[In]In-RM2: a high potential agent for SPECT imaging of GRPR-expressing tumors.

Gastrin-releasing peptide receptors (GRPRs) overexpressed in many cancers are known as promising biomarkers to target tumors such as prostate, breast, and lung cancers. As the early diagnosis of the cancers can serve for better treatment of the patients, [In]In-DOTA-Pip-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 ([In]In-RM2) was prepared using an in-house developed Sn/In generator. 0.

Influence of Newborns' Sex on Minor and Trace Element Concentrations in Human Milk During Early Lactation.

This study aimed to investigate the influence of newborns' sex on the concentrations of minor and trace elements in the human milk of lactating mothers during early lactation. The elemental analysis focused on calcium (Ca), potassium (K), sodium (Na), and chlorine (Cl) as minor elements and iodine (I), aluminum (Al), bromine (Br), and rubidium (Rb) as trace elements. Breast milk samples were collected from 75 lactating mothers in Tehran, Iran, during the early feeding stage.

Bioinformatics deciphers the thebaine biosynthesis pathway in opium poppy: Hub genes, network analysis, and miRNA regulation.

Thebaine, a vital precursor in the codeine and morphine pathway, shows promise in addiction treatment. We conducted a comprehensive study on the thebaine biosynthesis pathway in opium poppy, utilizing bioinformatics tools. The dataset comprising the thirteen genes associated with the thebaine biosynthesis pathway was compiled from an extensive review of published literature and validated using the NCBI BLAST tool.

Gamma radiation-induced enhancement of biocontrol agents for plant disease management.

Gamma radiation-induced mutations in microorganisms can enhance their properties for the biological control of plant diseases. Mutant strains of were found to have improved antifungal properties against and increased production of biosurfactants and biofilms. Furthermore, combining gamma radiation with antagonists was more effective in controlling postharvest than either treatment alone.

AI-enabled pipeline for virus detection, validation, and SNP discovery from next-generation sequencing data.

Background And Aims: The rapid and accurate detection of viruses and the discovery of single nucleotide polymorphisms (SNPs) are critical for disease management and understanding viral evolution. This study presents a pipeline for virus detection, validation, and SNP discovery from next-generation sequencing (NGS) data. The pipeline processes raw sequencing data to identify viral sequences with high accuracy and sensitivity by integrating state-of-the-art bioinformatics tools with artificial intelligence.

Determination of Minor and Trace Elements in Breast Milk of Lactating Mothers in Early Lactation from Tehran, Iran Using Neutron Activation Analysis Method.

This study aimed to evaluate the concentrations of both essential and non-essential elements in the breast milk of lactating mothers from Tehran, Iran, during the colostrum period. Neutron activation analysis (NAA) was used to measure the element concentrations. Additionally, the study assessed how these element concentrations were influenced by maternal factors such as age and economic status.

Advancing rice breeding for drought tolerance: a comprehensive study of traditional and mutant lines through agronomic performance and drought tolerance indices.

Background: Drought stress is a critical challenge to rice production, necessitating the development of drought-tolerant genotypes. This study aimed to evaluate the drought tolerance of rice genotypes, including traditional parental lines (Hashemi, Khazar, Fajr, and Tarom Mahalli) and their corresponding mutant lines, under normal and drought stress conditions.

Methods: Agronomic traits such as plant height, spike number, spike length, seed fertility, and yield were analyzed under both conditions.

Preclinical Aspects of [89Zr]Zr-DFO-Rituximab: A High Potential Agent for Immuno-PET Imaging.

Background: An early diagnosis of cancer can lead to choosing more effective treatment and increase the number of cancer survivors. In this study, the preparation and preclinical aspects of [89Zr]Zr-DFO-Rituximab, a high-potential agent for PET imaging of Non- Hodgkin Lymphoma (NHL), were evaluated.

Methods: DFO was conjugated to rituximab monoclonal antibody (mAb), and DFO-rituximab was successfully labeled with zirconium-89 (89Zr) at optimized conditions.

Identification of key genes and pathways involved in T-DM1-resistance in OE-19 esophageal cancer cells through bioinformatics analysis.

Introduction: Esophageal Cancer (EC) ranks among the most common malignancies worldwide. Most EC patients acquire drug resistance to chemotherapy either intrinsically or acquired after T-DM1 treatment, which shows that increasing or decreasing the expression of particular genes might influence chemotherapeutic sensitivity or resistance. Therefore, gaining a deeper understanding of the altered expression of genes involved in EC drug resistance and developing new therapeutic methods are essential targets for continued advancement in EC therapy.

Genetic analysis of tomato brown rugose fruit virus reveals evolutionary adaptation and codon usage bias patterns.

Tomato brown rugose fruit virus (ToBRFV) poses a significant threat to tomato production worldwide, prompting extensive research into its genetic diversity, evolutionary dynamics, and adaptive strategies. In this study, we conducted a comprehensive analysis of ToBRFV at the codon level, focusing on codon usage bias, selection pressures, and evolutionary patterns across multiple genes. Our analysis revealed distinct patterns of codon usage bias and selection pressures within the ToBRFV genome, with varying levels of genetic diversity and evolutionary constraints among different genes.

