Efficient Degradation of Ciprofloxacin in Water Using nZVI/g-CN Enhanced Dielectric Barrier Discharge Plasma Process.

Residual antibiotics in aquatic environments pose health and ecological risks due to their persistence and resistance to biodegradation. Thus, it is crucial to develop efficient technologies for the degradation of such antibiotics. This study presents a novel approach using a nano zero-valent iron/graphitic carbon nitride (nZVI/g-CN)-enhanced dielectric barrier discharge (DBD) plasma process for the degradation of ciprofloxacin (CIP).

Use of period- or fertility-tracking technologies pre- and post-Dobbs.

Objective: This study aimed to evaluate whether use of period- or fertility-tracking technologies decreased from pre- to post-Dobbs, and to identify user characteristics and changes in reasons for use.

Study Design: We used data from the Surveys of Women, population-based surveys on reproductive health among self-identified women aged 18-44 years, conducted in five states. We compared prevalence of use of period- or fertility-tracking technologies and reasons for use pre-Dobbs (2018-2019 in Iowa and Ohio; 2019-2020 in Arizona, New Jersey, and Wisconsin) and post-Dobbs (2022-2023 in all five states), overall and stratified by state.

Safety and efficacy of valoctocogene roxaparvovec with prophylactic glucocorticoids: 1-year results from the phase 3b, single-arm, open-label GENEr8-3 study.

Background: Valoctocogene roxaparvovec, an adeno-associated virus vector that transfers a human factor VIII (FVIII) coding sequence to hepatocytes, provides bleeding protection for people with severe hemophilia A (HA).

Objective: Determine the efficacy and safety of valoctocogene roxaparvovec with concomitant prophylactic glucocorticoids in the open-label, single-arm, phase 3b GENEr8-3 trial.

Methods: Participants with severe HA who were using HA prophylaxis received one 6x10 vg/kg infusion of valoctocogene roxaparvovec concomitantly with daily prophylactic glucocorticoids (40 mg prednisolone equivalent/d weeks 0‒8; taper to 5 mg/d weeks 9‒19).

Hybrid lipid nanoparticles with tumor antigen-primed dendritic cell membranes for post-surgical tumor immunotherapy.

Post-surgical tumor recurrence poses a major challenge in cancer treatment due to residual tumor cells and surgery-induced immunosuppression. Here, we developed hybrid nanoparticles, termed T-DCNPs, designed to promote antigen-specific activation of cytotoxic CD8+ T cells while concurrently inhibiting immunosuppressive pathways within the tumor microenvironment. T-DCNPs were formulated by co-extruding lipid nanoparticles containing a transforming growth factor β inhibitor with dendritic cells that were pre-treated with autologous neoantigens derived from surgically excised tumors.

A facile assay for zDHHC palmitoyl transferase activation elucidates effects of mutation and modification.

At least 10% of proteins constituting the human proteome are subject to S-acylation by a long-chain fatty acid, thioesterified to a Cys thiol side chain. Fatty S-acylation (prototypically, S-palmitoylation) operates across eukaryotic phylogeny and cell type. S-palmitoylation is carried out in mammalian cells by a family of 23-24 dedicated zDHHC palmitoyl transferase enzymes, and mutation of zDHHCs is associated with a number of human pathophysiologies.

Integrating the updated HONO formation mechanism to better understand urban O formation chemistry.

As a vital precursor of hydroxyl radicals (OH), atmospheric nitrous acid (HONO) plays a significant role in tropospheric chemistry and the production of secondary pollutants. However, knowledge of its sources remains insufficient. To comprehensively investigate the HONO chemistry in polluted cities and alleviate the O pollution, based on a comprehensive HONO-related field campaign in Zibo City, on the North China Plain, the parameterized formulas of additional HONO sources were validated in a box model (based on the default MCMv3.

Arteriovenous Fistula Creation and Care in an Office-Based Practice Compared to Hospital Based Care.

Objectives: This study evaluates and compares outcomes of arteriovenous fistulas (AVFs) created in a dialysis access dedicated office-based laboratory (OBL) and outpatient hospital setting.

Methods: All consecutive outpatient surgical autologous AVFs created at an academic hospital, community hospital, and an OBL from 2016-2020 were reviewed. Demographics, comorbidities, surgical procedure, complications, maturation, patency, and procedures for maintenance were assessed from time of surgical evaluation to latest available documentation.

Relationships between Chronic Cough and Asthma Control and Quality-of-Life in Patients with Severe Asthma: A 6-Month Longitudinal Analysis.

Background: The prevalence and clinical implications of chronic cough (CC) in patients with severe asthma receiving asthma treatment remain relatively unknown.

