ASSESSMENT OF THE SEVERITY OF GINGIVITIS IN CHILDREN WITH DISORDERS OF TEETH FORMATION SUFFERED AFTER THE CHORNOBYL NPP ACCIDENT.

Objective: to determine the severity of gingivitis in children with teeth formation disorders - residents of the ter-ritories contaminated with radionuclides as a result of Chornobyl Nuclear Power Plant (ChNPP) accident.

Materials And Methods: The object of the study is 1470 children aged 6-14 years with dental malformations, 528 amomg them are residents of areas contaminated with radionuclides as a result of the ChNPP with the identified types of disorders of teeth formation (DTF) (systemic enamel hypoplasia (SEH) and molar-incisor hypomineralization (MIH)), and different stages of the severity of gingivitis.

Results: Determining of the degree of severity of gingivitis in children with DTF indicates the presence of its lesion of a moderate degree of the severity with a prevalence in persons with SEH or MIH and chronic diseases of internal organs suffered after the ChNPP accident.

IONIZING RADIATION AND CYTOKINES: THE ROLE IN THE PATHOGENESIS OF PLASMA CELL MYELOMA (LITERATURE REVIEW).

The review presents literature data on the role of ionizing radiation as a negative environmental factor in the occurrence of plasma cell myeloma (PCM). The data of studies of various categories of irradiated persons regarding the incidence of PCM, in particular employees of nuclear enterprises and victims of the accident at the Chornobyl Nuclear Power Plant accident, are given. The effect of cytokines (interleukin-6 and interleukin-10) on PCM substrate cells was analyzed, including under conditions of combined action of IR and cytostatic agents in vitro.

MULTIPLE ACUTE POSTERIOR CIRCULATION STROKE WITH LESIONS IN THE PONS AND BOTH HEMISPHERES OF THE CEREBELLUM ASSOCIATED WITH OVARIAN HYPERSTIMULATION SYNDROME: A CASE REPORT OF A WHITE EUROPEAN ADULT IN UKRAINE.

We have presented a brief literature overview of the disease, supported by a clinical case of multiple acute posterior circulation strokes with lesions in the pons and both hemispheres of the cerebellum associated with ovarian hyperstimulation syndrome in a white young European adult in Ukraine. Specific features of posterior circulation stroke associated with ovarian hyperstimulation syndrome were determined, analyzed, and described. Complex posterior circulation cerebral infarction in the pons and both hemispheres of the cerebellum associated with ovarian hyperstimulation syndrome has not been reported before but has devastating consequences for both mother and fetus.

CLINICAL AND IMAGING FEATURES OF MEDIAL MEDULLARY INFARCTION: RESULTS OF A PROSPECTIVE HOSPITAL-BASED COHORT STUDY ILLUSTRATED WITH A CASE REPORT IN A WHITE EUROPEAN ADULT.

Objective: The aim: This study aims in a prospective hospital-based cohort study to determine clinical and imaging features of medial medullary infarction and report a relevant clinical case in a white European adult.

Patients And Methods: Materials and methods: We have prospectively enrolled one hundred twenty adult patients with acute posterior circulation stroke. All patients were admitted and enrolled in the study within 6 to 24 hours from the onset of the stroke symptoms.

THE ROLE OF ENTEROVIRUSES IN THE DEVELOPMENT OF ISCHEMIC STROKE AND ITS OUTCOMES.

Objective: The aim: To study the role of enteroviruses (EV) in the development of ischemic stroke and its outcome.

Patients And Methods: Materials and methods: The main group (MG) included 72 patients with acute cerebrovascular disorders were examined using the National Institutes of Health Stroke Scale and Barthel Index. The comparison group (CG) included 35 patients without cerebrovascular disease.

DEVELOPMENT OF ANOREXIA NERVOSA IN A FEMALE ADOLESCENT IN A DYSFUNCTIONAL FAMILY ENVIRONMENT WITH IMPAIRED ATTACHMENT AND EMOTIONAL REGULATION: A CASE REPORT.

