3 results match your criteria: "O'Brien Center for Acute Kidney Injury Research[Affiliation]"
Identification of Maltase Glucoamylase as a Biomarker of Acute Kidney Injury in Patients with Cirrhosis.
Crit Care Res Pract
April 2019
Biomarkers Laboratory, O'Brien Center for Acute Kidney Injury Research, Nephrology-Hypertension, UC San Diego, Department of Medicine, San Diego, USA.
Article Synopsis
- Acute kidney injury (AKI) common in decompensated cirrhosis is linked to higher mortality, and traditional biomarkers like serum creatinine may not accurately detect early kidney damage.* -
- The study involved analyzing urine samples from cirrhotic patients and healthy controls, identifying 1572 proteins in urinary exosomes, with maltase-glucoamylase found to be a key differentiating protein for kidney injury.* -
- The findings suggest that elevated levels of MGAM in urinary exosomes can help distinguish AKI in cirrhosis patients, but further research is needed to establish its clinical relevance.*
Proteomic analyses of Urine Exosomes reveal New Biomarkers of Diabetes in Pregnancy.
Madridge J Diabetes
February 2016
Departments of Medicine, Pathology and Pediatrics, UC San Diego, USA.
Objective: To evaluate 24 hour urine exosome protein content changes among pregnant US subjects with diabetes and obesity during early pregnancy.
Methods: The exosome proteome content from 24 hour urine samples of pregnant subjects with gestational diabetes mellitus (GDM, N=8) and pre-gestational Type 2 diabetes (PGD, N = 10) were compared with control samples (CTRL, N = 10) obtained at week 20 of pregnancy. Differences in exosome protein load between groups was identified by liquid chromatography/mass spectrometry, analyzed by linear regression in negative binomial distribution, visualized in MetaboAnalyst (version 3.
Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs. angiotensin II blockade.
Am J Physiol Renal Physiol
December 2010
Division of Nephrology-Hypertension, School of Medicine, and O'Brien Center for Acute Kidney Injury Research, University of California, and Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA.
The 5/6(th) nephrectomy or ablation/infarction (A/I) preparation has been used as a classic model of chronic kidney disease (CKD). We observed increased kidney oxygen consumption (Q(O2)) and altered renal hemodynamics in the A/I kidney that were normalized after combined angiotensin II (ANG II) blockade. Studies suggest hypoxia inducible factor as a protective influence in A/I.
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