Thermosensitive injectable dual drug-loaded chitosan-based hybrid hydrogel for treatment of orthopedic implant infections.

A myriad of therapeutic agents and drug delivery systems are available to the surgeons for treating orthopedic implant-associated infections (OIAI), but only very few have demonstrated their effectiveness in preventing bacteria colonization and biofilm formation due to challenges in the local and sustainable therapeutic release. To address this issue, in this work, a thermosensitive injectable hydrogel based on chitosan (CH)-integrated hydroxyapatite nanoparticles (HAP NPs) containing vancomycin (Van) and quercetin (QC)-loaded in F127 micelles (CH-HAP-FQ-Van hydrogel) was fabricated with potential application in the treatment of OIAI. This dual drug delivery system demonstrated a pH-sensitive drug release pattern.

Evasive actions to prevent pedestrian collisions in varying space/time contexts in diverse urban and non-urban areas.

This study aims to identify driver-safe evasive actions associated with pedestrian crash risk in diverse urban and non-urban areas. The research focuses on the integration of quantitative methods and granular naturalistic data to examine the impacts of different driving contexts on transportation system performance, safety, and reliability. The data is derived from real-life driving encounters between pedestrians and drivers in various settings, including urban areas (UAs), suburban areas (SUAs), marked crossing areas (MCAs), and unmarked crossing areas (UMCAs).

Isolation of cellulose nanofibers from rapeseed straw via chlorine-free purification method and its application as reinforcing agent in carboxymethyl cellulose-based films.

In this study, cellulose nanofibers (CNFs) were successfully isolated from rapeseed straw (RS) whose valorization has been rarely investigated to date. A combined bleaching method without chlorine was applied for the purification of cellulose fibers, previously unexplored for RS. Chemical composition analysis and Fourier-transform infrared spectroscopy (FTIR) indicated that the purification method eliminated hemicellulose and reduced lignin content from 24.

A novel technique for solving unsteady three-dimensional brownian motion of a thin film nanofluid flow over a rotating surface.

The motion of the fluid due to the swirling of a disk/sheet has many applications in engineering and industry. Investigating these types of problems is very difficult due to the non-linearity of the governing equations, especially when the governing equations are to be solved analytically. Time is also considered a challenge in problems, and times dependent problems are rare.

Fabrication of an ultra-sensitive electrochemical DNA biosensor based on CT-DNA/NiFeONPs/Au/CPE for detecting rizatriptan benzoate.

A novel and first electrochemical biosensor based on Deoxyribonucleic acid (DNA) as a biological component to measure an antimigraine drug, rizatriptan benzoate (RZB) for patients under treatment in biological samples was developed. A carbon paste electrode (CPE) was modified by calf thymus (CT) double-stranded (ds)-DNA, nickel ferrite magnetic nanoparticles (NiFeONPs), and gold nanoparticles (AuNPs). The morphology of the CT-DNA/NiFeONPs/AuNPs/CPE was characterized by Field emission scanning electron microscope (FESEM).

Comparison of the dried properties of Ganoderma lucidum produced by the convective dryer and infrared dryer.

Ganoderma lucidum is a promising medicine with a high amount of antioxidants and calcium. The selection of appropriate drying process methods in food science has a chief role to reach the best final characteristics. This study aimed to investigate the effects of air velocity and temperature in the convective dryer, sample distance, and infrared power in infrared dryers on the drying kinetics and quality of Ganoderma lucidum slices.

Design a novel internally illuminated mirror photobioreactor to improve microalgae production through homogeneous light distribution.

In this study, a novel internally illuminated mirror photobioreactor (IIM-PBR) was designed to improve microalgae biomass production through providing a homogenous light distribution in cultivation medium. The performance of the IIM-PBR was compared with internally illuminated control photobioreactor (IIC-PBR) and externally illuminated control photobioreactor (EIC-PBR) in terms of cell growth, wastewater treatment and bioproducts generation. Compared with the IIC-PBR and EIC-PBR, the IIM-PBR increased microalgae growth rate up to 60 % and 30%, respectively.