A 17-year-old female patient was admitted to the psychoneurological department of Kyiv Clinical Railway Hospital No. 1, due to deterioration of her mental state, a significant decrease in body weight, and no effect of outpatient treatment. The complex treatment program, directed on the correction of all multidimensional disorders with the preliminary psychodiagnostics examination of the patient and her parents according to the FACES-III, DERS, which were monitored in dynamics during the 3,6,9 and 12 months of treatment, was applied.

Recurrent Ameloblastoma: Clinical Manifestation and Disease-Free Survival Rate.

Objectives: Ameloblastoma is a slow-growing epithelial odontogenic neoplasm of the jaws with a high recurrence rate. The main treatment strategies for this lesion are radical or conservative surgical approaches. The aim of the present study was to analyze clinical presentations, histological types, and treatment strategies of recurrent ameloblastoma and to define its disease-free survival (DFS) rate.

RISK ASSESSMENT OF NEW PESTICIDES TO PUBLIC HEALTH AS POTENTIAL CONTAMINANTS OF UNDERGROUND AND SURFACE WATER SOURCES.

Objective: The aim: Risk assessment of amicarbazone, bicyclopyrone and pydiflumetofen to public health as potential contaminants of groundwater and surface water sources in soil and climatic conditions of Ukraine in comparison with other countries.

Patients And Methods: Materials and methods: Hazard assessment to public health was performed according to 3 methods: determination of integrated danger vector (R), integrated groundwater contamination hazard index (IGCHI), risk of adverse effects of studied pesticides to public health (RAEP).

Results: Results: The assessment of R and IGCHI indicators showed that the highest level of potential danger to public health due to possible contamination of water sources in Ukraine and other countries (EU, USA, Australia) is inherent in bicyclopyrone.

The efficacy of combined immunotherapy with Propes and Inflamafertin in adult patients with genetic deficiency of the folate cycle and selective deficiency of NK and NKT cells.

The purpose of the present study is to evaluate the efficacy of combination immunotherapy with Propes and Inflamafertin in GDFC adults with natural killer (NK) and/or natural killer T-lymphocyte (NKT) cell deficiency. This single-centre, retrospective, controlled, non-randomized clinical trial analysed medical records of 212 adult GDFC patients aged 19-50 years (study group [SG]). SG received Propes at a dose of 2 ml intramuscularly every other day at night for three consecutive months and Inflamafertin at a dose of 2 ml IM every other day at night for three consecutive months in rotation with Propes.

Spontaneous cessation of postpancreatectomy hemorrhage in a patient with celiac artery stenosis.

Postpancreatectomy hemorrhage (PPH) is a severe complication of pancreatic surgery. This condition often develops on the background of pancreatic fistula. In our report, we demonstrate an unusual case of spontaneous cessation of severe postpancreatectomy common hepatic artery (СHA) hemorrhage after distal pancreatectomy in a patient with celiac artery stenosis (CAS).

INTERDEPENDENCE OF THE MICROBIOCENOSE COMPOSITION OF BIOPELLICLE AND THE SEVERITY DEGREE OF CHANGES IN THE MUCOSA OF THE GUMS AFTER TEN WEEKS OF EXPERIMENTAL OPIOID EXPOSURE.

Objective: The aim: To study the relationship between the degree severity of changes in the tunica mucosa of the rats gums and the composition of the microbiota of tooth surface in the gingival margin under the ten-week action of the opioid.

Patients And Methods: Materials and methods: The study was performed on 34 male rats, weighing 160 - 255 g, aged 4.5 - 7 months.

ASEPTIC MENINGITIS AS AN EXTRAHEPATIC MANIFESTATION OF HEPATITIS C: A CLINICAL CASE PRESENTATIONIN A WHITE YOUNG FEMALE EUROPEAN ADULT.

We aimed to provide a clinical case presentation of aseptic meningitis as an extrahepatic manifestation of hepatitis C. A 28-year-old lady has been admitted to the Regional Clinical Center of Neurosurgery and Neurology, Uzhhorod City, Ukraine, with mild meningeal signs and symptoms upon admission. Complex neurological, clinical, laboratory, and imaging examination was performed within 24 hours of admission.

