensitization leads to exacerbated extrafollicular B-cell response.
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