Construction of bimetallic oxy-hydroxides based on Ni(OH) nanosheets for sensitive non-enzymatic glucose detection electrochemical oxidation and incorporation.

Due to their ease of synthesis and large specific surface area, Ni(OH) nanosheets have emerged as promising electrochemical sensing materials, attracting significant attention in recent years. Herein, a series of oxy-hydroxides based on Ni(OH) nanosheets, including NiO/Ni(OH)@NF and (MNi)O/Ni(OH)@NF (M = Co, Fe, or Cr), are successfully synthesized the electrochemical oxidation and incorporation strategies. Electrochemical tests demonstrate that these Ni(OH)-based oxy-hydroxides exhibit excellent electrochemical oxidation activity for glucose in alkaline electrolyte.

Homochiral layered indium phosphonates: solvent modulation of morphology and chiral discrimination adsorption.

Assembling chiral coordination polymers into nano/microflower structures may improve their performance in applications such as chiral recognition and separation. In this study, we chose a chiral metal phosphonate system, , In(NO)/-, -pempH [pempH = (1-phenylethylamino)methylphosphonic acid], and carried out systematic work on the self-assembly of this system in different alcohol/HO mixed solvents under solvothermal conditions. Enantiomeric compounds -, -[In(pempH)(μ-OH)(HO)](NO) (R-, S-1) were obtained showing dense layered structures, but their morphologies varied with alcohol solvent.

Solvent-Responsive Glass Transition Behavior of Polyelectrolyte Complexes.

Polyelectrolyte complexes (PECs) have attracted considerable attention owing to their unique physicochemical properties and potential applications as smart materials. Herein, the glass transitions of PECs solvated with varying alcohols are investigated in poly(diallyldimethylammonium)/poly(acrylic acid) (PDADMA/PAA) complexes by using modulated differential scanning calorimetry (MDSC). Solvents with one or two hydroxyl groups are selected to examine the effect of PAA-solvent interactions on the glass transition temperature ( ).

WearMoCap: multimodal pose tracking for ubiquitous robot control using a smartwatch.

We present WearMoCap, an open-source library to track the human pose from smartwatch sensor data and leveraging pose predictions for ubiquitous robot control. WearMoCap operates in three modes: 1) a Watch Only mode, which uses a smartwatch only, 2) a novel Upper Arm mode, which utilizes the smartphone strapped onto the upper arm and 3) a Pocket mode, which determines body orientation from a smartphone in any pocket. We evaluate all modes on large-scale datasets consisting of recordings from up to 8 human subjects using a range of consumer-grade devices.

Use of a novel claw-suture technique for localization of solitary pulmonary nodules: retrospective study and experience from one center.

Background: Video-assisted thoracoscopic surgery (VATS) is more effective for diagnosing and treating solitary pulmonary nodules (SPNs). It is sometimes difficult to localize through use of minimally invasive techniques. We evaluated the feasibility, effectiveness, and safety of a novel localization method for SPNs.

Insights into psychological characteristics of persons (not) agreeing to use an e-coach-application to reduce elevated Internet Use Disorder tendencies.

The present work aims to shed light on the question of whether certain psychological characteristics go along with choosing an e-coach offer to support healthy Internet use when reporting elevated Internet Use Disorder (IUD) tendencies. Data were from a large-scale stepped care approach study to treat persons with varying degrees of IUD tendencies. Recruitment for advertising the download of a smartphone app included social media, videos by influencers, paid ads, TV, radio, newspapers, workshops, and vocational schools.

Periorbital necrobiotic xanthogranuloma resolved with three years of systemic lenalidomide treatment.

Purpose: To describe a case report of the successful management of necrobiotic xanthogranuloma (NXG), a rare periorbital disease.

Observations: A 61-year-old patient presented with bilateral upper and lower lid lesions which were initially misdiagnosed as xanthelasmas and later confirmed to be NXG. Further investigation also uncovered a diagnosis of multiple myeloma.

Do delayed responses introduce bias in ecological momentary assessment? Evidence from comparisons between self-reported and objective physical activity.

Introduction: Delayed responses are a common yet often overlooked aspect of participant compliance in ecological momentary assessment (EMA) research. This study investigated whether response delays introduce selection bias in the moments captured by EMA.

Methods: Participants ( = 339) self-reported their physical activity behaviors using EMA five times a day over 7 days while wearing a continuous physical activity monitor.

Investigation of a Novel Noninvasive Risk Analytics Algorithm With Laboratory Central Venous Oxygen Saturation Measurements in Critically Ill Pediatric Patients.

