819 results match your criteria: "Nottingham Digestive Diseases Centre.[Affiliation]"

A comparison of the top 500 papers in Clinical Nutrition ranked by citation and Altmetric Attention Scores.

Clin Nutr

August 2024

Nottingham Digestive Diseases Centre, Division of Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK; National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen's Medical Centre, Nottingham, UK; MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, School of Life Sciences, University of Nottingham, Queen's Medical Centre, Nottingham, UK; Division of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: https://twitter.com/DL08OMD.

Background And Aims: Citation scores (CS) have been traditionally used to measure the impact of scientific publications. Sourced from the Internet, Altmetric Attention Scores (AAS) are complementary metrics that assess how often publications are discussed and used globally. We compared by rank the top 500 papers by CS and AAS published in Clinical Nutrition with corresponding AAS and CS.

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The Impact of the Covid-19 Pandemic on Annual Review of Competency Progression Outcomes Issued to General Surgical Trainees.

J Surg Educ

August 2024

Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham, Royal Derby Hospital, Derby, United Kingdom.

Background: The Covid-19 pandemic had a profound impact on surgical training. In this longitudinal cohort study, we quantify the effects of the pandemic on United Kingdom (UK) surgeons in higher specialty training by analyzing the Annual Review of Competency Progression (ARCP) Outcomes issued to them prior to, and during, the pandemic.

Methods: Anonymized records were provided from the UK training management system- the Intercollegiate Surgical Curriculum Programme (ISCP)- on the ARCP Outcomes of higher specialty trainees in General Surgery over the period between January 2017 and December 2022.

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Article Synopsis
  • * The study found higher SARS-CoV-2 positivity rates and viral loads in urban samples compared to rural ones, with key factors like population density and humidity affecting the virus's spread.
  • * Using a modified SEIPR model, researchers estimated that unreported COVID-19 cases could be significantly higher than confirmed cases, suggesting wastewater surveillance could help authorities manage future outbreaks more effectively.
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Immunohistochemical inflammation in histologically normal gallbladders containing gallstones.

World J Surg

July 2024

Division of Translational Medical Sciences, Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, UK.

Background: The aim of this study was to establish features of inflammation in histologically normal gallbladders with gallstones and compare the expression of inflammatory markers in acutely and chronically inflamed gallbladders.

Methods: Immunohistochemistry was performed on formalin-fixed paraffin-embedded gallbladders for tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-2R, and substance p in three groups: Group I (n = 60) chronic cholecystitis, Group II (n = 57) acute cholecystitis and Group III (n = 45) histologically normal gallbladders with gallstones. Expression was quantified using the H-scoring system.

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SUDD, post-diverticulitis pain and IBS: are they really different?

Intern Emerg Med

August 2024

Gastrointestinal Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Lungarno Pacinotti 43, 56126, Pisa, Italy.

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The effect of diabetes mellitus on perioperative outcomes after colorectal resection: a national cohort study.

Br J Anaesth

July 2024

Nottingham Digestive Diseases Centre, Division of Translation Medical Sciences, School of Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, UK; National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen's Medical Centre, Nottingham, UK.

Background: Diabetes mellitus is a significant modulator of postoperative outcomes and is an important risk factor in the patient selection process. We aimed to investigate the effect of diabetes mellitus and use of insulin on outcomes after colorectal resection using a national cohort.

Methods: Adults with a recorded colorectal resection in England between 2010 and 2020 were identified from Hospital Episode Statistics data linked to the Clinical Practice Research Database.

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Postinfectious Disorders of Gut-Brain Interaction: A Brainstorming Story.

Clin Gastroenterol Hepatol

January 2025

University of North Carolina at Chapel Hill Center for Functional Gastrointestinal and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Medicine, Gastrointestinal Unit, Il Cerchio Med HealthCare, Verona Center, Verona, Italy.

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Pancreatic neuroendocrine tumours: a comparison of cytological classification systems.

