10 results match your criteria: "OH (F.A.A.); and Royal Melbourne Hospital[Affiliation]"
Diet-omics in the Study of Urban and Rural Crohn disease Evolution (SOURCE) cohort.
Nat Commun
May 2024
Sheba Medical Center, Tel-Hashomer, Affiliated with the Tel Aviv University, Tel Aviv, Israel.
Article Synopsis
- - The increase in Crohn disease (CD) cases, especially with urbanization and globalization, is more related to environmental factors rather than genetics, suggesting changes in lifestyle impact gut health.
- - The SOURCE study examined diet, microbiome, and genetic expression among newly diagnosed CD patients and controls from rural and urban settings in China and Israel to uncover links between lifestyle changes and CD.
- - Findings reveal that time spent in urban environments alters gut bacteria and metabolites in rural residents, with specific dietary factors like coffee and vitamin D showing potential protective roles against CD-related changes.
Shigella spp. are a leading bacterial cause of diarrhea. No widely licensed vaccines are available and there is no generally accepted correlate of protection.
View Article and Find Full Text PDFRobotic-Assisted Bronchoscopy: A Comprehensive Review of System Functions and Analysis of Outcome Data.
Diagnostics (Basel)
February 2024
Department of Pulmonary Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.
The past two decades have witnessed a revolutionary era for peripheral bronchoscopy. Though the initial description of radial endobronchial ultrasound can be traced back to 1992, it was not until the mid-2000s that its utilization became commonplace, primarily due to the introduction of electromagnetic navigation (EMN) bronchoscopy. While the diagnostic yield of EMN-assisted sampling has shown substantial improvement over historical fluoroscopy-assisted bronchoscopic biopsy, its diagnostic yield plateaued at around 70%.
View Article and Find Full Text PDFArrhythmias in Female Patients: Incidence, Presentation and Management.
Circ Res
February 2022
Division of Cardiology, Cooper Medical School of Rowan University, Camden, NJ (F.S., A.M.R.).
There is a growing appreciation for differences in epidemiology, treatment, and outcomes of cardiovascular conditions by sex. Historically, cardiovascular clinical trials have under-represented females, but findings have nonetheless been applied to clinical care in a sex-agnostic manner. Thus, much of the collective knowledge about sex-specific cardiovascular outcomes result from post hoc and secondary analyses.
View Article and Find Full Text PDFInternational Multi-Site Initiative to Develop an MRI-Inclusive Nomogram for Side-Specific Prediction of Extraprostatic Extension of Prostate Cancer.
Cancers (Basel)
May 2021
Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Background: To develop an international, multi-site nomogram for side-specific prediction of extraprostatic extension (EPE) of prostate cancer based on clinical, biopsy, and magnetic resonance imaging- (MRI) derived data.
Methods: Ten institutions from the USA and Europe contributed clinical and side-specific biopsy and MRI variables of consecutive patients who underwent prostatectomy. A logistic regression model was used to develop a nomogram for predicting side-specific EPE on prostatectomy specimens.
The Capillary Index Score as a Marker of Viable Cerebral Tissue: Proof of Concept-The Capillary Index Score in the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) Trial.
Stroke
September 2016
From the Departments of Neuro Interventional Surgery (F.A.-A.) and Research (W.P.Y., J.J.E.), Cleveland Clinic Akron General, Akron, OH; Departments of Radiology (O.A.B., C.B.L.M.M.) and Neurology (Y.B.W.E.M.R.), Academic Medical Center, Amsterdam, The Netherlands; Department of Medicine, Northeast Ohio Medical University, Rootstown (E.N.B.); Departments of Neurology (O.A.B., D.W.J.D., W.v.Z.), Public Health (H.F.L.), and Radiology (A.v.d.L.), Erasmus MC University Medical Center, Rotterdam, The Netherlands; Departments of Radiology (O.A.B.) and Neurology (R.J.v.O.), Maastricht University Medical Center and Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands; and Department of Radiology, University of California San Francisco (W.P.D.).
Background And Purpose: The capillary index score (CIS) is based on the hypothesis that areas lacking capillary blush on pretreatment cerebral digital subtraction angiograms correspond to nonviable cerebral tissue.
