Investigating Additional Cochlear Parameters: A follow-up systematic review and meta-analysis.

Objectives: The movement towards personalization of cochlear implantation has continued to generate interest about variabilities in cochlear size. In a recent meta-analysis, Atalay et al. (2022) examined organ of corti length, cochlear lateral wall, and "A" value and found that most covariates, other than congenital sensorineural hearing loss, did not impact cochlear size via these measurements.

Child-Pugh Score and Vitamin D: Exploring a New Frontier in Liver Cirrhosis Assessment.

This study investigates the relationship between vitamin D levels and liver cirrhosis severity, a leading cause of global morbidity and mortality. Chronic liver diseases, stemming from conditions such as hepatitis, alcohol use, non-alcoholic fatty liver disease, autoimmune diseases, and cryptogenic disorders, disrupt vitamin D metabolism, as the liver converts dietary and skin-derived vitamin D into 25-hydroxyvitamin D (25[OH]D), the primary circulating form. The cross-sectional study conducted at the Department of General Medicine of BLDE (DU) Shri.

An Observational Study on the Analysis of Vitamin D Deficiency in COVID-19 Patients With No Comorbidities: A Retrospective Analysis.

Introduction:  Vitamin D deficiency is an important problem when facing a viral disease. Vitamin D deficiency is widely prevalent in India and plays an important role in immunoregulation. The deficiency can lead to severe viral infections.

Genome Sequence of the Bacteriophage Eugenia.

We report the discovery and genome sequence of mycobacteriophage Eugenia, isolated from soil samples collected in Akron, OH. Eugenia is a double-stranded DNA virus with a genome size of 69,139 bp, featuring 104 predicted protein-encoding genes, with 32 of these genes assigned putative functions.

Erratum to "Dietary intake by patients taking GLP-1 and dual GIP/GLP-1 receptor agonists: A narrative review and discussion of research needs" [Obesity Pillars 11C (2024)100121].

[This corrects the article DOI: 10.1016/j.obpill.

Efficacy of avilamycin on the incidence and severity of diarrhea associated with pathogenic and the subsequent growth performance of nursery pigs.

A total of 3,329 commercial crossbred barrows and gilts were used to compare the efficacy of avilamycin on incidence and severity of diarrhea and growth performance of pigs naturally infected with . An incomplete block design was used with a 2 × 4 factorial arrangement of treatments: 1) Stocking density (Single: 0.67 sq.

Association between 25(OH) vitamin D and schizophrenia: shared genetic correlation, pleiotropy, and causality.

Background: This study delves into the complex interplay between genetics, 25-hydroxyvitamin D (25OHD), and schizophrenia (SCZ). It leverages extensive sample data derived from Genome-Wide Association Studies (GWAS) to uncover genetic correlations.

Methods: Employing Linkage Disequilibrium Score Regression (LDSC) and S-LDSC, this study investigates genetic connections between 25OHD and SCZ.

Individual differences in autism-like traits are associated with reduced goal emulation in a computational model of observational learning.

One's ability to infer the goals and intentions of others is crucial for social interactions, and such social capabilities are broadly distributed across individuals. Autism-like traits (i.e.

Validation of the Korean Version of the Huntington's Disease Quality of Life Battery for Carers.

Objectives: The Huntington's Disease Quality of Life Battery for Carers (HDQoL-C) evaluates caregiver quality of life. This study aims to develop and validate the Korean version (K-HDQoL-C) to assess the burden on Korean caregivers of HD patients.

Methods: Nineteen HD caregivers (7 females, mean age 55.

Prognostic Implications of the Bethesda System in Fine-Needle Aspiration for Follicular Thyroid Carcinoma.

Context.—: Fine-needle aspiration is an effective tool for sampling thyroid nodules; its results are classified according to the Bethesda System for Reporting Thyroid Cytopathology (BSRTC), whose categories define malignancy risks.

Objective.

Misfolding PRSS1 variant p.Ala61Val in a case of suspected intrauterine pancreatitis.

Background/objectives: Genetic variants in PRSS1 encoding human cationic trypsinogen are associated with hereditary pancreatitis. The clinically frequent variants exert their pathogenic effect by increasing intrapancreatic trypsin activity, while a distinct subset of variants causes disease via mutation-induced trypsinogen misfolding and endoplasmic reticulum (ER) stress. Here, we report a novel misfolding PRSS1 variant.

Anthropometric Changes in Female Participants Enrolled in a Combined Aerobic and Resistance Training Program for Longer than 1 Year: A Cohort Study.

Background: To analyze the anthropometric changes in women who had participated in a combined resistance and aerobic training program for more than a year and to determine the effect of the exercise on weight loss.

Methods: A total of 9,128 women aged between 20 and 60 years who registered in the Curves program, which employs a combination of resistance and aerobic training exercises, and who participated for more than 1 year were included in our analysis. The women were divided into groups according to exercise frequency: <1, 1, 2, and ≥3 days/week.

Development of a Body of Knowledge for the Clinical Bioinformatician: Perspectives from the Association for Molecular Pathology's Clinical Genomics Bioinformatician Body of Knowledge Steering Committee.

The use of next-generation sequencing (NGS) and other high-throughput technologies in the clinical molecular diagnostics laboratory requires the application of bioinformatics pipelines and other computational tools to analyze, visualize, and store these clinical data. Clinical Bioinformaticians, individuals with the skills to develop, validate, and deploy these tools in a clinical setting, are needed to ensure that these molecular diagnostic technologies can be appropriately used for clinical care. Building on existing expertise in informatics, NGS, and clinical molecular diagnostics, the Association for Molecular Pathology (AMP) has generated a series to establish an initial Clinical Bioinformatician Body of Knowledge.

