Measuring Debilitating and Facilitating Anxiety Within Nursing Simulation.

Background: Anxiety in simulations can be influenced by various factors that either motivate or immobilize students. Understanding simulation anxiety is crucial for educators to design appropriately challenging scenarios without overwhelming students. No instruments have yet been tested to differentiate between debilitating and facilitating anxiety within nursing simulations.

sp. for the Attenuation of Metabolic Dysfunction-Associated Steatotic Liver Disease in Mice.

Probiotics are studied for their therapeutic potential in the treatment of several diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). Part of the significant progress made in understanding the pathogenesis of steatosis has come from identifying the complex interplay between the gut microbiome and liver function. Recently, probiotics have shown beneficial effects for the treatment and prevention of steatosis and MASLD in rodent models and in clinical trials.

Collective modes in terahertz field response of disordered superconductors.

We consider a problem of nonlinear response to an external electromagnetic radiation in conventional disordered superconductors which contain a small amount of weak magnetic impurities. We focus on the diffusive limit and use Usadel equation to analyze the excitation energy and dispersion relation of the collective modes. We determine the resonant frequency and dispersion of both amplitude (Schmidt-Higgs) and phase (Carlson-Goldman) modes for moderate strength of magnetic scattering.

A self-assembling nanoplatform for pyroptosis and ferroptosis enhanced cancer photoimmunotherapy.

The microenvironment of immunosuppression and low immunogenicity of tumor cells has led to unsatisfactory therapeutic effects of the currently developed nanoplatforms. Immunogenic cell death, such as pyroptosis and ferroptosis, can efficiently boost antitumor immunity. However, the exploration of nanoplatform for dual function inducers and combined immune activators that simultaneously trigger pyroptosis and ferroptosis remains limited.

Housing stability, employment, and survival behaviors among young mothers experiencing homelessness: A randomized controlled trial of a housing intervention.

The present study examined the efficacy of a comprehensive housing intervention (Ecologically-Based Treatment - temporary housing and supportive services) on the longitudinal co-occurring patterns of housing stability, employment, and survival behaviors among a sample of young mothers experiencing homelessness. Participants were randomly assigned to: (1) temporary housing + supportive services (n = 80), (2) housing-only (n = 80), or (3) services as usual (n = 80). Follow-up assessments were completed at 3-, 6-, 9-, and 12-months post-baseline.

Improved enzyme functional annotation prediction using contrastive learning with structural inference.

Recent years have witnessed the remarkable progress of deep learning within the realm of scientific disciplines, yielding a wealth of promising outcomes. A prominent challenge within this domain has been the task of predicting enzyme function, a complex problem that has seen the development of numerous computational methods, particularly those rooted in deep learning techniques. However, the majority of these methods have primarily focused on either amino acid sequence data or protein structure data, neglecting the potential synergy of combining both modalities.

Low field electrocaloric effect at isotropic-ferroelectric nematic phase transition.

Electrocaloric effects (ECE) in solid state materials, such as ferroelectric ceramics and ferroelectric polymers, have a great impact in developing cooling systems. Herein, we describe the ECE of a newly synthesized ferroelectric nematic liquid crystal compound at the isotropic-ferroelectric nematic (I-N) phase transition. While the Joule heat completely suppressed the ECE in a DC field, in an AC field with < 1.

Self-Assembled Metal Complexes in Biomedical Research.

Cisplatin is widely used in clinical cancer treatment; however, its application is often hindered by severe side effects, particularly inherent or acquired resistance of target cells. To address these challenges, an effective strategy is to modify the metal core of the complex and introduce alternative coordination modes or valence states, leading to the development of a series of metal complexes, such as platinum (IV) prodrugs and cyclometalated complexes. Recent advances in nanotechnology have facilitated the development of multifunctional nanomaterials that can selectively deliver drugs to tumor cells, thereby overcoming the pharmacological limitations of metal-based drugs.

A Concise Review on Porous Adsorbents for Benzene and Other Volatile Organic Compounds.

Emissions of volatile organic compounds (VOCs) such as benzene, toluene, xylene, styrene, hexane, tetrachloroethylene, acetone, acetaldehyde, formaldehyde, isopropanol, etc., increase dramatically with accelerated industrialization and economic growth. Most VOCs cause serious environmental pollution and threaten human health due to their toxic and carcinogenic nature.

Directional Swimming of B. Subtilis Bacteria Near a Switchable Polar Surface.

The dynamics of swimming bacteria depend on the properties of their habitat media. Recently it is shown that the motion of swimming bacteria dispersed directly in a non-toxic water-based lyotropic chromonic liquid crystal can be controlled by the director field of the liquid crystal. Here, we investigate whether the macroscopic polar order of a ferroelectric nematic liquid crystal (N) can be recognized by bacteria B.

Corrosion-resistant NiFe anode towards kilowatt-scale alkaline seawater electrolysis.

Development of large-scale alkaline seawater electrolysis requires robust and corrosion-resistant anodes. Here we propose engineering NiFe layered double hydroxide (LDH)-based anodes by incorporating a series of anions into the LDH interlayers. The most optimal NiFe LDH anode with intercalated phosphates demonstrates stable operation at a high current density of 1.

