30 results match your criteria: "Norway O.A.S.; and Methodist DeBakey Heart and Vascular Center[Affiliation]"
Medical Therapies for Heart Failure With Preserved Ejection Fraction.
Hypertension
January 2020
Universite de Lorraine, Inserm, Centre d'Investigations Cliniques-1433 and F-CRIN INI CRCT, Nancy, France (F.Z.).
Current cardiovascular pharmacotherapy targets maladaptive overactivation of the renin-angiotensin-aldosterone system (RAAS), which occurs throughout the continuum of cardiovascular disease spanning from hypertension to heart failure with reduced ejection fraction. Over the past 16 years, 4 prospective, randomized, placebo-controlled clinical trials using candesartan, perindopril, irbesartan, and spironolactone in patients with heart failure with preserved ejection fraction (HFpEF) failed to demonstrate increased efficacy of RAAS blockade added to guideline-directed medical therapy. We reappraise these trials and their weaknesses, which precluded statistically significant findings.
View Article and Find Full Text PDFInterobserver Variability in Applying American Society of Echocardiography/European Association of Cardiovascular Imaging 2016 Guidelines for Estimation of Left Ventricular Filling Pressure.
Circ Cardiovasc Imaging
December 2019
Methodist DeBakey Heart and Vascular Center, Center for Outcomes Research, Houston Methodist Research Institute, TX (S.F.N., M.A.C.-p., K.C.E.t., J.X.).
Background: Assessment of left ventricular (LV) filling pressure is among the important components of a comprehensive echocardiographic report. Previous studies noted wide limits of agreement using 2009 American Society of Echocardiography/European Association of Echocardiography guidelines, but reproducibility of 2016 guidelines update in estimating LV filling pressure is unknown.
Methods: Echocardiographic and hemodynamic data were obtained from 50 patients undergoing cardiac catheterization for clinical indications.
Genome-wide analysis yields new loci associating with aortic valve stenosis.
Nat Commun
March 2018
deCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.
Aortic valve stenosis (AS) is the most common valvular heart disease, and valve replacement is the only definitive treatment. Here we report a large genome-wide association (GWA) study of 2,457 Icelandic AS cases and 349,342 controls with a follow-up in up to 4,850 cases and 451,731 controls of European ancestry. We identify two new AS loci, on chromosome 1p21 near PALMD (rs7543130; odds ratio (OR) = 1.
View Article and Find Full Text PDFLetter by Smiseth and Nagueh et al Regarding Article, "Role of Diastolic Stress Testing in the Evaluation for Heart Failure With Preserved Ejection Fraction: A Simultaneous Invasive-Echocardiographic Study".
Circulation
July 2017
From Division of Cardiovascular and Pulmonary Diseases, Oslo University Hospital and University of Oslo, Norway (O.A.S.); and Methodist DeBakey Heart and Vascular Center, Houston Texas (S.F.N.).
Assessment of regional myocardial work in rats.
Circ Cardiovasc Imaging
February 2015
From the Institute for Experimental Medical Research (E.K.S.E., J.M.A., G.S.E., L.Z., I.S.) and Center for Cardiological Innovation (O.A.S., T.E., M.E.), Oslo University Hospital and University of Oslo, Oslo, Norway; KG Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway (E.K.S.E., G.S.E., L.Z., I.S.); Bjørknes College, Oslo, Norway (J.M.A.); Norwegian Institute of Public Health, Oslo, Norway (G.S.E.); and Department of Cardiology (O.A.S., T.E.) and Institute for Surgical Research (O.A.S., T.E., M.E.), Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Background: Left ventricular (LV) motion and deformation is dependent on mechanical load and do therefore not reflect myocardial energy consumption directly. Regional myocardial work, however, constitutes a more complete assessment of myocardial function.
Methods And Results: Strain was measured using high-resolution phase-contrast MRI in 9 adult male rats with myocardial infarction (MI) and in 5 sham-operated control animals.