Assessing the Long-Term Impact of Non-Surgical Rhinoplasty on Patient Satisfaction and Quality of Life: A Prospective Study Using FACE-Q.

Introduction: Non-surgical alternatives to rhinoplasty are gaining interest but, despite its popularity, research on the long-term psychological impact and post-rhinofiller patients' satisfaction is limited. This study evaluates patient-reported satisfaction and quality of life immediately after and 6 months post-non-surgical rhinoplasty using the FACE-Q questionnaire.

Patients And Methods: This prospective study was conducted from May 2023 to March 2024, involving 83 patients who underwent rhinofiller treatments for esthetic purposes.

A randomized comparison of bencycloquidium bromide, mometasone furoate and a combination for persistent allergic rhinitis.

Background: Moderate to severe persistent allergic rhinitis (AR) poses a substantial socioeconomic burden.

Objectives: We aimed to establish the superiority of bencycloquidium bromide (BCQB) nasal spray and BCQB combined with mometasone furoate nasal spray (MFNS) over MFNS alone in adults with moderate-to-severe persistent AR.

Methods: In this multicentre, randomised controlled clinical trial (NCT05038202), adults with moderate-to-severe persistent AR were randomly assigned to receive the BCQB, MFNS, or a combination treatment, for 4-week periods.

Impact of posterior septectomy on olfaction in endoscopic endonasal transsphenoidal surgery.

Background: Endoscopic endonasal transsphenoidal surgery is widely used to resect pituitary adenomas, yet its impact on olfactory function after resection of the posterosuperior nasal septum remains a concern. To optimize surgical techniques to preserve olfactory function, it is essential to understand the relationship between the extent of septal resection and olfactory outcomes.

Methods: This retrospective study analyzed 295 patients who underwent pituitary adenoma surgery.

Nanosystems at Nexus: Navigating Nose-to-Brain Delivery for Glioblastoma Treatment.

Glioblastoma multiforme (GBM) is considered to be one of the most devastating brain tumors with a shorter life expectancy. Several factors contribute to the dismal prognosis of GBM patients including the complicated nature of GBM, the ability of tumor cells to resist treatment, and the difficulty of delivering drugs to the brain because of barriers like the blood-brain barrier (BBB) and blood-tumor barrier (BTB). The unique challenges posed by the BBB in delivering therapeutic agents to the brain have led to the development of innovative nanotechnology-based approaches.

Contribution of paranasal sinus, chest, and abdomen/pelvis computed tomography in patients with febrile neutropenia.

Objective: Febrile neutropenia (FN) is a serious clinical event, associated with significant morbidity and mortality. Imaging has a central role in the identification of the fever cause. The study objectives were to assess abnormalities of potential infectious origin on paranasal sinus, chest and abdomen/pelvis CT scans performed during an episode of FN, in patients with or without specific clinical signs, and to evaluate their impact on the frequency of changes in treatment.

A Penetrable AAV2 Capsid Variant for Efficient Intravitreal Gene Delivery to the Retina.

Purpose: This study aimed to identify a novel recombinant adeno-associated virus (rAAV) capsid variant that can widely transfect the deep retina through intravitreal injection and to assess their effectiveness and safety in gene delivery.

Methods: By adopting the sequences of various cell-penetrating peptides and inserting them into the capsid modification region of AAV2, we generated several novel variants. The green fluorescent protein (GFP)-carrying variants were screened following intravitreal injection.

Neuroimmune signalling pathways in chronic rhinosinusitis with nasal polyps.

Purpose Of Review: To evaluate the role of neuroimmune signalling pathways in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP).

Recent Findings: The sinonasal mucosa is densely infiltrated by immune cells and neuronal structures that share an intimate spatial relationship within tissue compartments. Together, such neuroimmune units play a critical role in airway defence and homeostatic function.

Modifying reaction time tasks parameters in the automated IntelliCage identifies heightened impulsivity and impaired attention in the 3xTg-AD model of Alzheimer's disease.

Background: The 3xTg-AD transgenic mouse model of Alzheimer's disease (AD) is an important tool to investigate the relationship between development of pathological amyloid-β (Aβ) and tau, neuroinflammation, and cognitive impairments. Traditional behavioral tasks assessing aspects of learning and memory, such as mazes requiring spatial navigation, unfortunately suffer from several shortcomings, including the stress of human handling and not probing species-typical behavior. The automated IntelliCage system was developed to circumvent such issues by testing mice in a social environment while measuring multiple aspects of cognition.

Comparison of nasal swabs and handmade foam cubes for detecting equine herpesvirus 5 (EHV-5) by quantitative polymerase chain reaction (qPCR).

The control of equine respiratory infections is a biosecurity challenge. Respiratory viruses are often rapidly detected using quantitative polymerase chain reaction (qPCR) on nasal swabs. In the past, some laboratories developed handmade techniques to increase the amount of nasal secretions collected, without comparing them with nasal swabs when qPCR replaced the use of viral culture.

Human Nasal Turbinate-Derived Stem Cells for Tissue Engineering and Regenerative Medicine.