J Clin Pathol

May 2024

Department of Cellular Pathology, Nottingham University Hospitals NHS Trust, Queen's Medical Centre, Nottingham, UK

Article Synopsis
  • This study compares three cytological classification systems (C1-C5, Papanicolaou, and WHO) for evaluating pancreatic neuroendocrine lesions in 73 resections over 12 years at a UK center.
  • Results showed that the WHO classification had the highest accuracy in categorizing these lesions, while the Papanicolaou system excelled in differentiating neuroendocrine tumors from more aggressive forms like pancreatic adenocarcinoma.
  • Overall, the study suggests that while the WHO system reduces ambiguity in malignancy classification, the Papanicolaou system provides practical management benefits without sacrificing accuracy.
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SUMMARYGiven the importance of gut microbial homeostasis in maintaining health, there has been considerable interest in developing innovative therapeutic strategies for restoring gut microbiota. One such approach, fecal microbiota transplantation (FMT), is the main "whole gut microbiome replacement" strategy and has been integrated into clinical practice guidelines for treating recurrent infection (rCDI). Furthermore, the potential application of FMT in other indications such as inflammatory bowel disease (IBD), metabolic syndrome, and solid tumor malignancies is an area of intense interest and active research.

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Background: Primary sclerosing cholangitis is a progressive inflammatory liver disease characterized by biliary and liver fibrosis. Vascular adhesion protein-1 (VAP-1) is important in the inflammatory process driving liver fibrosis. We evaluated the safety and efficacy of VAP-1 blockade with a monoclonal antibody (timolumab, BTT1023) in patients with primary sclerosing cholangitis.

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Pulse oximetry has limited utility in identifying potential patients for long-term oxygen therapy.

Int J Tuberc Lung Dis

May 2024

NIHR Nottingham Biomedical Research Centre (BRC), Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK, Nottingham University Hospitals NHS Trust, UK, Lifespan and Population Health, School of Medicine, University of Nottingham, Nottingham, UK.

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Case Series: Efficacy of Polyclonal Intravenous Immunoglobulin for Refractory Infection.

Antibodies (Basel)

April 2024

NIHR Nottingham Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham NG7 2UH, UK.

Background: Intravenous immunoglobulin (IVIg) for infection (CDI) no longer features in treatment guidelines. However, IVIg is still used by some clinicians for severe or recurrent CDI (rCDI) cases. The main objective of this study was to investigate the efficacy of IVIg and to identify possible predictors of disease resolution post IVIg administration for patients with CDI.

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New insights into the characterization of the mechanism of action of hyoscine butylbromide in the human colon ex vivo.

Eur J Pharmacol

June 2024

Universitat Autònoma de Barcelona, Department of Cell Biology, Physiology and Immunology, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain. Electronic address:

Introduction: Hyoscine butylbromide (HBB) is one of the most used antispasmodics in clinical practice. Recent translational consensus has demonstrated a similarity between human colonic motor patterns studied ex vivo and in vivo, suggesting ex vivo can predict in vivo results. It is unclear whether the mechanism of action of antispasmodics can predict different use in clinical practice.

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Background: Allopurinol is a xanthine oxidase inhibitor that lowers serum uric acid and is used to prevent acute gout flares in patients with gout. Observational and small interventional studies have suggested beneficial cardiovascular effects of allopurinol.

Objective: To determine whether allopurinol improves major cardiovascular outcomes in patients with ischaemic heart disease.

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People with diabetes undergoing surgery: Level of knowledge of fluid prescribing in trainees in diabetes.

Diabet Med

July 2024

Nottingham Digestive Diseases Centre, Division of Translational Medical Sciences, School of Medicine, Queen's Medical Centre, University of Nottingham, Nottingham, UK.

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Objective: To explore the acceptability of an individualised risk-stratified approach to monitoring for target-organ toxicity in adult patients with immune-mediated inflammatory diseases established on immune-suppressing treatment(s).

