Optimized Production and Biological Evaluation of Ga-PDTMP as a New Agent for PET Bone Scanning.

Introduction: In this study, Ga-PDTMP was introduced as a novel agent for PET bone scanning.

Methods: Ga-PDTMP was prepared with radiochemical purity of higher than 98% at the optimized conditions.

Results: Stability tests showed no decrease in radiochemical purity, even after 120 min.

New Tc(CO) -radiolabeled arylpiperazine pharmacophore as potent 5HT serotonin receptor radiotracer: Docking studies, chemical synthesis, radiolabeling, and biological evaluation.

In spite of previous efforts, there is lack of a radiotracer for imaging the 5HT receptor density in human brain, which is involved in several neurological brain disorders. The aim of this study was to prepare a new derivative of 1-(2-methoxyphenyl)piperazine (MPP) as a main chemical structure of 5HT receptor antagonist with 3-carbon linker and radiolabeled by [ Tc][Tc(CO) (H O) ] precursor. Docking studies before chemical synthesis showed similar fashion of interaction for both WAY100635 (potent 5HT receptor antagonist) and new designed ligand, despite of addition of Tc(CO) group in the structure of new ligand.

A study of the protective actions for a hypothetical accident of the Bushehr nuclear power plant at different meteorological conditions.

In this work, protective actions have been studied assuming a hypothetical severe accident of the Bushehr nuclear power plant at different meteorological conditions. Simulations of the atmospheric dispersion of accidental airborne releases were performed using the RASCAL code. Total effective dose equivalent (TEDE) and thyroid dose received by members of the public living within a radius of 40 km around the reactor site were calculated for various atmospheric stability classes and weather conditions.

Gamma and neutron dosimetry of Tehran Research Reactor containment during and after LOCA accident.

The radiation effects of loss of coolant accident on the reactor operators are critical issues. In the present study, computational codes were used to investigate gamma and neutron dose rates inside the 5 MW pool-type Tehran Research Reactor containment. The carried out calculations showed, when the remaining coolant over the core is decreasing less than 1 m, the containment should be evacuated.

Simulation of radionuclide atmospheric dispersion and dose assessment for inhabitants of Tehran province after a hypothetical accident of the Tehran Research Reactor.

Radiological dose assessment is one of the main categories of safety assessment for nuclear reactors and facilities. The radiation risks to the public and to the environment that may arise from these facilities have to be assessed and, if necessary, controlled. The main objective of this paper is the assessment of radiation doses to residents of Tehran province after a hypothetical accident of the Tehran Research Reactor (TRR) including the determination of any protective actions that might be needed for the benefit of people's health.

Radiolabeling of Preformed Niosomes with [Tc]: In Vitro Stability, Biodistribution, and In Vivo Performance.

Nanocarriers radiolabeled with [Tc] can be used for diagnostic imaging and radionuclide therapy, as well as tracking their pharmacokinetic and biodistribution characteristics. Due to the advantages of niosomes as an ideal drug delivery system, in this study, the radiolabeling procedure of niosomes by [Tc]-HMPAO complexes was investigated and optimized. Glutathione (GSH)-loaded niosomes were prepared using a thin-film hydration method.

Preparation of a radiolabeled GnRH-I analogue derivative with In as a new anti-proliferative agent.

The new GnRH-Ιanalogue developed in this paper was based on the D-Trp -GnRH-Ι-scaffold, and its potency was increased by the replacement Gly-NH by NH-NH binding to the Gly at position 10. Triptorelin-Hydrazide analogue was synthesized using solid phase. For In labeling, synthesized peptide was followed by conjugation with DOTA using pSCN-Bn-DOTA.

The sensitivity and specificity of Tc-IgG radiotracer to differentiate infection lesions induced by Staphylococcus aureus and sterile inflammation lesions induced by carrageenan assay in rat's foot.

Background: Detection and identification of infection from sterile inflammation foci has a crucial role in diagnosis and therapy of patients in clinical practice.

Objective: To assess the efficiency of labeled human polyclonal immunoglobulin with technetium 99m in order to detect septic or aseptic lesions which were induced in a rat model.