Background: Accurate assessment of oxygen delivery relative to oxygen demand is crucial in the care of a critically ill patient. The central venous oxygen saturation (Svo) enables an estimate of cardiac output yet obtaining these clinical data requires invasive procedures and repeated blood sampling. Interpretation remains subjective and vulnerable to error.

Evaluating the Adequacy of Central Line-Associated Bloodstream Infection As a Quality Measure: A Cross-Sectional Analysis at a Single Tertiary Care Center.

Importance: The current definition of central line-associated bloodstream infection (CLABSI) may overestimate the true incidence of CLABSI as it is often unclear whether the bloodstream infection (BSI) is secondary to the central line or due to another infectious source.

Objectives: We aimed to assess the prevalence and outcomes of central CLABSI at our institution, to identify opportunities for improvement, appropriately direct efforts for infection reduction, and identify gaps in the CLABSI definition and its application as a quality measure.

Design Setting And Participants: Retrospective cross-sectional study of patients identified to have a CLABSI in the period 2018-2022 cared for at the value-based purchasing (VBP) units of a 1200-bed tertiary care hospital located in Cleveland, OH.

Long-term high fat diet aggravates the risk of lung fibrosis and lung cancer: transcriptomic analysis in the lung tissues of obese mice.

Background: Previous studies reported significant relationships between obesity and pulmonary dysfunction. Here, we investigated genetic alterations in the lung tissues of high fat diet (HFD) induced obese mouse through transcriptomic and molecular analyses.

Methods: Eight-week-old male C57BL/6J mice were fed either a normal chow diet (NCD) or HFD for 12 weeks.

Online Measurements during Simulated Atmospheric Aging Track the Strongly Increasing Oxidative Potential of Complex Combustion Aerosols Relative to Their Primary Emissions.

Oxidative potential (OP) is increasingly recognized as a more health-relevant metric than particulate matter (PM) mass concentration because of its response to varying chemical compositions. Given the limited research on the OP of complex combustion aerosols, the effects of aging processes on their OP remain underexplored. We used online instruments to track the evolution of OP [via dithiothreitol (DTT) assays] during the aging of wood burning and coal combustion emissions by hydroxyl-radical-driven photooxidation and dark ozonolysis.

PdRu bimetallic nanoalloys with improved photothermal effect for amplified ROS-mediated tumor therapy.

An emerging strategy in cancer therapy involves inducing reactive oxygen species (ROS), specifically within tumors using nanozymes. However, existing nanozymes suffer from limitations such as low reactivity, poor biocompatibility, and limited targeting capabilities, hindering their therapeutic efficacy. In response, the PdRu@PEI bimetallic nanoalloys were constructed with well-catalytic activities and effective separation of charges, which can catalyze hydrogen peroxide (HO) to toxic hydroxyl radical (·OH) under near-infrared laser stimulation.

Siderophore-based targeted antibody recruitment for promoting immune responses towards Gram-negative pathogens.

Antibody-recruiting molecules (ARMs) have emerged as a promising strategy for enhancing immune responses against pathogens and cancer cells. In this study, we developed a novel class of antibacterial ARMs utilizing siderophores, small iron-chelating compounds, as targeting motifs. Siderophores naturally exhibit high specificity for bacterial pathogens due to their role in iron acquisition, making them ideal candidates for selective targeting.

Consensus Recommendations for the Management of Neurosarcoidosis: A Delphi Survey of Experts Across the United States.

Background And Objectives: Neurosarcoidosis poses a diagnostic and management challenge due to its rarity, phenotypic variability, and lack of randomized controlled studies to guide treatment selection. Recommendations for management based on expert opinion are useful in clinical practice and provide a framework for designing prospective studies.

Methods: In this Delphi survey study, specialists with experience in managing patients with neurosarcoidosis were invited to anonymously complete 2 surveys about key elements of evaluation, diagnosis, treatment, monitoring, and long-term management of neurosarcoidosis.

The Impact of Idiopathic Intracranial Hypertension on Cardiovascular Disease Risk Among UK Women: An Obesity-Adjusted Analysis.

Introduction: Idiopathic intracranial hypertension (IIH) is known to elevate cardiovascular disease (CVD) risk, but the extent to which obesity and IIH-specific factors contribute to this risk is not well understood. WE aim to separate the effects of obesity from IIH-specific factors on the risk of stroke and CVD, building on previous findings that indicate a two-fold increase in cardiovascular events in women with IIH compared to BMI-matched controls.

