229 results match your criteria: "Nuclear Science and Technology Research Institute NSTRI[Affiliation]"

Although the role of long non-coding RNAs (lncRNAs) in key biological processes in animals and plants has been confirmed for decades, their identification in fungi remains limited. In this study, we discovered and characterized lncRNAs in Aspergillus flavus in response to changes in water activity, CO concentration, and temperature, and predicted their regulatory roles in cellular functions. A total of 472 lncRNAs were identified in the genome of A.

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Sickleweed (Falcaria vulgaris) is the name of a species of annual, and perennial herbaceous plants of the genus Falcaria. Climate change could negatively influnces the performance of various plant species in plant kingdom. In this study, 15 different sickleweed populations from seven provinces of the country were collected based on an unbalanced nest design with 10 replications and the percentage of essential oil, types of chlorophyll, phenol, proline, protein, and carotenoids were measured on them.

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Development of Lu-Cetuximab-PAMAM dendrimeric nanosystem: a novel theranostic radioimmunoconjugate.

J Cancer Res Clin Oncol

August 2023

Department of Life Science Engineering, Faculty of Modern Science and Technology, Nano Biotechnology Group, University of Tehran, Tehran, 1439957131, Iran.

Purpose: Epidermal growth factor receptors (EGFRs) are overexpressed in a wide range of tumors and are attractive candidates to target in targeted therapies. This study aimed to introduce a novel radiolabeled compound, Lu-cetuximab-PAMAM G4, for the treatment of EGFR-expressing tumors.

Methods: In this study, the cetuximab mAb was bound to PAMAM G4 and labeled with Lu via DTPA-CHX chelator.

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Maize Iranian mosaic virus (MIMV, family Rhabdoviridae) is one of the factors limiting cereal production in Iran. In the present study, we sought to find critical genes and key pathways involved in MIMV infection and analyzed gene networks, pathways and promoters using transcriptome data. We determined the hub genes involved in pathways related to the proteasome and ubiquitin.

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As an important component in medical applications, dosimetry, and radiotherapy studies, the effective atomic number of body tissue, tissue equivalent substances, and dosimetry compounds are investigated. In this research, considering the Coulomb interaction of charged particles, using the collision stopping power and the NIST library data, the effective atomic number of various materials at different energies is calculated for common radiotherapy particles such as electron, proton, alpha, and carbon ions. Taking into account the direct calculation method based on the collision stopping power, the effective atomic number for electron, proton, alpha, and carbon particles is determined for a group of dosimetry and tissue equivalent materials.

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Article Synopsis
  • Ionizing radiation, specifically gamma rays, can enhance the development of new grape varieties like the 'Yaghouti' by studying how different radiation doses affect plant traits.
  • The study measured the impact of varying gamma ray doses on the survival, growth, and morphometric traits of 'Yaghouti' grape plants, identifying the lethal doses and growth reduction levels associated with radiation exposure.
  • Results indicate that a gamma ray dose of 30 Gy is optimal for promoting biological changes in 'Yaghouti' grapes, with higher doses negatively affecting growth metrics such as plant height, root number, and leaf area.
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The word "pstk" [pistag], used in the ancient Persian language, is the linguistic root from which the current name "pistachio", used worldwide, derives. The word pistachio is generally used to designate the plants and fruits of a single species: L. Both the plant and its fruits have been used by mankind for thousands of years, specifically the consumption of its fruits by Neanderthals has been dated to about 300,000 years ago.

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This study aims to produce and quality control of a new porphyrin complex labeled with Ti for PET imaging, so at the first step, the cross-section of Sc(p,n)Ti was investigated by TALYS-1.6 and the optimal target thickness and theoretical yield were calculated by SRIM code. The purified Ti was labeled with the anticancer agent of tetrakis (pentafluorophenyl) porphyrin (TFPP).

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This minireview describes the global situation of ongoing research and development and the clinical application of alpha emitter labeled immunoconjugates with various alpha emitters with an overview of the future trends. The potentially helpful alpha emitter radioisotopes for medical applications, chelators, and immunomolecules of interest for future alpha radioimmunotherapy are discussed. Challenges and some suggested future works on chelators are also presented.

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Angiogenesis phenomenon, as a highly affecting factor on the growth and spread of cancer cells, depends on specific molecular interactions between components of the extracellular matrix and vascular cells. αv integrin acts as a cell adhesive molecule involved in tumor invasion and angiogenesis. Among the various combinations of integrin subunits expressed on the surface of cells, αβ integrin has a particularly interesting expression pattern during angiogenesis.

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To investigate the effects of converting forests into vineyards typical to Zarivar Lake watershed, Iran, which occurred mainly in the 1970s and 80s, on soil erosion,Cs and Pb, being mid-and-long-term soil loss tracers, were applied. In Chernobyl-contaminated areas like those found in some parts of Europe and Asia, the proportion of Cs Chernobyl fallout needs to be determined to convert Cs inventories into soil erosion rates. To do so, Pu radioisotopes were applied for the first time in Iran.

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Reducing nitrogen losses can be accomplished by mixing fertilizers with nitrification inhibitors (NI). In some agricultural systems, increasing soil N supply capacity by the use of NI could lead to improved N use efficiency (NUE) and increased crop yields. This study examined the effect of different N rates and NI in maize in the north of Iran.