Methods: Pretreatment digital subtraction angiograms and post-treatment noncontrast enhanced computed tomographic scans from the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) trial were evaluated for areas lacking capillary blush and with tissue hypodensity, respectively. Because the superior and middle zones of the CIS correspond to the 7 cerebral cortex regions of the Alberta Stroke Program Early CT (ASPECT) score, capillary blush was scored in these 2 zones (0-2), called sub-CIS, and compared with the ASPECT score in these 7 regions (0-7), called hypodensity score.
Relative Influence of Capillary Index Score, Revascularization, and Time on Stroke Outcomes From the Interventional Management of Stroke III Trial.
Stroke
June 2015
From the Departments of Neuro-Interventional Surgery (F.A.-A.) and Research (J.J.E.), Akron General Medical Center, OH; Department of Radiology, University of Cincinnati Academic Health Center, OH (T.A.T.); Neurovascular Imaging Research Core & UCLA Department of Neurology, Los Angeles, CA (D.S.L.); and Department of Neurology, University of Cincinnati Academic Health Center, OH (J.P.B.).
Background And Purpose: Until recently, acute ischemic stroke (AIS) trials have failed to show a benefit of endovascular therapy compared with standard therapy, leading some authors to recommend decreasing the time from ictus to revascularization to improve outcomes. We hypothesize that improving patient selection using the capillary index score (CIS) may also be a useful strategy.
Methods: CIS was calculated, blinded to outcome, from pretreatment diagnostic cerebral angiograms for 78 subjects in the Interventional Management of Stroke III database with internal carotid artery and middle cerebral artery trunk occlusion.
Capillary Index Score in the Interventional Management of Stroke trials I and II.
Stroke
July 2014
From the Division of Neurointerventional Surgery, CNS Healthcare Foundation, Akron, OH (F.A.-A., G.Z.M., Z.A.-A.); Department of Radiology (T.A.T.) and Department of Neurology and Rehabilitation Medicine (J.P.B.), University of Cincinnati Neuroscience Institute, OH; Department of Radiology, Vanderbilt University Medical Center, Nashville, TN (J.J.C.); and Department of Neurology (J.M.G.) and Department of Research (J.J.E.), Akron General Medical Center, OH.
Background And Purpose: The Capillary Index Score (CIS) is a simple angiography-based scale for assessing viable tissue in the ischemic territory. We retrospectively applied it to Interventional Management of Stroke (IMS) trials I and II to evaluate the predictive value for good outcomes.
Methods: CIS was calculated from pretreatment diagnostic cerebral angiograms blinded to outcome.
Collaterals at angiography and outcomes in the Interventional Management of Stroke (IMS) III trial.
Stroke
March 2014
From UCLA Stroke Center, Los Angeles, CA (D.S.L.); University of Cincinnati, Cincinnati, OH (T.A.T., J.C., P.K., J.P.B.); Medical University of South Carolina, Charleston, SC (L.D.F., S.D.Y., Y.Y.P.); Departments of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (A.M.D., M.G., B.K.M.); UPMC Stroke Institute, Pittsburgh, PA (T.G.J.); Department of Neuroradiology, University of Dresden, Dresden, Germany (R.v.K.); University of Mississippi, Jackson, MS (R.M.S.); Medical College of Wisconsin/Froedtert Hospital, Milwaukee, WI (O.O.Z.); Michigan State University, East Lansing, MI (S.I.H.); Summit Neurovascular Specialties and Akron General Hospital, Akron, OH (F.A.A.); and Royal Melbourne Hospital, Parkville, Victoria, Australia (B.Y.).
Background And Purpose: Endovascular strategies provide unique opportunity to correlate angiographic measures of collateral circulation at the time of endovascular therapy. We conducted systematic analyses of collaterals at conventional angiography on recanalization, reperfusion, and clinical outcomes in the endovascular treatment arm of the Interventional Management of Stroke (IMS) III trial.
Methods: Prospective evaluation of angiographic collaterals was conducted via central review of subjects treated with endovascular therapy in IMS III (n=331).