Methods: The freeze-dried IgG kits have been reconstituted by Tc.

Major and trace elements' concentrations in hard and soft tissues of kutum, Rutilus kutum, from the Caspian Sea and their potential use as biomonitoring tools.

The potential use of different hard and soft parts (otolith, scale, eye lens, dorsal spine, vertebral bone, muscle, and liver) of Rutilus kutum for biomonitoring of 13 major and trace elements (Br, Ca, Cl, Cu, Fe, K, Mg, Mn, Na, P, S, Sr, and Zn) was evaluated, for the first time. The specimens were sampled from three sampling sites in the Southern Caspian Sea in May 2016. Twenty specimens were collected from each site.

Feasibility of Sm production using MNSR research reactor through a multi-stage approach.

The main objective of this study was to explore the feasibility of producing Sm radioisotope in miniature neutron source reactors (MNSRs) in Isfahan-Iran. As the first step of this study, the MNSR's geometry was created by using the MCNP6.2 simulation code and afterwards a validity check was performed by comparing the results with the experimental data.

Preparation and Dosimetry Evaluation of a Carrier- Free 90Y Labeled DOTMP as a Promising Agent for Bone Marrow Ablation.

Background And Objective: Skeletal uptake of 90Y-1,4,7,10-tetraazacyclododecane-1,4,7,10- tetramethylene-phosphonate (DOTMP) is used to deliver high doses of this radiopharmaceutical to the bone marrow.

Methods: In this research, carrier-free (c.f.

Preparation and evaluation of Re sulfide colloidal nanoparticles loaded biodegradable poly (L-lactic acid) microspheres for radioembolization therapy.

Radioembolization with radioactive microspheres has been an effective method for the treatment of liver lesions. The aim of this study was to prepare carrier-free Re loaded poly (L-lactic acid) (PLLA) microspheres through Re sulfide colloidal nanoparticles ( Re-SC nanoparticles). The formation of Re-SC nanoparticles was confirmed by ultraviolet-visible spectrophotometry.

Preclinical Evaluation of Ga-MAA from Commercial Available Tc-MAA Kit.

Tc-Macroaggregated Albumin (Tc-MAA) has been used as a perfusion agent. This study described development of the Ga-MAA via commercially available kits from Pars-Isotopes Company as a Tc-MAA kit. Ge/Ga generator was eluted with suprapure HCl (0.

Development of a Tc-Labeled CXCR4 Antagonist Derivative as a New Tumor Radiotracer.

Due to high expression of CXCR4 (CXC chemokine receptor type 4) receptors in many tumors and metastasis, synthesis and labeling of CXCR4 receptor-targeted analogs as tumor imaging agents have been encouraged. Herein, CXCR4 receptor-targeted peptide antagonist was prepared and thereafter its labeling with Tc by a bifunctional chelating agent and tricine coligand was developed. Radiotracer purity, stability, and tumor cell binding were assessed.

Thermal and epithermal neutron flux distributions measurement in thermal column of TRR using an experimental-simulation method.

For designing an appropriate neutron beam, the determination of neutron flux at any irradiation facility is an important key factor. Due to the importance of determining the thermal and epithermal neutron fluxes in a typical thermal column of a reactor, a simple and accurate technique is introduced in this study. Absolute thermal and epithermal fluxes were measured experimentally at a certain point using the foil activation method by neutron bombardment of bare and cadmium covered Au foils.

Evaluation of the Possible Utilization of Ga-DOTATOC in Diagnosis of Adenocarcinoma Breast Cancer.

Objectives: Studies have indicated advantageous properties of [DOTA-DPhe, Tyr] octreotide (DOTATOC) in tumor models and labeling with gallium. Breast cancer is the second leading cause of cancer mortality in women, and most of these cancers are often an adenocarcinoma. Due to the importance of target to non-target ratios in the efficacy of diagnosis, the pharmacokinetic of Ga-DOTATOC in an adenocarcinoma breast cancer animal model was studied in this research, and the optimized time for imaging was determined.

An efficient approach to integrated MeV ion imaging.