Development of Plantago ovata seed mucilage and xanthan gum-based edible coating with prominent optical and barrier properties.

This study investigates the fabrication of edible coating based on Plantago ovata seed mucilage (POSM). The films were prepared from POSM (1 %, w/v), glycerol (75 %, based on POSM mass), and xanthan gum (XG: 20, 30 and 40 %, based on POSM mass) by a casting method, and their physicochemical, mechanical, thermal, morphological, and barrier properties were determined. Results indicated the development of highly transparent (transparency values: 1.

Numerical simulation for impact of implement of reflector and turbulator within the solar system in existence of nanomaterial.

Turbulent flow of oil based hybrid nanofluid within an absorber tube of concentrated solar system has been evaluated in this article. To concentrate the solar irradiation, the parabolic plate has been located below the tube and variable heat flux was considered as the boundary condition of the tube. The presence of a turbulator within the circular tube causes secondary flow to increase.

Immune checkpoint inhibitors promising role in cancer therapy: clinical evidence and immune-related adverse events.

The advent of immune checkpoint inhibitors (ICIs) has led to noteworthy progressions in the management of diverse cancer types, as evidenced by the pioneering "ipilimumab" medication authorized by US FDA in 2011. Importantly, ICIs agents have demonstrated encouraging potential in bringing about transformation across diverse forms of cancer by selectively targeting the immune checkpoint pathways that are exploited by cancerous cells for dodging the immune system, culminating in progressive and favorable health outcomes for patients. The primary mechanism of action (MOA) of ICIs involves blocking inhibitory immune checkpoints.

An environmentally friendly approach for industrial wastewater treatment and bio-adsorption of heavy metals using Pistacia soft shell (PSS) through flocculation-adsorption process.

In this research, the potential application of Pistacia soft shell (PSS) was investigated as a novel bio-based flocculant for pulp and paper wastewater (PPWW) treatment. In line with this, after characterization of the PSS, the removal efficiencies of chemical oxygen demand (COD), turbidity and heavy metals (Cu and Pb) from PPWW were investigated with different dosage of PSS. The results were compared with alum as a reference flocculant.

The influence of sac centreline on saccular aneurysm rupture: computational study.

The geometric characteristics of a saccular aneurysm play a crucial role in its rupturing. This article thoroughly investigates the impact of the sac centerline on aneurysm rupture, with a focus on identifying significant factors related to rupture at different time intervals. The study employs comprehensive computational simulations of six models of the ICA with varying coiling porosities and blood HCTs, using CFD analysis to examine WSS, OSI, pressure, and velocity within the saccular aneurysm for different sac centerlines.

Modeling and experimental investigation of the effect of carbon source on the performance of tubular microbial fuel cell.

Microbial fuel cells (MFCs) serve two main purposes: clean energy production and wastewater treatment. This study examines the impact of different carbon sources on MFC performance and develops a mathematical model to replicate the polarization curve. The biological reactor employed three types of carbon sources: glucose as a simple feed, microcrystalline cellulose (MCC), and a slurry of the organic component of municipal solid waste (SOMSW) as complex feeds.

The HAN method for a thermal analysis of forced non-Newtonian MHD Reiner-Rivlin viscoelastic fluid motion between two disks.

In this article, the semi-analytical technique of the Hybrid Analytical and Numerical Method (the HAN Method) is used to study the non-transient forced non-Newtonian MHD Reiner-Rivlin viscoelastic fluid motion that is constrained between two plates. The magnetic field is also present in this model. The governing equations are in the PDE form and by using the Von Kármán similarity variables, they transformed into a set of ODEs.

On the possibility of using waste disposable gloves as recycled fibers in sustainable 3D concrete printing using different additives.

Due to the Covid-19 pandemic, using large amounts of personal protective equipment (PPE) throughout the world has extensively increased in recent years. The lack of a practical method to dispose of these recycled materials is one of the main concerns of researchers. Hence, comprehensive experimental tests were conducted in the present study to investigate the feasibility of using disposable gloves in mortars to achieve a sustainable mixture.