Mesenchymal stem cells (MSCs) are multipotent progenitor cells present in adult tissues that are recognized as promising candidates for cell therapy due to their ease of access, straightforward isolation, and capacity for bio-preservation with minimal loss of potency. However, the clinical application of MSCs faces significant challenges, such as donor site morbidity, underscoring the need for alternative sources. Recent studies have suggested that inferior turbinate tissues, which are commonly removed during turbinate surgery, may be a viable donor site for MSCs.

A Review of the Long-Term Efficacy of Submucosal Medpor Implantation for Empty Nose Syndrome: A Short Communication.

To evaluate the long-term effects of submucosal Medpor implants in patients with empty nose syndrome (ENS), using the Sinonasal Outcome Test (SNOT) score as a measure of clinical improvement. A comprehensive search of six databases was conducted up to October 2024. The analysis included studies that examined the impact of submucosal Medpor implants on refractory ENS symptoms, as assessed by various symptom-specific questionnaires.

Prolonged fecal shedding of replication-competent virus, lasting immune activation, and intestinal inflammation in a rhesus macaque after experimental SARS-CoV-2 infection.

Infection of an adult rhesus macaque with SARS-CoV-2 led to viral RNAemia in nose, throat, and lungs. The animal also presented extended fecal shedding of viral genomic and subgenomic messenger RNA and replication-competent virus for more than 3 weeks after infection. Positron emission tomography revealed increased intestinal glucose metabolism which was histologically related to inflammation of the ileum.

Feasibility of classification of drainage and river water quality using machine learning methods based on multidimensional data from a gas sensor array.

Objective: The aim of the study is to verify whether the electronic nose system - an array of 17 gas sensors with a signal analysis system - is a useful tool for the classification and preliminary assessment of the quality of drainage water.

Material And Methods: Water samples for analysis were collected in the Park Ludowy (People's Park), located next to the Bystrzyca River, near the city center of Lublin in eastern Poland. Drainage water was sampled at 4 different points.

Comparison of the inverted internal limiting membrane flap technique without versus with an autologous blood clot for treating macular hole-associated retinal detachment.

Background: To investigate the anatomical and functional outcomes of macular hole-associated retinal detachment (MHRD) after vitrectomy using the inverted internal limiting membrane (ILM) flap technique with autologous blood clot (ABC).

Methods: This retrospective observational study included 80 eyes with MHRD that underwent vitrectomy with ILM flap without (46 eyes) or with ABC (34 eyes). Fundus photography and optical coherence tomography were evaluated.

Cavernous Hemangioma of the External Auditory Canal Involving the Tympanic Membrane: Case Report and Literature Review.

Cavernous hemangiomas of the external auditory canal simultaneously affecting the tympanic membrane are extremely rare. Endoscopic otosurgery has been successfully used for resecting various ear lesions because of its wider surgical field of view and minimal trauma. We report the case of a 50-year-old male patient who presented with a 6-month history of left ear congestion.

A Novel Classification System for the Anatomical Variations of the Infraorbital Ethmoidal (Haller) Air Cells.

Infraorbital ethmoidal air cells (IOEAc) are ethmoidal cells that pneumatizes inferior to the orbital floor and lateral to a line parallel to the lamina papyracea. Studies have shown considerable anatomical variation with different extensions in humans. To identify and categorize the anatomical variations of the IOEAc creating a new, comprehensive variation classification system.

Comparison of the Efficacy of Endoscopic Continuous Perfusion Combined With Y-Shaped Incision and Microscopic Retroauricular Incision in the Treatment of Attic Cholesteatoma: A Randomized Prospective Study.

This study aimed to compare the efficacy of continuous perfusion of underwater bone grinding combined with a -shaped incision versus a microscopic posterior ear incision in the treatment of attic cholesteatoma. Clinical trials were prospective studies from the Northern Jiangsu People's Hospital. Adult patients with middle ear cholesteatoma requiring ear surgery agreed to participate between September 2019 and September 2023 (age > 18).

Radiofrequency Coblation Inferior Turbinoplasty with Modified UPPP for the Treatment of Obstructive Sleep Apnea-Hypopnea Syndrome.

To compare the efficacy of surgical treatment in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) involving a standalone modified uvulopalatopharyngoplasty (mUPPP) and radiofrequency coblation inferior turbinoplasty with mUPPP. In this study, a retrospective analysis of 79 OSAHS patients with inferior turbinate hypertrophy and oropharyngeal obstruction undergoing surgical treatment was performed. According to the different surgical methods, the patients were divided into 2 groups (Group A and Group B).

A Unique Case of Metastatic Oral Kaposi Sarcoma in an HIV-Negative Patient.

Kaposi's sarcoma (KS) is a tumor involving blood vessels and lymphatic tissue. It is caused by human herpes virus-8, typically in HIV infection in individuals with AIDS. There are 4 major types of KS including classic, endemic, immunosuppression, and AIDS-related.

Role of Free Flaps in Facial Burn Reconstructions.

Traditionally, burn reconstructions have been performed by the use of skin grafting or local flaps. Recently free flaps are being used with increasing frequency. Although not very common in the head neck region, free flaps are mostly used for secondary reconstructions of cervicofacial contractures.