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Pheomelanin-coated iron oxide magnetic nanoparticles: a promising candidate for negative T2 contrast enhancement in magnetic resonance imaging.

Chem Commun (Camb)

June 2015

Academic Department of Health and Services, Nucleus of Clinical Technology, Instituto Federal de Educação, Ciência e Tecnologia de Santa Catarina, Campus Florianópolis, SC, 88020-300, Brazil.

We describe herein a novel type of monodisperse water-soluble magnetite nanoparticle coated with pheomelanin using an environmentally-friendly approach in aqueous medium. The results indicate superparamagnetic behaviour at room temperature and show improved negative contrast in T2-weighted MRI with a transverse relaxivity of 218 mM(-1) s(-1).

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