Objective: This study aimed to evaluate the relationships between CC and asthma control and quality-of-life (QoL) in patients with severe asthma through longitudinal analysis.

Methods: Baseline and 6-month follow-up data from the Korean Severe Asthma Registry were analyzed.

Accessing renewable magnetic cellulose nanofiber adsorbent to enhance separation efficiency for adsorption and recovery of Cd.

To address the issue of toxic cadmium pollution and meet the need for rapid separation from water body, a magnetic bio-composite material, marked as CFeMg, was prepared via a facile method. It explicitly includes components of cellulose nanofiber (CNF), FeO and Mg (OH). The microstructures and morphology were characterized and analyzed using XRD, FT-IR, SEM, and TEM.

Korean Guidelines for Diagnosis and Management of Interstitial Lung Diseases: Connective Tissue Disease Associated Interstitial Lung Disease.

Connective tissue disease (CTD) comprising a various range of autoimmune disorders is often accompanied by lung involvement, which can lead to life-threatening complications. The main types of CTDs that can present as interstitial lung disease (ILD) include rheumatoid arthritis, systemic sclerosis, Sjögren's syndrome, mixed connective tissue disease, idiopathic inflammatory myopathies, and systemic lupus erythematosus. CTD-ILD poses a significant challenge in clinical diagnosis and management due to its heterogeneous nature and variable prognosis.

Craniofacial growth prediction models based on cephalometric landmarks in Korean and American children.

Objectives: To compare differences in craniofacial growth prediction results for Korean and American children according to growth prediction models developed using Korean and American longitudinal growth data.

Materials And Methods: Growth prediction models based on cephalometric landmarks were built for each population using longitudinally taken lateral cephalograms of Korean children and American children of northern European origin. The sample sizes of the serial datasets were 679 and 1257 for Korean and American children, respectively.

Orthodontic treatment for preserving periodontally hopeless teeth in a middle-aged patient: a case report.

In this case report, we show a strategic approach to prolonging the lifespan of pathologically migrated maxillary canines with a hopeless prognosis in a 57-year-old female patient, highlighting the potential of orthodontic management for middle-aged patients to enhance both occlusion and facial esthetics while minimizing the need for extensive prosthetic treatment. According to the visual treatment objective, the nonextraction treatment plan showed advantages in the type of orthodontic tooth movement and final occlusal relationship. Therefore, considering the favorable periodontal treatment results and single-root teeth, the hopelessly migrated maxillary canines were relocated, eliminating the existing trauma from occlusion.

Tapinarof cream 1% once daily was well tolerated in adults and children with atopic dermatitis in two phase 3 randomized trials.

Tapinarof cream 1% once daily (QD) demonstrated significant efficacy in patients down to age 2 years with atopic dermatitis (AD) in the ADORING 1 and 2 phase 3 trials. We report local tolerability outcomes. Patients received Tapinarof or vehicle cream QD for 8 weeks.

A ratiometric fluorescent probe with dual near infrared emission for in vivo ratio imaging of cysteine.

Accurately detecting cysteine (Cys) in vivo is crucial for diagnosing Cys-related diseases. A novel ratiometric fluorescent probe featuring dual near-infrared emission is developed in this study for the in vivo ratio imaging of Cys. The probe comprises a hemicyanine organic small-molecule dye (HCy-CYS) with specific Cys recognition capabilities covalently coupled with carbon dots (CDs) synthesized using glutathione (GSH) as the carbon source (GCDs), forming a unique composite nanofluorescent probe (GCDs@CYS).

Spotted fever group rickettsiae in black rats, pets, and humans in Zungarococha community, A rural area in the surroundings of Iquitos, Peru.

Rickettsiae are a family of ectoparasite-borne bacteria that can produce high morbidity and mortality among humans. There are scarce data on rickettsial ecology in rural areas of the Peruvian Amazon basin, where seroprevalence has not been determined, and the identities of animals acting as reservoirs of these bacteria are not known. We conducted a cross-sectional study in Zungarococha (between 2019 and 2021), a rural community located approximately 20 km away from Iquitos city.

Role of PI3K/AKT signaling pathway during capacitation.

Spermatozoa must undergo a complex maturation process within the female genital tract known as capacitation. This process entails the phosphorylation or dephosphorylation of various proteins, and multiple signaling pathways are recognized to play a role. The present study aims to identify alterations in the expression of proteins related to the phosphatidylinositol-3 kinase (PI3K)/protein kinase B (AKT) signaling pathway and assess sperm functions during capacitation.