LATERAL MEDULLARY INFARCTION: A PROSPECTIVE HOSPITAL-BASED COHORT STUDY OF CLINICAL AND IMAGING FEATURES AND A CASE REPORT IN A WHITE ADULT.

Objective: The aim: The purpose of this study is to determine clinical and imaging features of lateral medullary infarction in a prospective hospital-based cohort study, illustrated with a clinical case presentation in a white adult.

Patients And Methods: Materials and methods: We prospectively recruited 120 acute posterior circulation stroke patients, admitted to the Neurological Center of the University Hospital (Oleksandrivska Clinical Hospital) in Kyiv, Ukraine, within 6 to 24 hours from the onset of the stroke symptoms. Comprehensive neurological, clinical, laboratory, ultrasound, and imaging examination was performed on all patients.

A survey on the correlation between PM concentration and the incidence of suspected and positive cases of COVID-19 referred to medical centers: A case study of Tehran.

COVID-19, one of the greatest health challenges of the present century, has infected millions of people and caused more than 6 million deaths worldwide. The causative agent of this disease is the new virus SARS-CoV-2; which continues to spread globally and sometimes with new and more complex aspects than before. The present study is an observational study aimed to investigate the role of AQI; PM and its relationship with the incidence of suspected cases (SC) and positive cases (PC) of COVID-19 at different levels of the air quality index (AQI) in Tehran, the capital of Iran in the period from Feb 20th, 2020 to Feb 22nd, 2021.

and Estimation of Structure and Biological Affinity of 1,3- Oxazoles: Fragment-to-fragment Approach.

Background: The fragment-to-fragment approach for the estimation of the biological affinity of the pharmacophores with biologically active molecules has been proposed. It is the next step in the elaboration of molecular docking and using the quantum-chemical methods for the complex modeling of pharmacophores with biomolecule fragments.

Methods: The parameter φ 0 was used to estimate the contribution of π-electron interactions in biological affinity.

Breakthrough SARS-CoV-2 infections after vaccination: a critical review.

At the beginning of the current pandemic, it was believed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection would induce lifelong immunity and that reinfections would be unlikely. However, after several cases of reinfection were documented in previously infected patients, this was understood to be a false assumption, and this waning humoral immunity has raised significant concerns. Accordingly, long-term and durable vaccine-induced antibody protection against infection have also become a challenge, as several breakthroughs of COVID-19 infection have been identified in individuals who were fully vaccinated.

Routine laboratory parameters in patients with necrotizing pancreatitis by the time of operative pancreatic debridement: Food for thought.

Background: Timing of invasive intervention such as operative pancreatic debridement (OPD) in patients with acute necrotizing pancreatitis (ANP) is linked to the degree of encapsulation in necrotic collections and controlled inflammation. Additional markers of these processes might assist decision-making on the timing of surgical intervention. In our opinion, it is logical to search for such markers among routine laboratory parameters traditionally used in ANP patients, considering simplicity and cost-efficacy of routine laboratory methodologies.

CLINICAL AND IMAGING FEATURES OF LACUNAR AND NON-LACUNAR SUBTYPES OF ISCHEMIC POSTERIOR CIRCULATION STROKE.

Objective: The aim: The purpose of this study is to determine clinical and imaging features of etiological subtypes of posterior circulation stroke in a prospective hospital-based cohort study.

Patients And Methods: Materials and methods: We prospectively recruited 120 acute posterior circulation stroke patients, admitted to the Neurological Center of the University Hospital (Oleksandrivska Clinical Hospital) in Kyiv, Ukraine, within 6 to 24 hours from the onset of the stroke symptoms. Comprehensive neurological, clinical, laboratory, ultrasound, and imaging examination was performed on all patients.

Challenges posed by COVID-19 in cancer patients: A narrative review.

