Consumption patterns before and during the COVID-19 pandemic among patients admitted to inpatient drug detoxification treatment: Results of two cross-sectional surveys from 2018 and 2021.

Background: The lockdown measures during the SARS-CoV-2 pandemic could have influenced drug consumption patterns of persons with drug use disorder, especially due to a reduced availability of drugs, an increased consumption of sedating substances as a coping strategy, or a shift to novel psychotropic substances (NPS) associated with an increased drug buying in the internet. In this study, the consumption patterns of people mainly with opioid use disorder entering inpatient drug detoxification treatment were investigated in the same hospitals with the same methods before and during the pandemic.

Methods: At admission, patients were interviewed regarding their consumption patterns using the EuropASI questionnaire.

Influence of conduction heterogeneities on transient spatiotemporal chaos in cardiac excitable media.

Life-threatening cardiac arrhythmias such as ventricular fibrillation are often based on chaotic spiral or scroll wave dynamics which can be self-terminating. In this work, we investigate the influence of conduction heterogeneities on the duration of such chaotic transients in generic models of excitable cardiac media. We observe that low and medium densities of heterogeneities extend the average transient lifetime, while at high densities very long transients, potentially persistent chaos, and periodic attractors occur.

European Committee for the Prevention of Torture and Inhuman or Degrading Treatment reporting on the provision of prison needle and syringe programmes in the Council of Europe region.

Background: Prisons in Europe remain high-risk environments and conducive for infectious disease transmission, often related to injection drug use. Many infected people living in prison unaware of their infection status (HIV, hepatitis C). Despite all Council of Europe (CoE) member states providing community needle and syringe programmes (NSP), prison NSP are limited to seven countries.

Lens Fragmentation with Picosecond Laser Pulses After Artificial Cataract Induction with Microwaves.

In this work we demonstrate the first laboratory study results of lens fragmentation with low-energy picosecond ultrashort laser pulses after artificial induction of cataract with microwave radiation on an ex vivo animal model. This method will be evaluated with regard to the further development of lens fragmentation with novel ultrashort picosecond laser systems instead of ultrasonic phacoemulsification or the significantly more complex femtosecond laser fragmentation. As samples we used postmortem porcine eyes.

Chaos control in cardiac dynamics: terminating chaotic states with local minima pacing.

Current treatments of cardiac arrhythmias like ventricular fibrillation involve the application of a high-energy electric shock, that induces significant electrical currents in the myocardium and therefore involves severe side effects like possible tissue damage and post-traumatic stress. Using numerical simulations on four different models of 2D excitable media, this study demonstrates that low energy pulses applied shortly after local minima in the mean value of the transmembrane potential provide high success rates. We evaluate the performance of this approach for ten initial conditions of each model, ten spatially different stimuli, and different shock amplitudes.

Research collaboration data platform ensuring general data protection.

Translational data is of paramount importance for medical research and clinical innovation. It has the potential to benefit individuals and organizations, however, the protection of personal data must be guaranteed. Collecting diverse omics data and electronic health records (EHR), re-using the minimized data, as well as providing a reliable data transfer between different institutions are mandatory steps for the development of the promising field of big data and artificial intelligence in medical research.

Scanning electrochemical microscopy for the differentiation of radical-induced degradation mechanisms in polymer electrolyte membranes.

In this work, a spatially resolved analytical method based on scanning electrochemical microscopy (SECM) to distinguish different degradation phenomena in polymer electrolyte membranes was developed. SECM was combined with a Franz diffusion cell to distinguish between radical-induced aging of a sulfonated tetrafluoroethylene based fluoropolymer-copolymer due to deactivation of the sulfonic acid groups followed by a decreased proton conductivity, and the radical-induced formation of cracks and holes in the polymer. The experiments were performed with ferrocyanide as redox mediator to detect holes and cracks, and protons (sulfuric acid) to determine the through-plane proton conductivity, respectively.