Artificial intelligence with wrapper multioutput regression to identify chemical contents of fresh and dried manure samples using NIR spectroscopy.

Analyzing manure nutrients such as total ammonium nitrogen (NH), dry matter (DM), calcium oxide (CaO), total nitrogen (-N), phosphorus pentoxide (PO), magnesium oxide (MgO), and potassium oxide (KO) helps in fulfilling crop nutritional needs while improving the profitability and a lower risk of pollutants. This study used two Near Infra Red (NIR) spectral datasets of fresh and dried manure. The freshly prepared NHCl, CaO, Ca(OH), PO, MgO, and KO samples were used for spectral signature peak identification and calibration.

3D printed titanium banana interbody cages versus titanium-coated PEEK bullet cages for TLIF.

Introduction: Lumbar degenerative spinal disease is a common, major cause of pain and disability. Titanium and polyetheretherketone (PEEK) are popular materials for interbody implants although evidence is mixed on which material is superior in terms of fusion and subsidence. The purpose of this study was to evaluate the clinical outcome of 3D printed titanium (3DPT) cages in patients undergoing TLIFs, as well as complication profiles based on widely used outcome metrics and reoperation events.

The Operating Room and Learning Environment for US-Based Muslim Women in Medicine.

Objective: As the number of women in medical training rises, there has been increased interest in understanding the perspectives of minority women. Although Muslim women face unique challenges in pursuing medical training, there are no current studies dedicated to understanding the experience of Muslim women as healthcare professionals. This study aims to present insight into perspectives of United States-based Muslim women physicians, residents, and medical students on discrimination and allyship, the operating room environment, mentorship, and institutional resources.

Compound K promotes thermogenic signature and mitochondrial biogenesis via the UCP1-SIRT3-PGC1α signaling pathway.

Compound K (CK), an active ingredient in ginseng, has anti-cancer, anti-inflammatory, and antioxidant properties. However, its effects on thermogenesis and mitochondrial dynamics in white adipose tissue (WAT) adipocytes are not well understood. This study explores CK's impact on thermogenesis and mitochondrial metabolism in cold-exposed mice and mouse stromal vascular fraction (SVF) cells.

Electrocatalytic methane conversion via in-situ generated superoxide radicals in an aprotic ionic liquid.

The electrochemical activation and partial oxidation of methane are highly attractive to enable the direct conversion in a sustainable and decentralized way. Herein, we report an electrochemical system in a non-diaphragm electrochemical bath to convert CH to CHOH and CHCHOH at room temperature, in which VO·HO as the anodic catalyst to activate CH and an aprotic ionic liquid [BMIM]BF as supporting electrolyte to control superoxide radicals (O) as the main active oxygen species generated on cathode. As a result, methanol and ethanol were identified as the liquid products, and the superior methanol Faraday efficiency (FE) of 32.

Phosphate-adsorbed metal organic framework as a recycled material for catalytic degradation of ceftriaxone sodium via peroxymonosulfate activation.

In this study, the zirconium-based metal organic framework (Zr-MOF) was applied as the adsorbent for phosphorus (P) pollution in water. Then the phosphate-adsorbed metal organic frameworks (MOFs) were used as a recycled raw material and calcined to obtain P-doped MOFs-derived carbon material (ZrP@Zr-BTC). Next, the ZrP@Zr-BTC was used for peroxymonosulfate (PMS) activation for the ceftriaxone sodium degradation.

Preclinical evaluation of the efficacy and safety of AAV8-TNAP-D10 in Alpl-/- and AlplPrx1/Prx1 mouse models for the treatment of early and late-onset hypophosphatasia.

We previously documented successful resolution of skeletal and dental disease in the infantile and late-onset murine models of hypophosphatasia (HPP), with a single injection of an adeno-associated serotype 8 vector encoding mineral-targeted TNAP (AAV8-TNAP-D10). Here, we conducted dosing studies in both HPP mouse models. A single escalating dose from 4x108 up to 4x1010 (vg/b) was intramuscularly injected into 4-day-old Alpl-/- mice (an infantile HPP model) and a single dose from 4x106 up to 4x109 (vg/b) was administered to 8-week-old AlplPrx1/Prx1 mice (a late-onset HPP model).

Enhanced recovery after surgery (ERAS) in stoma reversal surgery: a systematic review and meta-analysis.

Stoma reversal surgery is known for relatively high complication rates. While Enhanced Recovery After Surgery (ERAS) protocols are extensively validated for colorectal surgery, their use in stoma reversal remains underexplored. This systematic review and meta-analysis evaluates clinical outcomes of stoma reversal surgery under ERAS protocols compared to standard care (SC) practices.