Prediction of Novel Drug Targets and Vaccine Candidates against Human Lice (Insecta), Acari (Arachnida), and Their Associated Pathogens.

The emergence of drug-resistant lice, acari, and their associated pathogens (APs) is associated with economic losses; thus, it is essential to find new appropriate therapeutic approaches. In the present study, a subtractive proteomics approach was used to predict suitable therapeutics against these vectors and their infectious agents. We found 9701 proteins in the lice ( var.

Bovine Leukaemia Virus: Current Epidemiological Circumstance and Future Prospective.

Bovine leukaemia virus (BLV) is a deltaretrovirus that is closely related to human T-cell leukaemia virus types 1 and 2 (HTLV-1 and -2). It causes enzootic bovine leukosis (EBL), which is the most important neoplastic disease in cattle. Most BLV-infected cattle are asymptomatic, which potentiates extremely high shedding rates of the virus in many cattle populations.

Cynaroside inhibits Leishmania donovani UDP-galactopyranose mutase and induces reactive oxygen species to exert antileishmanial response.

Cynaroside, a flavonoid, has been shown to have antibacterial, antifungal and anticancer activities. Here, we evaluated its antileishmanial properties and its mechanism of action through different in silico and in vitro assays. Cynaroside exhibited antileishmanial activity in time- and dose-dependent manner with 50% of inhibitory concentration (IC50) value of 49.

Triaxial Accelerometer-Based Falls and Activities of Daily Life Detection Using Machine Learning.

The detection of activities of daily living (ADL) and the detection of falls is of utmost importance for addressing the issue of serious injuries and death as a consequence of elderly people falling. Wearable sensors can provide a viable solution for monitoring people in danger of falls with minimal external involvement from health or care home workers. In this work, we recorded accelerometer data from 35 healthy individuals performing various ADLs, as well as falls.

The effect of ethanol vapour exposure on atrial and ventricular walls of chick embryos.

Objective: To study the effects of ethanol vapour exposure on atrial and ventricular walls of heart in chick embryo.

Methods: The study design was experimental, conducted at Islamabad Centre of College of Physicians and Surgeons, Pakistan. One hundred and eighty chicken eggs were divided into two groups, experimental and control, of 90 eggs each.