98 results match your criteria: "Nuclear Science Research Institute[Affiliation]"

An attempt was made to estimate organ doses of a victim in a high-dose non-homogeneous exposure accident caused by a sealed 192Ir gamma-ray source. The Gilan accident was selected as a case study. Organ doses including testis, red bone marrow and so on were properly estimated by applying the Monte Carlo calculation with the state-of-the-art adult male Mesh type Reference Computational Phantom.

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Article Synopsis
  • A dosimeter must be calibrated in a field with energy and dose rates similar to its intended measurement environment, especially in areas like nuclear reactors and radiation therapy where high-energy photons are present.
  • The Japan Atomic Energy Agency and National Metrology Institute of Japan provide high-energy reference fields for testing dosimeters, containing photon energies above several megaelectronvolts.
  • The study assessed the performance of two-cavity ionization chambers in these high-energy fields, confirming their accuracy for air kerma measurements with an acceptable level of uncertainty.
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  • - Burn injuries are a significant global health issue that requires treatment strategies addressing both skin healing and inflammation regulation, as systemic inflammatory responses can impede recovery.
  • - The study highlights the effectiveness of low-temperature pulverization-specific extract (LPSHE) from marine sources in improving burn wound healing by enhancing skin cell recovery and reducing harmful reactive oxygen species (ROS) levels.
  • - Results from experiments on mice and keratinocyte cells suggest that LPSHE not only promotes healing but also governs inflammation, indicating its potential as a novel therapeutic option for burn treatment.
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ECM stiffness regulates calcium influx into mitochondria via tubulin and VDAC1 activity.

Anim Cells Syst (Seoul)

August 2024

Department of Integrated Biological Science, College of Natural Sciences, Pusan National University, Busan, Republic of Korea.

Calcium ions (Ca) play pivotal roles in regulating numerous cellular functions, including metabolism and growth, in normal and cancerous cells. Consequently, Ca signaling is a vital determinant of cell fate and influences both cell survival and death. These intracellular signals are susceptible to modulation by various factors, including changes in the extracellular environment, which leads to mechanical alterations.

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Establishment of a 241Am gamma calibration field based on international standards and its conversion coefficients.

Radiat Prot Dosimetry

September 2024

Department of Radiation Protection, Nuclear Science Research Institute, Japan Atomic Energy Agency, 2-4 Shirakata, Tokai-mura, Naka-gun, Ibaraki 319-1195, Japan.

A 241Am gamma (γ)-ray calibration field that meets the requirements for a γ-ray reference field as specified in the ISO 4037 standard series was established in the Facility of Radiation Standards of the Japan Atomic Energy Agency. The reference air kerma rates were measured using a reference ionization chamber calibrated by the N-80 quality X-ray calibration field of the national metrology standard in Japan and with a correction to account for differences in photon energy due to the calibration field. Conversion coefficients for the 241Am γ-ray calibration field, including those not listed in the ISO 4037 standard series, were calculated based on the measured γ-ray fluence rate spectra.

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Understanding radioactive Cs contamination has been a central issue at Fukushima Daiichi and other nuclear legacy sites; however, atomic-scale characterization of radioactive Cs in environmental samples has never been achieved. Here we report, for the first time, the direct imaging of radioactive Cs atoms using high-resolution high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM). In Cs-rich microparticles collected from Japan, we document inclusions that contain 27 - 36 wt% of Cs (reported as CsO) in a zeolite: pollucite.

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The increasing prevalence of endocrine-disrupting chemicals (EDCs) in our environment is a growing concern, with numerous studies highlighting their adverse effects on the human endocrine system. Among the EDCs, estrogenic endocrine-disrupting chemicals (eEDCs) are exogenous compounds that perturb estrogenic hormone function by interfering with estrogen receptor (ER) homo (α/α, β/β) or hetero (α/β) dimerization. To date, a comprehensive screening approach for eEDCs affecting all ER dimer forms in live cells is lacking.

