15 results match your criteria: "Nova Scotia Cancer Center[Affiliation]"

Article Synopsis
  • - The study aimed to evaluate how testosterone (T) levels recover in prostate cancer patients treated with varying durations of androgen deprivation therapy (ADT) after radiotherapy.
  • - Results showed that testosterone recovery rates decreased significantly with longer ADT durations, with only 43.2% recovering normal T after 36 months compared to 87.4% after no ADT.
  • - Factors influencing T recovery included baseline testosterone levels, age, and duration of ADT, with longer treatment being the most critical factor for recovery outcomes.
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hENT1 Expression Predicts Response to Gemcitabine and Nab-Paclitaxel in Advanced Pancreatic Ductal Adenocarcinoma.

Clin Cancer Res

December 2022

Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.

Purpose: Modified FOLFIRINOX (mFFX) and gemcitabine/nab-paclitaxel (GnP) remain standard first-line options for patients with advanced pancreatic ductal adenocarcinoma (PDAC). Human equilibrative nucleoside transporter 1 (hENT1) was hypothesized to be a biomarker of gemcitabine in the adjuvant setting, with conflicting results. In this study, we explore hENT1 mRNA expression as a predictive biomarker in advanced PDAC.

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Article Synopsis
  • This study aimed to determine which patients with intermediate-risk prostate cancer could safely reduce their treatment intensity, specifically regarding androgen deprivation therapy and radiation dose.
  • The original trial included 600 patients and compared different treatment regimens while analyzing outcomes based on intermediate risk factors like Gleason score and prostate-specific antigen levels.
  • Results indicated that patients with favorable intermediate risk had similar outcomes across treatment arms, while those with unfavorable intermediate risk faced worse survival rates and responded better to treatments involving androgen deprivation therapy.
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Article Synopsis
  • The study investigated the effects of androgen deprivation therapy (ADT) combined with either standard or higher doses of radiotherapy (RT) on patients with intermediate-risk prostate cancer (IRPC).
  • Over 600 patients participated in a trial comparing outcomes among three treatment groups: ADT + RT 70 Gy, ADT + dose-escalated RT 76 Gy, and RT 76 Gy alone.
  • Results showed that the highest biochemical failure rates and prostate cancer progression were linked to RT 76 Gy alone, while adding ADT improved outcomes without increasing overall survival, although higher doses of RT led to more gastrointestinal toxicity.
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Introduction: Physicians entering independent practice often express apprehension in managing the non-clinical aspects of practice. This study examined the perceived preparedness of radiation oncology (RO) residents for independent practice, identified education gaps, and discussed how these deficiencies could be addressed.

Materials And Methods: Focus groups with senior RO residents, fellows, new-to-practice radiation oncologists (ROs), and residency program directors were conducted.

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Purpose: Adjuvant partial breast radiotherapy is the standard of care for early-stage favorable breast cancer. We report dosimetry, acute and late tolerance for 67 permanent breast seed implants.

Materials And Methods: From July 2012 to October 2018, 67 postmenopausal women with unifocal pT1pN0 invasive ductal or ductal carcinoma in situ received partial breast radiotherapy using stranded Pd-103 seeds after breast-conserving surgery, delivering 90 Gy to the seroma + margin (1.

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Use of Protoporphyrin Fluorescence to Determine Clinical Target Volume for Non-melanotic Skin Cancers Treated with Primary Radiotherapy.

Cureus

September 2016

Department of Radiation Oncology, London Regional Cancer Program, Western University, London, Ontario, CA ; Schulich School of Medicine & Dentistry, Western University, London, Ontario, CA.

Purpose: Non-melanotic skin cancers remain the most commonly diagnosed cancers. Radiotherapy and surgery are the most common treatment options. Radiotherapy has a recurrence rate of up to 20% for basal or squamous cell cancers.

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Background: The pan-Canadian Oncology Symptom Triage and Remote Support (COSTaRS) team developed 13 evidence-informed protocols for symptom management.

Aim: To build an effective and sustainable approach for implementing the COSTaRS protocols for nurses providing telephone-based symptom support to cancer patients.

Methods: A comparative case study was guided by the Knowledge to Action Framework.

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Purpose: Incident investigation, reporting, and learning are core elements of quality improvement in radiation treatment. This report describes the development of a Canadian National System for Incident Reporting in Radiation Treatment (NSIR-RT), focusing especially on the taxonomy.

Methods And Materials: The NSIR-RT was developed to provide a framework in Canada for reporting and analyzing radiation treatment incidents.

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A pan-Canadian survey of peer review practices in radiation oncology.

Pract Radiat Oncol

March 2017

Division of Cancer Care and Epidemiology, Queen's Cancer Research Institute, Kingston, ON, Canada; Department of Oncology, Queen's University, Kingston, ON, Canada. Electronic address:

Purpose: Peer review (PR) of treatment plans has been recognized internationally as a key component of quality care in radiation oncology programs (ROPs). We conducted a survey of Canadian ROPs to describe current PR practices and identify barriers/facilitators to PR optimization.

Methods And Materials: A 42-item e-survey was sent to all Canadian ROPs (n = 44).

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Purpose: To compare 30-day seed displacement and seed loss of standard loose seeds to specially engineered coated seeds.

Methods And Materials: Forty patients with prostate cancer were randomized and treated with either loose seeds or loose "coated" seeds. Implants were preplanned using transrectal ultrasound and performed using preloaded needles containing either standard or coated iodine-125 seeds according to randomization.

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Purpose: Postplan evaluation is essential for quality assurance in prostate brachytherapy. MRI has demonstrated greater interobserver consistency in prostate contouring compared with CT. Although a valuable tool in postimplant assessment, MRI is costly and not always available.

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Sex or survival: short-term versus long-term androgen deprivation in patients with locally advanced prostate cancer treated with radiotherapy.

Cancer

April 2010

Department of Radiation Oncology, Nova Scotia Cancer Center, Queen Elizabeth II Health Sciences Center, Dalhousie University, Halifax, Nova Scotia, Canada.

Background: Combined long-term androgen deprivation (LTAD) and radiation conveys a prostate cancer-specific survival advantage over combined short-term androgen deprivation (STAD) and radiation. The seminal question is whether or not the gains are worth the adverse effects of LTAD with respect to patient preferences.

Methods: Preferences for LTAD compared with STAD were elicited by direct patient interview using the probability trade-off method.

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Purpose: The role of an elective axillary lymph node dissection (AxLND) in the initial management of patients with early stage breast cancer has recently become controversial. The objective of this current study is to review the reasons as to why patients from a single institution were managed without an initial AxLND and their outcome in terms of survival and recurrence rates.

Materials And Methods: A retrospective analysis was conducted on 126 women referred to the Princess Margaret Hospital with the diagnosis of breast cancer who did not undergo an initial AxLND.

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