16,059 results match your criteria: "Nunes; and Hospital da Crianca Santo Antonio[Affiliation]"

Background: Interstitial lung disease (ILD) is rarer in children (chILD) than adults, but with increasing diagnostic awareness, more cases are being discovered. chILD prognosis is often poor, but increasing numbers are now surviving into adulthood.

Aim: To characterize chILD-survivors and identify their impact on adult-ILD centers.

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Impact of peripheral immune cells in experimental neonatal hypoxia-ischemia: A systematic review and meta-analysis.

Int Immunopharmacol

January 2025

Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil. Electronic address:

Infiltration of peripheral immune cells into the brain following neonatal hypoxia-ischemia (HI) contributes to increased neuroinflammation and brain injury. However, the specific roles of different immune cell types in neonatal brain injury remain poorly understood. Although existing evidence suggests a potential role for sexual dimorphism in HI outcomes, this aspect has been insufficiently investigated.

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Chronic Intestinal Failure and Short Bowel Syndrome in Adults: The State of the Art.

GE Port J Gastroenterol

December 2024

GENE - Artificial Feeding Team, Gastroenterology Department, Hospital Garcia de Orta, Almada, Portugal.

Background: Short bowel syndrome (SBS) is a devastating malabsorptive condition and the most common cause of chronic intestinal failure (CIF). During the intestinal rehabilitation process, patients may need parenteral support for months or years, parenteral nutrition (PN), or hydration/electrolyte supplementation, as a bridge for the desired enteral autonomy.

Summary: Several classification criteria have been highlighted to reflect different perspectives in CIF.

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PIK3CA-Related Overgrowth Spectrum: Exploring brain growth from fetus to infant.

Pediatr Neurol

February 2025

Department of Neonatology, Unidade Local de Saúde de Vila Nova de Gaia, Vila Nova de Gaia, Portugal.

Article Synopsis
  • MCAP (Megalencephaly-capillary malformation-polymicrogyria syndrome) is a rare neurological disorder caused by mutations in the PIK3CA gene, leading to abnormal brain growth, vascular issues, and body overgrowth.
  • A clinical report details an infant diagnosed with MCAP, who showed signs of the disorder from prenatal imaging, which identified megalencephaly and a confirmed PIK3CA mutation postnatally, followed by early medical interventions.
  • Despite these interventions, the patient faced ongoing challenges such as macrocrania, hydrocephalus, and neurodevelopmental delays, highlighting the importance of multidisciplinary care and monitoring to manage the complexities of the disorder and emphasizing potential future therapies for better outcomes.
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In this piece Nunes addresses the importance of population health approaches and Multi-Hazards Early Warning Systems (MHEWS) in public health, particularly considering climate change and its associated risks and hazards. The article aims to highlight the challenges posed by climate change to public health and how integrating MHEWS with population health approaches can help address these challenges effectively.

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Exploring Opioid Use Disorder Outcomes by Quantitative Urinalysis: Post Hoc Analysis of a Phase 3 Randomized Clinical Trial.

J Addict Med

December 2024

From Camurus AB, Lund, Sweden (SP, FT); New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, NY (EVN); and Center on Drug and Alcohol Research, University of Kentucky College of Medicine, Lexington, KY (MRL, SLW).

Article Synopsis
  • Opioid use disorder (OUD) is a pressing global issue, and while urine drug screenings help monitor treatment responses, they typically provide only yes/no results, complicating comparisons between studies due to varying analytical cutoffs.
  • This study analyzed data from a 31-week trial involving 428 participants to compare the efficacy of CAM2038 (subcutaneous buprenorphine) to daily sublingual buprenorphine/naloxone, using quantitative urine drug tests to evaluate different cutoffs for opioid detection.
  • Results showed that higher cutoff values led to more pronounced differences in treatment effectiveness favoring CAM2038, suggesting that quantitative urinalysis can offer
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A 56-year-old female with class 3 obesity, was previously submitted to laparoscopic sleeve gastrectomy (LSG) two weeks before current admission. The patient was admitted due to fever, abdominal pain and vomiting. CT revealed a 13.