Anthropogenic and climatic impacts on historic sediment, carbon, and phosphorus accumulation rates using Pb and Cs in a sub-watershed linked to Zarivar Lake, Iran.

To estimate a watershed's response to climate change, it is crucial to understand how human activities and climatic extremes have interacted over time. Over the last century, the Zarivar Lake watershed, Iran, has been subjected to various anthropogenic activates, including deforestation and inappropriate land-management practices alongside the implementation of conservation measures like check dams. To understand the effects of these changes on the magnitude of sediment, organic carbon (OC), and phosphorus supplies in a small sub-watershed connected to the lake over the last century, a lake sediment core was dated using Pb and Cs as geochronometers.

Enhancing Photosynthesis and Plant Productivity through Genetic Modification.

Enhancing crop photosynthesis through genetic engineering technologies offers numerous opportunities to increase plant productivity. Key approaches include optimizing light utilization, increasing cytochrome complex levels, and improving carbon fixation. Modifications to Rubisco and the photosynthetic electron transport chain are central to these strategies.

Investigating the effect of gliding discharge plasma on polystyrene and Polyamide6 by positron annihilation lifetime spectroscopy.

Polymers are widely used today and the changes in their properties are investigated by different methods such as plasma irradiation. One of the most important methods for modifying polymers is cold plasma, by which the surface properties of the polymers can be changed under atmospheric pressure. In this study, the effect of plasma on Polystyrene (PS) and Polyamide 6 (PA6) samples was investigated.

CTGF, FN1, IL-6, THBS1, and WISP1 genes and PI3K-Akt signaling pathway as prognostic and therapeutic targets in gastric cancer identified by gene network modeling.

Objective: Gastric cancer (GC) is one of the most common malignancies worldwide and it is considered the fourth most common cause of cancer death. This study aimed to find critical genes/pathways in GC pathogenesis to be used as biomarkers or therapeutic targets.

Methods: Differentially expressed genes were explored between human gastric cancerous and noncancerous tissues, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes signaling pathway enrichment analyses were done.

Optimizing sustainable control of Meloidogyne javanica in tomato plants through gamma radiation-induced mutants of Trichoderma harzianum and Bacillus velezensis.

This study investigates the efficacy of Trichoderma spp. and Bacillus spp., as well as their gamma radiation-induced mutants, as potential biological control agents against Meloidogyne javanica (Mj) in tomato plants.

Optimized Production of Re-HYNIC-Bombesin: New Therapeutic Agent for GRPR Targeting.

Purpose: One of the most interesting methods to deliver therapeutic doses of ionizing radiation to tumor sites is radiolabeled compounds. Bombesin peptide binds to gastrin-releasing peptide receptors (GRPRs) with great affinity. Through its appropriate physical characteristics and accessibility as the W/Re generator, Re can be effectively used to develop a therapeutic radio complex.

Optimal production and purification of n.c.a.Pr as a promising palliative agent for the treatment of metastatic bone pain.

This study proposes the beta-emitting radioisotope Pr as a promising candidate for palliative treatment of metastatic bone pain due to its desirable physical decay characteristics. An optimized process was developed for the production and purification of non-carrier-added Pr using a medium flux research reactor. Calculations were performed to determine the optimal irradiation time and cooling period for irradiating 1 mg of natural cerium oxide to indirectly produce Pr through the decay of Ce.

Preclinical studies and absorbed dose estimation of [Zr]Zr-DFO-Bevacizumab for PET imaging of VEGF-expressing tumors.

This study aimed to carry out the preclinical studies of [Zr]Zr-DFO-Bevacizumab. The radiolabeled compound was prepared with radiochemical purity >99% (ITLC), and a specific activity of 74 GBq/g. Cellular studies indicated the great capability of [Zr]Zr-DFO-Bevacizumab for binding to SKOV3 cell lines.

Gross alpha/beta and radionuclide activity concentrations in soil, plant and some fruits around the Tehran Research Reactor.

Human activities usually have some contamination as effluents from chemical industries and radionuclides from nuclear reactors. For assessing the probable radioactive contamination in vicinity of Tehran Research Reactor, The gross alpha and beta radioactivity concentrations in soil, pine and cedar leaves and some selected fruits (fig, apple, berry and pomegranate) were investigated using an alpha/beta spectrometer during 2021-2022. Also, the concentrations of artificial and natural radionuclides in samples were investigated by the method of gamma spectroscopy.

Exploring low-dose gamma radiation effects on monoterpene biosynthesis in Thymus vulgaris: insights into plant defense mechanisms.

Thymus vulgaris, commonly known as thyme, is a plant renowned for producing monoterpenes. This study aimed to understand the effects of low-dose gamma radiation, specifically in the range of 1-5 Gy, on various traits of Thymus vulgaris, providing context on its importance in agricultural and medicinal applications. The research explored morpho-physiological, biochemical, and gene-expression responses in thyme plants under no gamma- and gamma-ray exposure conditions.

Creating a novel genetic diversity of by γ-radiation for xylanase-cellulase production.

Creating novel sources of a microbial strain using induced mutation can increase enzyme production for industrial use. According to this, we have developed a mutant strain of by Co gamma irradiation. mutants were isolated from an optimum dose of 250 Gy.