Interfacial sorption of 17β-E2 on nano-microplastics: effects of particle size, functional groups and hydrochemical conditions.

Nano-microplastics and 17β-E2 have been frequently detected as emerging high-concern pollutants in aquatic systems, and their interaction at the solid/liquid interface has become a research focus in environmental studies. The interfacial sorption kinetics and equilibrium characteristics of 17β-estradiol (17β-E2) on nano-polystyrene (Nano-PS) with different particle sizes and organic functional group modifications were systematically investigated in aqueous environments in this study. The interfacial interaction mechanism between Nano-PS particles and 17β-E2 was elucidated by utilizing SEM, FTIR, XPS and BET techniques.

What is the Learning Curve for Endoscopic Spine Surgery? A Comprehensive Systematic Review.

Background Context: Endoscopic spine surgery (ESS) is rapidly emerging as a viable minimally invasive technique to successfully treat symptomatic degenerative spinal conditions. Widespread adoption has been limited in part due to the learning curve.

Purpose: To systematically review the learning curve for uniportal and biportal ESS and compare the two techniques.

Molecular basis of vitamin K driven γ-carboxylation at membrane interface.

The γ-carboxylation of glutamate residues enables Ca-mediated membrane assembly of protein complexes that support broad physiological functions including hemostasis, calcium homeostasis, immune response, and endocrine regulation. Modulating γ-carboxylation level provides prevalent treatments for hemorrhagic and thromboembolic diseases. This unique posttranslational modification requires vitamin K hydroquinone (KH) to drive highly demanding reactions catalyzed by the membrane-integrated γ-carboxylase (VKGC).

Examining the human-centred challenges of human-swarm interaction.

We adopt a tripart approach in describing the human-centred challenges with human-swarm interaction. First, the results of large-N laboratory studies will be discussed which found evidence of trust biases (e.g.

O-H/N-H bond dissociation energies in 1,4-hydroquinone, 4-hydroxydiphenylamine, N,N'-diphenyl-1,4-phenylenediamine, and their phenoxyl and aminyl radicals.

Gas phase bond dissociation energies (BDE) O-H/N-H in hydroquinone (HQ), 4-aminophenol (AP), 1,4-phenylenediamine (PDA), 4-hydroxydiphenylamine (HDPA), N,N'-diphenyl-1,4-phenylenediamine (DPPDA) as well as in their phenoxyl/aminyl radicals have been determined using a combined technique of quantum chemical calculation. The technique included a series of DFT (PBE1PBE, TPSSTPSS, M06-2X), ab initio (DLPNO-CCSD(T)) methods with valence 3ξ-basis sets, composite methods of Gaussian family (G4) and Weizmann theory with ab initio Brueckner Doubles (W1BD), as well as reference reactions of different levels of structural similarity. W1BD method was used in combination with isodesmic reactions for BDE estimation (kJ∙mol) of compounds with the only aromatic fragment: BDE = 352.

Periodate activation by plasma coupled with FeNC for contaminant removal: Machine learning assisted catalyst optimization and electron shuttle mechanism.

Emerging contaminants (ECs) pose great challenges to water treatment technology due to their complexity and high harm. In this paper, the method of dielectric barrier discharge (DBD) plasma coupled with iron-based catalyst (FeNC) activating periodate (PI) was first designed for ECs removal. The ingenious introduction of FeNC not only promotes the Fenton-like reaction of DBD system but also reduces the PI activation energy barrier and accelerates the electron shuttle between PI and pollutants.

Mealtime challenges from the perspectives of adolescents with anorexia nervosa and atypical anorexia nervosa and their caregivers enrolled in family-based treatment.

Objective: This study identified mealtime challenges and emotions experienced during challenges among adolescents with anorexia nervosa (AN) or atypical anorexia nervosa (AAN) and their caregivers during the early phase of family-based treatment (FBT).

Method: Caregivers with high expressed emotion (i.e.

A call to action for disrupting microaggressions, improving interprofessional collaboration, and optimizing outcomes: Nurse leaders have a role.

Background: Microaggressions are pervasive in clinical and academic environments, often unnoticed by those unaware of the privileges and power dynamics tied to socially constructed hierarchies. These subtle manifestations of bias and prejudice are typically directed toward historically marginalized individuals and groups (HMIGs), contributing to a toxic culture that undermines interprofessional communication, collaboration, and healthcare delivery.