Ethylene Scavenging Films Based on Ecofriendly Plastic Materials and Nano-TiO: Preparation, Characterization, and In Vivo Evaluation.

It is known that ethylene plays an important role in the quality characteristics of fruits, especially in storage. To avoid the deterioration of fruits caused by ethylene, titanium dioxide (TiO) has been used due to its photocatalytic capacity. The aim of this study was to develop films based on two types of biopolymers, Mater-Bi (MB) and poly-lactic acid (PLA), with nanoparticles of TiO and to determine their ethylene removal capacity and its application in bananas.

Ophthalmic surgeries on porcine eyes with picosecond ultrashort laser pulses.

Purpose: This work demonstrates significant advantages in ophthalmic surgeries through the use of picosecond ultrashort laser pulses instead of state-of-the-art nanosecond laser pulses. These ultrashort lasers shall serve as universal tools more effectively combining advantages of high precision, low impact and economic advantages compared to existing instruments.

Methods: As samples, we used post-mortem porcine eyes on which we performed the experiments with both picosecond and nanosecond lasers.

Dynamic accelerated stress test and coupled on-line analysis program to elucidate aging processes in proton exchange membrane fuel cells.

The application of hydrogen proton exchange membrane fuel cells (PEMFC) in greenhouse gas emission free heavy-duty vehicles requires extremely durable PEMFC components with service lives in the range of 30,000 h. Hence suitable test and analysis methods are required that reflect realistic operation scenarios, but significantly accelerate aging. For this purpose, a dynamic accelerated stress test was developed, which is coupled with a comprehensive in-depth in-situ and ex-situ analysis program to determine the aging processes of a PEMFC membrane electrode assembly (MEA).

What contributes to the long-term implementation of an evidence-based early childhood intervention: a qualitative study from Germany.

Background: Rigorous research trials have demonstrated that early childhood interventions can reach socially disadvantaged families and can have a lasting impact on the healthy development of their children. However, little is known about the internal and contextual factors that contribute to the long-term implementation of such interventions. In this study, we investigated the development of the home visiting program Pro Kind.

A Time-of-Flight and Radar Dataset of a neonatal Thorax Simulator with synchronized Reference Sensor Signals for respiratory Rate Detection.

In this paper we present an open-source Time-of-Flight and radar dataset of a neonatal thorax simulator for the development of respiratory rate detection algorithms. As it is very difficult to gain recordings of (preterm) neonates and there is hardly any open-source data available, we built our own neonatal thorax simulator which simulates the movement of the thorax due to respiration. We recorded Time-of-Flight (ToF) and radar data at different respiratory rates in a range of 5 to 80 breaths per minute (BPM) and with varying upstroke heights.

Antifragility as a complex system's response to perturbations, volatility, and time.

Antifragility characterizes the benefit of a dynamical system derived from the variability in environmental perturbations. Antifragility carries a precise definition that quantifies a system's output response to input variability. Systems may respond poorly to perturbations (fragile) or benefit from perturbations (antifragile).

Listen to the patients! Identifying CML patients' needs analyzing patient-generated content with AI-driven methodologies.

Background: Various patient support programs exist to provide successful therapy options for patients. Pharmaceutical companies are increasingly recognizing the importance of actively supporting patients in their long-term treatment. In order to effectively assist patients, it is crucial to understand their current needs by taking a look at the patients' opinions.

VEPdgets: Towards Richer Interaction Elements Based on Visually Evoked Potentials.

For brain-computer interfaces, a variety of technologies and applications already exist. However, current approaches use visual evoked potentials (VEP) only as action triggers or in combination with other input technologies. This paper shows that the losing visually evoked potentials after looking away from a stimulus is a reliable temporal parameter.

Study of Ethylene-Removing Materials Based on Eco-Friendly Composites with Nano-TiO.