Methods: Adults (≥18 years) taking immune-suppressing treatment(s) for at-least six months, and healthcare professionals (HCPs) with experience of either prescribing and/or monitoring immune-suppressing drugs were invited to participate in a single, remote, one-to-one, semi-structured interview. Interviews were conducted by a trained qualitative researcher and explored their views and experiences of current monitoring and acceptability of a proposed risk-stratified monitoring plan.

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Objective: The uptake and safety of pneumococcal vaccination in people with immune mediated inflammatory diseases (IMIDs) is poorly understood. We investigated the UK wide pneumococcal vaccine uptake in adults with IMIDs and explored the association between vaccination and IMID flare.

Methods: Adults with IMIDs diagnosed on or before 01/09/2018, prescribed steroid-sparing drugs within the last 12 months and contributing data to the Clinical Practice Research Datalink Gold were included.

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Article Synopsis
  • The study aimed to overcome barriers in creating effective cancer vaccines by combining hTERT peptides with therapies that target regulatory T cells (Tregs) and reduce immune suppression from COX2.
  • A Phase 1 trial involved 29 patients with advanced solid tumors, focusing on safety and immune response while monitoring side effects like fatigue and nausea.
  • Findings showed that while the treatment was safe and led to some immune cell expansion specific to hTERT, further improvement in clinical effectiveness may come from adding anti-PD1 therapies to tackle exhausted T cells.
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Background: Heat treatments of dairy, including pasteurization and ultra-high temperature (UHT) processing, alter milk macromolecular structures, and ultimately affect digestion. In vitro, animal, and human studies show faster nutrient release or circulating appearance after consuming UHT milk (UHT-M) compared with pasteurized milk (PAST-M), with a faster gastric emptying (GE) rate proposed as a possible mechanism.

Objectives: To investigate the impact of milk heat treatment on GE as a mechanism of faster nutrient appearance in blood.

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Objective: To describe patients with NSAID-DILI, including genetic factors associated with idiosyncratic DILI.

Methods: In DILIN, subjects with presumed DILI are enrolled and followed for at least 6 months. Causality is adjudicated by a Delphic approach.

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The bidirectional communication between the gut and brain or gut-brain axis is regulated by several gut microbes and microbial derived metabolites, such as short-chain fatty acids, trimethylamine N-oxide, and lipopolysaccharides. The Gut microbiota (GM) produce neuroactives, specifically neurotransmitters that modulates local and central neuronal brain functions. An imbalance between intestinal commensals and pathobionts leads to a disruption in the gut microbiota or dysbiosis, which affects intestinal barrier integrity and gut-immune and neuroimmune systems.

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Exploring the need for reconsideration of trial design in perioperative outcomes research: a narrative review.

EClinicalMedicine

April 2024

Nottingham Digestive Diseases Centre, Division of Translational Medical Sciences, School of Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom.

Unlabelled: "Enhanced recovery after surgery" is a multimodal effort to control perioperative pathophysiology and improve outcome. However, despite advances in perioperative care, postoperative complications and the need for hospitalisation and prolonged recovery continue to be challenging. This is further complicated by procedure-specific and patient-associated risk factors, given the increase in the number of elderly and frail patients with multiple comorbidities undergoing surgery.

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Use of Magnetic Resonance Imaging for Visualization of Oral Dosage Forms in the Human Stomach: A Scoping Review.

Mol Pharm

April 2024

Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham NG7 2UH, U.K.

Oral dosage forms are the most widely and frequently used formulations to deliver active pharmaceutical ingredients (APIs), due to their ease of administration and noninvasiveness. Knowledge of intragastric release rates and gastric mixing is crucial for predicting the API release profile, especially for immediate release formulations. However, knowledge of the intragastric fate of oral dosage forms to date is limited, particularly for dosage forms administered when the stomach is in the fed state.

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