197 results match your criteria: "Nummular Dermatitis"
Five-year real-world drug survival of dupilumab in severe atopic dermatitis and associate predictors.
J Dermatolog Treat
December 2024
Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Background: Atopic dermatitis (AD) profoundly impacts patients' lives, necessitating long-term systemic treatments.
Methods: This retrospective study involved 709 severe AD patients receiving dupilumab. Drug survival (DS) was analyzed using Kaplan-Meier curves, evaluating reasons for discontinuation.
Hand eczema in Italian patients referred for patch testing: A retrospective SIDAPA study (2016-2023).
Contact Dermatitis
August 2024
Section of Dermatology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Article Synopsis
- Hand eczema (HE) significantly impacts quality of life and lacks comprehensive data for Italian patients undergoing patch testing, highlighting the need for a better understanding of this condition.
- A study analyzed 1,597 HE patients over seven years, revealing key demographic and clinical information, such as that 60.2% were in the HE-only group and 33.2% of these had occupational dermatitis.
- Results showed common allergic and irritant responses in HE-only patients, with significant patch test reactions primarily to nickel and various preservatives, emphasizing unique traits within this patient population.
Presentations of Cutaneous Disease in Various Skin Pigmentations: Porokeratosis.
HCA Healthc J Med
April 2024
Medical City Fort Worth, Fort Worth, TX.
Article Synopsis
- Porokeratosis is a rare skin disorder with over 9 subtypes, first described in 1893, characterized by well-defined, raised lesions with an atrophic center and scaly border.
- It can mimic various skin conditions, including squamous cell carcinoma and psoriasis, making accurate diagnosis crucial due to the risk of malignant transformation.
- The clinical review emphasizes identifying porokeratosis across a diverse range of skin tones to improve diagnosis and treatment.
Article Synopsis
- Atopic dermatitis (AD) is a long-lasting skin condition that can start in childhood and continue into adulthood, or emerge for the first time in adults.
- A study was conducted to compare the clinical characteristics of adults with either pediatric-onset or adult-onset AD using medical records from a large academic center.
- Results showed that adults with adult-onset AD had different signs and symptoms compared to those with pediatric-onset AD, suggesting that current diagnostic criteria may not fully recognize adult-onset AD, potentially leading to underdiagnosis.
Triggered Skin Sensitivity: Understanding Contact Dermatitis.
Cureus
May 2024
Biochemistry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Article Synopsis
- * Accurate diagnosis of contact dermatitis requires a comprehensive history and various testing methods, including patch testing and evaluations related to suspected allergens, to help identify the cause and facilitate effective treatment.
- * Corticosteroids are the primary treatment option for allergic contact dermatitis (ACD), which can affect both kids and adults; however, less than 10% of pediatric dermatitis patients are tested for ACD, despite its prevalence linked to common allergens like metals and fragrances. *
Higher Expression of Lympho-epithelial Kazal-type-Related Inhibitor-1 Fragments and Decreased Desquamation in the Lesional Skin of Nummular Eczema.
Acta Derm Venereol
March 2024
Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul, Republic of Korea; Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea; Institute on Aging, Seoul National University, Seoul, Republic of Korea.
Article Synopsis
- Nummular eczema, a chronic skin condition marked by coin-shaped lesions, has unclear underlying mechanisms despite being recognized since 1857.
- A study analyzing skin samples from affected and healthy individuals revealed that the desquamation process, which is essential for skin renewal, is impaired in nummular eczema due to disorganization and increased expression of certain skin proteins.
- The research also indicated that higher levels of an inhibitor (Kazal-type-related inhibitor-1) in affected skin might prevent the normal breakdown of structures that facilitate skin shedding, contributing to delayed desquamation and symptom persistence.
Effectiveness of dupilumab in pediatric patients with a nummular phenotype of atopic dermatitis.
Pediatr Dermatol
May 2024
Harvard Medical School, Boston, Massachusetts, USA.
Article Synopsis
- * A study reviewing patient charts assessed how well dupilumab worked for children with these skin lesions.
- * Results showed 12 out of 14 patients improved significantly within about 2.5 months, with only one mild side effect noted.
Predictive Factors of Early Response to Dupilumab in Patients with Moderate-to-Severe Atopic Dermatitis.
J Clin Med
October 2023
Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Article Synopsis
- * Key predictors of achieving better results (defined as an EASI score of ≤ 7) within 4 weeks included specific disease phenotypes like classic lichenoid and inflammatory types, as well as lower baseline EASI scores.
- * The findings emphasize the significance of starting biological treatments early for patients with AD to improve their chances of achieving mild disease levels quickly.