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Introduction: The advancement of antimicrobial resistance is a significant public health issue today. With the spread of resistant bacterial strains in water resources, especially in urban sewage, metagenomic studies enable the investigation of the microbial composition and resistance genes present in these locations. This study characterized the bacterial community and antibiotic resistance genes in a sewage system that receives effluents from various sources through metagenomics.

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Observational studies suggest a U-shaped association between serum potassium (K⁺) levels and mortality in patients with chronic heart failure (CHF). However, the mode of death in patients with HF and K⁺ disorders remains speculative. To investigate the association between potassium disorders and the mode of death in patients with CHF.

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Article Synopsis
  • The study aims to explore how inflammatory biomarkers relate to corneal epithelial measurements in patients with keratoconus compared to healthy individuals.
  • It involved a comparison of tear cytokine levels and hair cortisol concentrations from 100 patients, divided into 48 with keratoconus and 52 healthy controls, using advanced measurement techniques.
  • Results showed that keratoconus patients had significantly higher levels of certain cytokines and cortisol, with notable correlations found between IL6 levels and specific epithelial thickness metrics.
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Article Synopsis
  • Atopic dermatitis (AD) and mycosis fungoides (MF) can be difficult to distinguish because they exhibit similar symptoms like inflamed and itchy skin lesions.
  • A case study of a 19-year-old male with a past AD history highlights the diagnostic confusion when he developed atypical eczema-like lesions that required advanced testing to confirm MF after initial misdiagnosis.
  • The case underscores the importance of accurate and early diagnosis to differentiate between AD and MF, as MF requires specific treatments, and it encourages further research into shared mechanisms for improved patient care.
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Background: Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare disease that may progress towards pulmonary fibrosis. Data about fibrosis prevalence and risk factors are lacking.

Methods: In this retrospective multicentre nationwide cohort, we included patients newly diagnosed with aPAP between 2008 and 2018 in France and Belgium.

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Alterations in white matter (WM) microstructure are commonly found in migraine patients. Here, we employ a longitudinal study of episodic migraine without aura using diffusion magnetic resonance imaging (dMRI) to investigate whether such WM microstructure alterations vary through the different phases of the pain cycle. Fourteen patients with episodic migraine without aura related with menstruation were scanned through four phases of their (spontaneous) migraine cycle (interictal, preictal, ictal, and postictal).

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By March 2020, the first COVID-19 cases were detected in Portugal. Anecdotal evidence showed that the National Health Service absenteeism rate rose. The present study aimed to quantify and characterize the absenteeism rate among these healthcare workers during the COVID-19 pandemic in Portugal.

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Alternating and Pulsed Current Electrolysis for Atom Transfer Radical Polymerization.

Chempluschem

December 2024

Centre for Mechanical Engineering Materials and Processes (CEMMPRE), ARISE, Department of Chemical Engineering, University of Coimbra, Rua Sílvio Lima, Pólo II, 3030-790, Coimbra, Portugal.

Article Synopsis
  • * AC electrolysis can be adjusted to enhance the specificity of reactions, reduce unwanted side reactions, and improve both product selectivity and reagent efficiency.
  • * The text also addresses challenges with AC electrolysis and includes a summary of recent advancements in electro-organic synthesis utilizing this technique, with a focus on future potential in polymer synthesis.
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Article Synopsis
  • The study investigates why some physiotherapists prefer non-academic sources for clinical information and how personal factors like age, recent graduation, and education level impact this preference.
  • A survey of 610 physiotherapists revealed that nearly 25% prefer non-academic sources, particularly those over 34 years old who feel unable to apply scientific findings.
  • The findings suggest a need for improved training in evidence-based practice to boost confidence and competency in utilizing academic resources in patient care.
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Impact of fraud in Europe: Causes and effects.

Heliyon

November 2024

Instituto Politécnico de Castelo Branco, Portugal.