Ethylene is a phytohormone that is responsible of fruit and vegetable ripening. TiO has been studied as a possible solution to slowing down unwanted ripening processes, due to its photocatalytic capacity which enables it to remove ethylene. Thus, the objective of this study was to develop nanocomposites based on two types of eco-friendly materials: Mater-Bi (MB) and poly(lactic acid) (PLA) combined with nano-TiO for ethylene removal and to determine their ethylene-removal capacity.

The True Price of External Health Effects from Food Consumption.

Although global food consumption costs more in terms of impact on human life than money is spent on it, health costs have not been consistently quantified or included in food prices to date. In this paper, a method to determine the external health costs of nutrition and dietetics is developed by employing the cost-of-illness (COI) and true cost accounting (TCA) approaches. This is done exemplarily for the reference country Germany.

Sensor Fusion for the Robust Detection of Facial Regions of Neonates Using Neural Networks.

The monitoring of vital signs and increasing patient comfort are cornerstones of modern neonatal intensive care. Commonly used monitoring methods are based on skin contact which can cause irritations and discomfort in preterm neonates. Therefore, non-contact approaches are the subject of current research aiming to resolve this dichotomy.

An Integrated Framework for Data Quality Fusion in Embedded Sensor Systems.

The advancement of embedded sensor systems allowed the monitoring of complex processes based on connected devices. As more and more data are produced by these sensor systems, and as the data are used in increasingly vital areas of applications, it is of growing importance to also track the data quality of these systems. We propose a framework to fuse sensor data streams and associated data quality attributes into a single meaningful and interpretable value that represents the current underlying data quality.

Owl-Neck-Spine-Inspired, Additively Manufactured, Joint Assemblies with Shape Memory Alloy Wire Actuators.

Nature provides a considerable number of good examples for simple and very efficient joint assemblies. One example is the enormously flexible cervical spine of American barn owls, which consists of 14 cervical vertebrae. Each pair of vertebrae produces a comparatively small individual movement in order to provide a large overall movement of the entire cervical spine.

The role of pulse timing in cardiac defibrillation.

Life-threatening cardiac arrhythmias require immediate defibrillation. For state-of-the-art shock treatments, a high field strength is required to achieve a sufficient success rate for terminating the complex spiral wave (rotor) dynamics underlying cardiac fibrillation. However, such high energy shocks have many adverse side effects due to the large electric currents applied.

Complement Proteins C5/C5a, Cathepsin D and Prolactin in Chondrocytes: A Possible Crosstalk in the Pathogenesis of Osteoarthritis.

Introduction: Both increased activity of the complement system (CS) and the role of the pituitary hormone prolactin (PRL) are implicated in osteoarthritis (OA) pathogenesis. Besides, Cathepsin D (CatD) activity is increased in the context of OA and can exert not only proteolytic but also non-proteolytic effects on cells. For the first time, possible crosstalk between two separate humoral systems: the CS and the PRL hormone systems in chondrocytes are examined together.

A Smart Capacitive Sensor Skin with Embedded Data Quality Indication for Enhanced Safety in Human-Robot Interaction.

Smart sensors are an integral part of the Fourth Industrial Revolution and are widely used to add safety measures to human-robot interaction applications. With the advancement of machine learning methods in resource-constrained environments, smart sensor systems have become increasingly powerful. As more data-driven approaches are deployed on the sensors, it is of growing importance to monitor data quality at all times of system operation.

Minispheroids as a Tool for Ligament Tissue Engineering: Do the Self-Assembly Techniques and Spheroid Dimensions Influence the Cruciate Ligamentocyte Phenotype?

Spheroid culture might stabilize the ligamentocyte phenotype. Therefore, the phenotype of lapine cruciate ligamentocyte (L-CLs) minispheroids prepared either by hanging drop (HD) method or by using a novel spheroid plate (SP) and the option of methyl cellulose (MC) for tuning spheroid formation was tested. A total of 250 and 1000 L-CLs per spheroid were seeded as HDs or on an SP before performing cell viability assay, morphometry, gene expression (qRT-PCR) and protein immunolocalization after 7 (HD/SP) and 14 (SP) days.