Topical and Oral Roflumilast in Dermatology: A Narrative Review.
Actas Dermosifiliogr
March 2024
Servicio de Dermatología, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, España; Servicio de Dermatología, Hospital de Figueres, Fundació Salut Empordà, Figueres, Girona, España. Electronic address:
Article Synopsis
- - Roflumilast is a phosphodiesterase-4 inhibitor used for preventing flare-ups in chronic obstructive pulmonary disease and chronic bronchitis, and it’s FDA-approved for treating plaque psoriasis and mild to moderate seborrheic dermatitis in dermatology.
- - Research highlights its off-label uses, showing effectiveness in conditions like hidradenitis suppurativa, oral aphthosis, nummular eczema, lichen planus, and Behçet disease through trials and case reports.
- - It has a good safety profile similar to apremilast, is more affordable compared to newer drugs and some immunosuppressants, and the paper reviews its pharmacokinetics, adverse effects, and both approved and off-label
Lipidomics Profile Change of Skin Surface Lipids in Nummular Eczema.
J Invest Dermatol
May 2023
Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul, Republic of Korea; Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address:
Persulphates allergic contact dermatitis from spa: A new aetiology of nummular contact dermatitis.
Contact Dermatitis
August 2023
Department of Dermatology, Montpellier University Hospital and Montpellier University, Montpellier, France.
The neglected twin: Nummular eczema is a variant of atopic dermatitis with codominant T2/T17 immune response.
J Allergy Clin Immunol
August 2023
Department of Medicine, Division of Dermatology and Venerology, Karolinska Institute, Stockholm, Sweden; Department of Dermatology and Venerology, Medical Center, University of Freiburg, Freiburg, Germany.
Background: Nummular eczema (NE) is a common chronic inflammatory skin disease characterized by multiple, pruritic, discoid-shaped lesions. Since the underlying immune mechanisms are not fully understood, it is unclear whether NE should be regarded as variant of atopic dermatitis (AD) or a distinct disease.
Objective: We compared the clinical, histopathologic, and molecular signatures of NE with that of type 2 and type 3 skin diseases.
Association of Adult Atopic Dermatitis Severity With Bacterial, Viral, and Fungal Skin Infections.
Dermatitis
March 2023
†Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.
Article Synopsis
- The study aimed to investigate the connection between the severity and characteristics of atopic dermatitis (AD) and the occurrence of skin infections in adults, involving 559 participants.
- Results showed that patients with moderate to severe AD were significantly more likely to have skin infections, particularly bacterial ones, compared to those with mild AD.
- The findings suggest that while skin infections relate to AD severity, they do not correlate with specific AD phenotypes, indicating that better management of AD could potentially reduce the risk of skin infections.
Localized Nummular Dermatitis of the Bilateral Breasts Developing 4 Months After Breast Reduction Surgery.
Dermatitis
November 2023
Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
An Unexpected Postsurgical Phenomenon After Total Knee Arthroplasty: Nummular Eczema: A Case Report and Literature Review.
JBJS Case Connect
January 2023
Albert Einstein College of Medicine, Montefiore Medical Center, New York, New York.
Article Synopsis
- Two elderly women developed a red, circular rash on one side of their bodies one year after undergoing knee replacement surgery for osteoarthritis, which was diagnosed as postsurgical nummular eczema (NE).
- They were successfully treated with topical corticosteroids.
- The cases emphasize the importance of recognizing postsurgical NE, which can resemble other conditions, helping avoid unnecessary medical tests and surgeries.
SCABIES CASES MISDIAGNOSED AND TREATED AS ALLERGIC DISEASES: ITCH AS ALARM.
Acta Clin Croat
August 2022
Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
Article Synopsis
- Physicians often confuse scabies with similar skin conditions like eczema or allergies, leading to misdiagnosis.
- This study highlights 6 cases of patients who were treated for other skin diseases before their scabies was correctly identified.
- It emphasizes the need for doctors to rule out scabies through thorough patient history and skin exams to ensure timely and effective treatment.
Discoid (nummular) eczema in the paediatric setting - An Australian/New Zealand narrative.
Australas J Dermatol
November 2022
Royal Children's Hospital, Melbourne, Victoria, Australia.
Article Synopsis
- * It shares management principles with atopic dermatitis but has distinct characteristics that require specific attention.
- * Key treatment strategies include identifying triggers, using potent topical corticosteroids with occlusion, supporting the skin barrier, and managing itching, although some cases may eventually need systemic immunomodulatory treatment.
Cutaneous Adverse Reactions Associated with Monoclonal Antibodies Treatment in Multiple Sclerosis: Case Reports and Short Literature Review.