This research aims to explore the impact of fraud on society, in general, and in the European Union, in particular. Methodologically, this research is divided into two analyses. Firstly, a theoretical analysis based on a systematic literature review of fraud and its impact on society and the economy.

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Establishment of a 3D multi-layered in vitro model of inflammatory bowel disease.

J Control Release

January 2025

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; IUCS-CESPU - Instituto Universitário de Ciências da Saúde, Rua Central de Gandra 1317, 4585-116 Gandra, Portugal. Electronic address:

Article Synopsis
  • Crohn's Disease and Ulcerative Colitis are serious gastrointestinal disorders that currently have no cure, emphasizing the need for better research models to test new therapies.
  • A new three-dimensional (3D) in vitro model mimics the IBD environment by incorporating multiple layers of tissue and immune responses, which includes human intestinal cells and macrophages.
  • This innovative model allows for inducing inflammation similar to that seen in IBD, improving drug testing accuracy and potentially reducing reliance on animal studies while aiding in the understanding of disease mechanisms.
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Article Synopsis
  • * The study involved 34 women receiving ten weeks of individualized therapy that included perineal massage, vaginal dilation, and pelvic floor exercises, with evaluations before and after treatment.
  • * Results showed significant improvements in vaginal length, diameter, muscle strength, and quality of life metrics, with about 66.7% of participants experiencing resolution of vaginal stenosis post-intervention.
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Enhancing Ventricular Tachycardia Ablation Outcomes: The Impact of Functional Mapping in Chagas Cardiomyopathy.

JACC Clin Electrophysiol

January 2025

Unit of Cardiology and Cardiovascular Surgery, Clinics Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Advanced Arrhythmia Treatment Center, Belo Horizonte, Brazil. Electronic address:

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The barred grunt, Conodon nobilis (Linnaeus, 1758), is one of the most important marine-estuarine fish along the Brazilian coast. The present study evaluated the parasite fauna of this haemulid fish along the Southern Atlantic coast. From September 2010 to July 2011, a total of 100 specimens of C.

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Melissopalynological methodologies for investigating honey samples - a critical approach.

An Acad Bras Cienc

November 2024

Universidade Federal de Santa Catarina, Departamento de Fitotecnia, Laboratório de Morfogênese e Bioquímica Vegetal - LMBV, Rodovia Admar Gonzaga, 1346, Itacorubi, 88034-000 Florianópolis, SC, Brazil.

Article Synopsis
  • Melissopalynological techniques analyze pollen grains in honey for botanical identification.
  • Three different methods were tested: alcian blue dye, basic fuchsin, and traditional acetolysis (without dye).
  • The alcian blue method provided better separation of pollen grains while being safer and more cost-effective than acetolysis, which is known for using toxic substances and being time-consuming.
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Complete centered finite difference method for Helmholtz equation.

An Acad Bras Cienc

November 2024

Universidade Federal Fluminense, Departamento de Ciências Exatas, Av. dos Trabalhadores, 420, Vila Santa Cecília, 27255-125 Volta Redonda, RJ, Brazil.

A new approach in the finite difference framework is developed, which consists of three steps: choosing the dimension of the local approximation subspace, constructing a vector basis for this subspace, and determining the coefficients of the linear combination. New schemes were developed to form the basis of the local approximation subspace, which were derived by approximating only the k 2 u term of the Helmholtz equation. The construction of a basis of the local approximation subspace allows the new approach to be able to represent any finite difference scheme that belongs to this subspace.

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The first identification of Lutzomyia longipalpis (Lutz & Neiva, 1912) in Macapá, Amapá.

Rev Saude Publica

November 2024

Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Epidemiologia. São Paulo, SP, Brasil.

Lutzomyia longipalpis (Lutz & Neiva, 1912) constitutes the most epidemiologically relevant vector of visceral leishmaniasis (VL) in the New World. On October 25, 2023, the Macapá Center for Strategic Information in Health Surveillance registered a case of VL in the Km9 neighborhood, in Macapá. This study aimed to describe the Phlebotominae species in this area to assist the confirmation of the autochthony of the case.

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