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Cranial irradiation is used for prophylactic brain radiotherapy as well as the treatment of primary brain tumors. Despite its high efficiency, it often induces unexpected side effects, including cognitive dysfunction. Herein, we observed that mice exposed to cranial irradiation exhibited cognitive dysfunction, including altered spontaneous behavior, decreased spatial memory, and reduced novel object recognition.

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Mitochondrial glutamate transporter SLC25A22 uni-directionally export glutamate for metabolic rewiring in radioresistant glioblastoma.

Int J Biol Macromol

December 2023

Department of Integrated Biological Science, Pusan National University, Busan 46241, Republic of Korea; Nuclear Science Research Institute, Pusan National University, Busan 46241, Republic of Korea; Department of Biological Sciences, Pusan National University, Busan 46241, Republic of Korea. Electronic address:

Glioblastoma Multiforme (GBM) is a malignant primary brain tumor. Radiotherapy, one of the standard treatments for GBM patients, could induce GBM radioresistance via rewiring cellular metabolism. However, the precise mechanism attributing to GBM radioresistance or targeting strategies to overcome GBM radioresistance are lacking.

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An additional extremity monitoring using a ring badge must be appropriately conducted for inhomogeneous exposure around radiation workers' extremity. Commercially available glass dosemeters are characterized in terms of Hp(0.07) for the application of additional extremity monitoring.

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Alpha-particle discrimination using ultra-thin plastic scintillator sheets for measuring the activity of α-emitters under the existence of α- and β-emitters was investigated. Am, P and Ra were also used to evaluate the applicability of the present technique to α-emitters for medicine, and the self-absorption effect due to additives was investigated for validation. The results demonstrated that ≥95% of detection efficiency for α-particles emitted from Am with ≤1% β-contribution of P for the low carrier salt concentration solution.

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Article Synopsis
  • The DS02 dosimetry system, used to assess cancer risks among atomic bomb survivors, employs three simplified body models but lacks accurate representation for fetal organ doses, relying instead on the uterine wall of an adult phantom.
  • To improve accuracy, the RERF Working Group has developed the J45 series of high-resolution voxel phantoms that include various body types from newborns to adults, along with four pregnant female models at different gestational ages.
  • Recent comparisons show that organ doses calculated using these new J45 phantoms, especially in realistic postures like kneeling and lying down, reveal that the DS02 system may overestimate doses by up to 1.45 times for certain exposure scenarios.
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  • Scientists learned about the effects of radiation on unborn babies by studying women who were pregnant during the atomic bomb explosions in Hiroshima and Nagasaki.
  • They used special models called phantoms to estimate how much radiation the babies inside these women received at different pregnancy stages.
  • The study found that the previous estimates of radiation exposure were too high, especially for the babies' brains later in pregnancy.
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We performed an experimental investigation on occupational exposure of the eye lens and the extremity of radiation workers engaged in handling of highly activated materials in a small research accelerator facility. Using a simplified physical phantom to simulate the relevant inhomogeneous radiation exposure situations, the personal dose equivalents obtained at the eye lens and the extremities of radiation workers handling heavily radioactive converters were measured together with the dose measured by personal dosemeters worn on their trunk. Results of mockup experiments and the Monte Carlo calculations suggest that the quantitative estimation of the eye lens doses can be estimated from the trunk dose, while the extremity doses vary considerably from the dose readings from the trunk, depending on the use of simple point-source or volume source geometry.

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Corrosion Behavior of Aluminium-Coated Cans.

Materials (Basel)

January 2023

Materials Science Research Institute, King Abdulaziz City for Science and Technology, Riyadh 11442, Saudi Arabia.

Hundreds of billions of aluminium-based cans are manufactured and used every year worldwide including those containing soft drinks. This study investigates and evaluates the performance and quality of two well-known energy and soft drinks brands, Green Cola and Red Bull. Recent health hazards and concerns have been associated with aluminium leakage and bisphenol A (BPA) dissociation from the can's internal protective coating.