New horizon in fuzzy distributions: statistical distributions in continuous domains generated by Choquet integral.

In this paper, some statistical properties of the Choquet integral are discussed. As an interesting application of Choquet integral and fuzzy measures, we introduce a new class of exponential-like distributions related to monotone set functions, called , by combining the properties of Choquet integral with the exponential distribution. We show some famous statistical distributions such as gamma, logistic, exponential, Rayleigh and other distributions are a special class of Choquet distributions.

Multi-objective home health care routing: a variable neighborhood search method.

Health and convenience are two indispensable indicators of the society promotion. Nowadays, to improve community health levels, the comfort of patients and those in need of health services has received much attention. Providing Home Health Care (HHC) services is one of the critical issues of health care to improve the patient convenience.

Nickel-Cobalt Salen Organometallic Complexes Encapsulated in Mesoporous NaA Nanozeolite for Electrocatalytic Quantification of Ascorbic Acid and Paracetamol.

Goal of current study was fabrication of novel voltammetric nanosensor for the synchronize quantification of ascorbic acid (AA) and paracetamol (PAR) by nickel-cobalt salen complexes encapsulated in the supercages of NaA nanozeolite modified carbon paste electrode (NiCoSalenA/CPE). For this purpose, NiCoSalenA nanocomposite was firstly prepared and characterized by various methods. Also, cyclic voltammetry (CV), choronoamperometry (CHA) and differential pulse voltammetry (DPV) were utilized to evaluate performance of the modified electrodes.

Designing a dairy supply chain network considering sustainability and resilience: a multistage decision-making framework.

Unlabelled: The crucial role of sustainable development and resiliency strategies is undeniable in today's competitive market space, especially after the Coronavirus outbreak. Hence, this research develops a multistage decision-making framework to investigate the supply chain network design problem considering the sustainability and resiliency dimensions. In this way, the scores of the potential suppliers based on the sustainability and resilience dimensions were calculated using the MADM methods, and then, these scores were applied as inputs in the proposed mathematical model (the second stage), which determined which supplier should be selected.

Fabrication of a gradient AZ91-bioactive glass composite with good biodegradability.

This study used friction stir-back extrusion to fabricate the AZ91 + 3 wt% bioactive glass gradient composite wire. The microstructure, mechanical properties, and corrosion resistance of a material in a simulated body fluid were investigated. Three 2-mm diameter holes with varying hole patterns were drilled in the cross-section of the AZ91 rod to apply 3 wt % bioactive glass to the AZ91 matrix.

Design, synthesis, in vitro anti-α-glucosidase evaluations, and computational studies of new phthalimide-phenoxy-1,2,3-triazole-N-phenyl (or benzyl) acetamides as potential anti-diabetic agents.

An important target in the treatment of type 2 diabetes is α-glucosidase. Inhibition of this enzyme led to delay in glucose absorption and decrease in postprandial hyperglycemia. A new series of phthalimide-phenoxy-1,2,3-triazole-N-phenyl (or benzyl) acetamides 11a-n were designed based on the reported potent α-glucosidase inhibitors.

A novel brain source reconstruction using a multivariate mode decomposition.

. Brain source reconstruction through electroencephalogram is a challenging issue in brain research with possible applications in cognitive science as well as brain damage and dysfunction recognition. Its goal is to estimate the location of each source in the brain along with the signal being produced.

How do driving behavior and attitudes toward road safety vary between developed and developing countries? Evidence from Iran and the Netherlands.

Introduction: The rates of road traffic injuries and fatalities in developing countries are significantly higher than in developed countries. This study examines the differences in driving behavior, road safety attitudes, and driving habits between a developed country (the Netherlands) and a developing country (Iran), which bear major differences in terms of crash involvement per population.

Method: In this context, this study assesses the statistical association of crash involvement with errors, lapses, aggressive driving incidents, and non-compliance with traffic rules, attitudes, and habits.