The CD74 inhibitor DRhQ improves short-term memory and mitochondrial function in 5xFAD mouse model of Aβ accumulation.

Neuroinflammation and mitochondrial dysfunction are early events in Alzheimer's disease (AD) and contribute to neurodegeneration and cognitive impairment. Evidence suggests that the inflammatory axis mediated by macrophage migration inhibitory factor (MIF) binding to its receptor, CD74, plays an important role in many central nervous system (CNS) disorders such as AD. Our group has developed DRhQ, a novel CD74 binding construct which competitively inhibits MIF binding, blocks macrophage activation and migration into the CNS, enhances anti-inflammatory microglia cell numbers and reduces pro-inflammatory gene expression.

Cardiometabolic Multimorbidity and Dementia Onset among Middle-aged and Older Adults: Differences by Race/Ethnicity.

Background: Racial/ethnic minoritized groups in the U.S. have higher prevalence of cardiometabolic multimorbidity and experience higher risk of dementia.

Public hospital-based care for abortive events in Mexico: complication rates and socio-demographic factors, 2018-2022.

Background: Abortion-related complications are difficult to measure due to lack of standardized definitions and limited available data. We describe the proportion of abortive events that result in a documented complication in Mexico's public sector hospitals.

Methods: We used ICD-10 codes from Mexico's hospital discharge system (2018-2022), Subsistema Automatizado de Egresos Hospitalarios (SAEH), to describe abortive events admitted to hospitals: complications for excessive bleeding, infection, embolism, and unspecified; patient socio-demographic and clinical characteristics; and municipality-level structural vulnerability.

Assessment of Real-Time Natural Language Processing for Improving Diagnostic Specificity: A Prospective, Crossover Exploratory Study.

Background Reliable, precise, timely, and clear documentation of diagnoses is difficult. Poor specificity or the absence of diagnostic documentation can lead to decreased revenue and increased payor denials, audits, and queries to providers. Nuance's Dragon Medical Advisor (DMA) is a computer-assisted physician documentation (CAPD) product.

Chronic conditions among transgender Medicare beneficiaries: Variation by race, ethnicity, and Medicaid dual-enrollment.

Background: Transgender and gender diverse (TGD) adults experience disability at twice the rate of cisgender (non-TGD) adults in the US. TGD people of color and low-income TGD people experience intersecting discrimination that may compound chronic conditions and disability. To our knowledge, no research has focused on chronic conditions among TGD Medicare beneficiaries with disabilities.

The role of greenspace in vitamin D status: cross-sectional, observational evidence from the UK Biobank.

Background: Exposure to greenspace is associated with positive health outcomes. This relationship is poorly understood, with limited knowledge on the mechanisms through which greenspace affects health, including biomarkers of greenspace effects.

Methods: We used data from the UK Biobank to examine the cross-sectional association between greenspace exposure and serum 25-hydroxyvitamin D [25(OH)D].

Effectiveness and Durability of a Workplace Sedentary Behavior Intervention Based on the Approach.

We used the approach to develop a multi-component workplace sedentary behavior intervention and tested intervention effectiveness in a cluster randomized trial. Participants ( = 198; 75% female) were recruited from three call-centers (two intervention and one usual practice control). All worksites received pedal stand active workstations.

Immigration Policy Climate and contraceptive use among Mexican-origin women in the United States: Support for the "spill-over" hypothesis.

Objectives: This study aimed to examine the association between state-level Immigration Policy Climate (IPC) and the use of most or moderately effective contraceptive methods among US-born White, US-born Mexican-origin, and foreign-born Mexican-origin women.

Study Design: We linked nationally representative survey data from three waves of the National Survey of Family Growth (2013-2019) with a novel and dynamic state-level measure of IPC. We compared the use of a most or moderately effective contraceptive method at the time of the survey among the three ethnicity and nativity groups alone and as an interaction with state IPC index score above or below the national mean in the year of the survey.

Supporting knowledge justice through community science air quality monitoring and a reciprocal reporting process.

In community science on air quality, low-cost air monitors have emerged as an opportunity to democratize data reporting and support knowledge justice by providing participants with instantaneous access to air quality data. In this study, we equipped residents in four environmental justice communities in North Denver with low-cost air monitors to collect real-time air quality data for four separate 30-day field deployments over two years. We conceptualize an improvement to conventional report-back processes by suggesting a 3-part approach - a reciprocal reporting process that includes 1) bidirectional open channels of communication with participants, 2) democratized data access via instant monitor data and written data summaries, and 3) responsive intervention opportunities to respond in real-time to participants air quality concerns.

Breakthroughs and insights: A comprehensive review of yellow fever vaccine breakthrough infection across 8 decades.