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Regulatory non-coding RNA: The core defense mechanism against plant pathogens.

J Biotechnol

November 2022

Plant Virology Research Center, College of Agriculture, Shiraz University, Shiraz, the Islamic Republic of Iran.

Plant pathogens damage crops and threaten global food security. Plants have evolved complex defense networks against pathogens, using crosstalk among various signaling pathways. Key regulators conferring plant immunity through signaling pathways include protein-coding genes and non-coding RNAs (ncRNAs).

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Background: HYNIC-Bombesin (BBN) is a potential peptide for targeted radionuclide therapy in gastrin-releasing peptide receptor (GRPr)-positive malignancies. The Re-HYNICBBN is a promising radiopharmaceutical for use in prostate cancer therapy.

Objective: The aim of this study was to estimate the absorbed dose due to Re-HYNIC-BBN radio-complex in human organs based on bio-distribution data of rats.

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There has been impressive growth in the use of radiopharmaceuticals for therapy, selective toxic payload delivery, and noninvasive diagnostic imaging of disease. The increasing timeframes and costs involved in the discovery and development of new radiopharmaceuticals have driven the development of more efficient strategies for this process. Computer-Aided Drug Design (CADD) methods and Machine Learning (ML) have become more effective over the last two decades for drug and materials discovery and optimization.

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Root-knot nematodes are the most important plantparasitic nematodes worldwide. Many efforts have been made to find non-chemical, risk-free, and environmentally friendly methods for nematode control. In this study, the effects of compost and vermicompost of arugula (Eruca sativa) on Meloidogyne javanica were investigated in three glasshouse experiments.

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Gamma (γ)-radiation can target viral genome replication and preserve viral structural proteins compared to formalin inactivation. Thus, a stronger immunity could be induced after the inoculation of the irradiated virus. In this study, γ-irradiated low-pathogenic avian influenza virus-H9N2 (LPAIV-H9N2) was used to immunize the broiler chicken in two formulations, including γ-irradiated LPAIV-H9N2 with 20% Trehalose intranasally (IVT.

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In this work, Sn and Ag doped PbS/PVA nanocomposites, in three different concentrations were successfully prepared using the low-cost and simple method of chemical bath deposition (CBD). X-ray diffraction patterns confirmed the formation of the PbS cubic phase in all of the nanocomposites. FE-SEM images showed that PbS NPs are cubic in shape and the doping can alter the shape of grains.

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IAEA Contribution to Nanosized Targeted Radiopharmaceuticals for Drug Delivery.

Pharmaceutics

May 2022

Department of Radiology, Institute of Green Nanotechnology, School of Medicine, University of Missouri, University of Missouri Research Reactor (MURR), Medical School, One Hospital Drive, Columbia, MO 65212, USA.

The rapidly growing interest in the application of nanoscience in the future design of radiopharmaceuticals and the development of nanosized radiopharmaceuticals in the late 2000's, resulted in the creation of a Coordinated Research Project (CRP) by the International Atomic Energy Agency (IAEA) in 2014. This CRP entitled ' involved a team of expert scientist from various member states. This team of scientists worked on a number of cutting-edge areas of nanoscience with a focus on developing well-defined, highly effective and site-specific delivery systems of radiopharmaceuticals.

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The goal of using radiopharmaceuticals for therapeutic purposes is twofold: first, the most damage to cancer cells and, second, the most negligible dose transfers to healthy tissues. As Lu has the potential to cure a wide range of malignancies due to its varied range of beta energies, Lu-BBN-GABA-DOTA has been developed for therapeutic applications. In addition, Lu-BBN-GABA-DOTA can be over-expressed on gastrin-releasing peptide (GRP) receptors of the prostate, breast, small cell lung cancer, gastric, and colon tumors.

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Density functional theory (DFT) calculations were applied to study the ability of B to adsorb HS, SO, SO, CHSH, (CH)S, and CHS gases. Several exchange-correlation including B97D, PBE, B3LYP, M062X, and WB97XD were utilized to evaluate adsorption energies. The initial results showed that boundary boron atoms are the most appropriate interaction sites.

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SARS-CoV-2, the causal agent of COVID-19, is primarily a pulmonary virus that can directly or indirectly infect several organs. Despite many studies carried out during the current COVID-19 pandemic, some pathological features of SARS-CoV-2 have remained unclear. It has been recently attempted to address the current knowledge gaps on the viral pathogenicity and pathological mechanisms via cellular-level tropism of SARS-CoV-2 using human proteomics, visualization of virus-host protein-protein interactions (PPIs), and enrichment analysis of experimental results.

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In this work, an outstanding nano-structured composite electrode is fabricated through the co-deposition of Co(OH) nanoplates and porous reduced GO (p-rGO) nanosheets onto Ni foam (NF). Through field emission scanning electron microscopy and transmission electron microscopy observations, it was confirmed that porous reduced graphene oxide sheets are completely wrapped by uniform hexagonal Co(OH) plates. Due to the unique architecture of both components of the prepared composite, a high surface area of 234.

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