Purpose: This article aims to explore the concept of microaggressions and their impact on healthcare environments.

Key Strategies to Promote Professional Wellness and Reduce Burnout in Oncology Clinicians.

Burnout in oncologists has been increasing, especially after the COVID-19 pandemic. This is concerning because burnout can have both personal and professional repercussions, as well as a negative impact on patients and organizational financial health. Drawing on information and ideas discussed at an ASCO Town Hall session at the 2023 Annual Meeting developed by the State of Cancer Care in America Editorial Board, this study reviews key organizational strategies for improving professional well-being and argues for the importance of measuring and researching the well-being of the oncology workforce to ensure healthy work environments.

MELANOMAS, SARCOMAS, AND RENAL METASTASES IN THE LIVER: HOW TO TREAT?

Liver metastases from melanomas, sarcomas, and renal tumors are less frequent. Treatment and prognosis will depend on whether they are isolated or multiple, size and location, the presence or absence of extrahepatic neoplastic disease, age, stage of the initial disease, initial treatments instituted, time of evolution, and clinical condition of the patient. Recently, a high number of oncological therapies including monotherapy or in combination, neoadjuvants or adjuvants, and immuno-oncological treatments have been developed and tested, increasing disease-free time and survival.

Patient-derived Organoids and Xenografts Uncover Therapeutic Vulnerabilities in Colorectal Signet Ring Cell Carcinomas.

Purpose: Identifying therapeutic targets for Signet Ring Cell Carcinoma (SRCC) of the colon and rectum is a clinical challenge due to the lack of Patient-Derived Organoids (PDO) or Xenografts (PDX). We present a robust method to establish PDO and PDX models to answer address this unmet need. We demonstrate that these models identify novel therapeutic strategies targeting therapy resistance and peritoneal metastasis.

Design Characteristics of Augmentative and Alternative Communication Interfaces for Children With Cortical Visual Impairment: Results From Two Focus Groups With Vision Professionals.

Purpose: The purpose of the current study was to gain insight on augmentative and alternative communication (AAC) interface designs for children with cortical visual impairment (CVI). Children with CVI frequently require AAC and specific interface supports, and customization may be necessary to support access and use of speech-generating devices.

Method: A focus group methodology was selected to gain feedback from vision professionals on helpful AAC features for children with CVI.

Classification-based pathway analysis using GPNet with novel P-value computation.

Pathway analysis plays a critical role in bioinformatics, enabling researchers to identify biological pathways associated with various conditions by analyzing gene expression data. However, the rise of large, multi-center datasets has highlighted limitations in traditional methods like Over-Representation Analysis (ORA) and Functional Class Scoring (FCS), which struggle with low signal-to-noise ratios (SNR) and large sample sizes. To tackle these challenges, we use a deep learning-based classification method, Gene PointNet, and a novel $P$-value computation approach leveraging the confusion matrix to address pathway analysis tasks.

Scrub typhus association with autoimmune biomarkers and clinical implications.

Background: Scrub typhus, a disease caused by Orientia tsutsugamushi, triggers systemic vasculitis and is prevalent in Eastern and Southern Asia. This study aimed to uncover the relationship between scrub typhus and autoimmune responses, focusing on antinuclear antibodies (ANAs) and the implications of elevated ANA titers during infection.

Method: Data from a total of 139 patients diagnosed with scrub typhus and 30 healthy controls were retrospectively analyzed through serum samples to assess the levels of ANAs and related autoantibodies.

Bacterial sensor evolved by decreasing complexity.

Bacterial receptors feed into multiple signal transduction pathways that regulate a variety of cellular processes including gene expression, second messenger levels, and motility. Receptors are typically activated by signal binding to ligand-binding domains (LBDs). Cache domains are omnipresent LBDs found in bacteria, archaea, and eukaryotes, including humans.

REACH assessment of humans exposed to chemicals indirectly via the environment: screening modeling in EUSES versus state of the science.

The assessment of humans indirectly exposed to chemicals via the environment (HvE) is an assessment element of the Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH) regulation. The European Union System for the Evaluation of Substances (EUSES) is the default screening tool, aimed at prioritizing chemicals for further refinement/higher tier assessment. This review summarizes the approach used in EUSES, evaluates the state of the science in human exposure modeling via the environment, and identifies areas for further research to strengthen the confidence and applicability of EUSES for assessing HvE.