The yellow fever vaccine 17D is one of the most successful live-attenuated vaccines ever developed, controlling mosquito-borne yellow fever virus and yellow fever disease worldwide. Introduced in 1937, 17D never underwent rigorous phase III clinical trials to evaluate safety or efficacy, and while protection in the field was quickly established, no prospective evaluation of vaccine efficacy has ever been conducted. One important measure of vaccine efficacy is breakthrough infection resulting from vaccine failure.

Neighborhood socioeconomic disparities in cancer incidence following a hypothetical intervention to increase residential greenspace cover in the UK Biobank cohort.

Background: Higher greenspace exposure has been associated with lower risk of certain cancers. However, few studies have evaluated potential benefits of increasing population-level exposure to greenspace on cancer disparities. We estimated the impact of a hypothetical intervention to increase residential greenspace cover on neighborhood socioeconomic disparities in total, breast, colorectal, lung, and prostate cancer incidence.

Improving screening, brief intervention and referral to treatment for unhealthy alcohol use in diverse, low-resourced primary care clinics.

Background: Implementation of screening brief intervention and referral to treatment (SBIRT) and medication-assisted treatment for alcohol use disorder (MAUD) remains low in primary care. ANTECEDENT (Partnerships to Enhance Alcohol Screening, Treatment, and Intervention) was a practice-facilitator led implementation study to increase SBIRT and MAUD use in diverse primary care clinics.

Methods: From November 2019 - April 2023, we conducted a convergent parallel mixed methods evaluation.

Does ethnic concentration buffer effects of neighborhood deprivation on early childhood growth?

Background: Neighborhood socioeconomic marginalization and racial residential segregation are associated with differential health outcomes in adulthood and pregnancy, but the intergenerational effects of these exposures on early childhood growth are underexplored. Our objective was to investigate racial and ethnic differences in the association between neighborhood deprivation and early childhood growth trajectories, with modification by neighborhood racial concentration.

Methods: Using longitudinal clinical data among 58,860 children receiving care in community-based clinics in the ADVANCE Clinical Data Research Network, we identified four early childhood (0-24 months) body mass index (BMI) trajectories using group-based trajectory modeling: Low, Catch-Up, Moderate, and High.

Harmonizing data across the accelerating colorectal cancer screening and follow-up through implementation science (ACCSIS) program to enhance data quality and promote data sharing.

Background: The purpose of the Accelerating Colorectal Cancer Screening and Follow-up through Implementation Science (ACCSIS) Program, a Cancer Moonshot℠ Initiative, is to support research to build the evidence base on multilevel interventions that increase rates of colorectal cancer screening, follow-up, and referral to care to address disparities in colorectal cancer screening. The National Cancer Institute funded eight Research Projects to implement multilevel interventions to improve colorectal cancer screening among communities who traditionally have been medically underserved. To analyze the impact of ACCSIS across Research Projects, the consortium developed a set of common data elements.

Characteristics of interventions that address racism in the United States and opportunities to integrate equity principles: a scoping review.

Background: As a driver of racial and health inequities, racism is deeply ingrained in the interconnected systems that affect health and well-being. Currently, no common frame is employed across researchers, interventionists, and funders to design, implement, and evaluate comprehensive interventions to address racism. Consequently, there is a need to examine the characteristics of interventions implemented in the United States that address racism across social and structural determinants of health and socio-ecological levels.

Co-created improvement goals and strategies for implementing SBIRT and MAUD in primary care settings in a facilitator-supported, tailored implementation study.

Evidence-based approaches to screening and treatment for unhealthy alcohol use have the potential to reduce morbidity and mortality but are currently underutilized in primary care settings. To support implementation of screening, brief intervention, and referral to treatment (SBIRT) and medication-assisted treatment for alcohol use disorder (MAUD) by identifying goals co-developed by clinics and practice facilitators in a flexible implementation study. In a pragmatic implementation study, we used practice facilitation to support the implementation of SBIRT and MAUD in 48 clinical practices across Oregon, Washington, and Idaho.

Learning from employer experiences with paid leave policy expansions during the COVID-19 pandemic.

The United States does not have a federal policy offering employees paid leave. We study employer attitudes toward the Families First Coronavirus Response Act (FFCRA) federal emergency paid leave policies temporarily adopted during the COVID-19 pandemic to draw lessons for proposed permanent federal paid leave policies. We analyzed a 2021 survey of 300 San Francisco Bay Area employers to examine employers' experiences with paid sick leave (PSL) and paid family leave (PFL) policies during the COVID-19 pandemic, along with their attitudes regarding FFCRA paid leave.

Hearing Loss, Incident Parkinson Disease, and Treatment With Hearing Aids.

Importance: The risk of developing Parkinson disease (PD) after objective hearing loss is unknown. PD studies using self-reported hearing loss are insensitive, and objective data are lacking.

Objective: To examine the association of hearing loss with incident PD in US veterans and its effect modification by well-established prodromal conditions and hearing aids.