An ionoluminescence (IL) spectral imaging system, besides the common MeV ion imaging facilities such as µ-PIXE and µ-RBS, is implemented at the Van de Graaff laboratory of Tehran. A versatile processing software is required to handle the large amount of data concurrently collected in µ-IL and common MeV ion imaging measurements through the respective methodologies. The open-source freeware PyMca, with image processing and multivariate analysis capabilities, is employed to simultaneously process common MeV ion imaging and µ-IL data.

Evaluation of a Tc-tricine Vascular Disrupting Agent as an Imaging in 4T1 Mouse Breast Tumor Model.

Colchicine as a vascular disrupting agent creates microtubule destabilization which induces vessel blockage and consequently cell death. Accordingly, colchicines and its analogues radiolabeled with Tc may have potential for visualization of tumor. In this work, deacetylcolchicine a colchicine analogue was labeled with Tc via tricine as a coligand and characterized for its tumor targeting properties.

Absorbed doses in humans from Re-Rituximab in the free form and bound to superparamagnetic iron oxide nanoparticles: Biodistribution study in mice.

Absorbed doses to human organs from Re-Rituximab in the free form and bound to superparamagnetic iron oxide nanoparticles were predicted from results of the radiopharmaceutical biodistribution studies in mice by the RADAR method. Overall, equivalent and effective doses to human organs from the radiopharmaceutical on the nanoparticles were higher because of the enhanced permeability and retention effect. Liver, spleen and kidneys received higher equivalent doses than other organs (5.

The feasibility study of Lu production in Miniature Neutron Source Reactors using a multi-stage approach in Isfahan, Iran.

Miniature neutron source reactors (MNSRs) are among the safest and economic research reactors with potentials to be used for neutron studies. This manuscript explores the feasibility of Lu production in Isfahan MNSR reactor using direct production route. In this study, to assess the specific activity of the produced radioisotope, a simulation was carried out through the MCNPX2.

Study on a new design of Tehran Research Reactor for radionuclide production based on fast neutrons using MCNPX code.

The aim of this work is to increase the magnitude of the fast neutron flux inside the flux trap where radionuclides are produced. For this purpose, three new designs of the flux trap are proposed and the obtained fast and thermal neutron fluxes compared with each other. The first and second proposed designs were a sealed cube contained air and DO, respectively.

Diagnostic value of 99mTc-ubiquicidin scintigraphy in differentiation between osteomyelitis and bone tumors.

Aim: The differentiation of osteomyelitis from bone tumors is of great importance in clinical decision-making; however, the features of both osteomyelitis and bone tumors are noncontributory. Tc-ubiquicidin scintigraphy is a new promising method with the ability to specifically localize the infection site by bacterial cell membrane binding. This study aimed to evaluate the ability of this radiopeptide for the differentiation of these two entities.

Development of DOTA-Rituximab to be Labeled with Y for Radioimmunotherapy of B-cell Non-Hodgkin Lymphoma.

NHL is the most common hematologic cancer in adults. Rituximab is the FDA approved treatment of relapsed or refractory low grade B-cell Non-Hodgkin Lymphoma (NHL). But patients eventually become resistant to rituximab.

Technetium-99m Tricarbonyl Labeled a Broad-spectrum Quinolone as a Specific Imaging Agent in Infection Diseases.

Nuclear medicine imaging has been used to localize infection sites, and efforts have been continued to develop modified infection specific radiopharmaceuticals. In this study gemifloxacin as a broad-spectrum quinolone has been labeled with [Tc (CO) (HO)] core in order to evaluate its feasibility as an infection imaging agent for use. The stability of radioconjugate was checked in human serum at 37 °C and biodistribution was studied in mice.

Synthesis and evaluation of a Tc-labeled chemokine receptor antagonist peptide for imaging of chemokine receptor expressing tumors.

Objective: The chemokine receptor CXCR4 is highly expressed in tumor cells and plays an important role in tumor metastasis. In the present study, we report on the evaluation of a new radiopharmaceutical peptide for its potential to visualization for CXCR4-expressing tumors in vivo.

Methods: A CXCR4 antagonist analogue was synthesized using a standard Fmoc solid phase strategy and labeled with Tc via HYNIC and EDDA/tricine as coligands.