Combining the CRISPR Activation and Interference Capabilities Using dCas9 and G-Quadruplex Structures.

We demonstrate that both CRISPR interference and CRISPR activation can be achieved at RNA and protein levels by targeting the vicinity of a putative G-quadruplex forming sequence (PQS) in the promoter with nuclease-dead Cas9 (dCas9). The achieved suppression and activation in Burkitťs Lymphoma cell line and in studies are at or beyond those reported with alternative approaches. When the template strand (contains the PQS) was targeted with CRISPR-dCas9, the G-quadruplex was destabilized and mRNA and protein levels increased by 2.

Assessing Changes in Motor Function and Mobility in Individuals with Parkinson's Disease After 12 Sessions of Patient-Specific Adaptive Dynamic Cycling.

Background And Purpose: This pilot randomized controlled trial evaluated the effects of 12 sessions of patient-specific adaptive dynamic cycling (PSADC) versus non-adaptive cycling (NA) on motor function and mobility in individuals with Parkinson's disease (PD), using inertial measurement unit (IMU) sensors for objective assessment.

Methods: Twenty-three participants with PD (13 in the PSADC group and 10 in the NA group) completed the study over a 4-week period. Motor function was measured using the Kinesia™ sensors and the MDS-UPDRS Motor III, while mobility was assessed with the TUG test using OPAL IMU sensors.

Temporal and spatial layout of endocannabinoid system components in the mouse suprachiasmatic nucleus.

Environmental light serves as the main entraining signal for the central circadian pacemaker, the suprachiasmatic nucleus of the hypothalamus (SCN). To shift clock timing with the changing environment, minute adjustments are necessary and the endocannabinoid system (ECS) acts as a neuromodulatory signaling mechanism in the SCN. These systems exert bidirectional effects on one another, still, limited knowledge exists about the role of endocannabinoids in circadian rhythm regulation.

Young Black and White adults prefer in-person to telehealth for primary care visits and group health promotion programs.

Telehealth utilization has increased since the coronavirus disease 2019 pandemic, reducing barriers to healthcare and, potentially, reducing participation in group health-promotion interventions. However, preferences for telehealth versus in-person formats have not been established. To examine preferences for telehealth and in-person format for primary care and group health-promotion interventions among Black and White women and men aged 20-39.

Association between sleep quality, sleep duration, and physical frailty among adults aged 50 years and older in India.

Background: Considering the significant growth in India's aging population, it is imperative to identify factors associated with frailty among older Indians. This study examined the association between sleep quality, sleep duration, and physical frailty among older adults in India. Moreover, we examined whether the associations between sleep quality, sleep duration, and physical frailty varied by gender.

DNA Catalysis: Design, Function, and Optimization.

Catalytic DNA has gained significant attention in recent decades as a highly efficient and tunable catalyst, thanks to its flexible structures, exceptional specificity, and ease of optimization. Despite being composed of just four monomers, DNA's complex conformational intricacies enable a wide range of nuanced functions, including scaffolding, electrocatalysis, enantioselectivity, and mechano-electro spin coupling. DNA catalysts, ranging from traditional DNAzymes to innovative DNAzyme hybrids, highlight the remarkable potential of DNA in catalysis.

Membrane-Free Water Electrolysis for Hydrogen Generation with Low Cost.

Conventional water electrolysis relies on expensive membrane-electrode assemblies and sluggish oxygen evolution reaction (OER) at the anode, which makes the cost of green hydrogen (H) generation much higher than that of grey H. Here, we develop an innovative and efficient membrane-free water electrolysis system to overcome these two obstacles simultaneously. This system utilizes the thermodynamically more favorable urea oxidation reaction (UOR) to generate clean N over a new class of Cu-based catalyst (CuO) for replacing OER, fundamentally eliminating the explosion risk of H and O mixing while removing the need for membranes.

A Survey on Explainable Artificial Intelligence (XAI) Techniques for Visualizing Deep Learning Models in Medical Imaging.

The combination of medical imaging and deep learning has significantly improved diagnostic and prognostic capabilities in the healthcare domain. Nevertheless, the inherent complexity of deep learning models poses challenges in understanding their decision-making processes. Interpretability and visualization techniques have emerged as crucial tools to unravel the black-box nature of these models, providing insights into their inner workings and enhancing trust in their predictions.

Light-Operated Diverse Logic Gates Enabled by Modulating Time-Dependent Fluorescence of Dissipative Self-Assemblies.

Light-fueled dissipative self-assembly possesses enormous potential in the field of optical information due to controllable time-dependent optical signals, but remains a great challenge for constructing intelligent light-operated logic circuits due to the limited availability of optical signal inputs and outputs. Herein, a series of light-fueled dissipative self-assembly systems with variable optical signals are reported to realize diverse logic gates by modulating time-dependent fluorescence variations of the loaded fluorophores. Three kinds of alkyl trimethylammonium homologs are employed to co-assemble with a merocyanine-based photoinduced amphiphile separately to construct a series of dissipative self-assemblies, showing unexpectedly different fluorescence control behaviors of loaded fluorophores during light irradiation and thermal relaxation processes.