Patterns of recurrence following radiation and ADT for pathologic lymph node positive prostate cancer: A multi-institutional study.

Background And Objective: We evaluate prognostic factors and patterns of recurrence in patients who received RT ± androgen deprivation therapy (ADT) for pathologic node-positive (pN1) prostate cancer (PCa) in a multi-institutional cohort.

Methods: Data from patients with pN1 PCa and received RT with short term (ST, ≤6 mo) or long term (LT, >6 mo) ADT were obtained from 4 academic institutions. Biochemical progression free survival (bPFS) and distant metastasis free survival (DMFS) were evaluated.

Monitoring of organochlorine pesticides using pine needle, pine bark, and soil samples across South Korea: Source apportionment and implications for atmospheric transport.

Pine needle, pine bark, and soil samples were collected from various regions in South Korea, considering the suitability of vegetation samples as passive samplers. A total of 27 organochlorine pesticides (OCPs) were analyzed using gas chromatography/high-resolution mass spectrometry (GC/HRMS). The total concentrations of OCPs ranged between 650 and 3,652 pg/g dw in soil, 215 and 1384 pg/g ww in pine needles, and 456 and 1,723 pg/g ww in pine bark.

Enhanced tetracycline degradation using carbonized PEI-grafted lignin microspheres supported Fe-loading catalyst across a wide pH range in Fenton-like reactions.

Traditional homogeneous Fenton systems face limitations, including a narrow pH range, potential secondary pollution, and poor repeatability. In this study, these bottlenecks in tetracycline wastewater treatment were addressed with using carbonized porous polyethyleneimine-grafted lignin microspheres (PLMs) supported Fe-loading catalysts (PLMs/Fe-C). An optimized PLMs/Fe-C catalyst under specific conditions (carbonization temperature: 350 °C, PLMs: Fe = 1:1, and alkali lignin: PEI = 1:4) was developed, which proved to be an efficient Fenton-like catalyst for tetracycline (TC) degradation.

Pediatric Transplant and Cellular Therapy Consortium RESILIENT Conference on Pediatric Chronic Graft-Versus-Host Disease Survivorship After Hematopoietic Cell Transplantation: Part IV. Patient Important Outcomes.

Chronic graft versus host disease (cGVHD), occurs in approximately one in five pediatric allogeneic HCT patients and is a leading cause of late morbidity and mortality. Late effects of HCT may lead to long-term chronic health conditions and shortened life expectancy. In addition to direct physiological challenges from cGVHD and other late-effects, numerous patient-important outcomes impact the quality of life (QOL) of patients and their families.

The Feasibility of Personalized Endpoints in Assessing Treatment Outcomes in Rare Disease: A Pilot Study of Goal Attainment Scaling in SCN2A-Associated Developmental Epileptic Encephalopathy.

Objectives: For individuals living with rare neurodevelopmental disorders, especially those who are at the most severe end of the spectrum, standardized outcome measures may lack the sensitivity to capture small but meaningful changes. Personalized endpoints such as Goal Attainment Scaling (GAS) allow the assessment of treatment response across variable baseline states and disease manifestations and thus provide a highly sensitive measure of efficacy. The current study tested the feasibility of using GAS in rare SCN2A-associated developmental and epileptic encephalopathy (SCN2A-DEE).

Resazurin dye is an in vivo sensor of kidney tubular function.

Glomerular filtration rate (GFR) is the main functional index of kidney health and disease. Currently, no methods are available to directly measure tubular mass and function. Here, we report a serendipitous finding that the in vitro cell viability dye resazurin can be used in mice as an exogenous sensor of tubular function.

Typical endocrine disrupting chemicals in newborns with congenital hypothyroidism: Concentrations, exposure assessment, and potential risks.

Congenital hypothyroidism (CH) has been reported as a prevalent endocrine disorder in newborns. Endocrine disrupting chemicals (EDCs) have been widely detected in humans and can influence endocrine function, especially thyroid function, and neonates as a susceptible population may be more prone to suffer from CH through exposure to various EDCs. In this study, the concentrations and composition profiles of several typical EDCs were determined in 266 serum samples collected from newborns with (n = 136) and without CH (n = 130) in Beijing, China from 2018 to 2020.

Enhanced TOC removal from paper mill wastewater using air dielectric barrier discharge plasma with persulfate sources: Mechanistic insights and continuous flow operation performance evaluation.

This study investigates the removal of total organic carbon (TOC) from paper mill wastewater using air dielectric barrier discharge (DBD) plasma, combined with various persulfate sources, namely potassium peroxymonosulfate (PMS), potassium peroxydisulfate (PDS), and sodium persulfate (SPS). Mechanistic insights into the activation of plasma-PDS and -PMS were obtained through quenching experiments and electron spin resonance (ESR) techniques. The addition of persulfate to air DBD plasma increased TOC removal kinetics by approximately 1.

Chromatographic differentiation in SOA fingerprint identification: A study on naphthalene and α-pinene oxidation.

The evolution of precursors to form secondary organic aerosol (SOA) is still a challenge in atmospheric chemistry. Chamber experiments were conducted to simulate the ambient OH oxidation of naphthalene and α-pinene, which are typical markers of anthropogenic and biogenic emissions. Particulate matters were sampled by quartz filters and were analyzed by comprehensive two-dimensional gas chromatography (GC×GC) coupled with a thermal desorption system (TD) and a mass spectrometer (MS).