Literature Commentary.

In this issue of JNO, Drs. Deborah I. Friedman and Mark L.

Inactivation of , and multidrug-resistant with dielectric barrier discharged cold atmospheric plasma: a comparative study with antimicrobial drugs.

Cold atmospheric plasma (CAP) has emerged as a promising technology for neutralizing microbes, including multidrug-resistant strains. This study investigates CAP's potential as an alternative to traditional antimicrobial drugs for microbial inactivation. In the era of increasing antimicrobial resistance, there is a persistent need for alternative antimicrobial strategies.

Competitive Effect of Surface Hydrophobicity-Hydrophilicity and the Number of Accessible Protons on Water-Assisted Proton Conductivity in Metal-Organic Frameworks: Dielectric σ-Relaxation Triggered by Disordered Guest Ionic Migration and Its Mechanism.

The rapid upsurge of metal-organic frameworks (MOFs) has sparked profound interest in their potential as proton conductors for proton exchange membrane fuel cells. However, proton-conducting behaviors of hydrophobic MOFs remain poorly understood compared with their hydrophilic counterparts, largely due to the absence of a microscopic phase separation structure akin to that found in Nafion membranes. Herein, we demonstrate a strategy for regulating the structures and proton conductivities of MOFs by separately incorporating hydrophobic -C(CF)- group alongside hydrophilic -O- and -SO- groups into organic ligands as linkers.

Targeted insertion of heterogenous DNA using Cas9-gRNA ribonucleoprotein-mediated gene editing in .

Gene editing is emerging as a powerful tool for introducing novel functionalities in mushrooms. While CRISPR/Cas9-induced double-strand breaks (DSBs) typically rely on non-homologous end joining (NHEJ) for gene disruption, precise insertion of heterologous DNA in mushrooms is less explored. Here, we evaluated the efficacy of inserting donor DNAs (8-1008 bp) with or without homologous arms at Cas9-gRNA RNP-induced DSBs.

Constructing well-dispersed active phase spontaneous redox for electrochemical nitrate reduction to ammonia.

In this study, a distinctive multiple core-shell structure of Co nanoparticles inserted into N-doped carbon dodecahedron@Co hydroxide (Co/NCD@Co(OH)) was synthesized a spontaneous redox reaction between metallic Co and NO, ultimately materializing the fine dispersion and exposure of the active sites. The electronic interaction existing between the Co/NCD core and the Co(OH) shell brings a synergistic effect, conspicuously lessens the overpotential, and reinforces the yield-rate and faradaic efficiency of NH for electrochemical nitrate-ammonia conversion. This study underlines the spontaneous redox between the catalysts and substrate, rendering it as a synthetic strategy for designing genuine and well-dispersed active sites.

Simultaneous Unbinned Differential Cross-Section Measurement of Twenty-Four Z+jets Kinematic Observables with the ATLAS Detector.

Z boson events at the Large Hadron Collider can be selected with high purity and are sensitive to a diverse range of QCD phenomena. As a result, these events are often used to probe the nature of the strong force, improve Monte Carlo event generators, and search for deviations from standard model predictions. All previous measurements of Z boson production characterize the event properties using a small number of observables and present the results as differential cross sections in predetermined bins.

Association Between Preterm Birth and Fulfillment of Desired Permanent Contraception.

Objectives: In cases of preterm delivery, the Medicaid sterilization policy mandates a signed consent form at least 72 h before surgery for permanent contraception, which is less than the 30 day minimum waiting period for term births. This study evaluated the association between preterm birth and fulfillment of planned permanent contraception.

Study Design: This was a secondary analysis of a multi-center retrospective cohort study of 3013 patients with a postpartum contraceptive plan of permanent contraception.

Effect of Feeding Mice Soluble Metals and Heavy Metal Contaminated Soil on Feces Metal Concentrations.

The effect of heavy metal availability and interaction in feed on feces heavy metal excretion in mice has rarely been investigated. In this work, feed containing a polluted soil (total Cd = 6.34, total Pb = 387 mg kg) amended with phosphate, bentonite and lime, or feed spiked with soluble Pb and Cd were fed to mice for 10 days.