J Clin Med
June 2022
Department of Dermatology, 'Dr. Carol Davila' Central Military Emergency University Hospital, 010242 Bucharest, Romania.
Article Synopsis
- Multiple sclerosis treatment often involves monoclonal antibodies, which can lead to skin complications that require careful management by clinicians.
- The study presents two cases of adverse skin reactions: one patient developed chronic spongiotic dermatitis after long-term use of natalizumab, and another had nummular eczema following ocrelizumab treatment.
- The authors highlight the need for more research on the relationship between monoclonal antibody therapies and skin reactions, stressing that healthcare providers should be vigilant about these potential side effects.
Clinical phenotypes of adult atopic dermatitis and related therapies.
Curr Opin Allergy Clin Immunol
August 2022
Department of Medicine and Health Sciences Vincenzo Tiberio, University of Molise, Campobasso, Italy.
Article Synopsis
- The review discusses the clinical phenotypes of adult atopic dermatitis, which can complicate diagnosis and treatment, affecting around 10% of adults.
- Although systemic treatments are often required for more severe cases, there are limited approved drugs for atopic dermatitis in many countries, and few studies focus on treatment based on different phenotypes.
- Current effective treatments include cyclosporine for prurigo nodularis, alitretinoin primarily for hand dermatitis, and dupilumab showing effectiveness across various phenotypes, particularly in elderly patients with limb fold involvement.
Rapid clearing of refractory nummular dermatitis with oral roflumilast therapy.
J Eur Acad Dermatol Venereol
October 2022
Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Contact allergy to and allergic contact dermatitis from formaldehyde and formaldehyde releasers: A clinical review and update.
Contact Dermatitis
July 2022
Department of Dermatology, University Hospital Antwerp (UZA) and Research group Immunology, INFLA-MED Centre of Excellence, University of Antwerp, Antwerp, Belgium.
Article Synopsis
- This review discusses the role of formaldehyde and its five main releasers in causing contact allergies and dermatitis, highlighting their presence in various everyday products.
- In Europe, the use of some formaldehyde releasers in cosmetics is banned, and allergy rates are stable or decreasing, but these substances can still trigger various skin reactions.
- For accurate diagnosis of allergies, specific concentration patch tests for formaldehyde and its releasers are recommended, and avoidance of these substances is advised if sensitization occurs.
Papulosquamous annular diseases.
Clin Dermatol
December 2022
Department of Dermatology and Venereology, Istanbul Arel University, School of Medicine; Department of Dermatology, Memorial Health Group, Atasehir and Sisli Hospital. Electronic address:
Article Synopsis
- - Papulosquamous diseases are a group of skin disorders characterized by papules and plaques, which can appear in various shapes, including ring-shaped (annular) forms.
- - Some skin disorders like pityriasis rosea and subcorneal pustular dermatosis typically appear in annular patterns, while others, such as psoriasis vulgaris and seborrheic dermatitis, can start or change into these shapes.
- - The text reviews common papulosquamous diseases with annular lesions, detailing their appearances and differentiating them from similar conditions.
Characterization of Classical Flexural and Nummular Forms of Atopic Dermatitis in Childhood with Regard to Anamnestic, Clinical and Epidermal Barrier Aspects.
Acta Derm Venereol
March 2022
Department of Dermatology, Venereology and Allergology, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller Str. 3, DE-24105 Kiel, Germany.
Article Synopsis
- Nummular and classical atopic dermatitis have different appearances but share some underlying characteristics; this study aimed to explore their differences and similarities in children.
- Researchers examined 10 children with nummular atopic dermatitis, 14 with classical atopic dermatitis, and 10 healthy controls, finding that nummular dermatitis occurred more in boys and less often in infants compared to classical dermatitis.
- Both types showed issues like lower skin hydration and higher moisture loss, but nummular dermatitis showed more variation in eczema patterns and more severe keratosis pilaris, suggesting that they should be treated as separate conditions with distinct therapeutic strategies.
The effects of alcohol and illicit drug use on the skin.
Clin Dermatol
November 2021
Department of Dermatology, University of Connecticut School of Medicine, Farmington, Connecticut, USA. Electronic address:
Article Synopsis
- Early identification of skin issues related to alcohol and drug use is crucial for proper diagnosis and treatment, as these conditions can lead to serious health problems.
- Alcohol misuse can cause skin-related symptoms like jaundice, itching, and risk factors for skin cancer, while also affecting other health issues such as nutritional deficiencies and various skin diseases.
- Illicit drug use leads to a range of cutaneous problems, including infections and scarring, highlighting the need for dermatologists to recognize these signs to better support patients struggling with addiction.