2 results match your criteria: "Nottingham City Hospital National Health Service Trust[Affiliation]"
Tubular carcinoma of the breast: further evidence to support its excellent prognosis.
J Clin Oncol
January 2010
FRCPath, Molecular Medical Sciences, University of Nottingham, Department of Histopathology, Nottingham City Hospital National Health Service Trust, Hucknall Rd, Nottingham, NG5 1PB, United Kingdom.
PURPOSE Although tubular carcinoma (TC) is known to have a favorable prognosis, it is still unknown whether this subtype represents a distinct type of breast carcinoma or whether it behaves like other low-grade luminal A-type breast carcinomas. METHODS In this study, we performed a retrospective analysis of a large well-characterized series of breast cancers (2,608 carcinomas) to assess the clinicopathologic and molecular features and prognostic value of TC compared with grade 1 ductal carcinomas of the breast. Results When compared with grade 1 ductal carcinoma (n = 212), TC (n = 102) was more likely to be detected on mammographic screening, had smaller median size, and less frequently showed lymphovascular invasion.
View Article and Find Full Text PDFInfluence of E-cadherin expression on the mammographic appearance of invasive nonlobular breast carcinoma detected at screening.
Radiology
October 2009
Department of Histopathology, Nottingham City Hospital National Health Service Trust, Nottingham Breast Institute, University of Nottingham, Hucknall Road, NG5 1PB Nottingham, England.
Purpose: To determine whether E-cadherin loss causes nonlobular cancers (NLCs) detected at mammographic screening to have different mammographic appearances than do NLCs with normal E-cadherin expression.
Materials And Methods: This study design had hospital ethics committee approval; informed consent was waived. Membranous expression of E-cadherin was assessed immunohistochemically in patients younger than 70 years from a consecutive series of 1944 operable invasive breast cancers.