A novel coronavirus, or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified as the causative agent of coronavirus disease 2019 (COVID-19). In early 2020, the World Health Organization declared COVID-19 the sixth public health emergency of international concern. The COVID-19 pandemic has substantially affected many groups within the general population, but particularly those with extant clinical conditions, such as having or being treated for cancer.

PROSPECTIVE ANALYSIS OF THE EPIDEMIOLOGY OF CEREBROVASCULAR DISEASE AND STROKE AMONG THE ADULT POPULATION OF KYIV CITY, UKRAINE.

Objective: The aim: We aimed to conduct a prospective analysis of the epidemiology of cerebrovascular disease and stroke among the adult population of Kyiv City, Ukraine the last 12 years.

Patients And Methods: Materials and methods: We analyzed sectoral statistical reports of cerebrovascular disease and stroke in Kyiv City for 2009-2020. The statistical method and the method of system approach were used in this study.

ACHIEVEMENT OF CLINICAL REMISSION IN PATIENTS WITH RHEUMATOID ARTHRITIS DEPENDING ON THE ACCP- AND RF-SEROLOGICAL STATUS.

In this clinical study, the effect of serological status of rheumatoid arthritis (RA) on the possibility and timing of clinical remission while taking the main non-biological disease modifying anti-rheumatic drugs (DMARD) was analyzed. The relationship between presence and levels of antibodies to cyclic citrullinated peptide (ACCP) and/or rheumatoid factor (RF) and remission in RA has also been studied. It was found that the frequency of remission, including early one (during the first 6 months of treatment), is three times higher in ACCP negative patients with RA.

Sarcotubular Myopathy Due to Novel Mutation in Association with Multiple Sclerosis.

Azerbaijani 28-year-old female showed weakness (MRC (Medical Research Council Scale for Muscle Strength) grade 4 in the proximal part of the upper and MRC grade 2-3 in the lower extremities), difficulty in stair lifting, positive symptom of Hoover's rising, «waddling gait», decline deep reflexes symmetrical, lack of surface reflexes, positive Babinsky's reflex on the right, urinary incontinence during sneezing, prolonged walking and exercise from puberty. Additional methods made it possible to identify minor violations of conduction of the left ventricle, electromyography signs of primary muscular disease with predominant involvement of the proximal muscles of the lower extremities, elevation of serum creatine kinase (746.81 U/l), active foci of demyelination in the left frontal lobe, intrathecal synthesis of oligoclonal IgG bands (type 2) in cerebrospinal fluid, atrophy and fatty degeneration of all muscles of the shins, homozygous Variant of Uncertain Significance (VUS) c.

Peroxidative degradation of proteins and lipids in undifferentiated connective tissue dysplasia in children, Ukraine.

The aim of the study was to assess the state of lipid and protein peroxidation in children with undifferentiated connective tissue dysplasia (UCTD). In this study, 63 children (33 children with UCTD and 30 children without UCTD were recruited and the indicators of lipid and protein peroxidation were measured. The enzymatic, colorimetric method was used to measure the level of total cholesterol (TC).

Systemic chemotherapeutic treatment of patients with breast cancer brain metastases.

Brain metastases of solid tumors are the most common intracranial neoplasms in adults. We provide a short overview of the role of the blood-brain barrier ​​in the pathogenesis of breast cancer brain metastases, and the effectiveness of systemic anticancer therapy in the treatment of such patients.

A STUDY OF PHYSICAL ACTIVITY LEVELS AND QUALITY OF LIFE IN YOUNG ADULTS DURING THE COVID-19 PANDEMIC.

Objective: The aim: To investigate the impact of the COVID-19 pandemic on the level of physical activity and quality of life in young adults.

Patients And Methods: Materials and methods: A survey of 327 young people aged 18-25 years was conducted; the SF-36 (Medical Outcomes Study-Short Form) questionnaire was used to determine the quality of life; a questionnaire taking into account the WHO Global Recommendations on Physical Activity for Health in order to determine the level of physical activity was applied.

Results: Results: Young adults men 88 (27%) and 239 women (73%), mean age 21.