Methods: An obesity-adjusted risk analysis was conducted using Indirect Standardization based on data from a cohort study by Adderley et al.

Consortium-driven rapid software validation for Research Electronic Data Capture (REDCap).

There is a growing trend for studies run by academic and nonprofit organizations to have regulatory submission requirements. As a result, there is greater reliance on REDCap, an electronic data capture (EDC) widely used by researchers in these organizations. This paper discusses the development and implementation of the Rapid Validation Process (RVP) developed by the REDCap Consortium, aimed at enhancing regulatory compliance and operational efficiency in response to the dynamic demands of modern clinical research.

Prevalence of Vitamin D Deficiency Among Healthy Young Adults at Kuwait University.

Objective:  This study aims to investigate the prevalence of vitamin D deficiency among healthy young medical and dental students at Kuwait University.

Methods: This cross-sectional study included a total of 201 medical and dental students (male = 99; female = 102) at Kuwait University. Blood samples were collected to assess 25-hydroxyvitamin D (25(OH)D) by electrochemiluminescence (ECL) immunoassay, and a questionnaire was distributed to address related qualitative data.

The Efficacy of Single-Application NPWTi-d for the Salvage of Infected Breast Prostheses: A Multi-Center Study.

Background: Breast prosthesis infections are challenging and traditionally managed with prosthesis removal and delayed reconstruction. Single-application negative pressure wound therapy with instillation and dwell (NPWTi-d) has shown promise for salvaging infected implants, though prior studies have been small and heterogeneous. This study analyzes outcomes and compares protocols from four institutions.

Tumor microenvironment-responsive and modulatory manganese-based nanoenzyme for enhanced tumor immunotherapy.

The characteristics of the tumor microenvironment (TME) have a close and internal correlation with the effect of cancer immunotherapy, significantly affecting the progression and metastasis of cancer. The rational design of nanoenzymes that possess the ability to respond to and regulate the TME is driving a new direction in catalytic immunotherapy. In this study, we designed a multifunctional manganese (Mn)-based nanoenzyme that is responsive to acidic pH and overxpressed HO at tumor site and holds capability of modulating hypoxic and immunosuppressive TME for synergistic anti-tumor photothermal/photodynamic/immunotherapy.

Wood-loving magic mushrooms from Australia are saprotrophic invaders in the Northern Hemisphere.

Magic mushrooms are fungi that produce psilocybin, an entheogen with long-term cultural use and a breakthrough compound for treatment of mental health disorders. Fungal populations separated by geography are candidates for allopatric speciation, yet species connectivity typically persists because there is minimal divergence at functional parts of mating compatibility genes. We studied whether connectivity is maintained across populations of a widespread species complex of magic mushrooms that has infiltrated the Northern Hemisphere from a hypothesised centre of origin in Australasia.

Examining psychological correlates of vaccine hesitancy: a comparative study between the US and Israel.

It is important to identify psychological correlates of vaccine hesitancy, including among people not from the United States (U.S.).

Successful treatment of adult cherubism with a 60 mg denosumab 6-monthly regimen.

Cherubism is a rare autosomal dominant skeletal dysplasia, affecting the maxilla and/or mandible. The condition typically has childhood onset, followed by progression until puberty, with subsequent regression. Cherubism lesions share histological features with giant cell tumor of bone, where high-dose monthly denosumab is an effective medical treatment.

Soil microbial carbon use efficiency differs between mycorrhizal trees: insights from substrate stoichiometry and microbial networks.

The role of mycorrhizal associations in controlling forest soil carbon storage remains under debate. This uncertainty is potentially due to an incomplete understanding of their influence on the free-living soil microbiome and its functions. In this study, rhizosphere and non-rhizosphere soils were collected from eight arbuscular mycorrhizal (AM) and seven ectomycorrhizal (ECM) tree species in a temperate forest.

Enhanced Proton Conductivity Promoted by Structural Transition in a 2D Interwoven Metal-Organic Framework.

We report enhanced proton conductivity promoted by a structural phase transition of MFM-504(Cu)-DMF to MFM-504(Cu)-MeOH and to MFM-504(Cu)-OH via ligand substitution upon exposure to MeOH and HO vapors, respectively. MFM-504(Cu)-DMF can be synthesized by the solvothermal reaction of Cu(NO)·3HO and the flexible zwitterionic ligand, imidazolium-1,3-bis(methylenedicarboxylate) (imidc), to afford a unique layered interwoven network structure. MFM-504(Cu)-OH shows a proton conductivity of 5.