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Radioactive cesium-rich microparticles (CsMPs) derived from the Fukushima Daiichi Nnuclear Power Plant accident were detected from soils and river water around Fukushima Prefecture, Japan. Because CsMPs are insoluble and rich in radioactive cesium (RCs), they may cause the overestimation of solid-water distribution coefficient (K) for RCs in the water. Previous studies showed the proportion of RCs derived from CsMPs on RCs concentration in soils collected from areas with different contaminated levels.

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Nanofiltration membranes were successfully created using multi-walled carbon nanotubes (MWCNTs) and MWCNTs modified with amine (MWCNT-NH2) and carboxylic groups (MWCNT-COOH). Chitosan (CHIT) and chitosan−glutaraldehyde (CHIT-G) were utilized as dispersants. Sonication, SEM, and contact angle were used to characterize the as-prepared membranes.

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The usage of radiation is mandatory for modern life; in the same manner, controlling the outflow of harmful radiation is vital and could be achieved via employing a shielding material to eliminate any potential nuclear and radiation accidents and incidents. Considering this point, this study aims to manufacture composite samples based on waste marble as novel radiation shields. The physical and radiation shielding ability of the prepared shields were determined and analyzed.

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The rising significance of the field of biopolymers has driven the rapid progress of this distinctive class of polymeric materials in the past decades. Biodegradable polymers have acquired much attention because they play an essential role in humans' lives due to their specific tunable electrical conductivity and biodegradability characteristics, making them fascinating in many applications. Herein, we debated the recent progress in developing biodegradable polymers and their applications.

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Overcoming therapeutic resistance in glioblastoma (GBM) is an essential strategy for improving cancer therapy. However, cancer cells possess various evasion mechanisms, such as metabolic reprogramming, which promote cell survival and limit therapy. The diverse metabolic fuel sources that are produced by autophagy provide tumors with metabolic plasticity and are known to induce drug or radioresistance in GBM.

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Photocatalysis is one of the promising method to degrade harmful organic pollutants under visible light exposure. In this work, a novel NiVO/BiVO nanocomposite has been prepared by one-pot hydrothermal method, and investigated through X-ray diffraction, FT-IR, UV-visible diffuse reflectance spectroscopy, scanning and transmission electron microscopy and photoluminescence techniques. Subsequently, the photocatalytic performance of NiVO/BiVO nanocomposite has been examined by degrading AO7 under visible light illumination.

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We demonstrate a practical calibration method and its applicability for a commercially available radiophotoluminescence dosemeter (RPLD), i.e. the GD-352M (AGC Techno Glass, Shizuoka, Japan) to eye lens dose monitoring, by performing the calibration according to the ISO recommendations.

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Radiation exposure to the lens of the eye for Japanese nuclear power plant workers.

J Radiol Prot

July 2022

Radiation Protection Department, Nuclear Fuel Cycle Engineering Laboratories, Japan Atomic Energy Agency, 4-33, Muramatsu, Tokai-mura, Ibaraki 319-1194, Japan.

In Japan, the radiation-dose limit for the lens of the eye was revised in April 2021. Consequently, for workers, the numerical values of the equivalent dose to the lens of the eye are equal to those of the effective dose. Radiation workers, radiation safety officers and licensees must comply with regulations related to radiation protection and optimize protection.

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Creep-fatigue interaction occurs in many structural components of high-temperature systems operating under cyclic and steady-state service conditions, such as in nuclear power plants, aerospace, naval, and other industrial applications. Thus, understanding micromechanisms governing high-temperature creep-fatigue behavior is essential for safety and design considerations. In this work, stress-controlled creep-fatigue tests of advanced austenitic stainless steel (Alloy 709) were performed at a 400 MPa stress range and 750 °C with tensile hold times of 0, 60, 600, 1800, and 3600 s, followed by microstructural examinations.

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Antibiotics are essential medications for human and animal health, as they are used to battle urinary infections and bacterial diseases. Therefore, the rapid determination of antibiotic drugs in biological samples is necessary to address the current clinical challenge. Here, we developed a heterojunction ternary composite of BiOCl/BiVO nanosheets enriched with graphene oxide (BiOCl/BiVO@GO) for accurate and minimal-level detection of an antihistamine (promethazine hydrochloride, PMZ) in urine samples.

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